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1,501 results for “fatty acid”
A Novel Alzheimer's Disease Drug Candidate Targeting Inflammation and Fatty Acid Metabolism
GEO Series GSE93678. Mus musculus. 13 samples. Type: Expression profiling by high throughput sequencing.
Fatty acid-binding protein 4 drives neuroinflammation after intracerebral hemorrhage
GEO Series GSE295108. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Figure 2 from: Iosypenko OO, Kyslychenko VS, Omelchenko ZI, Burlaka IS (2019) Fatty acid composition of vegetable marrows and zucchini leaves. Pharmacia 66(4): 201-207. https://doi.org/10.3897/pharmacia.66.e37893
Figure 2 Scheme of chromatography of fatty acid composition of yellow zucchini leaves.
Figure 3 from: Iosypenko OO, Kyslychenko VS, Omelchenko ZI, Burlaka IS (2019) Fatty acid composition of vegetable marrows and zucchini leaves. Pharmacia 66(4): 201-207. https://doi.org/10.3897/pharmacia.66.e37893
Figure 3 Scheme of chromatography of fatty acid composition of green zucchini leaves.
Figure 1 from: Iosypenko OO, Kyslychenko VS, Omelchenko ZI, Burlaka IS (2019) Fatty acid composition of vegetable marrows and zucchini leaves. Pharmacia 66(4): 201-207. https://doi.org/10.3897/pharmacia.66.e37893
Figure 1 Scheme of chromatography of fatty acid composition of vegetable marrows leaves.
Figure 2 from: Savych A, Marchyshyn S, Basaraba R (2020) Determination of fatty acid composition content in the herbal antidiabetic collections. Pharmacia 67(3): 153-159. https://doi.org/10.3897/pharmacia.67.e51812
Figure 2 Chomatogram of fatty acids in the herbal antidiabetic collection № 4.
Figure 1 from: Savych A, Marchyshyn S, Basaraba R (2020) Determination of fatty acid composition content in the herbal antidiabetic collections. Pharmacia 67(3): 153-159. https://doi.org/10.3897/pharmacia.67.e51812
Figure 1 Chomatogram of fatty acids in the herbal antidiabetic collection № 3.
Figure 4 from: Savych A, Marchyshyn S, Basaraba R (2020) Determination of fatty acid composition content in the herbal antidiabetic collections. Pharmacia 67(3): 153-159. https://doi.org/10.3897/pharmacia.67.e51812
Figure 4 Chomatogram of fatty acids in the herbal antidiabetic collection № 13.
Figure 3 from: Savych A, Marchyshyn S, Basaraba R (2020) Determination of fatty acid composition content in the herbal antidiabetic collections. Pharmacia 67(3): 153-159. https://doi.org/10.3897/pharmacia.67.e51812
Figure 3 Chomatogram of fatty acids in the herbal antidiabetic collection № 7.
Figure 5 from: Savych A, Marchyshyn S, Basaraba R (2020) Determination of fatty acid composition content in the herbal antidiabetic collections. Pharmacia 67(3): 153-159. https://doi.org/10.3897/pharmacia.67.e51812
Figure 5 Chomatogram of fatty acids in the herbal antidiabetic collection № 19.
Data set for Fatty acid binding protein 5 forms higher order assemblies with FLAP or COX-2 in LPS-stimulated macrophages
<p>Data set for Fatty acid binding protein 5 forms higher order assemblies with FLAP or COX-2 in LPS-stimulated macrophages</p>
Data from: Divergence of cuticular hydrocarbons in two sympatric grasshopper species and the evolution of fatty acid synthases and elongases across insects
Cuticular hydrocarbons (CHCs) play a major role in the evolution of reproductive isolation between insect species. The CHC profiles of two closely related sympatric grasshopper species, Chorthippus biguttulus and C. mollis, differ mainly in the position of the first methyl group in major methyl-branched CHCs. The position of methyl branches is determined either by a fatty acid synthase (FAS) or by elongases. Both protein families showed an expansion in insects. Interestingly, the FAS family showed several lineage-specific expansions, especially in insect orders with highly diverse methyl-branched CHC profiles. We found five putative FASs and 12 putative elongases in the reference transcriptomes for both species. A dN/dS test showed no evidence for positive selection acting on FASs and elongases in these grasshoppers. However, one candidate FAS showed species-specific transcriptional differences and may contribute to the shift of the methyl-branch position between the species. In addition, transcript levels of four elongases were expressed differentially between the sexes. Our study indicates that complex methyl-branched CHC profiles are linked to an expansion of FASs genes, but that species differences can also mediated at the transcriptional level.
Data from: Tang-Nai-Kang alleviates pre-diabetes and metabolic disorders by inducing a gene expression switch toward fatty acid oxidation in SHR.Cg-Leprcp ⁄NDmcr rats
Increased energy intake and reduced physical activity can lead to obesity, diabetes and metabolic syndrome. Transcriptional modulation of metabolic networks has become a focus of current drug discovery research into the prevention and treatment of metabolic disorders associated with energy surplus and obesity. Tang-Nai-Kang (TNK), a mixture of five herbal plant extracts, has been shown to improve abnormal glucose metabolism in patients with pre-diabetes. Here, we report the metabolic phenotype of SHR.Cg-Leprcp/NDmcr (SHR/cp) rats treated with TNK. Pre-diabetic SHR/cp rats were randomly divided into control, TNK low-dose (1.67 g/kg) and TNK high-dose (3.24 g/kg) groups. After high-dose treatment for 2 weeks, the serum triglycerides and free fatty acids in SHR/cp rats were markedly reduced compared to controls. After 3 weeks of administration, the high dose of TNK significantly reduced the body weight and fat mass of SHR/cp rats without affecting food consumption. Serum fasting glucose and insulin levels in the TNK-treated groups decreased after 6 weeks of treatment. Furthermore, TNK-treated rats exhibited obvious improvements in glucose intolerance and insulin resistance. The improved glucose metabolism may be caused by the substantial reduction in serum lipids and body weight observed in SHR/cp rats starting at 3 weeks of TNK treatment. The mRNA expression of NAD+-dependent deacetylase sirtuin 1 (SIRT1) and genes related to fatty acid oxidation was markedly up-regulated in the muscle, liver and adipose tissue after TNK treatment. Furthermore, TNK promoted the deacetylation of two well-established SIRT1 targets, PPARγ coactivator 1α (PGC1α) and forkhead transcription factor 1 (FOXO1), and induced the phosphorylation of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) in different tissues. These observations suggested that TNK may be an alternative treatment for pre-diabetes and metabolic syndrome by inducing a gene expression switch toward fat oxidation through the activation of SIRT1 and AMPK signaling.
Figure 2 from: Slobodianiuk L, Budniak L, Feshchenko H, Sverstiuk A, Palaniza Y (2022) Quantitative analysis of fatty acids and monosaccharides composition in Chamerion angustifolium L. by GC/MS method. Pharmacia 69(1): 167-174. https://doi.org/10.3897/pharmacia.69.e76687
Figure 2 GC/MS chromatogram of fatty acids in the sample
Figure 1 from: Slobodianiuk L, Budniak L, Feshchenko H, Sverstiuk A, Palaniza Y (2022) Quantitative analysis of fatty acids and monosaccharides composition in Chamerion angustifolium L. by GC/MS method. Pharmacia 69(1): 167-174. https://doi.org/10.3897/pharmacia.69.e76687
Figure 1 GC/MS chromatogram of monosaccharides in C. angustifolium herb
Acyl-CoA dehydrogenases involved in fatty acid degradation of Pseudomonas aeruginosa: substrate specificity
<p>MD trajectories raw data </p>
Fig. 1 in An Effectiveness Of Artemia Nauplii Enrichment With Polyunsaturated Fatty Acids Using A Supplement Easy Dha Selco
Fig. 1. The content of TBARS in Artemia nauplii during bioencapsulation with Easy DHA Selco.
Data for 'Fatty acid capped, metal oxo clusters as smallest conceivable nanocrystal prototypes'
<p>The <em>.pxp</em> documents contain the experimental data of the figures in the manuscript and they can be opened/edited with the software IGOR Pro 8.0 or higher.</p> <p>Figure 3: Experimental PDF of zirconium oxo clusters with different capping ligands. The C-C, Zr-O, and Zr-Zr distances are assigned. We make a distinction between the Zr-Zr distances within one Zr6 cluster and the Zr-Zr distances that are characteristic for the dimer</p> <p>Figure 4: PDF refinement of the Zr12-acetate cluster with various models, derived from the reported crystal structure. 4 The best fit is obtained when including the oxygen and carbon atoms from the acetate ligands. The refined parameters are given in Table S1</p> <p>Figure 5: PDF refinement for Zr12-butanoate and Zr12-octanoate using the Zr12-acetate structure model. PDF refinement of Zr6- methylbutanoate using the Zr6-acetate structure model. Finally, the PDF refinement of Zr12-oleate using the Zr12-propionate structure model, with or without background correction in reciprocal space. If applied in the refinement, the exponentially dampening sine wave is shown (orange dotted lines). The refined parameters are given in Table S3.</p> <p>Figure 6: FTIR spectra of Zr12-acetate, -propionate, -hexanoate, -oleate and Zr6-methylheptanoate. The weak band at 1750 cm-1 in the spectrum of Zr12-acetate is assigned to a small amount of acetic acid that is not involved in hydrogen bonding of any kind. 71<br> An ester impurity is ruled out because of the absence of any signal around 4 ppm in NMR, (see Figure S10).</p> <p>Figure 7: (A) NMR spectra in CDCl3 of Zr12-acetate, -propionate, -hexanoate, -oleate and Zr6-methylheptanoate. (B) DOSY of the Zr12-acetate cluster with one faster diffusing species and a set of three resonances pertaining to a slowly diffusing species (the cluster)</p> <p>Figure 8: ESI-HR-MS analysis of the dimeric Zr12-butanoate cluster and of the monomeric Zr6-methylbutanoate cluster. Both the ex- perimental and simulated spectra are shown.</p> <p>Figure 10: (A) PDF fit for Hf12-acetate, Hf6-methylbutanoate and Hf12-oleate clusters with exponentially dampening sine wave con- tribution. The refined parameters are indicated in Table S9. (B) FTIR spectra of the hafnium oxo clusters synthesized via bottom up.</p> <p>Figure 11: Catalytic esterification of oleic acid with ethanol, catalyzed by either Zr12-oleate (green) or ZrO2 nanoparticles (gray). In both cases, 10 mol% Zr, with respect to the carboxylic acid substrate, was added.</p>
The Impact of Omega-3 Fatty Acid Supplements on Fibromyalgia Symptoms
ClinicalTrials.gov study NCT01352013. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Iron Isotope Study of an Iron Fatty Acid Complex
ClinicalTrials.gov study NCT03895424. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.