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◂Fig. 5 Cells of phylogenetically related strains (light microscopy). a Thecate cell in dorsal view. b Thecate cell in ventral view, note the sulcus extending onto the epitheca (arrow). c Putatively necrotic, thecate cell. d Thecate cell with one bulge on the epitheca (arrow), note that this was the only such cell among thousands of inspected cells. e, f Coccoid cells, apparently without thecae. g Two thecate cells enclosed in the parental theca. h Two connected, immotile cells enclosed in the parental thecae. j Lid of epitheca in dorsal-apical view (mirrored), composed of plates 2′‒4′, all intercalary plates and plates 2′′‒6′′. l‒m Same opened theca in ventral view (l) and dorsal view (m), note the sulcus extending onto the epitheca (arrow), the dorsal opening and all apical and all intercalary plates and plates 3′′‒5′′ remaining with the hypotheca. n Chloroplasts (as inferred from autofluorescence), note the space occupied by the nucleus. Plate labelling follows the Kofoidean notation, n′: apical plate; n′′: precingular plate; n′′′: postcingular plate; na: anterior intercalary plate. Scale= 10 µm in Bumps on the back: An unusual morphology in phylogenetically distinct Peridinium aff. cinctum (= Peridinium tuberosum; Peridiniales, Dinophyceae)
◂Fig. 5 Cells of phylogenetically related strains (light microscopy). a Thecate cell in dorsal view. b Thecate cell in ventral view, note the sulcus extending onto the epitheca (arrow). c Putatively necrotic, thecate cell. d Thecate cell with one bulge on the epitheca (arrow), note that this was the only such cell among thousands of inspected cells. e, f Coccoid cells, apparently without thecae. g Two thecate cells enclosed in the parental theca. h Two connected, immotile cells enclosed in the parental thecae. j Lid of epitheca in dorsal-apical view (mirrored), composed of plates 2′‒4′, all intercalary plates and plates 2′′‒6′′. l‒m Same opened theca in ventral view (l) and dorsal view (m), note the sulcus extending onto the epitheca (arrow), the dorsal opening and all apical and all intercalary plates and plates 3′′‒5′′ remaining with the hypotheca. n Chloroplasts (as inferred from autofluorescence), note the space occupied by the nucleus. Plate labelling follows the Kofoidean notation, n′: apical plate; n′′: precingular plate; n′′′: postcingular plate; na: anterior intercalary plate. Scale= 10 µm
Extending the gene regulatory network model for B cell differentiation
<p>Scripts used for modelling the gene regulatory network of B cell differentiation</p>
Benchmarking tree and ancestral sequence inference for B cell receptor sequences
<p>Simulation data used and described in associated article.</p>
Schematic representing the vehicle–to–cell hierarchical overview of a typical electrified powertrain architecture. This represents the system-level context within which the proposed layer optimisation framework has been developed. Two xEV powertrains — a) BEV and b) series PHEV — are chosen as examples to demonstrate how the methodology facilitates common module designs for such battery packs.
<p>Schematic representing the vehicle–to–cell hierarchical overview of a typical electrified powertrain architecture. This represents the<br> system-level context within which the proposed layer optimisation framework has been developed. Two xEV powertrains — a) BEV and b) series PHEV — are chosen as examples to demonstrate how the methodology facilitates common module designs for such battery packs.</p>
Text-fig. 2. Caryanthus sp., no. F03286, locality Zliv-Řídká Blana A – Inflorescence, three bisexual flowers / fruits, central flower inserted slightly higher than the two lateral ones, scale bar 0.5 mm; B – Lateral flowers arranged at an angle of about 45˚ relative to each other, hp. – hypanthium with grooves, scale bar 0.5 mm; C – Epidermal cells of hypanthium, scale bar 0.1 mm; D – Detail of epidermal cells, scale bar 50 µm; E – Lateral flower, basal parts of six filaments and basal parts of two anthers styles, f – filaments, s – styles, scale bar 0.3 mm; F – Central flower, scale bar 0.3 mm; G – Stoma, scale bar 30 µm. in A New Record Of The Genus Caryanthus From The Cretaceous Of South Bohemia (Czech Republic)
Text-fig. 2. Caryanthus sp., no. F03286, locality Zliv-Řídká Blana A – Inflorescence, three bisexual flowers / fruits, central flower inserted slightly higher than the two lateral ones, scale bar 0.5 mm; B – Lateral flowers arranged at an angle of about 45˚ relative to each other, hp. – hypanthium with grooves, scale bar 0.5 mm; C – Epidermal cells of hypanthium, scale bar 0.1 mm; D – Detail of epidermal cells, scale bar 50 µm; E – Lateral flower, basal parts of six filaments and basal parts of two anthers styles, f – filaments, s – styles, scale bar 0.3 mm; F – Central flower, scale bar 0.3 mm; G – Stoma, scale bar 30 µm.
A Pan-Cancer Single-Cell RNA-seq Atlas of Intratumoral B Cells
<p>Seurat object associated with publication 'A Pan-Cancer Single-Cell RNA-seq Atlas of Intratumoral B Cells' (Fitzsimons et al. Cancer Cell 2024)</p>
Data from: Enhanced B-cell receptor recognition of the autoantigen transglutaminase 2 by efficient catalytic self-multimerization
A hallmark of the gluten-driven enteropathy celiac disease is autoantibody production towards the enzyme transglutaminase 2 (TG2) that catalyzes the formation of covalent protein-protein cross-links. Activation of TG2-specific B cells likely involves gluten-specific CD4 T cells as production of the antibodies is dependent on disease-associated HLA-DQ allotypes and dietary intake of gluten. IgA plasma cells producing TG2 antibodies with few mutations are abundant in the celiac gut lesion. These plasma cells and serum antibodies to TG2 drop rapidly after initiation of a gluten-free diet, suggestive of extrafollicular responses or germinal center reactions of short duration. High antigen avidity is known to promote such responses, and is also important for breakage of self-tolerance. We here inquired whether TG2 avidity could be a feature relevant to celiac disease. Using recombinant enzyme we show by dynamic light scattering and gel electrophoresis that TG2 efficiently utilizes itself as a substrate due to conformation-dependent homotypic association, which involves the C-terminal domains of the enzyme. This leads to the formation of covalently linked TG2 multimers. The presence of exogenous substrate such as gluten peptide does not inhibit TG2 self-cross-linking, but rather results in formation of TG2-TG2-gluten complexes. The celiac disease autoantibody epitopes, clustered in the N-terminal part of TG2, are conserved in the TG2-multimers as determined by mass spectrometry and immunoprecipitation analysis. TG2 multimers are superior to TG2 monomer in activating A20 B cells transduced with TG2-specific B-cell receptor, and uptake of TG2-TG2-gluten multimers leads to efficient activation of gluten-specific T cells. Efficient catalytic self-multimerization of TG2 and generation of multivalent TG2 antigen decorated with gluten peptides suggest a mechanism by which self-reactive B cells are activated to give abundant numbers of plasma cells in celiac disease. Importantly, high avidity of the antigen could explain why TG2-specific plasma cells show signs of an extrafollicular generation pathway.
Data from: Reprogramming the antigen specificity of B cells using genome-editing technologies
We have developed a method to introduce novel paratopes into the human antibody repertoire by modifying the immunoglobulin (Ig) genes of mature B cells directly using genome editing technologies. We used CRISPR-Cas9 in a homology directed repair strategy, to replace the heavy chain (HC) variable region in B cell lines with that from an HIV broadly neutralizing antibody, PG9. Our strategy is designed to function in cells that have undergone VDJ recombination using any combination of variable (V), diversity (D) and joining (J) genes. The modified locus expresses PG9 HC which pairs with native light chains resulting in the cell surface expression of HIV specific B cell receptors (BCRs). Endogenous activation-induced cytidine deaminase (AID) in engineered cells allowed for Ig class switching and generated BCR variants with improved anti-HIV neutralizing activity. Thus, BCRs engineered in this way retain the genetic flexibility normally required for affinity maturation during adaptive immune responses. Peripheral blood derived primary B cells from three different donors were edited using this strategy. Engineered cells could bind the PG9 epitope by FACS and sequenced mRNA from these cells showed PG9 HC expressed as several different isotypes after culture with CD40 ligand and IL-4.
Text-fig. 12. Silutanispermum kvacekiorum gen. et sp. nov. seeds from the Early Cretaceous Famalicão locality (sample 025), Portugal; Synchrotron radiation X-ray tomographic microscopy (SRXTM, orthoslices). a) Longitudinal orthoslice (yz1170) through the median plane of the seed (S170238) in the micropylar region showing exotestal cells lining the micropylar slit (mi) and hilum (hi); note the well-preserved mesotestal cells (me). b) Longitudinal orthoslice (xz0805) of seed perpendicular to the median plane through the micropylar region showing the transverse micropylar slit (mi) lined by radiating exotestal cells; note abundant mesotestal cells (me). c) Transverse orthoslice (xy0768) through seed below hilum and micropyle showing exotesta (ex) and mesotesta (me) that is strongly developed along the raphe (ra) (S174352). d) Transverse orthoslice (xy2113) through middle of the seed showing well-preserved cellular nutritive tissue with empty cells; note that the raphe (ra) is enclosed in mesotestal tissue (S174352). e) Longitudinal orthoslice (yz0970) through seed coat showing exotesta (ex) of tall palisade-shaped cells and thick mesotesta (me) of low cells (S174352). Scale bars = 500 µm (a, c, d); 250 µm (b); 125 µm (e). in Extinct Taxa Of Exotestal Seeds Close To Austrobaileyales And Nymphaeales From The Early Cretaceous Of Portugal
Text-fig. 12. Silutanispermum kvacekiorum gen. et sp. nov. seeds from the Early Cretaceous Famalicão locality (sample 025), Portugal; Synchrotron radiation X-ray tomographic microscopy (SRXTM, orthoslices). a) Longitudinal orthoslice (yz1170) through the median plane of the seed (S170238) in the micropylar region showing exotestal cells lining the micropylar slit (mi) and hilum (hi); note the well-preserved mesotestal cells (me). b) Longitudinal orthoslice (xz0805) of seed perpendicular to the median plane through the micropylar region showing the transverse micropylar slit (mi) lined by radiating exotestal cells; note abundant mesotestal cells (me). c) Transverse orthoslice (xy0768) through seed below hilum and micropyle showing exotesta (ex) and mesotesta (me) that is strongly developed along the raphe (ra) (S174352). d) Transverse orthoslice (xy2113) through middle of the seed showing well-preserved cellular nutritive tissue with empty cells; note that the raphe (ra) is enclosed in mesotestal tissue (S174352). e) Longitudinal orthoslice (yz0970) through seed coat showing exotesta (ex) of tall palisade-shaped cells and thick mesotesta (me) of low cells (S174352). Scale bars = 500 µm (a, c, d); 250 µm (b); 125 µm (e).
Fig. 1. a-b in Response of mucous cells of the gills of traíra (Hoplias malabaricus) and jeju (Hoplerythrinus unitaeniatus) (Teleostei: Erythrinidae)
Fig. 1. a-b. Saggital section of gill filament showing filament and lamellar epithelium. c-d. Cross section of filament showing the distribution of mucous cells (arrowheads). a and c, Hoplias malabaricus. b and d, Hoplerythrinus unitaeniatus. Scale bar in mm. aa - filament afferent artery, c - cartilage, cc - chloride cell, cvs - central venous sinus, ea - filament efferent artery, L - lamella.
Text-fig. 36. Synchrotron radiation X-ray tomographic microscopy (SRXTM, a–e) images of "Paisia-like follicle"; Catefica locality, Portugal. a, b) Volume rendering of follicle in lateral (a) and ventral (b) views showing the decurrent stigmatic region that extends from the follicle base to the apex but lacks a distinct papillate zone; c) Longitudinal section (volume rendering cut at orthoslice yz0341) of follicle showing under-developed ovules towards the base and numerous well-developed ovules/seeds in the upper part suggesting that the follicle is probably mature; d) Dorsal view of follicle apex showing the cleft in the presumed stigmatic apical region; e) Transverse section (orthoslice xy1294) of follicle with one dorsal and two ventral bundles and two placentae bulging into the locule, one on either side of the ventral suture; note the strongly compressed outer epidermis and the homogenized cells of the mesocarp. Specimen, Catefica 49-S174915 (a–e). Scale bars = 300 Μm (a–d), 100 Μm (e). in The Early Cretaceous Mesofossil Flora Of Catefica, Portugal: Angiosperms
Text-fig. 36. Synchrotron radiation X-ray tomographic microscopy (SRXTM, a–e) images of "Paisia-like follicle"; Catefica locality, Portugal. a, b) Volume rendering of follicle in lateral (a) and ventral (b) views showing the decurrent stigmatic region that extends from the follicle base to the apex but lacks a distinct papillate zone; c) Longitudinal section (volume rendering cut at orthoslice yz0341) of follicle showing under-developed ovules towards the base and numerous well-developed ovules/seeds in the upper part suggesting that the follicle is probably mature; d) Dorsal view of follicle apex showing the cleft in the presumed stigmatic apical region; e) Transverse section (orthoslice xy1294) of follicle with one dorsal and two ventral bundles and two placentae bulging into the locule, one on either side of the ventral suture; note the strongly compressed outer epidermis and the homogenized cells of the mesocarp. Specimen, Catefica 49-S174915 (a–e). Scale bars = 300 Μm (a–d), 100 Μm (e).
Text-fig. 35. Scanning electron microscope (SEM, a, b, d) and synchrotron radiation X-ray tomographic microscopy (SRXTM, c, e) images of "Paisia-like follicle"; Catefica locality, Portugal. a) Lateral view of slender follicle with an almost straight ventral margin and a slightly curved dorsal margin; b) Lateral view of small, broad follicle with slightly sinuous ventral margin and rounded dorsal margin; c) Lateral view of small, broad follicle with slightly sinuous ventral margin and rounded dorsal margin; d) Apical part of follicle in (a) showing the slight apical cleft in the probable stigmatic region; e) Transverse section (orthoslice xy0407) of follicle showing ovules and distinct follicle wall with small, thin-walled cells of the outer epidermis (arrow), larger, isodiametric cells of the mesocarp and an inner layer of smaller, thin-walled cells. Specimens, Catefica 50-S171523 (a, d), Catefica 343-S171515 (b), Catefica 49-S174929 (c, e). Scale bars = 300 Μm (a–c), 100 Μm (d, e). in The Early Cretaceous Mesofossil Flora Of Catefica, Portugal: Angiosperms
Text-fig. 35. Scanning electron microscope (SEM, a, b, d) and synchrotron radiation X-ray tomographic microscopy (SRXTM, c, e) images of "Paisia-like follicle"; Catefica locality, Portugal. a) Lateral view of slender follicle with an almost straight ventral margin and a slightly curved dorsal margin; b) Lateral view of small, broad follicle with slightly sinuous ventral margin and rounded dorsal margin; c) Lateral view of small, broad follicle with slightly sinuous ventral margin and rounded dorsal margin; d) Apical part of follicle in (a) showing the slight apical cleft in the probable stigmatic region; e) Transverse section (orthoslice xy0407) of follicle showing ovules and distinct follicle wall with small, thin-walled cells of the outer epidermis (arrow), larger, isodiametric cells of the mesocarp and an inner layer of smaller, thin-walled cells. Specimens, Catefica 50-S171523 (a, d), Catefica 343-S171515 (b), Catefica 49-S174929 (c, e). Scale bars = 300 Μm (a–c), 100 Μm (d, e).
Text-fig. 34. Synchrotron radiation X-ray tomographic microscopy (SRXTM, a–h) images of "Paisia-like follicle"; Catefica locality, Portugal. a–d) Volume rendering of follicles in lateral (a, c) and ventral (b, d) views showing the decurrent stigmatic region that extends from base of the follicle to the apex; note papillate zone forming a probable stigma along the full length of the ventral suture; e) Longitudinal section (volume rendering cut at orthoslice yz0326) near the base of the follicle showing two ovules with a striate-reticulate surface (asterisks); note transverse fibers lining the inner follicle wall and large cells of the mesocarp; f) Transverse section (volume rendering cut at orthoslice xy2475) of follicle showing two rows of ovules borne on placentae on either side of the ventral suture (asterisks); note also the pronounced and densely-spaced papillae around the ventral suture; g) Transverse section (orthoslice xy1988) of follicle showing two ventral vascular bundles and one dorsal bundle (arrows) and ovules/seeds borne on two placentae, one on either side of the ventral suture; note the remains of the small thin-walled cells of the outer epidermis that cover the thicker-walled cells of the mesocarp; h) Transverse section (orthoslice xy2860) of follicle showing two ventral bundles and one dorsal bundle (arrows) and ovules/seeds in two rows on the placentae, one on either side of the ventral suture; note the remains of small epidermal cells and the large rounded cells of the mesocarp with thicker walls. Specimens, Catefica 49-S174916 (a, b), Catefica 49-S174917 (c–f, h), Catefica 50-S171525 (g). Scale bars = 300 Μm (a–d), 100 Μm (e–h). in The Early Cretaceous Mesofossil Flora Of Catefica, Portugal: Angiosperms
Text-fig. 34. Synchrotron radiation X-ray tomographic microscopy (SRXTM, a–h) images of "Paisia-like follicle"; Catefica locality, Portugal. a–d) Volume rendering of follicles in lateral (a, c) and ventral (b, d) views showing the decurrent stigmatic region that extends from base of the follicle to the apex; note papillate zone forming a probable stigma along the full length of the ventral suture; e) Longitudinal section (volume rendering cut at orthoslice yz0326) near the base of the follicle showing two ovules with a striate-reticulate surface (asterisks); note transverse fibers lining the inner follicle wall and large cells of the mesocarp; f) Transverse section (volume rendering cut at orthoslice xy2475) of follicle showing two rows of ovules borne on placentae on either side of the ventral suture (asterisks); note also the pronounced and densely-spaced papillae around the ventral suture; g) Transverse section (orthoslice xy1988) of follicle showing two ventral vascular bundles and one dorsal bundle (arrows) and ovules/seeds borne on two placentae, one on either side of the ventral suture; note the remains of the small thin-walled cells of the outer epidermis that cover the thicker-walled cells of the mesocarp; h) Transverse section (orthoslice xy2860) of follicle showing two ventral bundles and one dorsal bundle (arrows) and ovules/seeds in two rows on the placentae, one on either side of the ventral suture; note the remains of small epidermal cells and the large rounded cells of the mesocarp with thicker walls. Specimens, Catefica 49-S174916 (a, b), Catefica 49-S174917 (c–f, h), Catefica 50-S171525 (g). Scale bars = 300 Μm (a–d), 100 Μm (e–h).
Text-fig. 4. Synchrotron radiation X-ray tomographic microscopy (SRXTM) images of seeds of Canrightia foveolata sp. nov.; Catefica locality, Portugal. a–d) Volume renderings of abraded seeds in ventral (a), lateral (b, d) and apical (c) views showing the slightly protruding chalaza (arrows) and dense longitudinal grooves with shallow pits in the surface of the endotesta; e) Transverse section of seed (orthoslice xy0665) showing the irregular grooved surface of the endotesta (oi-en) and the tegmen comprised of two layers of thick-walled cells that surround the cells of the prominent endothelium (asterisk); f) Longitudinal section (orthoslice xz1195) through seed showing the thin-walled endothelium cells (asterisk) surrounded by the thicker cells of the outer tegmen and endotesta; g) Longitudinal section (orthoslice yz0727) through seed showing outlines of angular crystals evenly distributed in cells of the endotesta (oi-en); note the outer epidermis of the tegmen (ii-o) composed of thick-walled cells; h) Longitudinal section (orthoslice xz0940) of seed showing details of the chalazal region with course of the vascular bundle (vb), cells of the prominent endothelium (asterisk), crystalliferous endotesta of the outer integument (oi-en) and the distinct thick walled cells of the outer cells of the tegmen (ii-o); i) Longitudinal and tangential section (orthoslice yz0542) through the endotesta (oi-en) showing the outlines of densely spaced crystals. Specimens, Catefica 242-S175178 (a–c, e–h), Catefica 49-S175179 (d, i). Scale bars = 300 Μm (a–d), 100 Μm (e, f, h, i), 50 Μm (g). in The Early Cretaceous Mesofossil Flora Of Catefica, Portugal: Angiosperms
Text-fig. 4. Synchrotron radiation X-ray tomographic microscopy (SRXTM) images of seeds of Canrightia foveolata sp. nov.; Catefica locality, Portugal. a–d) Volume renderings of abraded seeds in ventral (a), lateral (b, d) and apical (c) views showing the slightly protruding chalaza (arrows) and dense longitudinal grooves with shallow pits in the surface of the endotesta; e) Transverse section of seed (orthoslice xy0665) showing the irregular grooved surface of the endotesta (oi-en) and the tegmen comprised of two layers of thick-walled cells that surround the cells of the prominent endothelium (asterisk); f) Longitudinal section (orthoslice xz1195) through seed showing the thin-walled endothelium cells (asterisk) surrounded by the thicker cells of the outer tegmen and endotesta; g) Longitudinal section (orthoslice yz0727) through seed showing outlines of angular crystals evenly distributed in cells of the endotesta (oi-en); note the outer epidermis of the tegmen (ii-o) composed of thick-walled cells; h) Longitudinal section (orthoslice xz0940) of seed showing details of the chalazal region with course of the vascular bundle (vb), cells of the prominent endothelium (asterisk), crystalliferous endotesta of the outer integument (oi-en) and the distinct thick walled cells of the outer cells of the tegmen (ii-o); i) Longitudinal and tangential section (orthoslice yz0542) through the endotesta (oi-en) showing the outlines of densely spaced crystals. Specimens, Catefica 242-S175178 (a–c, e–h), Catefica 49-S175179 (d, i). Scale bars = 300 Μm (a–d), 100 Μm (e, f, h, i), 50 Μm (g).
Text-fig. 23. Synchrotron radiation X-ray tomographic microscopy (SRXTM) images of Ibericarpus cuneiformis gen. et sp. nov.; Catefica locality, Portugal. a) Longitudinal section (orthoslice yz0827) showing fruitlet with apical stigmatic region and a single seed enclosed within the fruitlet wall that has a thick epidermal cuticle; note the tiny embryo (emb) internal to the micropyle (mi) and oriented toward the base of the fruitlet; b) Transverse section through apical part of two fruitlets (orthoslice xy0810) showing the fruitlet wall (fr) composed of small thin-walled cells covered by an epidermis of isodiametric cells (ep) with a thick outer cuticle (cu); c) Longitudinal section (orthoslice xz0370) through basal part of fruitlet perpendicular to section in (a) showing the micropyle (mi), embryo (emb) composed of tiny cells, and the thick cuticle (cu) covering the bulging cells of the fruitlet epidermis. Specimen, Catefica 50-S174907 (a–c). Scale bars = 300 Μm (a–c). in The Early Cretaceous Mesofossil Flora Of Catefica, Portugal: Angiosperms
Text-fig. 23. Synchrotron radiation X-ray tomographic microscopy (SRXTM) images of Ibericarpus cuneiformis gen. et sp. nov.; Catefica locality, Portugal. a) Longitudinal section (orthoslice yz0827) showing fruitlet with apical stigmatic region and a single seed enclosed within the fruitlet wall that has a thick epidermal cuticle; note the tiny embryo (emb) internal to the micropyle (mi) and oriented toward the base of the fruitlet; b) Transverse section through apical part of two fruitlets (orthoslice xy0810) showing the fruitlet wall (fr) composed of small thin-walled cells covered by an epidermis of isodiametric cells (ep) with a thick outer cuticle (cu); c) Longitudinal section (orthoslice xz0370) through basal part of fruitlet perpendicular to section in (a) showing the micropyle (mi), embryo (emb) composed of tiny cells, and the thick cuticle (cu) covering the bulging cells of the fruitlet epidermis. Specimen, Catefica 50-S174907 (a–c). Scale bars = 300 Μm (a–c).
Ibrutinib Before and After Stem Cell Transplant in Treating Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma
ClinicalTrials.gov study NCT02443077. IPD Sharing: Not stated. Countries: 2. Publications: 0.
Mosunetuzumab With or Without Polatuzumab Vedotin and Obinutuzumab for the Treatment of Untreated Indolent B-Cell Non-Hodgkin Lymphoma
ClinicalTrials.gov study NCT05169658. IPD Sharing: NO. Countries: 1. Publications: 0.
Safety and Efficacy Study of Loncastuximab Tesirine + Ibrutinib in Diffuse Large B-Cell or Mantle Cell Lymphoma
ClinicalTrials.gov study NCT03684694. IPD Sharing: NO. Countries: 6. Publications: 0.
Patients With Relapsed or Refractory Diffuse Large B Cell Non Hodgkin Lymphomas
ClinicalTrials.gov study NCT01078922. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Subcutaneous Alemtuzumab (CAMPATH®, MabCampath®) in Relapsed/Refractory B-Cell Chronic Lymphocytic Leukemia
ClinicalTrials.gov study NCT00328198. IPD Sharing: Not stated. Countries: 6. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.