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126,115 results for “Patients”
Serum aminoacid levels in patients with spinocelular cancer of head and neck: anonymized dataset
<p><strong>Dataset containing analysis of free serum amino acid concentrations in patients with head and neck spinocellular tumors.</strong></p> <p>The study was conducted in accord with the Helsinki Declaration of 1964 and all subsequent revisions thereof. It was approved by the ethical committee of St. Anne’s Faculty Hospital, Brno, and by ethical committee of University Hospital Motol, Prague, Czech Republic.</p> <p>All blood samples were obtained from HNSCC patients who developed histologically verified primary HNSCC after they signed the informed consent. Blood samples were obtained by venipuncture. The blood samples were centrifuged at 3000 rpm at 4°C for 10 min within 60 min after collection. Serum was aliquoted and stored at −80°C until analysis.</p> <p>The inclusion criteria were: age 40-95 years; no prior chemotherapy; no endocrinologic or metabolic disorders; no uncontrolled hypertension or infections; normal liver, heart and kidney function; and adequate bone marrow reserve.</p> <p>Amino acid profiles were examined using ion-exchange liquid chromatography (AAA-400, Ingos, Prague, Czech Republic) with post-column derivatization by ninhydrin and absorbance detector in visible light range (IEC-Vis).</p>
Comparative Study of Intravenous Esmolol & Magnesium Sulphate in Attenuating Hemodynamic Response during Laryngoscopy & Endotracheal Intubation in Patients Undergoing Valvular Heart Surgery: a Randomised Clinical Trial
<p>The present study aimed to compare the effectiveness of esmolol & magnesium sulphate in attenuating the hemodynamic response<br> to endotracheal intubation and to note any signifi cant side effects caused by these drugs.<br> Background: Induction with endotracheal intubation in patients undergoing valvular heart replacement pose lot of hemodynamic<br> variations. Obtunding hemodynamic response which can be deleterious in such patients pose a challenge to the cardiac anaesthetist. We<br> hypothesized that using esmolol as compared to magnesium sulphate will attenuate the hemodynamic response during laryngoscopy &<br> endotracheal intubation in patients undergoing valvular heart replacement.<br> Methods: This was a double blind, randomised, single centre, interventional, prospective study. In this study 96 patients were divided<br> into two groups with 48 patients each (n = 48) by sealed enveloped method of randomisation. Group E received esmolol 1.5 mg/ kg i.v<br> and Group M received magnesium sulphate 50 mg/ kg i.v each diluted in normal saline to make up a volume of 50 ml & given via infusion<br> slowly over 5 minutes by a burette set. Hemodynamic parameters like Heart Rate (HR), Mean Arterial Pressure (MAP), Systolic Blood<br> Pressure (SBP), Diastolic Blood Pressure (DBP) at baseline, 5 minutes after premedication, just before intubation 3, 5, 10 & 15 minutes<br> post intubation were recorded. The last observation at the end of 15 minutes post intubation was considered as the end of study.<br> Results: All the enrolled patients were analyzed. The esmolol group showed a decrease in the H.R from baseline (86.13 ± 15.87)<br> as compared to magnesium sulphate (98.51 ± 16.81 with a 95% CI, 4.62-4.69, p value < 0.001) 5 minute after premedication. There was<br> statistically signifi cant difference in H.R between both groups 5 minutes after drug administration.<br> Conclusion: Administration of esmolol before intubation in valvular heart patients undergoing valve replacement surgery controls the<br> hemodynamic response much better as compared to magnesium sulphate.</p>
Analysis of patient-specific stimulation with segmented leads in the subthalamic nucleus
<p>Supporting information for PLOS ONE article titled "Analysis of patient-specific stimulation with segmented leads in the subthalamic nucleus" by Nguyen et al. (2019)</p>
Optimisation of viability assay for DIPG patient-derived cell lines
<p>Evaluation of the efficacy of M4K compounds in DIPG patient-derived cell lines is essential before any promising compounds can be further tested in mouse xenograft models. This approach can aid in narrowing down clinical compound candidates and reduce the time, resources and animal sacrifice needed downstream.</p> <p>A robust and efficient readout for the changes in the viability of the DIPG cells needs to be established before it can be used to evaluate the M4K compounds. In addition, the amount of cells to be seeded at the beginning of the experiment has to be optimised to avoid overcrowding and starvation of the cells after extended culture times. Overcrowding and starvation will lead to increased cell death and prevent accurate estimation of the potency of M4K compounds (EC50).</p>
Different methods to evaluate the effects of M4K compounds on DIPG patient-derived cell lines
<p>Aside from determining the optimal numbers of DIPG cells to be seeded for viability assay, it is also important to validate that measurements using CellTiter Glo are in agreement with other methods of determining cell viability.</p> <p>For my blog post about this experiment, please visit my opennotebook page.</p> <p>https://openlabnotebooks.org/different-methods-to-evaluate-the-effects-of-m4k-compounds-on-dipg-patient-derived-cell-lines/</p>
Dataset: Quality of Life of Patients with Dementia in Acute Hospitals
<p>Dataset for a publication (working title "Quality of Life of Patients with Dementia in Acute Hospitals: Comparing a regular ward to a special care ward with dementia care concept. A Bayesian Multilevel Model Analysis.").</p>
Evaluating the effect of 8 M4K compounds on the viability of DIPG patient-derived cells (SU-DIPG-VI, HSJD-DIPG-007 and SU-DIPG-IV)
<p>Viability assay using Celltiter Glo kit has been chosen as the main method for evaluating the efficacy of ALK2 inhibitors on DIPG patient-derived cells due to its robustness. As a pilot experiment, 8 ALK2 inhibitors with differing potencies were chosen and evaluated in 3 DIPG patient-derived cell lines (one with wild-type ALK2 and two with mutant ALK2).</p>
Keratinocytes derived from patient-specific iPSCs recapitulate the genetic signature of psoriasis disease
<p>Induced pluripotent stem cells (iPSCs) were generated from control (Ctrl) and two psoriasis patients (PsO1 and PsO2) having genetic background of psoriasis. The iPSCs were differentiated into epidermal keratinocytes as described in the article entitled "Keratinocytes derived from patient-specific iPSCs recapitulate the genetic signature of psoriasis disease" by Gowher et al. The dataset represent RNA-seq data generated from keratiocytes derived from ctrl-iPSCs and psoriasis patients iPSCs (PsO1 and PsO2).</p> <p>The file name is : Sample name with replicate_overall sample number_read direction_001 where:</p> <p>- Ctrl Rep1 and Ctrl Rep2: Keratinocytes derived from control (Ctrl-iPSCs). </p> <p>- PSO1 Rep1 and PSO1 Rep2: Keratinocytes derived from psoriasis patient iPSCs (PSO1-iPSCs)</p> <p>- PSO2 Rep1 and PSO2 Rep2: Keratinocytes derived from psoriasis patient iPSCs (PSO2-iPSCs).</p> <p>- RNA-seq data was generated from two biological repliicates (Rep1 and Rep2).</p> <p>- Read direction: R1 (Forward), R2 (Reverse).</p> <p> </p>
ROS-Specific Huntingtin Interactions: Testing PARG activity in HD patient fibroblasts
<p>Comparison nuclear PAR levels in wild type and HD (TruHD) fibroblasts in response to a PARG inhibitor concentration gradient (as a measure of PARG activity).</p>
Microscopy images - "An elevated rate of whole-genome duplications associated with carcinogen exposure in Black cancer patients"
<p>This repository contains microscopy data from the manuscript "An elevated rate of whole-genome duplications associated with carcinogen exposure in Black cancer patients" by Leanne M. Brown, Ryan A. Hagenson, Tilen Koklič, Iztok Urbančič, Janez Strancar, and Jason M. Sheltzer (preprint: 10.1101/2023.11.10.23298349; accepted for publication in Nature Communications).</p> <p> </p> <p>Each zip contains the set of images from individual multi-channel multi-position time-lapse experiment with different combinations of cells exposed to one nanomaterial. Files are named as: IMGxxxx_[ExperimentCode]_ROIxx_tile[TileNumber]_[Channel]_[CellType]_t[Timepoint].tif, where each of the varying elements in [..] denotes the following:</p> <ul> <li>[ExperimentCode]: tells which material the cells were exposed to - see decoding table in the file "material-codes.xlsx"</li> <li>[TileNumber]: two xy-tiles per condition</li> <li>[Channel]: cytoplasm of epi cells (LA4), membrane (MEM), cytoplasm of imu cells and tubulin (MHSTUB), nanomaterial (NANO)</li> <li>[CellType]: mono-culture of lung epithelial cells (epi), their coculture with macrophages (epiimu)</li> <li>[Timepoint]: consecutive number of the frame in the time-lapse</li> </ul> <p> </p>
Fragment coordinates from shallow WGS of colorectal cancer from patients in Pakistan
<p>BED files indicating fragment coordinates from whole genome sequencing of FFPE tumors and adjacent normal tissue samples. Sequencing data was aligned to hg19 using bwa-mem, prior to conversion to BED format. Tumor samples are indicated with suffix "_T" and normal samples are indicated with suffix "_N"</p>
Assessment of changes in circRNA expression based on transcripts of genes encoding ADAMTS proteins in patients with non-small cell lung carcinoma compared to normal tissue
Open the record for dataset details and reuse information.
Data from "Exploring Gut Microbiota Profile Induced by Antipsychotics in Schizophrenic Patients: Insights from an Eastern European Pilot Study", Nita (Ilie) et al. 2025
<p>Dataset containing raw demultiplexed FASTQ files of the sequenced samples, generated by the Illumina MiSeq platform. </p> <p>MiSeq_demultiplexed-V3_V4-HC_SCZ.zip - MiSeq raw sequences of the V3-V4 region 16S rRNA gene from subject fecal material. This ZIP file contains the FASTQ files of the paired-end reads (R1: forward reads; R2: reverse reads) produced for each sample using the MiSeq platform.</p> <p>metadata-HC_SCZ.csv - The list of sequenced samples and associated metadata.</p>
Data from: Molecular landscapes of glioblastoma cell lines revealed a group of patients that do not benefit from WWOX tumor suppressor expression
<p>Supporting data for the article "Molecular landscapes of glioblastoma cell lines revealed a group of patients that do not benefit from WWOX tumor suppressor expression", published in Frontiers in Neuroscience (DOI: 10.3389/fnins.2023.1260409).</p>
Genomic data from a pharmacogenetic study based on the efficacy of Tocilizumab in severe COVID-19 patients
<p>These data correspond to a pharmacogenetic study aimed to explore genetic associations related to the efficacy of Tocilizumab in severe COVID-19 patients. The study comprised two sets of patients, an initial subset consisted of 425 patients to whom a in-dpeth sequencing of a thermofisher sequencing panel of immune-related genes was performed, as well as a second set of 245 patients with the information of the genotyping of three selected SNPs</p>
Assessment of Patient Safety Culture and Associated Factors among Healthcare Professionals in Public Hospitals of Bahir Dar City, Northwest Ethiopia: A Mixed-Methods Study
<p>This data set contains HSOPSC on the <span>Assessment of Patient Safety Culture and Associated Factors among Healthcare Professionals in Public Hospitals of Bahir Dar City, Northwest Ethiopia: A Mixed-Methods Study</span></p>
Minimally Invasive Transaxillary Approach: Aortic Valve Replacement in a Patient with BMI >50 kg/m²
<p>This video demonstrates the successful application of the transaxillary MICLAT-S (<em>M</em>inimally <em>I</em>nvasive <em>C</em>ardiac <em>L</em>ateral <em>S</em>urgery) approach for aortic valve replacement (AVR) in a patient with a BMI >50 kg/m². The procedure showcases the feasibility and safety of the MICLAT-S technique in a high-risk, morbidly obese patient, a group traditionally considered challenging for minimally invasive surgery. By sparing the sternum and utilizing a lateral, transaxillary access route, the MICLAT-S method minimizes surgical trauma, reduces the risk of postoperative wound complications, and preserves thoracic stability, even in patients with extreme obesity.</p> <p>Despite the patient’s elevated BMI, the surgical team was able to maintain excellent access to the aortic valve, ensuring a smooth and efficient valve replacement. This video further supports the findings of our study, which demonstrate that the transaxillary concept of MICLAT-S is a viable alternative to traditional sternotomy, offering significant advantages, particularly in obese patients.</p> <p>This description complements the video by tying it to the findings of the paper and underlining the advantages of the transaxillary concept of MICLAT-S technique in this specific patient population.</p>
Assessment of Patient Safety Culture and Associated Factors among Healthcare Professionals in Public Hospitals of Bahir Dar City, Northwest Ethiopia: A Mixed-Methods Study
<p><span>This dataset contains raw data on "regression analyses" on the assessment of patient safety culture among healthcare professionals in public hospitals of Bahir Dar City, Northwest Ethiopia."</span></p>
Assessment of Patient Safety Culture and Associated Factors among Healthcare Professionals in Public Hospitals of Bahir Dar City, Northwest Ethiopia: A Mixed-Methods Study
<p><span>This dataset contains raw data of " </span><span>Likert Scale Descriptive Analysis"on t</span><span>he assessment of patient safety culture among healthcare professionals in public hospitals of Bahir Dar City, Northwest Ethiopia.</span></p>
Characterization of Patient Activation Among Childhood Cancer Survivors in the St. Jude Lifetime Cohort (SJLIFE)
<p>This dataset corresponds to a manuscript titled "Characterization of Patient Activation Among Childhood Cancer Survivors in the St. Jude Lifetime Cohort (SJLIFE) which can be found in the journal <em>Cancers.</em></p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.