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opennotspecifiedNov 2021View details →

Fig. 1 in Characterization of NAC family genes in Salvia miltiorrhiza and NAC2 potentially involved in the biosynthesis of tanshinones

Fig. 1. Phylogenetic relationship among the NAC family members of S. miltiorrhiza and Arabidopsis. Full-length amino acid sequences were aligned using ClustalW, and the phylogenetic tree was constructed using the MEGA7 method. The tree clustered the NAC proteins into different groups, which are indicated by different colors within the clades. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)

opennotspecifiedNov 2021View details →

Fig. 3 in Characterization of NAC family genes in Salvia miltiorrhiza and NAC2 potentially involved in the biosynthesis of tanshinones

Fig. 3. Genetic transformation of Sm-NAC2 in S. miltiorrhiza transgenic roots. a, the mevalonate (MVA) and methylerythritol phosphate (MEP) pathways in tanshinone biosynthesis, and the expression of key enzyme-encoding genes HMGR, DXS, DXR, GGPPS, CPS, KSL, CYP76AH1 in the tanshinone biosynthetic pathway; b, the transgenic roots phenotypes; c, tanshinone I (T–I), tanshinone IIA (T-IIA), cryptotanshinone (CT), and dihydrotanshinone I (DT-I) contents in transgenic roots of S. miltiorrhiza transgenic and control lines.

Fig. 7 in Phylogeny, structural diversity and genome-wide expression analysis of fibrillin family genes in rice

Fig. 7. Expression profiles analysis of OsFBNs under different temperature stresses. Eleven OsFBN genes in rice were detected for their transcript levels in leave tissues of seedlings at the three-leaf stage with different time intervals after the 35 ̊C (heat stress) and 6 ̊C (cold stress) stresses in the growth chamber, separately. The OsUBQ gene was used as a normalization control; data was measured as the mean values ± SD of three replicates, respectively.

Fig. 4 in Phylogeny, structural diversity and genome-wide expression analysis of fibrillin family genes in rice

Fig. 4. Phylogenetic and exon-intron structure analysis of FBN family genes in rice and Arabidopsis. The phylogenetic analysis was performed using the amino acid sequences of 25 FBN family proteins in rice and Arabidopsis (Left). The unrooted phylogenetic tree was generated by the neighbor-joining method and displayed using MEGA7 software. Numbers above or below branches of the evolution tree indicated the bootstrap values; The exon-intron structures of 25 FBN family genes in rice and Arabidopsis were analyzed (Right), the exons were represented by yellow boxes, the UTR by blue, black lines connecting two exons were introns. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)

Fig. 6 in Phylogeny, structural diversity and genome-wide expression analysis of fibrillin family genes in rice

Fig. 6. The in vitro lipid binding assays of PAP-domains. A and C, schematic representations of the mutant residues in OsFBN2 and OsFBN4 proteins in the in vitro lipid binding assays. B and D, the in vitro lipid-binding activity assays were performed by a fluorescence lipid probe P-96 (1 mM), fatty acids with C12:0, C14:0, C16:0, C18:0, C20:0, C22:0, with each (0.5 mM) of wild type (Wt) and mutant fusion protein (Mut) of PAP domains in OsFBN2 and OsFBN4 proteins, respectively. Detection experiments were performed with three biological replicates. * and ** symbols indicated the significant difference levels of P <0.05 or P <0.01 between mutant and wild type, respectively.

Fig. 5 in Phylogeny, structural diversity and genome-wide expression analysis of fibrillin family genes in rice

Fig. 5. Subcellular localization of CTP domains-fused GFP proteins. These constructs of p35S-FBN1-11-CTP-GFP or p35S-Trxm5-GFP, separately, were transiently expressed in Nicotiana benthamiana mesophyll cells. The co-localizations of fluorescence patterns of CTP domains of ten OsFBN proteins except OsFBN8 fused GFP were observed with the autofluorescence of chlorophyll in chloroplasts in protoplasts. The Trxm5-GFP was used as a chloroplast marker.

Fig. 3 in Phylogeny, structural diversity and genome-wide expression analysis of fibrillin family genes in rice

Fig. 3. PKC domain analysis of FBN11 clade in plants. A, Homology analysis of PKC domain sequences in FBN11 clades; B, evolutionary tree analysis of PKC domain in five plant species (Oryza sativa (Os), Selaginella moellendorffii (Smo), Arabidopsis thaliana (At), Glycine max (Gm), and Zea mays (Zm)) and algae (Monoraphidium neglectum (Mon), Chlorella sorokiniana (Chlo), Chlamydomonas sp. UWO 241 (Chla), and Haemato coccus lacustris (Hae); C, the conserved motif analysis of PKC domain in FBN11 protein clades in higher plants.

Fig. 2 in Phylogeny, structural diversity and genome-wide expression analysis of fibrillin family genes in rice

Fig. 2. Box-plot graphs and motif analysis of CTP and PAP-domain in plants. The protein sequences of CTP domains and PAP domains were analyzed in six plant species: Selaginella moellendorffii (Smo), Physcomitrella patens (Ppa), Arabidopsis thaliana (At), Glycine max (Gm), Oryza sativa (Os), and Zea mays (Zm), The grand average of hydropathicity (GRAVY) and isoelectric point (pI) of CTP domains of FBN1-11 protein clades were showed in A and B, respectively; The GRAVY and pI of PAP domains in FBN1-11 protein clades were showed in C and D, respectively; The dotted line represented the average values of GRAVY and pI, respectively; The conserved motif sequence of PAP domains in these plants were showed in E.

Fig. 1 in Phylogeny, structural diversity and genome-wide expression analysis of fibrillin family genes in rice

Fig. 1. Phylogenetic tree analysis of 121 fibrillin family proteins from 10 representative species. The neighbor-joining tree was constructed using the sequences of 121 fibrillin family proteins in ten representative species: Synechococcus sp. PCC 7002 (Ssp), Erysimum siliculosus (Esi), Emiliania huxleyii (Ehu), Thalassiosira pseudonana (Tps), Chlamydomonas reinhardtii (Cre), Volvox carteri (Vca), Physcomitrella patens (Ppa), Selaginella moellendorffii (Smo), Arabidopsis thaliana (At) and Oryza sativa (Os). Bootstrap values were indicated on the branches. Each fibrillin protein was labeled by its name (Table S3). The green and red color meant the proteins present in algae or terrestrial plant, respectively; the blue color represents the proteins present in both algae and terrestrial plants. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)

closedIPD-NOFeb 2026View details →

The Jewels in Our Genes Study - an African American Family Study of Breast Cancer

ClinicalTrials.gov study NCT01380925. IPD Sharing: NO. Countries: 1. Publications: 1.

closedIPD-NOFeb 2026View details →

NGGT006 Gene Therapy for Homozygous Familial Hypercholesterolemia

ClinicalTrials.gov study NCT06125847. IPD Sharing: NO. Countries: 1. Publications: 0.

The Role of Angiotensinogen Gene Polymorphism in the Pathogenesis of Non-familial Sick Sinus Syndrome

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Sequencing to Identify Gene Variants in Familial Colorectal Cancer

ClinicalTrials.gov study NCT01904630. IPD Sharing: Not stated. Countries: 1. Publications: 1.

Safety, Tolerability, and Activity Study of ISIS SOD1Rx to Treat Familial Amyotrophic Lateral Sclerosis (ALS) Caused by SOD1 Gene Mutations

ClinicalTrials.gov study NCT01041222. IPD Sharing: Not stated. Countries: 1. Publications: 1.

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ClinicalTrials.gov study NCT01075061. IPD Sharing: Not stated. Countries: 1. Publications: 1.

French Digestive Polyposis Cohorte Family Adenomatous Polyposis With APC and MYH Gene Mutations , Cowden's Disease With PTEN Gene Mutation, Peutz Jeghers Disease With STK 11 Gene Mutation ,juvénil Pol

ClinicalTrials.gov study NCT01987518. IPD Sharing: Not stated. Countries: 1. Publications: 0.

Energy Balance Interventions in Increasing Physical Activity in Breast Cancer Gene Positive Patients, Lynch Syndrome-Positive Patients, CLL Survivors or High-Risk Family Members

ClinicalTrials.gov study NCT02194387. IPD Sharing: Not stated. Countries: 1. Publications: 1.

controlledIPD-YESFeb 2026View details →

Lessons Learned From the Family Gene Toolkit

ClinicalTrials.gov study NCT02154633. IPD Sharing: YES. Countries: 1. Publications: 1.

Identify the Genes Polymorphisms Related to Non-familial Bradyarrhythmia

ClinicalTrials.gov study NCT01310907. IPD Sharing: Not stated. Countries: 1. Publications: 1.