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opennotspecifiedFeb 2022View details →

Fig. 7 in 13,13a-seco-protoberberines from the tubers of Corydalis yanhusuo and their anti-inflammatory activity

Fig. 7. Effects of compound 4 on the production of inflammatory cytokines (A: TNF-α, B: IL-1β, and C: IL-6) in LPS-activated RAW264.7 cells using enzyme-linked immunoassay (ELISA). Data were expressed as mean values ± SD, n = 3. #p <0.05, ####p <0.0001, compared with the control group (without compound 4 and LPS), ****p <0.001, compared with the LPS-induced group (only treated with LPS).

Fig. 5 in Anti-inflammatory and anti-proliferative activities of chemical constituents from fungus Biscogniauxia whalleyi SWUF13-085

Fig. 5. Experimental ECD spectra of compounds 1 and 2 in CHCl3 compared with calculated spectra of (2R,3R,4R,6S,7S)-1 and (2S,3S,4S,6R,7R)-1.

Fig. 3. Key 1H in Anti-inflammatory and anti-proliferative activities of chemical constituents from fungus Biscogniauxia whalleyi SWUF13-085

Fig. 3. Key 1H NMR region of the bergamotene's bicyclic ring analogues (1 and 3) demonstrating the multiplicity and coupling constants (J) of the bridgering protons.

Fig. 1 in Anti-inflammatory and anti-proliferative activities of chemical constituents from fungus Biscogniauxia whalleyi SWUF13-085

Fig. 1. Chemical structures of compounds 1–35; the undescribed bergamotenes, α-pyrone, and guaiane in blue, red and green, respectively. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)

Fig. 7 in Anti-inflammatory and anti-proliferative activities of chemical constituents from fungus Biscogniauxia whalleyi SWUF13-085

Fig. 7. Experimental ECD spectrum of compound 6 in CHCl3 compared with calculated spectra of (1R,2S,6R, 7R)-6, (1S,2R,6S, 7S)-6, (1R,2S,6R, 7S)-6 and (1S,2R,6S, 7R)-6.

opennotspecifiedFeb 2020View details →

Fig. 5 in Anti-inflammatory and cytotoxic carbazole alkaloids from Murraya kwangsiensis

Fig. 5. Calculated and experimental ECD spectra of compound 17 (A) and experimental ECD spectra of 7 and 10 (B).

Fig. 6 in Anti-inflammatory and anti-proliferative activities of chemical constituents from fungus Biscogniauxia whalleyi SWUF13-085

Fig. 6. Experimental ECD spectra of compound 3 and the mixture of 4 and 5 in MeOH compared with calculated spectra of (2S,6S,7S)-3 and (2R,6R,7R)-3.

opennotspecifiedMar 2022View details →

Fig. 4. GLP-1 in Cucurbitane-type triterpenoids from the vines of Momordica charantia and their anti-inflammatory, cytotoxic, and antidiabetic activity

Fig. 4. GLP-1 secretory effects of compounds 1, 3, and 7 in STC-1 cells. GLP-1 secretory response under each condition was illustrated. Rutin (25 μg/mL) is positive control. Data represent Means ± SEM (n = 4). ***P <0.001, compared with None.

opennotspecifiedMar 2022View details →

Fig. 2. 2D in Cucurbitane-type triterpenoids from the vines of Momordica charantia and their anti-inflammatory, cytotoxic, and antidiabetic activity

Fig. 2. 2D-NMR correlations of the isolated cucurbitanes. (A) 1H–1H COSY and key HMBC correlations of compounds 1, 4, 5, and 6. (B) Main NOESY correlations of compounds 1, 2, 6, and 7.

Fig. 10 in Diterpenoids from Sigesbeckia glabrescens with anti-inflammatory and AChE inhibitory activities

Fig. 10. The inhibition kinetics of 3-O-acetyldarutigenol (15) towards AChE. (A) Lineweaver-Burk plots for the inhibition of AChE by 3-O-acetyldarutigenol. (B) Determination of Ki using the slopes from Lineweaver–Burk plot towards the concentration of 3-O-acetyldarutigenol.

Fig. 8. Siegetalis H in Diterpenoids from Sigesbeckia glabrescens with anti-inflammatory and AChE inhibitory activities

Fig. 8. Siegetalis H (11) blocks LPS-induced activation of the NF-κB pathway. (A) The phosphorylated and total protein levels of IκBα, as well as the protein level of β-actin, were quantified by immunoblotting in cell lysates of RAW264.7 cells. (B) The quantitative analysis of p- IκBα and IκBα protein levels, normalized against β-actin. (C) Immunoblot analysis of the cytoplasmic and nuclear distribution of p65 NF-κB in RAW264.7 cells. (D) Quantitative analysis of p65 protein levels, normalized against Histone H3 or β-actin. Data are presented as means ± SD, n = 3; #p <0.05, ##p <0.01, ###p <0.001, ####p <0.0001 vs control; *p <0.05, **p <0.01, ***p <0.001, ****p <0.0001 vs LPS only.

Fig. 7 in Diterpenoids from Sigesbeckia glabrescens with anti-inflammatory and AChE inhibitory activities

Fig. 7. Effect of siegetalis H (11) on inflammatory factors on LPS-induced RAW264.7 cells. (A) The cell lysates were collected to detect the expression of iNOS and COX-2. (B) Quantitative analysis of iNOS and COX-2 protein levels, normalized against β-actin. Data are presented as means ± SD, n = 3; #p <0.05, ##p <0.01, ###p <0.001, ####p <0.0001 vs control; *p <0.05, **p <0.01, ***p <0.001, ****p <0.0001 vs LPS only.

Fig. 6 in Chemical constituents of Rumex dentatus L. and their antimicrobial and anti-inflammatory activities

Fig. 6. Anti-inflammatory properties of the isolated compounds. (A): Effects of compounds 1–17 and 19 on LPS-induced NO production in RAW264.7 cells at a concentration of 50μM; (B): Effect of compound 9 on the viability of RAW264.7 cells; (C): Effects of compound9 on LPS-induced NO production in RAW264.7 cells at different concentrations.

Fig. 5 in Chemical constituents of Rumex dentatus L. and their antimicrobial and anti-inflammatory activities

Fig. 5. LC‒MS/MS identification. (A): Total ion chromatogram of crude ethanol extract in negative ion mode with numbers of identified compounds; (B): Total ion chromatogram of crude ethanol extract in positive ion mode; (C): HPLC chromatography of crude ethanol extract monitored at 254 nm and names of the two most abundant compounds.

Fig. 8. Compound 14 activated Nrf2 in Diterpenoids with anti-inflammatory activity from Euphorbia wallichii

Fig. 8. Compound 14 activated Nrf2/HO-1 signaling pathway. (A–C) The expressions of Nrf2 and HO-1 were determined by Western blot analysis and the quantification of protein expression was performed by Image J. (D) The inhibitory effect of 14 (16 μM) on the nuclear translocation of Nrf2 induced by LPS via confocal laser scanning microscopy. RAW264.7 cells stained for Nrf2 (red) and nuclei (DAPI, blue) (scale bar: 10 μm). The values are presented as mean ± SD of three independent experiments, n 3. ###p <0.001, vs. the control group; **p <0.01, ***p <0.001, vs. LPS-treated group. (For interpretation of the references to color in = this figure legend, the reader is referred to the Web version of this article.)

Fig. 7. Compound 14 in Diterpenoids with anti-inflammatory activity from Euphorbia wallichii

Fig. 7. Compound 14 reduced LPS-induced inflammatory factors production and inhibited NF-κB nuclear translocation. (A–C) The expressions of iNOS and COX-2 were determined by Western blot analysis. (D–F) The expressions of NF-κB, p-IκBα, and IκBα were determined by Western blot analysis. The quantification of protein expression was performed by Image J. (G) The inhibitory effect of compound 14 (16 μM) on the nuclear translocation of NF-κB p65 induced by LPS via confocal laser scanning microscopy. RAW264.7 cells stained for NF-κB (green) and nuclei (DAPI, blue) (scale bar: 10 μm). The values were presented as mean ± SD of three independent experiments, n 3. ###p <0.001, vs. the control group; **p <0.01, ***p <0.001, vs. LPS-treated group. (For interpretation of the references to color in = this figure legend, the reader is referred to the Web version of this article.)

Fig. 6. Compound 14 in Diterpenoids with anti-inflammatory activity from Euphorbia wallichii

Fig. 6. Compound 14 reduced LPS-induced pro-inflammatory cytokines release. (A) The NO inhibition curve of compound 14, with an IC50 of 3.84 ± 0.25 μM. (B) Cell viability rate of RAW264.7 cells treated with compound 14 (0, 3.125, 6.25, 12.5, 25, 50, 100 μM) for 24 h. (C–D) Effects of compound 14 on production of inflammatory cytokines (IL-6 and TNF-α) in LPS-induced RAW264.7 cells. ###, p <0.001 vs. control group. *, p <0.1, **, p <0.01 and ***, p <0.001 vs. LPStreated group.

Fig. 5 in Diterpenoids with anti-inflammatory activity from Euphorbia wallichii

Fig. 5. Effect of compounds 1–23 (20 μM) on LPS-induced NO production, using dexamethasone (Dex) as the reference drug.

opennotspecifiedApr 2023View details →

Fig. 9. Compounds 4 and 5 in Eremophilane-type and xanthanolide-type sesquiterpenes from the aerial parts of Xanthium sibiricum and their anti-inflammatory activities

Fig. 9. Compounds 4 and 5 inhibited the activation of the PI3K/AKT/mTOR signaling pathway in LPS induced RAW264.7 cells. Compound 4 (A) influenced the expression of relative proteins related to the PI3K/AKT/mTOR signaling pathway and the relative levels of P-mTOR/mTOR (B) and P-AKT/AKT (C) were quantified. Compound 5 (D) influenced the expression of relative proteins related to the PI3K/AKT/mTOR signaling pathway and the relative levels of P-mTOR/mTOR (E) and PAKT/AKT (F) were quantified. Data are presented as the mean ± SD (n = 3). ##p <0.01 and ###p <0.001, compared with the group untreated with LPS; *p <0.05, **p <0.01, and ***p <0.001 compared with the group treated with LPS.