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Figure 4 from: Bulbul MZH, Chowdhury TS, Misbah MMH, Ferdous J, Dey S, Hasan I, Fujii Y, Ozeki Y, Kawsar SMA (2021) Synthesis of new series of pyrimidine nucleoside derivatives bearing the acyl moieties as potential antimicrobial agents. Pharmacia 68(1): 23-34. https://doi.org/10.3897/pharmacia.68.e56543
Figure 4 MBC data for compounds 7, 9, and 14.
Figure 1 from: Bulbul MZH, Chowdhury TS, Misbah MMH, Ferdous J, Dey S, Hasan I, Fujii Y, Ozeki Y, Kawsar SMA (2021) Synthesis of new series of pyrimidine nucleoside derivatives bearing the acyl moieties as potential antimicrobial agents. Pharmacia 68(1): 23-34. https://doi.org/10.3897/pharmacia.68.e56543
Figure 1 Structure of the uridine (1).
Scheme 1 from: Vlasov SV, Borysov OV, Severina HI, Vlasov VS, Abu Sharkh AIM, Georgiyants VA (2024) Synthesis, in silico and in vitro antimicrobial activity of N-(benzyl)-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamides. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e110013
Scheme 1
Data from: Phenotypic antimicrobial resistance in Staphylococcus sp. and Enterococcus sp. isolated from surface water – a preliminary report
<p><span>Water as a vehicle of antimicrobial resistance (AMR) is a well-known phenomenon. Therefore, One Health inspired surveillance campaign to detect circulation of antimicrobial resistance through the ecosystem are very often based on investigation of water samples. Bacteria belonging to the genera <em>Staphylococcus</em> and <em>Enterococcus</em> are good models in One Health research because of their ubiquitous occurrence and effortless isolation techniques. In this study, we aimed to compare different types of water sources as potential spreaders of AMR staphylococci and enterococci in the ecosystem. For this reason, we took water samples from the Drava River and small waterholes in a forest area. We hypothesised that rivers could collect diverse bacteria and resistance from the catchment area, while forest waterholes gather bacterial contamination from the local wildlife, thus a less diverse resistant bacterial community characterise them. From 22 and 10 water samples, collected from waterholes and the Drava River active floodplain, we isolated 21 and 13 bacterial strains, respectively. The bacterial community of the river proved more diverse, while waterhole samples contained resistant bacteria to more antimicrobials. In waterhole samples, we detected two methicillin resistant coagulase negative Staphylococcus strains. The most conspicuous difference between the two habitats was the predominance of multidrug resistant <em>S. sciuri</em> in the forest waterholes. We could conclude that water could be a good indicator of AMR contamination of the ecosystem, and large-scale sampling could reveal the exact epidemiological role of different water habitats.</span></p>
Antimicrobial properties and cytotoxicity of LL37-derived syn-thetic peptides to treat orthopaedic infections
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Figure 4 from: Rupcic Z, Chepkirui C, Hernández-Restrepo M, Crous PW, Luangsa-ard JJ, Stadler M (2018) New nematicidal and antimicrobial secondary metabolites from a new species in the new genus, Pseudobambusicola thailandica. MycoKeys 33: 1-23. https://doi.org/10.3897/mycokeys.33.23341
Figure 4 COSY, HMBC and ROESY correlations of 1.
Figure 3 from: Rupcic Z, Chepkirui C, Hernández-Restrepo M, Crous PW, Luangsa-ard JJ, Stadler M (2018) New nematicidal and antimicrobial secondary metabolites from a new species in the new genus, Pseudobambusicola thailandica. MycoKeys 33: 1-23. https://doi.org/10.3897/mycokeys.33.23341
Figure 3 Chemical structures of thailanones A–F (1–6), monocerin (7) and deoxyphomalone (8).
Antimicrobial Action and Mechanism of Piscidin Against Helicobacter pylori
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Figure 8 from: Dadayan AS, Stepanyan LA, Sargsyan TH, Hovhannisyan AM, Dadayan SA (2021) Quantitative analysis of biologically active substances and the investigation of antioxidant and antimicrobial activities of some extracts of Osage orange fruits. Pharmacia 68(4): 731-739. https://doi.org/10.3897/pharmacia.68.e70180
Figure 8 Quantitative content of vitamin C in ethanol extract of Osage Orange.
Figure 7 from: Dadayan AS, Stepanyan LA, Sargsyan TH, Hovhannisyan AM, Dadayan SA (2021) Quantitative analysis of biologically active substances and the investigation of antioxidant and antimicrobial activities of some extracts of Osage orange fruits. Pharmacia 68(4): 731-739. https://doi.org/10.3897/pharmacia.68.e70180
Figure 7 Quantitative content of vitamin C in aqueous extract of Osage Orange.
Figure 3 from: Dadayan AS, Stepanyan LA, Sargsyan TH, Hovhannisyan AM, Dadayan SA (2021) Quantitative analysis of biologically active substances and the investigation of antioxidant and antimicrobial activities of some extracts of Osage orange fruits. Pharmacia 68(4): 731-739. https://doi.org/10.3897/pharmacia.68.e70180
Figure 3 Results of chromatography of organic acids in ethyl acetate extract of Osage Orange.
Figure 1 from: Dadayan AS, Stepanyan LA, Sargsyan TH, Hovhannisyan AM, Dadayan SA (2021) Quantitative analysis of biologically active substances and the investigation of antioxidant and antimicrobial activities of some extracts of Osage orange fruits. Pharmacia 68(4): 731-739. https://doi.org/10.3897/pharmacia.68.e70180
Figure 1 Results of chromatography of organic acids in aqueous extract of Osage Orange.
Figure 9 from: Dadayan AS, Stepanyan LA, Sargsyan TH, Hovhannisyan AM, Dadayan SA (2021) Quantitative analysis of biologically active substances and the investigation of antioxidant and antimicrobial activities of some extracts of Osage orange fruits. Pharmacia 68(4): 731-739. https://doi.org/10.3897/pharmacia.68.e70180
Figure 9 Quantitative content of vitamin C in ethyl acetate extract of Osage Orange.
Figure 2 from: Dadayan AS, Stepanyan LA, Sargsyan TH, Hovhannisyan AM, Dadayan SA (2021) Quantitative analysis of biologically active substances and the investigation of antioxidant and antimicrobial activities of some extracts of Osage orange fruits. Pharmacia 68(4): 731-739. https://doi.org/10.3897/pharmacia.68.e70180
Figure 2 Results of chromatography of organic acids in ethanol extract of Osage Orange.
Figure 4 from: Karpun Ye, Parchenko V, Fotina T, Demianenko D, Fotin A, Nahornyi V, Nahorna N (2021) The investigation of antimicrobial activity of some s-substituted bis-1,2,4-triazole-3-thiones. Pharmacia 68(4): 797-804. https://doi.org/10.3897/pharmacia.68.e65761
Figure 4 Visualization of 3D structure of the "ligand-enzyme" complex.
Figure 3 from: Karpun Ye, Parchenko V, Fotina T, Demianenko D, Fotin A, Nahornyi V, Nahorna N (2021) The investigation of antimicrobial activity of some s-substituted bis-1,2,4-triazole-3-thiones. Pharmacia 68(4): 797-804. https://doi.org/10.3897/pharmacia.68.e65761
Figure 3 Interaction network between the enzyme 4R4S and selected compounds.
Figure 1 from: Karpun Ye, Parchenko V, Fotina T, Demianenko D, Fotin A, Nahornyi V, Nahorna N (2021) The investigation of antimicrobial activity of some s-substituted bis-1,2,4-triazole-3-thiones. Pharmacia 68(4): 797-804. https://doi.org/10.3897/pharmacia.68.e65761
Figure 1 Algorithm of the research.
Aquaculture antimicrobial use point prevalence survey database legend
<p>Aquaculture antimicrobial use point prevalence survey database and legend accompanying https://doi.org/10.1038/s41598-020-78849-3</p>
A case for routine microbial diagnostics: Results from antimicrobial susceptibility testing in post-traumatic wound infections at a Ugandan tertiary care hospital
<p><strong>ABSTRACT</strong></p> <p>The global spread of antimicrobial resistance (AMR) is an increasing challenge for clinicians in Uganda, where microbiological diagnostics are not routinely available. The aim of this study was to determine pathogen prevalence and antibiotic resistance patterns in patients with wound infections following trauma at a national referral hospital in Kampala, Uganda. In addition, the suitability of currently used empirical treatment options in this setting was evaluated.</p> <p>This prospective, observational study analysed antimicrobial prescriptions, culture results and antimicrobial sensitivity testing (AST) of wound swabs and blood samples from patients with clinical signs of wound infections on the trauma ward.</p> <p>A total of 124 patients (n=99, 79.8% male) with a median age of 30 years (IQR 23-39) were enrolled between October 2021 and January 2022. Wound infections were classified as nosocomial in 69% of the cases. Pathogens were isolated from 122 wound swabs, yielding 238 bacterial isolates. The most prevalent pathogens were gram-negative bacteria including <em>Escherichia coli </em>(n=48, 20.2%) and <em>Acinetobacter </em>spp. (n=43, 18.1%). Empiric treatment consisted of ceftriaxone and gentamicin which was administered to 67.2% (n=78) and 62.1% (n=72) of patients, respectively. High rates of antimicrobial resistance could be demonstrated across gram-negative and gram-positive species towards the most common empiric antibiotics. Following the AST results, over 95% (n=111) of patients required a change of treatment.</p> <p>Our findings demonstrate that current empiric treatment for wound infections is missing its target in hospitalized patients in Kampala. Increased diagnostic capacity and structured antimicrobial stewardship are necessary to tackle the growing problem of AMR in Uganda.</p>
Interplay between strain fitness and transmission frequency determines prevalence of antimicrobial resistance
<p>Bogri A, Otani S, Aarestrup FM and Brinch C (2023) Interplay between strain fitness and transmission frequency determines prevalence of antimicrobial resistance. Front. Ecol. Evol. 11:981377. doi: 10.3389/fevo.2023.981377</p> <p>The folder contains all the simulations that were run in the above publication. Each subfolder corresponds to a simulation, and for navigation please refer to Supplementary Table 2. Within each subfolder you can find the Jupyter notebook with the python code used for the simulations, the resulting datasets, and the resulting figures. </p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.