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175 results for “toxic effects”
Randomized Multicenter Trial With SU11248 Evaluating Dosage,Tolerability,Toxicity and Effectiveness of a Multitargeted Receptor Tyrosine Kinase Inhibitor
ClinicalTrials.gov study NCT00543049. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Pragmatic Clinical Trial for a More Effective Concise and Less Toxic MDR-TB Treatment Regimen(s)
ClinicalTrials.gov study NCT02589782. IPD Sharing: YES. Countries: 3. Publications: 4.
Caloric Restriction and Exercise for Protection From Anthracycline Toxic Effects
ClinicalTrials.gov study NCT03131024. IPD Sharing: NO. Countries: 1. Publications: 1.
Effect of Hydrogen Gas on Hyperbaric Oxygen Toxicity
ClinicalTrials.gov study NCT07263399. IPD Sharing: UNDECIDED. Countries: 1. Publications: 4.
Effectiveness of Probiotics for the Prevention of Gastrointestinal Toxicity in Children with Leukemia
ClinicalTrials.gov study NCT06560879. IPD Sharing: NO. Countries: 1. Publications: 31.
A Phase I Clinical Trial To Evaluate the Toxicity, Antiviral and Immunomodulatory Effects of a Range of Doses of Ampligen in HIV-Infected Subjects
ClinicalTrials.gov study NCT00000713. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of Concurrent Hookah and Alcohol Consumption on Smoking Topography and Toxicant Exposure
ClinicalTrials.gov study NCT03096860. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: Timing of maternal exposure to toxic cyanobacteria and offspring fitness in Daphnia magna: implications for the evolution of anticipatory maternal effects
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Toxicity effect of five insecticides on the development and enzyme activities of Trichogramma ostriniae
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The direct and indirect effects of environmental toxicants on the health of bumble bees and their microbiomes
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Data from: Effects of biochar on fate and toxicity of herbicide fenoxaprop-ethyl in soil
The biochar as soil amendment in agriculture has attracted considerable attention. In the study, the fate and toxicity of the herbicide fenoxaprop-ethyl were evaluated in soils with and without 5% rice husk biochar amendment. Fenoxaprop-ethyl and metabolite fenoxaprop degraded followed first-order kinetics in the two soils. Fenoxaprop-ethyl decreased fast with half-lives less than 2 days. Large amounts of fenoxaprop formed and remained in control soil. However, fenoxaprop was much lower in biochar-amended soil with reduction over 85% at the 35th day. The estimated half-lives of fenoxaprop were 56.9 and 1.5 days in control and biochar-amended soils, respectively. Biochar restrained the formation and promoted the dissipation of fenoxaprop. Biological indicator earthworms (Eisenia fetida) were used in a 14-day acute toxicity test. Fenoxaprop-ethyl shown low toxic to earthworms with LC50 value of 322.9 μg/g. Biochar amendment was nontoxic to earthworms and effectively reduced the toxicity. The results suggested that the application of biochar may reduce the risks of fenoxaprop-ethyl in the soil environment.
Data from: Review on the effects of toxicants on freshwater ecosystem functions
We reviewed 122 peer-reviewed studies on the effects of organic toxicants and heavy metals on three fundamental ecosystem functions in freshwater ecosystems, i.e. leaf litter breakdown, primary production and community respiration. From each study meeting the inclusion criteria, the concentration resulting in a reduction of at least 20% in an ecosystem function was standardized based on median effect concentrations of standard test organisms (i.e. algae and daphnids). For pesticides, more than one third of observations indicated reductions in ecosystem functions at concentrations that are assumed being protective in regulation. Moreover, the reduction in leaf litter breakdown was more pronounced in the presence of invertebrate decomposers compared to studies where only microorganisms were involved in this function. High variability within and between studies hampered the derivation of a concentration–effect relationship. Hence, if ecosystem functions are to be included as protection goal in chemical risk assessment standardized methods are required.
Data from: Psychostimulant-induced testicular toxicity in mice: evidence of cocaine and caffeine effects on the local dopaminergic system
Several organ systems can be affected by psychostimulant toxicity. However, there is not sufficient evidence about the impact of psychostimulant intake on testicular physiology and catecholaminergic systems. The aim of the present study was to further explore potential toxic consequences of chronic exposure to cocaine, caffeine, and their combination on testicular physiology. Mice were injected with a 13-day chronic binge regimen of caffeine (3x5mg/kg), cocaine (3×10mg/kg), or combined administration. Mice treated with cocaine alone or combined with caffeine showed reduced volume of the seminiferous tubule associated to a reduction in the number of spermatogonia. Cocaine-only and combined treatments induced increased lipid peroxidation evaluated by TBARS assay and decreased glutathione peroxidase mRNA expression. Importantly, caffeine-cocaine combination potentiated the cocaine-induced germ cell loss, and induced pro-apoptotic BAX protein expression and diminished adenosine receptor A1 mRNA levels. We analyzed markers of dopaminergic function in the testis and detected the presence of tyrosine hydroxylase (TH) in the cytoplasm of androgen-producing Leydig cells, but also in meiotic germs cells within seminiferous tubules. Moreover, using transgenic BAC-Drd1a-tdTomato and D2R-eGFP mice, we report for the first time the presence of dopamine receptors (DRs) D1 and D2 in testicular mouse Leydig cells. Interestingly, the presence of DRD1 was also detected in the spermatogonia nearest the basal lamina of the seminiferous tubules, which did not show TH staining. We observed that psychostimulants induced downregulation of DRs mRNA expression and upregulation of TH protein expression in the testis. These findings suggest a potential role of the local dopaminergic system in psychostimulant-induced testicular pathology.
Removal of contaminants of emerging concern from the supernatant of anaerobically digested sludge by O3 and O3/H2O2: Ozone requirements, effects of the matrix, and toxicity
<p>Digestate is a rich source of nutrients that can be applied in agricultural fields as fertilizer or irrigation water.<br>However, most of the research about application of digestate have focused on its agronomic properties and<br>neglected the potential harm of the presence of contaminants of emerging concern (CECs). Aadvanced oxidation processes (AOPs) have proved to be effective for removing these compounds from drinking water, yet there are some constrains to treat wastewater and digestate mainly due to their complex matrix. In this study, the feasibility to remove different CECs from digestate using O3 and O3/H2O2 was assessed, and the general effect of the matrix in the oxidation was explained. While the lab-scale ozonation provided an ozone dose of 1.49 mg O3/mg DOC in 5 h treatment, almost all the compounds were removed at a lower ozone dose of maximum 0.48 mg O3/ mg DOC; only ibuprofen required a higher dose of 1.1 mg O3/mg DOC to be oxidized. The digestate matrix slowed down the kinetic ozonation rate to approximately 1% compared to the removal rate in demineralized water. The combined treatment (O3/H2O2) showed the additional contribution of H2O2 by decreasing the ozone demand by 59–75% for all the compounds. The acute toxicity of the digestate, measured by the inhibition of Vibrio fisheries luminescence, decreased by 18.1% during 5 h ozonation, and by 34% during 5 h O3/H2O2 treatment. Despite the high ozone consumption, the ozone dose (mg O3/mg DOC) required to remove all CECs from digestate supernatant was in the range or lower than what has been reported for other (waste-)water matrix, implying that ozonation can be considered as a post-AD treatment to produce cleaner stream for agricultural purposes.</p>
Toxicity Dataset for "Efficient solar disinfection (SODIS) using polypropylene based transparent jerrycans: An investigation into its effectiveness, viability, and water sample toxicity"
<p>Toxicity data including abosrbance and percentage viability obtainbed from research for three TJC Verison 1</p> <p> </p>
Does group living protect offspring from the toxic effects of cadmium ingestion in earwigs?
<p>Dataset and R script used in the study "Does group living protect offspring from the toxic effects of cadmium ingestion in earwigs?"</p>
Raw date of toxic effects of DEHP and MEHP
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Fig. 2 in Chemical constituents and toxic, repellent, and oviposition-deterrent effects of ethanol-extracted Myristica fragrans (Myristicaceae) oil on Bemisia tabaci (Hemiptera: Aleyrodidae)
Fig. 2. Contact toxicity of nutmeg essential oil to whitefly nymphs in laboratory experiments at concentrations of 10, 5, and 2.5 mg/mL. Values are the means of 8 replications. The mean numbers of nymphs were analyzed by 1-way ANOVA, with a Tukey HSD post-hoc test at a significance level of P <0.05; means topped by the same letter are not significantly different.
Fig. 1 in Chemical constituents and toxic, repellent, and oviposition-deterrent effects of ethanol-extracted Myristica fragrans (Myristicaceae) oil on Bemisia tabaci (Hemiptera: Aleyrodidae)
Fig. 1. Fumigant toxicity of nutmeg essential oil to whitefly adults in laboratory experiments at concentrations of 10, 5, and 2.5 mg/mL. Values are the means of 8 replications. The mean numbers of adults were analyzed by 1-way ANOVA, with a Tukey HSD post-hoc test at a significance level of P <0.05; means topped by the same letter are not significantly different.
Fig. 5 in Chemical constituents and toxic, repellent, and oviposition-deterrent effects of ethanol-extracted Myristica fragrans (Myristicaceae) oil on Bemisia tabaci (Hemiptera: Aleyrodidae)
Fig. 5. Greenhouse experiments with whitefly adults, testing nutmeg essential oil at concentrations of 10, 5, and 2.5 mg/mL. A. Repellency at 24 h, B. repellency at 48 h, C. oviposition at 24 h, D. oviposition at 48 h of exposure. Values are means of 8 replications. The mean numbers of adults and eggs were analyzed by 1-way ANOVA, with a Tukey HSD post-hoc test at a significance level of P <0.05; means topped by the same letter are not significantly different.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.