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1,048
datasets available to search
ShareScore release 0.9.0
Dataset results
1,048 results for “aging effects”
Characterising the effect of age and sex on post-transcriptional regulation in synovial joint tissues
GEO Series GSE306550. Equus caballus. 13 samples. Type: Expression profiling by high throughput sequencing.
Effect of Advanced Paternal Age on Copy Number Variation in Offspring
GEO Series GSE29456. Mus musculus. 49 samples. Type: Genome variation profiling by genome tiling array.
The effect of age on crystalline silica-induced pulmonary toxicity-aged rats
GEO Series GSE250537. Rattus norvegicus. 46 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic modifications associated to protective effect of Pedro-Ximenez must on p,p´- DDE-induced liver injury in aged Mus spretus mice
GEO Series GSE109254. Mus musculus; Mus spretus. 12 samples. Type: Expression profiling by array.
Therapeutic effects of Tie2 activation in treatment of neovascular age-related macular degeneration over conventional VEGF blockade.
GEO Series GSE88730. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Effect of short-term high fat diet consumption on hippocampal and amygdalar gene expression in adult and aged male rats
GEO Series GSE223802. Rattus norvegicus. 24 samples. Type: Expression profiling by high throughput sequencing.
Deep Phenotyping and Lifetime Trajectories Reveal Limited Effects of Longevity Regulators on the Aging Process
GEO Series GSE168068. Mus musculus. 102 samples. Type: Expression profiling by high throughput sequencing.
Effects of propranolol exposure to Pimephales promelas (fathead minnow) larva across age and duration
GEO Series GSE197442. Pimephales promelas. 270 samples. Type: Expression profiling by high throughput sequencing.
Dataset related to the article "Effects of RAGE Deletion on the Cardiac Transcriptome during Aging"
<p>This record contains raw data related to the article“Effects of RAGE Deletion on the Cardiac Transcriptome during Aging”</p> <p><strong>Abstract</strong></p> <p>Cardiac aging is characterized by increased cardiomyocyte hypertrophy, myocardial stiffness, and fibrosis, which enhance cardiovascular risk. The receptor for advanced glycation end-products (RAGE) is involved in several age-related diseases. RAGE knockout (Rage−/−) mice show an acceleration of cardiac dimension changes and interstitial fibrosis with aging. This study identifies the age-associated cardiac gene expression signature induced by RAGE deletion. We analyzed the left ventricle transcriptome of 2.5-(Young), 12-(Middle age, MA), and 21-(Old) months-old female Rage−/− and C57BL/6N (WT) mice. By comparing Young, MA, and Old Rage−/− versus age-matched WT mice, we identified 122, 192, and 12 differently expressed genes, respectively. Functional inference analysis showed that RAGE deletion is associated with: (i) down-regulation of genes involved in antigen processing and presentation of exogenous antigen, adaptive immune response, and cellular responses to interferon beta and gamma in Young animals; (ii) up-regulation of genes related to fatty acid oxidation, cardiac structure remodeling and cellular response to hypoxia in MA mice; (iii) up-regulation of few genes belonging to complement activation and triglyceride biosynthetic process in Old animals. Our findings show that the age-dependent cardiac phenotype of Rage−/− mice is associated with alterations of genes related to adaptive immunity and cardiac stress pathways.</p>
A Dietary Supplement Examined for Anti-ageing Effects
ClinicalTrials.gov study NCT06714162. IPD Sharing: YES. Countries: 0. Publications: 0.
Aging-associated inflammatory and oxidative changes in the rat urinary bladder and dorsal root ganglia - preventive effect of caloric restriction
GEO Series GSE63652. Rattus norvegicus. 24 samples. Type: Expression profiling by array.
Effect of MIT-001 on gene expression in aged mouse ovaries
GEO Series GSE232918. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Effects of hyperbaric oxygen on tissue-specific aging and senescence in mice and human stromal cells
GEO Series GSE296209. Mus musculus; Homo sapiens. 45 samples. Type: Expression profiling by high throughput sequencing.
Effect of Arg2 deletion on murine liver gene expression profiles in aging mice
GEO Series GSE228420. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Anti-aging and Rejuvenating Effects and Potential Mechanism of Dead Sea Water in Skin
GEO Series GSE240486. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Dynamical modeling reveals RNA decay mediates the effect of matrix stiffness on aged muscle stem cell fate
GEO Series GSE225583. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Aging-associated inflammatory and oxidative changes in the rat urinary bladder and dorsal root ganglia - preventive effect of caloric restriction [L6 dorsal root ganglia]
GEO Series GSE63651. Rattus norvegicus. 12 samples. Type: Expression profiling by array.
Effect of Astragalus Polysaccharide Combined with Metformin on Liver mRNA expression profile in aging type 2 diabetic mice and functional analysis
GEO Series GSE132599. Mus musculus. 4 samples. Type: Expression profiling by array.
effect of age liver
GEO Series GSE789. Rattus norvegicus. 7 samples. Type: Expression profiling by array.
RNA-Seq of BMDM from aged mice and the effect of trained immunity
GEO Series GSE198083. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.