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opennotspecifiedJun 2022View details →

Fig. 4 in Structures and neuroprotective activities of triterpenoids from Cynomorium coccineum subsp. songaricum (Rupr.) J. Leonard

Fig. 4. Neuroprotective effects against (A) Glu-induced and (B) OGD-induced SK-N-SH cell death of compounds isolated from C. coccineum subsp. songaricum. Donepezil (10 μM) or samples pretreated the cells for up to 1 h in a1/b1 subsets, whereas in a2/b2 subsets, donepezil (3 μM) or samples pretreated the cells for up to 4 h. The viability rate indicated a mean ± SD (n = 3), calculated as (ODOD)/(ODOD) × 100% with #P <0.05, ##P

Fig. 7 in Xylarinaps A-E, five pairs of naphthalenone derivatives with neuroprotective activities from Xylaria nigripes

Fig. 7. Effects of compounds 1–5 on SOD in OGD-induced PC12 cells. The values represent mean ± SD (n = 6). *P <0.05, **P <0.01 vs. the control group; #P <0.05, ##P <0.01 vs. the model group.

Fig. 8 in Xylarinaps A-E, five pairs of naphthalenone derivatives with neuroprotective activities from Xylaria nigripes

Fig. 8. Effects of compounds 1–5 on MDA in OGD-induced PC12 cells. The values represent mean ± SD (n = 6). *P <0.05, **P <0.01 vs. the control group; #P <0.05, ##P <0.01 vs. the model group.

Fig. 10 in Xylarinaps A-E, five pairs of naphthalenone derivatives with neuroprotective activities from Xylaria nigripes

Fig. 10. Effects of compounds 1–5 on OGD-induced apoptosis of PC12 cells. (A) Apoptosis of PC12 cells detected by Hochest staining. (B) Apoptosis rate of PC12 cells for compounds 1–5. The values represent mean ± SD (n = 6). *P <0.05, **P <0.01 vs. the control group; #P <0.05, ##P <0.01 vs. the model group.

Fig. 9 in Xylarinaps A-E, five pairs of naphthalenone derivatives with neuroprotective activities from Xylaria nigripes

Fig. 9. Effects of compounds 1–5 on GSH-Px in OGD-induced PC12 cells. The values represent mean ± SD (n =6). *P <0.05, **P <0.01 vs. the control group; #P <0.05, ##P <0.01 vs. the model group.

Fig. 6 in Xylarinaps A-E, five pairs of naphthalenone derivatives with neuroprotective activities from Xylaria nigripes

Fig. 6. Effects of compounds 1–5 on cell viability in OGD-induced PC12 cells. The values represent mean ± SD (n = 6). *P <0.05, **P <0.01 vs. the control group; #P <0.05, ##P <0.01 vs. the model group.

opencc-by-4.0Aug 2023View details →

Master data of the article "Effect of ethanol extract of nigella sativa L seeds and propofol on BDNF protein level as neuroplasticity and neuroprotection of traumatic brain injury in rats"

<p><strong>Master data of the article "Effect of ethanol extract of nigella sativa L seeds and propofol on BDNF protein level as neuroplasticity and neuroprotection of traumatic brain injury in rats"</strong></p>

Fig. 6 in Lignans and neolignans with isovaleroyloxy moiety from Solanum lyratum Thunb.: Chiral resolution, configurational assignment and neuroprotective effects

Fig. 6. The neuroprotective effects of 1a/1b, 2a/2b, 3, 4a/4b-9a/9b on H2O2-induced (180 μM) human neuroblastoma SH-SY5Y cell damage. The percentage of surviving cells was presented as the percentage of viable cells compared to the control group (cell viability 100%). Trolox was used as a positive control.

Fig. 7. Compounds 1a, 1b, 4a and 4b reduced H2O2-induced apoptosis. The cells were treated with 1a, 1b, 4a and 4b in Lignans and neolignans with isovaleroyloxy moiety from Solanum lyratum Thunb.: Chiral resolution, configurational assignment and neuroprotective effects

Fig. 7. Compounds 1a, 1b, 4a and 4b reduced H2O2-induced apoptosis. The cells were treated with 1a, 1b, 4a and 4b at 50 μM for 48 h. The nuclear changes were determined by Hoechst 33258 staining observed with a fluorescence microscope. Arrows: apoptotic cells. Scale bar: 50 μm.

Fig. 5 in Lignans and neolignans with isovaleroyloxy moiety from Solanum lyratum Thunb.: Chiral resolution, configurational assignment and neuroprotective effects

Fig. 5. The chemical shift differences of H-9a and H-9b for compounds 6 and 7 in different deuterated solvents.

Fig. 9. Compounds 1a, 1b, 4a and 4b in Lignans and neolignans with isovaleroyloxy moiety from Solanum lyratum Thunb.: Chiral resolution, configurational assignment and neuroprotective effects

Fig. 9. Compounds 1a, 1b, 4a and 4b reduced mitochondrial dysfunction in H2O2-induced SH-SY5Y cells. Cells were pretreated with 1a, 1b, 4a and 4b (50 μM), then treated with H2O2 (400 μM) for 4h. The loss of Δψm was determined by JC-1 staining.

Fig. 8 in Lignans and neolignans with isovaleroyloxy moiety from Solanum lyratum Thunb.: Chiral resolution, configurational assignment and neuroprotective effects

Fig. 8. Flow cytometry was used to detect apoptotic cells based on the Annexin V-FITC/PI double staining. Cells were pretreated with 1a, 1b, 4a and 4b (50 μM), then treated with H O (400 μM) for 4 h. Data were shown as mean � SD from three separate experiments. ##P 0.01 compared with the control group, **P 0.01, 2 2 <<*P <0.05 compared with the H2O2 group.

Fig. 8 in Guaiane-type sesquiterpenoids from the roots of Stellera chamaejasme L. and their neuroprotective activities

Fig. 8. Neuroprotective effects of 1–16 on H2O2-induced damage of human neuroblastoma SH-SY5Y cells. The percentage of surviving cells is presented as the percentage of viable cells compared to the control group (cell viability 100%). All data are presented as the means ± SD of three independent experiments. *p <0.05, **p <0.01, ***p <0.001 compared with the model.

Fig. 5 in Guaiane-type sesquiterpenoids from the roots of Stellera chamaejasme L. and their neuroprotective activities

Fig. 5. The calculated and experimental ECD curves of compounds 1–4 and 6–9 at B3LYP/6-31G(d)//B3LYP/6–311++ G(2d,p) level.

Fig. 9 in Guaiane-type sesquiterpenoids from the roots of Stellera chamaejasme L. and their neuroprotective activities

Fig. 9. Flow cytometry analysis of the protective effect of 13 on H2O2-induced (400 μM) SH-SY5Y cell apoptosis. All data were presented as the mean ± SD (n = 3). **p <0.05 compared with the control group. #p <0.1 compared with the H O group.

Fig. 2 in Guaiane-type sesquiterpenoids from the roots of Stellera chamaejasme L. and their neuroprotective activities

Fig. 2. Key HMBC correlations (blue) of compounds 1–9 (Magenta line represents part A, red line represents part B, and green line represents part C). (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)