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543
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Dataset results
543 results for “roles and responsibilities”
Role of Vit-D Supplementation on BioNTech, Pfizer Vaccine Side Effect and Immunoglobulin G Response
ClinicalTrials.gov study NCT05851313. IPD Sharing: NO. Countries: 1. Publications: 1.
Testing the Role of FDG-PET/CT to Predict Response to Therapy Prior to Surgery for HER2-positive Breast Cancer, The DIRECT Trial
ClinicalTrials.gov study NCT05710328. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Role of Glycaemic Index and High Protein Meal in Response of Blood Biomarkers for Pre-diabetes
ClinicalTrials.gov study NCT03309254. IPD Sharing: NO. Countries: 1. Publications: 1.
The Regulatory Role of Immune Response in Oral Lichen Planus
ClinicalTrials.gov study NCT05997173. IPD Sharing: NO. Countries: 1. Publications: 5.
Dataset of Rapid adaptive responses of rosette-type macrophyte Vallisneria natans juveniles to varying water depths: The role of leaf trait plasticity
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Data from: Uncovering a mitochondrial unfolded protein response in corals and its role in adapting to a changing world
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Data from: The role of platelets in mediating a response to human influenza infection
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Scale-dependent responses in spider and beetle communities to flooding: The role of dry refuges in wetlands
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Data from: Patterns and thresholds of grazing-induced changes in community structure and ecosystem functioning: species-level responses and the critical role of species traits
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Data from: Demographic responses of rare forest plants to multiple stressors: the role of deer, invasive species and nutrients
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Data from: Richness of plant communities plays a larger role than climate in determining responses of species richness to climate change
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Data from: Mimicking a rainfall gradient to test the role of soil microbiota for mediating plant species responses to drier conditions
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Changes in body surface temperature play an under-appreciated role in the avian immune response
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Data from: Teasing apart plant community responses to N enrichment: the roles of resource limitation, competition and soil microbes
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Data from: Fitness in invasive social wasps: the role of variation in viral load, immune response and paternity in predicting nest size and reproductive output
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Data from: Sex-specific responses to sexual familiarity, and the role of olfaction in Drosophila
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Developing a transformational digital strategy in an SME: The role of responsible management
<p>Ths is the dataset for our open source Emerald publication.</p>
The transcriptomic response of murine thyroid to iodide overload and the role of the Nrf2 antioxidant system
<p>Wild-type and Nrf2(Nfe2l2) knockout male C57BL6J mice 3-4 months old were administred 0.05% NaI in their drinking water for 7 days. Control mice were administered regular drinking water. After this treatment mice were euthanized and thyroids were excised for RNA preparation and then for mRNA and miRNA RNAseq. </p> <p>The file titled "metadata RNAseq mRNA thyroid" contains the experimental information as well as the allocation of sample numbers to the relevant groups. Briefly, </p> <p>806 Knockout Iodide</p> <p>829 Wild type Iodide</p> <p>815 Knockout Control</p> <p>811 Knockout Control</p> <p>801 Knockout Iodide</p> <p>836 Wild type Control</p> <p>838 Wild type Control</p> <p>807 Knockout Iodide</p> <p>834 Wild type Control</p> <p>827 Wild type Iodide</p> <p>831 Wild type Iodide</p> <p>804 Knockout Iodide</p> <p>825 Wild type Iodide</p> <p>841 Wild type Control</p> <p>812 Knockout Control</p> <p>803 Knockout Iodide</p> <p>810 Knockout Control</p> <p>The fastq data have been uploaded. The ones with "miRNA" in their file name refer to miRNA sequencing. All the others refer to mRNA sequencing.</p>
Revealing the roles of DnaA on the biological characteristics of Brucella and the inflammatory response to Brucella
<p>The <i>Brucella</i> cell cycle, including chromosomal replication and cell division, is coordinated with the virulence of the bacteria. DnaA, a chromosomal replication initiator protein, is an essential regulator of cell cycle progression and is tightly regulated both temporally and spatially because it is activated only once per cell cycle in bacteria. Although DnaA exists in many bacteria, the role of DnaA during <i>Brucella</i> infection, with the exception of its induction of the initiation of chromosome replication, remains unclear. Here, we generated a <i>Brucella</i> strain in which the expression of DnaA was conditionally controlled via anhydrotetracycline (ATc)-induced complementation of a deletion of the <i>dnaA </i>gene encoding the DnaA protein. We found that DnaA is required for <i>Brucella</i> division and activity to response various environmental stresses. As demonstrated by RNA-seq, DnaA was found to be involved in physiological processes, including the regulation of the cell cycle. Moreover, the inactivation of DnaA can inhibit <i>Brucella</i> intracellular trafficking through impaired replicative <i>Brucella</i>-containing vacuole (rBCV) biogenesis. In RAW 264.7 cells, the mutant strain promoted secretion of the proinflammatory cytokines interleukin 1β (IL-1β) and interleukin 6 (IL-6) and reduced survival. In addition, the inhibition of DnaA expression also attenuated the virulence of <i>Brucella</i>, but the resultant strain exhibited excellent immunogenicity to activate host immune responses in a mouse model. Altogether, these findings show that DnaA is involved in <i>Brucella</i> virulence in vitro and in vivo and could become a new target for the development of a safer and more efficient live attenuated <i>Brucella</i> vaccine.</p>
Data from: The role of bryophytes for tree seedling responses to winter climate change: implications for the stress gradient hypothesis
1.When tree seedlings establish beyond the current tree line due to climate warming, they encounter existing vegetation, such as bryophytes that often dominate in arctic and alpine tundra. The stress gradient hypothesis (SGH) predicts that plant interactions in tundra become increasingly negative as climate warms and conditions become less harsh. However, for seedlings climate warming might not result in lower winter stress, if insulating snow cover is reduced. 2.We aimed to understand to if bryophytes facilitate seedling survival in a changing winter climate and if these effects of bryophytes on tree seedlings comply with the SGH along elevational gradients under contrasting snow conditions. 3.In the Swedish subarctic, we transplanted intact bryophyte cores covered by each of three bryophyte species and bryophyte-free control soil from above the tree line to two field common-garden sites, representing current and future tree line air temperature conditions (i.e. current tree line elevation and a lower, warmer, elevation below the tree line). We planted seedlings of Betula pubescens and Pinus sylvestris into these cores and subjected them to experimental manipulation of snow cover during one winter. 4.In agreement with the SGH, milder conditions caused by increased snow cover enhanced the generally negative or neutral effects of bryophytes on seedlings immediately after winter. Further, survival of P. sylvestris seedlings after one full year was higher at lower elevation, especially when snow cover was thinner. However, in contrast with the SGH, impacts of bryophytes on over-winter survival of seedlings did not differ between elevations, and impacts on survival of B. pubescens seedlings after one year was more negative at lower elevation. Bryophyte species differed in their effect on seedling survival after winter, but these differences were not related to their insulating capacity. 5.Synthesis: Our study demonstrates that interactions from bryophytes can modify the impacts of winter climate change on tree seedlings, and vice versa. These responses do not always comply with SGH, but could ultimately have consequences for large-scale ecological processes such as tree-line shifts. These new insights need to be taken into account in predictions of plant species responses to climate change.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.