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2,642 results for “blindness”
This Was an Open-label, Single-arm Extension Study (CFTY720D2306E1) to a Double-blind, Randomized Multicenter, Placebo-controlled, Parallel-group Core Study (CFTY720D2306) in PPMS.
ClinicalTrials.gov study NCT00731692. IPD Sharing: UNDECIDED. Countries: 18. Publications: 7.
A Randomized, Double-blind Controlled Study Comparing LCZ696 to Medical Therapy for Comorbidities in HFpEF Patients
ClinicalTrials.gov study NCT03066804. IPD Sharing: YES. Countries: 32. Publications: 1.
A Multinational, Randomized, Double-blind, Placebo-controlled Study to Assess the Efficacy, Pharmacodynamics, Pharmacokinetics, and Safety of Venglustat in Late-onset GM2
ClinicalTrials.gov study NCT04221451. IPD Sharing: YES. Countries: 13. Publications: 1.
A Multi-part, Double Blind Study to Assess Safety, Tolerability and Efficacy of Tropifexor (LJN452) in PBC Patients
ClinicalTrials.gov study NCT02516605. IPD Sharing: YES. Countries: 6. Publications: 1.
Evolution of a central dopamine circuit underlies adaptation of light-evoked sensorimotor response in the blind cavefish, <em>Astyanax mexicanus</em>
Open the record for dataset details and reuse information.
The effects of a clinically feasible application of low-level laser therapy on the rate of orthodontic tooth movement: A triple-blinded split-mouth randomized controlled clinical trial.
<p>Dataset for all study's analyses.</p>
Social-like responses are inducible in the asocial and blind Mexican cavefish despite the continued exhibition of strong repetitive behavior
<p>Demo code and demo video files for the manuscript of "Social-like responses are inducible in the asocial and blind Mexican cavefish despite the continued exhibition of strong repetitive behavior." This zip file contains three folders, representing (1) ImageJ script for background subtraction; (2) python script to adjust swapped IDs in the result of idTracker analysis; and (3) MatLab script for detecting the social interactions</p>
Data from: Retinotopic-like maps of spatial sound in primary 'visual' cortex of blind human echolocators
The functional specialisations of cortical sensory areas were traditionally viewed as being tied to specific modalities. A radically different emerging view is that the brain is organized by task rather than sensory modality, but it has not yet been shown that this applies to primary sensory cortices. Here we report such evidence by showing that primary 'visual' cortex can be adapted to map spatial locations of sound in blind humans who regularly perceive space through sound echoes. Specifically, we objectively quantify the similarity between measured stimulus maps for sound eccentricity and predicted stimulus maps for visual eccentricity in primary 'visual' cortex (using a probabilistic atlas based on cortical anatomy) to find that stimulus maps for sound in expert echolocators are directly comparable to those for vision in sighted people. Furthermore, the degree of this similarity is positively related with echolocation ability. We also rule out explanations based on top-down modulation of brain activity – e.g. through imagery. This result is clear evidence that task-specific organization can extend even to primary sensory cortices, and in this way is pivotal in our reinterpretation of the functional organisation of the human brain.
A blinded, controlled trial of objective measurement in Parkinson's disease
<p>Medical conditions with effective therapies are usually managed with objective measurement and therapeutic targets. Parkinson's disease has effective therapies, but continuous objective measurement has only recently become available. This blinded, controlled study examined whether management of Parkinson's disease was improved when clinical assessment and therapeutic decisions were aided by objective measurement. The primary endpoint was improvement in the Movement Disorder Society-United Parkinson's Disease Rating Scale's (MDS-UPDRS) Total Score. In one arm, objective measurement assisted doctors to alter therapy over successive visits until objective measurement scores were in target. Patients in the other arm were conventionally assessed and therapies were changed until judged optimal. There were 75 subjects in the objective measurement arm and 79 in the arm with conventional assessment and treatment. There were statistically significant improvements in the moderate clinically meaningful range in the MDS-UPDRS Total, III, IV scales in the arm using objective measurement, but not in the conventionally treated arm. These findings show that global motor and non-motor disability is improved when the management of Parkinson's disease is assisted by objective measurement.</p>
Blind Gothic Portal
**map/mapa:** https://mapy.cz/s/dabeborane original model: 2,761,611tris original texture: 20,000px mysteryous insription :) https://drive.google.com/file/d/1j5hEUHVqzj6MzExdg_8t06qL2XxHaXG7/view?usp=sharing Source: Objaverse 1.0 / Sketchfab
CPDP blind biforium type 2a
Realized within the project of the sourced-based reconstruction of the New Synagogue in Wroclaw/Breslau (Poland). Link to the 3D model documentation: http://www.vfu-oppler.hs-mainz.de/en/wisski/navigate/4933/view?wisski_bundle=b0c45007d4aaa61f5961be4fb6902a6b. Supported by »The German Federal Government Commissioner for Culture and the Media « (02/2018-11/2019) and »The Foundation for Polish-German Cooperation« (05/2018). Magnified by https://architekturinstitut.hs-mainz.de/. Published under CC-BY-NC-SA 4.0. Source: Objaverse 1.0 / Sketchfab
De Blinde / The Blind by Rudolph Tegner
1949, cast in 1963 Tegners last, unfinished sculpture. Located at Rudolph Tegners Museum and Statue Park in Denmark. 250 shots in Polycam on Iphone 13. Source: Objaverse 1.0 / Sketchfab
A common mechanism for perceptual reversals in motion-induced blindness, the Troxler effect and perceptual filling-in
<p>This is a www.zenodo.org data upload for publication:</p> <p>Devyatko, Appelbaum and Mitroff (2016) A common mechanism for perceptual reversals in motion-induced blindness, the Troxler effect and perceptual filling-in. Perception. </p>
Pocket watch for the blind
The presented pocket watch told the time without the need to look at the dial. The front of the case takes the form of a lid with a convex arrow and was used as a dial. From the clockwork side there is a flap blocking the lid rotation. In order to determine the time, the lid with the arrow rotated counterclockwise until resistance of the flap. On the circumference of the watch there are balls indicating the sequential hours. They are not differentiated, except at 12.00, which is determined by the jump ring used to hang the watch. The arrow indicated the appropriate ball representing the hour. The minutes are not marked; they can only be estimated based on the position of the arrow between the hour points. Creator: Abraham Louis Breguet (1747–1823) Time and place of creation: early 19th century, Paris Jagiellonian University Museum Collegium Maius Inventory number: 1721; 1434/V https://muzea.malopolska.pl/en/objects-list/2739 Source: Objaverse 1.0 / Sketchfab
NPTP blind arcade
Realized within the project of the sourced-based reconstruction of the New Synagogue in Wroclaw/Breslau (Poland). Link to the 3D model documentation: http://www.vfu-oppler.hs-mainz.de/en/wisski/navigate/6276/view?wisski_bundle=b0c45007d4aaa61f5961be4fb6902a6b. Supported by »The German Federal Government Commissioner for Culture and the Media « (02/2018-11/2019) and »The Foundation for Polish-German Cooperation« (05/2018). Magnified by https://architekturinstitut.hs-mainz.de/. Published under CC-BY-NC-SA 4.0. Source: Objaverse 1.0 / Sketchfab
CPDP blind biforium type 1
Realized within the project of the sourced-based reconstruction of the New Synagogue in Wroclaw/Breslau (Poland). Link to the 3D model documentation: http://www.vfu-oppler.hs-mainz.de/en/wisski/navigate/4739/view?wisski_bundle=b0c45007d4aaa61f5961be4fb6902a6b. Supported by »The German Federal Government Commissioner for Culture and the Media « (02/2018-11/2019) and »The Foundation for Polish-German Cooperation« (05/2018). Magnified by https://architekturinstitut.hs-mainz.de/. Published under CC-BY-NC-SA 4.0. Source: Objaverse 1.0 / Sketchfab
SPTP blind arcade
Realized within the project of the sourced-based reconstruction of the New Synagogue in Wroclaw/Breslau (Poland). Link to the 3D model documentation: http://www.vfu-oppler.hs-mainz.de/en/wisski/navigate/5793/view. Supported by »The German Federal Government Commissioner for Culture and the Media « (02/2018-11/2019) and »The Foundation for Polish-German Cooperation« (05/2018). Magnified by https://architekturinstitut.hs-mainz.de/. Published under CC-BY-NC-SA 4.0. Source: Objaverse 1.0 / Sketchfab
Chlorhexidine oral rinses for symptomatic COPD: a randomized, blind, placebo-controlled preliminary study
<p>Background: Chlorhexidine oral rinses decrease ventilator-associated pneumonia but its effect on COPD is unknown.</p> <p>Research Question: Will a preliminary study of the effect of twice-daily chlorhexidine oral rinses on oral and lung microbiota biomass and respiratory symptoms, compared to placebo, support the conduct of a larger clinical trial?</p> <p>Study Design and Methods: Participants aged 40-85 with COPD and chronic respiratory symptoms were randomized 1:1 to twice-daily 0.12% chlorhexidine oral rinses vs. placebo.</p> <p>Results: Forty-four participants were recruited between September 8, 2014 and May 30, 2019. Our primary outcome was a change in oral and sputum microbiota biomass during the study as assessed by 16S rRNA copy numbers. Neither the oral microbiota nor the sputum microbiota biomass decreased significantly in those using chlorhexidine compared with placebo (oral microbiota mean log10 difference [SE] = -0.103 [0.23], 95% CI: -0.59, 0.38, p=0.665; sputum microbiota 0.80 [0.46], 95% CI: -0.15, 1.75, p=0.096). Chlorhexidine decreased both oral and sputum microbiota alpha (Shannon) diversity (linear regression estimate [SE] oral: -0.349 [0.091], p=0.001; sputum -0.622 [0.169], p=0.001). Chlorhexidine use did not decrease systemic inflammatory markers compared to placebo (CRP [chlorhexidine 1.8 ± 7.5 vs. placebo 0.4 ± 6.8, p=0.467], fibrinogen [22.5 ± 77.8 vs. 10.0 ± 77.0, p=0.406], or leukocytes [0.2 ± 1.8 vs. 0.5 ± 1.8, p=0.560]). Chlorhexidine use decreased St. George's Respiratory Questionnaire scores compared to placebo (chlorhexidine -4.7 ± 8.0 vs. placebo 1.7 ± 8.9, p=0.032).</p> <p>Interpretation: We did not detect a significant difference in microbiota biomass due to chlorhexidine use. Chlorhexidine decreased oral and sputum microbiota alpha diversity and improved respiratory health-related quality of life compared to placebo. Our results support the performance of a larger clinical trial.</p>
Supplementary materials for article: Ambient Intelligence System Enabling People With Blindness to Develop Electrotechnical Components and Their Drivers
<p><strong>Supplementary materials </strong>(Appendix E) for the article:</p> <p><strong><em>Ambient Intelligence System Enabling People With Blindness to Develop Electrotechnical Components and Their Drivers</em></strong></p> <p><em>Abstract: </em> Along with the development of new assistive technologies, including ambient intelligence (AmI) environments, new job opportunities are created for people with blindness or visual impairment. Whereas research on software development for people with blindness has been conducted since the 1960s, the design and development of electrotechnical equipment still lacks any way to compensate for the disability which would enable people with blindness to perform even the activities pertaining to this field. This article aims to introduce these new technological procedures enabling the compensation of the disability of people with blindness when designing and developing electrotechnical components (or prototypes) and their drivers by using the AmI system RUDO modules and other tools. This includes the modules enabling measuring electrotechnical quantities, tracing of oscilloscope curves, and ensuring a unified user interface for programming and operation of the devices connected. Other approaches are introduced herein that focused on the production of mechanical components for device construction. This article also contains an illustrative video of practical use of these technological procedures by a person with blindness. To assess the usability of the designed technological procedures to the work of a designer with blindness and one without visual impairment, the cognitive walkthrough method was used. The main contribution of this article is to broaden the knowledge base by the principles of involving people with blindness in the development and construction of electrotechnical components (or prototypes). These new possibilities can be used practically, for instance, in computer education, which can offer new curricula for visually impaired students and focused on more practical issues where hardware and software approaches meet.</p> <p>Hudec, M., & Smutny, Z. (2022). Ambient Intelligence System Enabling People With Blindness to Develop Electrotechnical Components and Their Drivers. <em>IEEE Access</em>, 10, 8539-8565. <a href="https://doi.org/10.1109/ACCESS.2022.3144109">https://doi.org/10.1109/ACCESS.2022.3144109</a></p> <p> </p> <p><strong>Appendix E - Description of the illustrative video</strong></p> <p>The video is divided into two parts.</p> <p><em><strong>Part 1: The way of connecting electrical circuits by a person with blindness without the need of assistance. </strong></em></p> <p>The example includes the connection of a DC/DC converter to a miniature screw terminal block and testing its functionality in a designed device. DC/DC converter is connected into miniature screw terminal block, commonly available in electrotechnical equipment stores. The DC/DC converter has six contacts, which means that in two cases two contacts are connected at the same time to one socket. After connecting the DC/DC converter, the laboratory power supply is switched on to keep the device energized. Person with blindness measures the voltage at the input and also at the output of the DC/DC converter. This will ensure that it works correctly in the given connection.</p> <p>A power switcher is connected to the constructed device. In our case, the power switcher should switch the power supply of the appliances to either photovoltaics or the mains. The device with DC / DC converter is connected to the LAN and via the second wire is connected to the power switcher, i.e.:</p> <ul> <li>the software on the home server will control this device with a DC/DC converter via LAN,</li> <li>a device with a DC/DC converter will command the power switcher to switch the power current.</li> </ul> <p>The power switcher is turned on and the person with blindness goes to the computer, where he runs a test program to test the entire connection. The test program taps the relay three times and waits a while. The test program repeats this sequence until it is interrupted. In the end, the contacts of the power relay were measured with an audible short-circuit meter, which always started to emit a whistling tone when the state was switched on. This debugged the functionality of the hardware and its data connection to the home server.</p> <p><em><strong>Part 2: Preparation of mechanical components for device construction.</strong></em></p> <p>The example includes cutting a board made of pertinax material on miter saw and its further modification. This modification involves grinding the edge of the cut board and drilling holes for further assembly of the board using a steel stencil and a meter marked in Braille. Finally, two miniature screw terminal blocks can be glued to the board prepared in this way.</p> <p> </p>
Results for blind docking Tocriscreen 2.0 compounds against AlphaFold2 structural modules of human and parasite proteins
<p>Docking (GNINA 1.0) of 1280 Tocriscreen 2.0 compounds against >4000 AlphaFold structures from humans and the parasitic nematode <em>Brugia malayi</em>. </p> <p>Results are provided as Pickle objects or GZipped CSVs.</p> <p>Tuned machine learning models (random forest and XGBoost) are also included for classifying actives/decoys.</p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.