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Dataset results
124 results for “somatic mutation”
Commonly altered genomic regions in acute myeloid leukemia are enriched for somatic mutations involved in chromatin-remodeling and splicing
GEO Series GSE38987. Homo sapiens. 17 samples. Type: Expression profiling by array.
Somatic mutations in Liver Cancer
GEO Series GSE34957. Homo sapiens. 40 samples. Type: Genome variation profiling by SNP array.
Somatic mutations in p85α promote tumorigenesis through p110α activation
GEO Series GSE18252. Homo sapiens. 162 samples. Type: Genome variation profiling by SNP array.
Somatic point mutation calling in low cellularity tumors
GEO Series GSE47904. Homo sapiens. 2 samples. Type: Genome variation profiling by SNP array.
Novel genetically engineered mouse models for clear cell renal cell carcinoma with somatic mutations in Bap1, Pbrm1 and Setd2
GEO Series GSE199795. Mus musculus. 7 samples. Type: Expression profiling by high throughput sequencing.
Analysis of Somatic Mutations in Pediatric AML FAB-M7 Subtype by Whole Transcriptome Sequencing
To define the mutation spectrum in non-Down syndrome acute megakaryoblastic leukemia (non-DS-AMKL), we performed transcriptome sequencing on diagnostic blasts from 14 pediatric patients and validated our findings in a recurrency/validation cohort consisting of 34 pediatric and 28 adult AMKL samples. Our analysis identified a cryptic chromosome 16 inversion (inv(16)(p13.3q24.3)) in 27% of pediatric cases, which encodes a CBFA2T3-GLIS2 fusion protein. Expression of CBFA2T3-GLIS2 in Drosophila and murine hematopoietic cells induced bone morphogenic protein (BMP) signaling and resulted in a marked increase in the self-renewal capacity of hematopoietic progenitors. These data suggest that expression of CBFA2T3-GLIS2 directly contributes to leukemogenesis.
Genome-wide analyses of DNA Copy Number and somatic mutations of high hyperdiploid acute lymphoblastic leukemia
<p>This is a data record for copy number analysis and somatic single nucleotide variants analysis of high hyperdiploid acute lymphoblastic leukemia (ALL) in the manuscript: Clonal origin and development of high hyperdiploidy in childhood acute lymphoblastic leukemia.</p> <p>mutations.zip included 22 samples with high hyperdiploid ALL collected from the Division of Clinical Genetics, Lund University, Sweden. All samples were subjected to whole genome sequencing and somatic variants were identified by the GDC DNA-Seq analysis pipeline (Zhang et al.,2021). The data was stored in variant call format (vcf) and the interpretation of the file is available at: https://docs.gdc.cancer.gov/Data/File_Formats/VCF_Format/.</p> <p>TAPS.zip included 577 samples with high hyperdiploid ALL that were collected from four different cohorts. All samples were genotyped using either the Affymetrix SNP Array, Illumina's BeadArray platform or the whole genome/exome sequencing. Copy number alterations analysis was performed using TAPS and the graphics produced by TAPS are available for download. The interpretation of the figure is available at: https://patchwork.r-forge.r-project.org. This dataset has been used for copy number aberrations analysis for high hyperdiploid ALL.</p> <p> </p>
Responses to Chemotherapy of Patients With Non-small Cell Lung Cancer Harboring a Known Somatic Activating HER2 Mutation
ClinicalTrials.gov study NCT02827357. IPD Sharing: NO. Countries: 0. Publications: 0.
Somatic mutations and DNA methylation identify a subgroup of poor prognosis within lower risk myelodysplastic syndromes
GEO Series GSE256396. Homo sapiens. 374 samples. Type: Expression profiling by high throughput sequencing; Methylation profiling by genome tiling array.
Somatic IRF4 mutations drive disease-defining expression signatures and thymic tropism in primary mediastinal large B-cell lymphoma [ATAC-seq]
GEO Series GSE294947. Homo sapiens. 10 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Lamin B1 regulates somatic mutations and progression of B cell malignancies
GEO Series GSE89869. Homo sapiens. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
An Oncogenic Super-Enhancer Formed through Somatic Mutation of a Noncoding Intergenic Element
GEO Series GSE59657. Homo sapiens. 20 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Epigenome analysis of schwannomas arising as part of segmental schwannomatosis due to somatic mosaic SOX10 indel mutations
GEO Series GSE239715. Homo sapiens. 6 samples. Type: Methylation profiling by genome tiling array.
Deep sequencing of gastric carcinoma reveals somatic mutations relevant to personalized medicine
GEO Series GSE29999. Homo sapiens. 199 samples. Type: Expression profiling by array; Genome variation profiling by SNP array; SNP genotyping by SNP array.
Somatic mtDNA Mutation Burden Shapes Metabolic Plasticity in Leukemogenesis
GEO Series GSE278440. Mus musculus. 14 samples. Type: Expression profiling by array.
Large Clones of Somatic Mutations in the Airway Epithelium of Nonsmokers and Smokers Without Cancer
GEO Series GSE107772. Homo sapiens. 59 samples. Type: Expression profiling by high throughput sequencing.
The genomic landscape of pediatric T-cell acute lymphoblastic leukemia reveals novel X-linked somatic mutations associated with apoptosis resistance. [RNA-Seq]
GEO Series GSE78785. Homo sapiens. 13 samples. Type: Expression profiling by high throughput sequencing.
Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma
GEO Series GSE69406. Homo sapiens. 13 samples. Type: Expression profiling by array.
Negative selection allows human primary fibroblasts to tolerate high somatic mutation loads induced by N-ethyl-N-nitrosourea
GEO Series GSE271867. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
The genomic landscape of pediatric T-cell acute lymphoblastic leukemia reveals novel X-linked somatic mutations associated with apoptosis resistance.
GEO Series GSE78786. Homo sapiens. 63 samples. Type: Expression profiling by high throughput sequencing; Other.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.