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Dataset related to article "Manipulating Sirtuin 3 pathway ameliorates renal damage in experimental diabetes"
<p><em>The files contain raw data related to the article "Manipulating Sirtuin 3 pathway ameliorates renal damage in experimental diabetes", available from <a href="https://www.nature.com/articles/s41598-020-65423-0">https://www.nature.com/articles/s41598-020-65423-0</a>.</em></p> <p><strong>Abstract of the manuscript</strong>: More effective treatments for diabetic nephropathy remain a major unmet clinical need. Increased oxidative stress is one of the most important pathological mechanisms that lead to kidney damage and functional impairment induced by diabetes. Sirtuin 3 (SIRT3) is the main mitochondrial deacetylase and critically regulates cellular reactive oxygen species (ROS) production and detoxification. Honokiol is a natural biphenolic compound that, by activating mitochondrial SIRT3, can carry out anti-oxidant, anti-inflammatory and anti-fibrotic activities. Here, we sought to investigate the renoprotective effects of honokiol in BTBR <em>ob/ob</em> mice with type 2 diabetes. Diabetic mice were treated with vehicle or honokiol between the ages of 8 and 14 weeks. Wild-type mice served as controls. Renal <em>Sirt3</em> expression was significantly reduced in BTBR <em>ob/ob</em> mice, and this was associated with a reduction in its activity and increased ROS levels. Selective activation of SIRT3 through honokiol administration translated into the attenuation of albuminuria, amelioration of glomerular damage, and a reduction in podocyte injury. SIRT3 activation preserved mitochondrial wellness through the activation of SOD2 and the restoration of PGC-1α expression in glomerular cells. Additionally, the protective role of SIRT3 in glomerular changes was associated with enhanced tubular <em>Sirt3</em> expression and upregulated renal <em>Nampt</em> levels, indicating a possible tubule-glomerulus retrograde interplay, which resulted in improved glomerular SIRT3 activity. Our results demonstrate the hitherto unknown renoprotective effect of SIRT3 against diabetic glomerular disease and suggest that the pharmacological modulation of SIRT3 activity is a possible novel approach to treating diabetic nephropathy.</p>
Figure 2 from: Dupont S, Price B, Blagoderov V (2015) IMp: The customizable LEGO® Pinned Insect Manipulator. ZooKeys 481: 131-138. https://doi.org/10.3897/zookeys.481.8788
Figure 2 - The IMp model shown from a side view (A), front view (B), top view (C) and without the stabilizing case exposing the pivot arm wherein the specimen is placed (D). Figure labels and abbreviations: pivot handle (1), 8 tooth gear (2), worm gear (3), connector peg that holds and rotates the specimen (4), axis of movement 1 (A1), axis of movement 2 (A2), axis of rotation 1 (R1) and axis of rotation 2 (R2).
Figure 1 from: Dupont S, Price B, Blagoderov V (2015) IMp: The customizable LEGO® Pinned Insect Manipulator. ZooKeys 481: 131-138. https://doi.org/10.3897/zookeys.481.8788
Figure 1 - The four different sized manipulators shown for comparison: a Giant-IMp b IMp models with encasing support beams c Open-IMp d Micro-IMp models that are not encased. The specimens in the manipulators are: a Nosa tristis (Hagen, 1853) – Neuroptera: Myrmeleontidae b Perissoneura paradoxa McLachlan, 1871 – Trichoptera: Odontoceridae c Pteronarcys californica Newport, 1848 – Plecoptera: Pteronarcyidae and d Psychopsis coelivaga (Walker, 1853) – Neuroptera: Psychopsidae.
Figure 3 from: Dupont S, Price B, Blagoderov V (2015) IMp: The customizable LEGO® Pinned Insect Manipulator. ZooKeys 481: 131-138. https://doi.org/10.3897/zookeys.481.8788
Figure 3 - Two options for the modification to the connector pegs (b) to allow for insertion of the specimen pin: a 3 mm diameter tube with 0.1 mm nylon fibers (a+b); or a small plastazote plug (b+c).
The effect of temporal changes in stamen position on reproductive success in flowers with many stamens: experimental manipulations of stamen position
<p class="MsoNormal"><span><strong>Premise of the study</strong>: </span><span>Male and female reproductive success is enhanced (increased outcrossing and seed production) by stamen movement</span><span> in species that have few stamens per flower.</span><span> Does such enhancement also occur in species that have many stamens per flower?</span></p> <p class="MsoNormal"><span><strong>Methods</strong>: </span><span>We examined the effects of stamen movement on male and female reproductive success in <em>Anemone flaccida</em>, which has </span><span>many stamens</span><span> per flower. We measured stamen movement, including temporal changes in anther-stigma and anther-anther distances. We controlled stamen movement experimentally.</span></p> <p class="MsoNormal"><span><strong>Key results</strong>: </span><span>The anthers moved horizontally away from the stigmas with increasing flower age, resulting in reduction in female-male interference. The dehisced anthers tended to move further away from the stigmas while the undehisced or dehiscing anthers remained nearer to them. The number of anthers touched per flower visit was higher in flowers whose stamens were fixed in the pre-movement position than in flowers whose stamens were fixed in the post-movement position or in flowers that were not manipulated. Thus, this position may promote male reproductive success. Seed production was lower for the untreated flowers than for the post-movement position flowers, suggesting that the post-movement stamen position is advantageous and stamen movement is suboptimal for female reproductive success.</span></p> <p class="MsoNormal"><span><strong>Conclusions</strong>: </span><span>Stamen movement promotes male reproductive success in the early flowering stage and female reproductive success in the late flowering stage. In species having many stamens per flower, female-male interference can be reduced, but not eliminated, by stamen movement due to the conflict between female and male reproductive successes.</span></p>
Dual clumped isotope analyses and model calculations constrain equilibrium, experimentally-manipulated kinetic isotope effects, and mixing effects in calcite
<p>Replicate data for standards and samples; XRD data. </p>
Data_Manipulation
<p>The dataset from Kaggel.This work is part of a Data Engineering Course</p>
Diabetes_Data_Engineering(Manipulation)
<p>Make tutorial of how to read, structure, and manipulate dataset, using pandas.</p>
A loop-type modular soft robot with integrated locomotion and manipulation capability
<p>Modular Soft Robot.</p>
Fig. 10 in Chemical epigenetic manipulation triggers the production of sesquiterpenes from the deep-sea derived Eutypella fungus
Fig. 10. ECD spectra of the Mo2(AcO)4 complex of 9 (A) and 16 (B) in DMSO.
Fig. 7 in Chemical epigenetic manipulation triggers the production of sesquiterpenes from the deep-sea derived Eutypella fungus
Fig. 7. ΔδH (δRS = δR ‒ δS) values of MPA esters of 3, 4, 7, 8, and 10.
Fig. 4 in Chemical epigenetic manipulation triggers the production of sesquiterpenes from the deep-sea derived Eutypella fungus
Fig. 4. Experimental ECD spectra of 1‒5 and 18 in MeOH.
Fig. 3 in Chemical epigenetic manipulation triggers the production of sesquiterpenes from the deep-sea derived Eutypella fungus
Fig. 3. Key NOE correlations of 1, 6, and 13–15.
Fig. 6 in Chemical epigenetic manipulation triggers the production of sesquiterpenes from the deep-sea derived Eutypella fungus
Fig. 6. Production of 2a and 2b and the ΔδH (δR ‒ δS) values of 2c and 2d.
Fig. 2 in Chemical epigenetic manipulation triggers the production of sesquiterpenes from the deep-sea derived Eutypella fungus
Fig. 2. Key COSY and HMBC correlations of 1, 6, and 13–15.
Fig. 8 in Chemical epigenetic manipulation triggers the production of sesquiterpenes from the deep-sea derived Eutypella fungus
Fig. 8. Experimental and calculated ECD spectra of 6, 11, 12, and 15 in MeOH.
Fig. 1 in Chemical epigenetic manipulation triggers the production of sesquiterpenes from the deep-sea derived Eutypella fungus
Fig. 1. Structures of sesquiterpenes 1–21.
Fig. 13 in Chemical epigenetic manipulation triggers the production of sesquiterpenes from the deep-sea derived Eutypella fungus
Fig. 13. Putative biogenetic relationships of the sesquiterpenes.
Fig. 12 in Chemical epigenetic manipulation triggers the production of sesquiterpenes from the deep-sea derived Eutypella fungus
Fig. 12. Key NOE correlations of 16 and 17.
Effect of Uterine Manipulator on Recurrence and Mortality of Endometrial Cancer
ClinicalTrials.gov study NCT02943811. IPD Sharing: NO. Countries: 0. Publications: 2.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.