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1,254
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Dataset results
1,254 results for “alpha-synuclein”
Genome-Wide Profiling of DNA Methylation and Gene Expression induced by Alpha-Synuclein in Murine Microglia [methylation]
GEO Series GSE158981. Mus musculus. 20 samples. Type: Methylation profiling by high throughput sequencing.
Alpha-synuclein overexpression is associated with epigenomic dysregulation of glutamate signaling and locomotor pathways
GEO Series GSE181126. Homo sapiens. 46 samples. Type: Methylation profiling by genome tiling array.
Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on alpha-synuclein
GEO Series GSE64304. Saccharomyces cerevisiae. 4 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Phenotypic manifestation of alpha-synuclein strains from Parkinson’s disease and multiple system atrophy in human dopaminergic neruons
GEO Series GSE149632. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
Genome-Wide Profiling of DNA Methylation and Gene Expression induced by Alpha-Synuclein in Murine Microglia [RNA-seq]
GEO Series GSE158980. Mus musculus. 19 samples. Type: Expression profiling by high throughput sequencing.
Mutant glucocerebrosidase impairs alpha-synuclein degradation by blockade of chaperone-mediated autophagy
GEO Series GSE189202. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
The small iridoid compound genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage
GEO Series GSE226744. Saccharomyces cerevisiae. 12 samples. Type: Expression profiling by high throughput sequencing.
Efavirenz and Fexofenadine ameliorates the propagation of alpha-synuclein
GEO Series GSE241257. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Hippocampal changes in the transcriptome of alpha-synuclein overexpressing mice housed in standard or chronic mild stress environment
GEO Series GSE116009. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
Uptake of alpha-synuclein preformed fibrils is suppressed by inflammation and induces an aberrant phenotype in human microglia
GEO Series GSE277636. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
Randomized CRISPR-Cas Transcriptional Perturbation Screening Reveals Protective Genes against Alpha-Synuclein Toxicity
GEO Series GSE87547. Saccharomyces cerevisiae. 4 samples. Type: Expression profiling by high throughput sequencing.
Progranulin–glucocerebrosidase complex regulates tau and alpha-synuclein inclusions to alter phenotypes in tauopathy
GEO Series GSE180672. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Failure of diet-induced transcriptional adaptations in A30P alpha-synuclein transgenic mice
GEO Series GSE197511. Mus musculus. 47 samples. Type: Expression profiling by high throughput sequencing.
Association between alpha-synuclein blood transcripts and early Parkinson's disease
GEO Series GSE57475. Homo sapiens. 142 samples. Type: Expression profiling by array.
Clinical datasets related DeNoPa olfaction, cerebrospinal fluid readouts and alpha-synuclein seeding aggregation assay
<p>These dataset files are associated with the manuscript: </p> <p>Mollenhauer B*, Li J*, Schade S, Weber S, Trenkwalder C, Concha-Marambio L, Tomlinson JJ, aSCENT-PD Investigators and Schlossmacher MG. <em>Persistent Hyposmia as Surrogate for alpha-Synuclein-Linked Brain Pathology. </em>Submitted 2023</p> <p>3 files:</p> <p>Data dictionary.csv</p> <p>Baseline_cut.csv</p> <p>Time_cut.csv</p> <p>The file "Data dictionary.csv" contains description of the two data files and the variables within.</p> <p>Clinical data used for this study is from the DeNoPa Cohort, led by Dr. Brit Mollenhauer, Department of Neurology, University of Goettingen, Kassel, Germany and the Paracelsus-Elena-Klinik. See references below for additional details.</p> <p>Mollenhauer B, Trautmann E, Sixel-Döring F, Wicke T, Ebentheuer J, Schaumburg M, Lang E, Focke NK, Kumar KR, Lohmann K, Klein C, Schlossmacher MG, Kohnen R, Friede T, Trenkwalder C; DeNoPa Study Group. Nonmotor and diagnostic findings in subjects with de novo Parkinson disease of the DeNoPa cohort. Neurology. 2013 Oct 1;81(14):1226-34. doi: 10.1212/WNL.0b013e3182a6cbd5</p> <p>Concha-Marambio L, Weber S, Farris CM, Dakna M, Lang E, Wicke T, Ma Y, Starke M, Ebentheuer J, Sixel-Döring F, Muntean ML, Schade S, Trenkwalder C, Soto C, Mollenhauer B. Accurate Detection of α-Synuclein Seeds in Cerebrospinal Fluid from Isolated Rapid Eye Movement Sleep Behavior Disorder and Patients with Parkinson's Disease in the DeNovo Parkinson (DeNoPa) Cohort. Mov Disord. 2023 Apr;38(4):567-578. doi: 10.1002/mds.29329</p>
Colonic Tissue Biopsy Detection of Phosphorylated Alpha-synuclein for Parkinson's Diagnosis or REM Sleep Behavior Disorder
ClinicalTrials.gov study NCT07217054. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Alpha-synuclein Rt-quic and Neurologic Symptoms in Persons With idiOpathic anosMiA
ClinicalTrials.gov study NCT05740683. IPD Sharing: NO. Countries: 1. Publications: 0.
Study to Evaluate a Potential PET Radioligand for Imaging Alpha-synuclein Deposits in the Brain
ClinicalTrials.gov study NCT06445465. IPD Sharing: NO. Countries: 1. Publications: 0.
A Pilot Biomarker Study Assessing Alpha-synuclein Aggregates Across Biofluid Reservoirs in Patients With Synucleinopathies
ClinicalTrials.gov study NCT04020198. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Alpha-Synuclein PET/CT in Various α-Syn-Related Disease
ClinicalTrials.gov study NCT06949670. IPD Sharing: NO. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.