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6,699 results for “DEPRESSION”
Stresses affect inbreeding depression in complex ways: Disentangling stress-specific genetic effects from effects of initial size in plants
<p>The magnitude of inbreeding depression (ID) varies unpredictably among environments. ID often increases in stressful environments suggesting that these expose more deleterious alleles to selection or increase their effects. More simply, ID could increase under conditions that amplify phenotypic variation (CV²), e.g. by accentuating size hierarchies among plants. These mechanisms are difficult to distinguish when stress increases both ID and phenotypic variation. We grew in- and outbred progeny of <i>Mimulus guttatus</i> under six abiotic stress treatments (control, waterlogging, drought, nutrient deficiency, copper addition and clipping) with and without competition by the grass <i>Poa palustris</i>. ID differed greatly among stress treatments with δ varying from 7% (control) to 61% (waterlogging) but did not consistently increase with stress intensity. <i>Poa</i> competition increased ID under nutrient deficiency but not other stresses. Analyzing effects of initial size on performance of outbred plants suggests that under some conditions (low N, clipping) competition increased ID by amplifying initial size differences. In other cases (e.g., high ID under waterlogging), particular environments amplified the deleterious genetic effects of inbreeding suggesting differential gene expression. Interestingly, conditions that increased the phenotypic variability of inbred progeny regularly increased ID whereas variability among outbred progeny showed no relationship to ID. Our study reconciles the stress- and phenotypic variability hypotheses by demonstrating how specific conditions (rather than stress <i>per se</i>) act to increase ID. Analyzing CV² separately in inbred and outbred progeny while including effects of initial plant size improve our ability to predict how ID and gene expression vary across environments.</p>
FIGURE 4 in A new species of Danakilia (Teleostei, Cichlidae) from Lake Abaeded in the Danakil Depression of Eritrea (East Africa)
FIGURE 4. Danakilia dinicolai (a) wild caught female and (b) wild caught male. Specimens not preserved or measured.
FIGURE 3 in A new species of Danakilia (Teleostei, Cichlidae) from Lake Abaeded in the Danakil Depression of Eritrea (East Africa)
FIGURE 3. Lower pharyngeal jaw (dorsal, posterior and lateral views), left mandible and isolated tooth in (a) Danakilia dinicolai, (b) Danakilia franchettii, (c) Iranocichla hormuzensis. Elements drawn in corresponding scale for each species. Posterior neurocranium and anterior vertebral elements, arrows indicate inferior vertebral apophysis of (d) Iranocichla hormuzensis.
FIGURE 1 in A new species of Danakilia (Teleostei, Cichlidae) from Lake Abaeded in the Danakil Depression of Eritrea (East Africa)
FIGURE 1. Scatter plot of PC1 vs. PC2. Danakilia franchettii (black stars), Danakilia dinicolai (grey stars).
FIGURE 5 in Two new species of Salmoneus Holthuis, 1955 with a deep dorsal depression on the carapace (Crustacea, Decapoda, Alpheidae)
FIGURE 5. Salmoneus depressus sp. nov. A–I, paratype, ovigerous specimen (cl 4.8 mm) from Bocas del Toro, Caribbean coast of Panama, MNHN-IU-2011-5175; A, major cheliped, mesial; B, same, lateral; C, major chela, lateral; D, minor cheliped, lateral; F, same, carpus and minor chela, mesial; G, second pereiopod, lateral; H, third pereiopod, lateral; I, fifth pereiopod, lateral. Scale bars as indicated.
FIGURE 4 in Two new species of Salmoneus Holthuis, 1955 with a deep dorsal depression on the carapace (Crustacea, Decapoda, Alpheidae)
FIGURE 4. Salmoneus depressus sp. nov. A–L, paratype, ovigerous specimen (cl 4.8 mm) from Bocas del Toro, Caribbean coast of Panama, MNHN-IU-2011-5175; M, holotype, ovigerous specimen (cl 5.4 mm) from Bocas del Toro, MNHN-IU-2011- 5174; A, anterior region of carapace and frontal appendages, dorsal; B, same, lateral; C, same, tip of rostrum; D, carapace, lateral; E, same, dorsolateral; F, same, dorsal; G, fifth and sixth abdominal somites, lateral; H, preanal plate of sixth abdominal somite, ventral; I, telson, dorsal; J, antennal scaphocerite, dorsal; K, second pleopod, appendix masculina and appendix interna, mesial; L, uropod, dorsal; M, frontal margin of carapace. Scale bars as indicated; fig. H drawn without scale.
FIGURE 3 in Two new species of Salmoneus Holthuis, 1955 with a deep dorsal depression on the carapace (Crustacea, Decapoda, Alpheidae)
FIGURE 3. Salmoneus excavatus sp. nov. A, B, holotype, ovigerous specimen (cl 4.9 mm) from Chumical, Pacific coast of Panama, MNHN-IU-2011-5173, dorsal and lateral; C, paratype, non-ovigerous specimen (cl 5.3 mm) from Chumical, RMNH D53455, lateral.
FIGURE 2 in Two new species of Salmoneus Holthuis, 1955 with a deep dorsal depression on the carapace (Crustacea, Decapoda, Alpheidae)
FIGURE 2. Salmoneus excavatus sp. nov. A–I, paratype, non-ovigerous specimen (cl 5.3 mm) from Chumical, Pacific coast of Panama RMNH D53455; A, third maxilliped, lateral; B, major cheliped, mesial; C, same, lateral; D, major chela, lateral; E, minor cheliped, lateral; F, minor chela, lateral; G, second pereiopod, lateral; H, third pereiopod, lateral; I, fifth pereiopod, lateral. Scale bars as indicated.
FIGURE 6 in Two new species of Salmoneus Holthuis, 1955 with a deep dorsal depression on the carapace (Crustacea, Decapoda, Alpheidae)
FIGURE 6. Salmoneus depressus sp. nov. A, B, holotype, ovigerous specimen (cl 5.4 mm) from Bocas del Toro, Caribbean coast of Panama, MNHN- IU-2011-5174, dorsal and lateral; C, paratype, ovigerous specimen (cl 3.7 mm) from Bocas del Toro, RMNH D53457, lateral.
FIGURE 1 in Two new species of Salmoneus Holthuis, 1955 with a deep dorsal depression on the carapace (Crustacea, Decapoda, Alpheidae)
FIGURE 1. Salmoneus excavatus sp. nov. A–M, paratype, non-ovigerous specimen (cl 5.3 mm) from Chumical, Pacific coast of Panama, RMNH D53455; N, O, holotype, ovigerous specimen (cl 4.9 mm) from Chumical, MNHN-IU-2011-5173; A, anterior region of carapace and frontal appendages, dorsal; B, same, lateral; C, same, tip of rostrum; D, carapace, lateral (note: posterior margin covered by pleuron of first abdominal somite); E, same, dorsolateral; F, same, dorsal; G, fifth and sixth abdominal somites, lateral; H, preanal plate of sixth abdominal somite, ventral; I, telson, dorsal (note: abnormal telson with three spiniform setae missing); J, tooth on ventromesial carina of first article of antennular peduncle, lateral; K, antennal scaphocerite, dorsal; L, second pleopod, appendix masculina and appendix interna, mesial; M, uropod, dorsal; N, frontal margin of carapace; O, telson, dorsal (note: typical configuration). Scale bars as indicated; fig. H drawn without scale.
GWAS Summary data generated for study: disease clusters and their genetic determinants following a diagnosis of depression
<p>Second version of GWAS summary data</p> <p>A1: effect allele</p> <p>A2: other allele</p> <p>Project github page: https://github.com/HZcohort/3D-Disease-Network</p>
Factors associated with Depression: Insights from a cross–sectional study among University students in Vietnam
<p>This is the supportive data for research on depression in Vietnamese Student</p>
The Effect of Perception of Poverty on Quality of Life in Old Women and the Mediation of Depression Dataset
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FIGURES 56–57. S. pannonicus adult. 56, round depression near trochanter IV. 57 in Morphological analysis of the oribatid mite species Scutovertex pannonicus Schuster and description of its juvenile stages (Acari: Oribatida: Scutoverticidae)
FIGURES 56–57. S. pannonicus adult. 56, round depression near trochanter IV. 57, anal plate; caudal view; with setae ad1.
PREVALENCE OF ALCOHOL USE, DEPRESSIVE AND ANXIETY DISORDERS AMONG PATIENTS OF OPIOID AGONIST TREATMENT PROGRAMMES IN UKRAINE
<p>Prevalence data collection was organised based on Opioid Assisted Treatment centres in three Ukrainian cities, Kyiv (one centre, centre of Ukraine), Sumy (one centre, east), and Lviv (one centre, west), during the period from October 2021 to January 2022 (before the full-scale Russian invasion). </p><p>The staff of OAT centres did all the data collection. Doctors, psychologists, or social workers who previously obtained detailed instructions made individual screenings for medication during patients' appointed visits. All the questionaries (AUDIT for alcohol use patterns, PHQ-9 for depression symptoms, GAD-7 for anxiety symptoms) were printed out in the Ukrainian language and filled in together with each patient. In addition, the number of missed visits on site for substitute medication for the last month was counted, and blood alcohol levels were recorded with the breath-alcohol measuring instrument (Drager Alcotest 6820). </p><p>The dataset is based on the results of the program of the Global Fund to Fight AIDS, Tuberculosis and Malaria, "Accelerating Progress in Reducing the Burden of Tuberculosis and HIV Infection in Ukraine", in accordance with the Grant Agreement between the Public Health Center of Ministry of Health of Ukraine and the Global Fund to Fight AIDS, Tuberculosis and Malaria No. 1936 of December 04, 2020. The donor was not involved in the study design, the collection, analysis and interpretation of data or the preparation of the article.</p>
Depressions and Boundary_Integrating Remote Sensing and Machine Learning for Developing Spatio-Temporal Model to Predict Aquatic Larval Habitats of Malaria
<p>Depressions and Boundary_Integrating Remote Sensing and Machine Learning for Developing Spatio-Temporal Model to Predict Aquatic Larval Habitats of Malaria</p>
Minimal dataset to run CAUSEWAY - 5 eQTLGen genes, PLINK european bfiles and 1 Depression MTAG sumstats
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Health care professionals' experiences of screening immigrant mothers for postpartum depression – a systematic review
<p>This is the dataset and supplementary material to a study looking at the health care professionals’ experiences of postpartum depression in immigrant mothers. Postpartum depression is considered a major public health problem, which immigrant mothers are at particular risk of being affected by, but it can also have long-lasting traumatic effects on the partner’s health and the child’s health and development. Previous studies have suggested that identifying signs of postpartum depression and performing screening on immigrant mothers is challenging for HCPs, and a meta-synthesis was therefore undertaken to describe their experiences. </p> <p><strong>Methods</strong></p> <p>The databases CINAHL, PubMed, PsycINFO, SocINDEX, Embase, and Cochrane were searched for papers published January 2000–December 2020, reporting qualitative data on immigrants, postpartum depression, and the Edinburgh Postnatal Depression Scale. Eight papers representing eight studies from four countries were included and the Critical Appraisal Skills Program was used to assess their quality. The synthesis of studies was guided by Noblit & Hare’s seven-step method based on meta-ethnography. The dataset is the information from the quality appraisal and grid of concepts from the analysis. </p> <p><strong>Findings</strong></p> <p>The synthesis resulted in two final themes: “I do my best, but I doubt that it’s enough” and “I can find no way forward”. The themes convey the fear and frustration that health care professionals experienced; fear of missing mothers with signs of postpartum depression, related to feeling uncomfortable in the cross-cultural setting and frustration in handling difficulties associated with communication, translated versions of the Edinburgh Postnatal Depression Scale and cultural implications of postpartum depression. </p> <p><strong>Conclusions and clinical implication</strong></p> <p>By supporting HCPs’ self-efficacy in handling cultural implications of postpartum depression and by developing evidence-based clinical guidelines for the use of interpreters and translated versions of the Edinburgh Postnatal Depression Scale the screening of immigrant mothers may be facilitated.</p>
Study data supporting the manuscript titled: Effect of buprenorphine on fentanyl-induced respiratory depression
<p><b>Background: </b>Opioid-induced respiratory depression driven by ligand binding to mu-opioid receptors is a leading cause of opioid-related fatalities. Buprenorphine, a partial agonist, binds with high affinity to mu-opioid receptors but displays partial respiratory depression effects. The authors examined whether sustained buprenorphine plasma concentrations similar to those achieved with some extended-release injections used to treat opioid use disorder could reduce the frequency and magnitude of fentanyl-induced respiratory depression.</p> <p><b>Methods:</b> In this two-period crossover, single-centre study, 14 healthy volunteers (single-blind, randomized) and eight opioid-tolerant (OT) patients taking daily opioid doses ≥90 mg oral morphine equivalents (open-label) received continuous intravenous buprenorphine or placebo for 360 minutes, targeting buprenorphine plasma concentrations of 0.2 or 0.5 ng/mL in healthy volunteers and 1.0, 2.0 or 5.0 ng/mL in OT patients. Upon reaching target concentrations, participants received up to four escalating intravenous doses of fentanyl. The primary endpoint was change in isohypercapnic minute ventilation (V<sub>E</sub>). Additionally, occurrence of apnea was recorded.</p> <p><b>Results:</b> Fentanyl-induced changes in V<sub>E</sub> were smaller at higher buprenorphine plasma concentrations. In healthy volunteers, at target buprenorphine concentration of 0.5 ng/mL, the first and second fentanyl boluses reduced V<sub>E</sub> by [LSmean (95% CI)] 26% (13-40%) and 47% (37-59%) compared to 51% (38-64%) and 79% (69-89%) during placebo infusion (<i>p</i>=0.001 and <.001, respectively). Discontinuations for apnea limited treatment comparisons beyond the second fentanyl injection. In OT patients, fentanyl reduced V<sub>E</sub> up to 49% (21-76%) during buprenorphine infusion (all concentration groups combined) versus up to 100% (68-132%) during placebo infusion (<i>p</i>=0.006). In OT patients, the risk of experiencing apnea requiring verbal stimulation following fentanyl boluses was lower with buprenorphine than with placebo (odds ratio: 0.07; 95% CI: 0.0 to 0.3; <i>p</i>=0.001).</p> <p><b>Interpretation:</b> Results from this proof-of-principle study provide the first clinical evidence that high sustained plasma concentrations of buprenorphine may protect against respiratory depression induced by potent opioids like fentanyl.</p>
A calcium-based plasticity model for predicting long-term potentiation and depression in the neocortex
<p>This dataset contains all (>1000) cell pairs as the Blue Brain Projects <a href="https://github.com/BlueBrain/EModelRunner">EModelRunner</a> packages as well as analysis code and analysed data used for the figures of our <a href="https://www.biorxiv.org/content/biorxiv/early/2020/04/20/2020.04.19.043117.full.pdf">preprint</a>: <em><strong>"A calcium-based plasticity model predicts long-term potentiation and depression in the neocortex"</strong></em>.</p> <p>More documentation will follow in the upcoming days.</p> <p><strong>Updates:</strong><br> v1.1 (31/12/2021): updated READMEs within cell_packages, added 2 extra authors for their contribution in EModelRunner.<br> v1.2 (31/12/2021): same as v1.1 but w/o MacOS junk<br> v1.3 (11/01/2022): added analysis notebooks<br> v2.0 (11/01/2022): same as v1.3 but w/o MacOS junk and proper version number<br> v2.1 (14/03/2022): fetching data from websites when possible instead of providing the downloaded csv files.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.