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11,745 results for “Disorder”
Disordered regions in proteusin peptides guide post-translational modification by a flavin-dependent RiPP brominase
<p>MD simulations for MprE7 alone and MprE7 in complex with SprI</p>
PREVALENCE OF ALCOHOL USE, DEPRESSIVE AND ANXIETY DISORDERS AMONG PATIENTS OF OPIOID AGONIST TREATMENT PROGRAMMES IN UKRAINE
<p>Prevalence data collection was organised based on Opioid Assisted Treatment centres in three Ukrainian cities, Kyiv (one centre, centre of Ukraine), Sumy (one centre, east), and Lviv (one centre, west), during the period from October 2021 to January 2022 (before the full-scale Russian invasion). </p><p>The staff of OAT centres did all the data collection. Doctors, psychologists, or social workers who previously obtained detailed instructions made individual screenings for medication during patients' appointed visits. All the questionaries (AUDIT for alcohol use patterns, PHQ-9 for depression symptoms, GAD-7 for anxiety symptoms) were printed out in the Ukrainian language and filled in together with each patient. In addition, the number of missed visits on site for substitute medication for the last month was counted, and blood alcohol levels were recorded with the breath-alcohol measuring instrument (Drager Alcotest 6820). </p><p>The dataset is based on the results of the program of the Global Fund to Fight AIDS, Tuberculosis and Malaria, "Accelerating Progress in Reducing the Burden of Tuberculosis and HIV Infection in Ukraine", in accordance with the Grant Agreement between the Public Health Center of Ministry of Health of Ukraine and the Global Fund to Fight AIDS, Tuberculosis and Malaria No. 1936 of December 04, 2020. The donor was not involved in the study design, the collection, analysis and interpretation of data or the preparation of the article.</p>
Lethal phenotypes in Mendelian disorders - Supplementary Files
Open the record for dataset details and reuse information.
Cost-effectiveness of preventative care for perinatal anxiety and associated disorders: A rapid review
<p><strong>Objectives: </strong>Perinatal mental health (PMH) problems affect one in five women and cost the United Kingdom (UK) £8.1 billion for every year of births, with 72% of this cost due to the long-term impact on the child. We conducted a rapid review of health economic evaluations of preventative care for perinatal anxiety and associated disorders.</p> <p><strong>Design: </strong>This study adopted a rapid review approach, using principles of the standard systematic review process to generate quality evidence. This methodology features a systematic database search, PRISMA diagram, screening of evidence, data extraction, critical appraisal, and narrative synthesis.</p> <p><strong>Data Sources: </strong>PubMed, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Cochrane Library, <em>Applied Social Sciences Index and Abstracts</em> (ASSIA), PsycINFO and MEDLINE.</p> <p><strong>Eligibility criteria for selecting studies: </strong>Studies that evaluated the costs and cost-effectiveness of preventative care for perinatal anxiety and associated disorders carried out within the National Health Service (NHS) and similar healthcare systems.</p> <p><strong>Data extraction and synthesis:</strong> A minimum of two independent reviewers used standardised methods to search, screen, critically appraise and synthesise included studies.</p> <p><strong>Results: </strong>The results indicate a lack of economic evaluation specifically for perinatal anxiety, with most studies focussing on postnatal depression (PND). Interventions to prevent postnatal mental health problems are cost-effective. Modelling studies have also been conducted, which suggest that treating PND with counselling would be cost-effective.</p> <p><strong>Conclusion:</strong> The costs of not intervening in maternal mental health outweigh the costs of preventative interventions. Preventative measures such as screening and counselling for maternal mental health are shown to be cost-effective interventions to improve outcomes for women and children.</p> <p><strong>PROSPERO registration number: </strong>CRD42022347859</p>
The Production of Jordanian Arabic Passive Structures by Children with Autism Spectrum Disorder
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Decoding the Brain Mosaic: Region and Cell Type-Specific Dysregulation Patterns in Stress and Psychiatric Disorders
<p>Supplementary Online Tables for the doctoral thesis "Decoding the Brain Mosaic: Region and Cell Type-Specific Dysregulation Patterns in Stress and Psychiatric Disorders" by Nathalie Gerstner. </p> <p>This repository includes complete lists of differentially expressed and differential hub genes, alongside the results of enrichment analysis for 8 brain regions examined in a mouse model for transcriptomic alterations following glucocorticoid stimulation (Online Tables 1-30). Additionally, the repository encompasses the complete results of differential expression and chromatin accessibility analyses across various cell types examined in postmortem brain tissue of the orbitofrontal cortex (Online Tables 31-37). These findings delineate the transcriptomic and epigenomic changes between psychiatric cases and controls, as well as between donors with high and low genetic risk for psychiatric disorders.</p> <p>The lists of all genes tested in the respective studies, not just the significant ones, can be found in the "GRactivation_MouseBrain_tables.zip" and the "SingleNuc_PostmortemBrain_Tables.zip" archives.</p> <p> </p>
Human umbilical cord mesenchymal stem cell-derived exosomes combined with mouse nerve growth factor can more effectively ameliorate the motor disorder and brain pathological injury in mice with cerebral palsy
<p>Supplementary Table 1.The statistics of the pole-climbing experiments and the horizontal network test</p> <p>Supplementary Table 2.Results of Kruskal–Wallis test as presented in pole-climbing experiments and the horizontal network test.</p> <p>Supplementary Figure 1. Identification of human umbilical cord mesenchymal stem cell exosomes (hUC-MSCs-exos)</p> <p>Supplementary Figure 2. Results of horizontal network test and pole-climbing experiments.</p> <p> </p>
Human umbilical cord mesenchymal stem cell-derived exosomes combined with mouse nerve growth factor can more effectively ameliorate themotor disorder and brain pathological injury inmice with cerebral palsy
<p>This research design.</p>
Principal component analysis as an efficient method for capturing multivariate brain signatures of complex disorders-ENIGMA study in people with bipolar disorders and obesity
<p>Multivariate techniques better fit the anatomy of complex neuropsychiatric disorders which are characterized not by alterations in a single region, but rather by variations across distributed brain networks. Here, we used principal component analysis (PCA) to identify patterns of covariance across brain regions and relate them to clinical and demographic variables in a large generalizable dataset of individuals with bipolar disorders and controls. We then compared performance of PCA and clustering on identical sample to identify which methodology was better in capturing links between brain and clinical measures. Using data from the ENIGMA-BD working group, we investigated T1-weighted structural MRI data from 2436 participants with BD and healthy controls, and applied PCA to cortical thickness and surface area measures. We then studied the association of principal components with clinical and demographic variables using mixed regression models. We compared the PCA model with our prior clustering analyses of the same data and also tested it in a replication sample of 327 participants with BD or schizophrenia and healthy controls. The first principal component, which indexed a greater cortical thickness across all 68 cortical regions, was negatively associated with BD, BMI, antipsychotic medications, and age and was positively associated with Li treatment. PCA demonstrated superior goodness of fit to clustering when predicting diagnosis and BMI. Moreover, applying the PCA model to the replication sample yielded significant differences in cortical thickness between healthy controls and individuals with BD or schizophrenia. Cortical thickness in the same widespread regional network as determined by PCA was negatively associated with different clinical and demographic variables, including diagnosis, age, BMI, and treatment with antipsychotic medications or lithium. PCA outperformed clustering and provided an easy-to-use and interpret method to study multivariate associations between brain structure and system-level variables. </p>
Supplemental tables of Growth, puberty and testicular function in boys born small for gestational age with non-specific disorder of sex development
<p>Being born small for gestational age (SGA) is frequently associated with unexplained disorder of sex development (non-specific DSD) in boys. Little is known about their future growth, puberty and testicular function. Our objective is to determine the long-term endocrine outcome of boys born SGA who have a non-specific DSD. Cases and controls were retrieved through the international DSD registry and retrospective data collected, based on a spreadsheet containing 102 items. 46,XY boys with a non-specific DSD (n = 179) were included. Males born SGA (n=115) were compared to males born appropriate for gestational age (AGA) (n=64). Their growth and pubertal development were compared. Serum LH, FSH, testosterone, AMH and inhibin B levels in infancy and puberty were analyzed to assess testicular function. At two years of age, 30% of boys born SGA had incomplete or absent catch-up growth. Boys born SGA also had higher LH during minipuberty and lower testosterone in stimulation tests (p=.037 and .040 respectively), as compared to boys with non-specific DSD born AGA. No differences were observed in timing or course of puberty or end-pubertal hormone levels. Almost one out of three SGA boys with a non-specific DSD experiences insufficient catch-up growth. In addition, our data suggest dysfunction of infantile Leydig cells or altered regulation of the hypothalamic-pituitary-gonadal axis in SGA boys during childhood. Sex steroid production during puberty seems unaffected. </p>
Supplemental materials for "Hyperthyroidism in Graves' disease causes sleep disorders related to sympathetic hypertonia"
<p>Supplemental Figure 1. Study protocol. On the first visit, all participants that met the inclusion criteria and did not meet the exclusion criteria were enrolled after providing written informed consent. On the second visit, an evaluation was performed for all participants (Evaluation No. 1). On the additional visit, patients in the HT group were observed for 12 months and reevaluated using the same parameters (Evaluation No.2).</p> <p>*Vital signs, general health conditions (renal dysfunction etc.), the Pittsburgh Sleep Quality Index, portable sleep monitoring, thyroid function test (TSH, Free thyroxine), TSH receptor autoantibody, and urinary total metanephrines were included in the evaluation.</p> <p>Abbreviations: CR, normal control; HT, hyperthyroidism; NF, normal thyroid function.</p>
How well does molecular simulation reproduce environment-specific conformations of the intrinsically disordered peptides PLP, TP2 and ONEG?
<p>Simulation trajectory dataset to accompany publication:</p> <p>Reid, L.M., Guzzetti, I., Svensson, T., Carlsson, A-C., Su, W., Leek, T., von Sydow, L., Czechtizky, W., Miljak, M., Verma, C., De Maria, L., Essex, J.W., Chem. Sci., 2022, DOI: 10.1039/d1sc03496k</p> <p> </p>
Data and analysis for the manuscript VISUAL NOISE EFFECT ON READING IN THREE DEVELOPMENTAL DISORDERS: ASD, ADHD, AND SLD
<p>These are raw data and their analysis for the manuscript VISUAL NOISE EFFECT ON READING IN THREE DEVELOPMENTAL DISORDERS: ASD, ADHD, AND SLD</p>
Data from: Olfactory testing in Parkinson's disease & REM behavior disorder: a machine learning approach
<p><span><span><span><span><span><span><span><span><span><span><span><b>Objective: </b></span></span></span></span></span></span></span></span></span></span></span><span><span><span><span><span><span><span><span><span><span><span>We sought to identify an abbreviated test of impaired olfaction, amenable for use in busy clinical environments in prodromal (isolated REM sleep Behavior Disorder (iRBD)) and manifest Parkinson's.</span></span></span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span><span><span><b>Methods: </b></span></span></span></span></span></span></span></span></span></span></span><span><span><span><span><span><span><span><span><span><span><span>890 PD and 313 control participants in the Discovery cohort study underwent Sniffin' stick odour identification assessment. Random forests were initially trained to distinguish individuals with poor (functional anosmia/hyposmia) and good (normosmia/super-smeller) smell ability using all 16 Sniffin' sticks. Models were retrained using the top 3 sticks ranked by order of predictor importance. One randomly selected 3-stick model was tested in a second independent Parkinson's dataset (n=452) and in two iRBD datasets (Discovery n=241; Marburg n=37) before being compared to previously described abbreviated Sniffin' stick combinations.</span></span></span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span><span><span><b>Results: </b></span></span></span></span></span></span></span></span></span></span></span><span><span><span><span><span><span><span><span><span><span><span>In differentiating poor from good smell ability, the overall area under the curve (AUC) value associated with the top 3 sticks (Anise, Licorice and Banana) was 0.95 in the development dataset (sensitivity:90%, specificity:92%, PPV:92%, NPV:90%). Internal and external validation confirmed AUCs≥0.90. The combination of 3-stick model determined poor smell and an RBD screening questionnaire score of ≥5, separated iRBD from controls with a sensitivity, specificity, PPV and NPV of 65%, 100%, 100% and 30%. </span></span></span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span><span><span><b>Conclusions: </b></span></span></span></span></span></span></span></span></span></span></span><span><span><span><span><span><span><span><span><span><span><span>Our 3-Sniffin'-stick model holds potential utility as a brief screening test in the stratification of individuals with Parkinson's and iRBD according to olfactory dysfunction.</span></span></span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span><span><span><b>Classification of Evidence: </b></span></span></span></span></span></span></span></span></span></span></span><span><span><span><span><span><span><span><span><span><span><span>This study provides Class III evidence that a 3-Sniffin'-stick model distinguishes individuals with poor and good smell ability and can be used to screen for individuals with iRBD.</span></span></span></span></span></span></span></span></span></span></span></p>
Multi-center study on overall clinical complexity of patients with prolonged disorders of consciousness of different etiologies
<p><strong>Aim</strong>: to assess overall clinical complexity of patients with acquired disorders of consciousness (DoC) in vegetative state/unresponsive wakefulness syndrome (VS/UWS) vs. minimally conscious state- MCS) and in different etiologies..<strong>Design:</strong> Multi-center cross-sectional observational study.<strong>Setting</strong>: 23 intensive neurorehabilitation units.<strong>Subjects</strong>: 264 patients with DoC in the post-acute phase: VS/UWS = 141, and MCS = 123 due to vascular (n = 125), traumatic (n = 83) or anoxic (n = 56) brain injury.<strong>Main Measures</strong>: Coma Recovery Scale-Revised, and Disability Rating Scale (DRS); presence of medical devices (e.g., for eating or breathing); occurrence and severity of medical complications.<strong>Results</strong>: patients in DoC, and particularly those in VS/UWS, showed severe overall clinical complexity. Anoxic patients had higher overall clinical complexity, lower level of responsiveness/consciousness, higher functional disability, and higher needs of medical devices. Vascular patients had worse premorbid clinical comorbidities. The two etiologies showed a comparable rate of MC, higher than that observed in traumatic etiology.<strong>Conclusion</strong>: overall clinical complexity is significantly higher in VS/UWS than in MCS, and in non-traumatic vs. traumatic etiology. These findings could explain the worse clinical evolution reported in anoxic and vascular etiologies and in VS/UWS patients and contribute to plan patient-tailored care and rehabilitation programmes.</p>
Multi-center observational study on occurrence and related clinical factors of neurogenic heterotopic ossification in patients with disorders of consciousness
<p><strong>Aims</strong>: to assess occurrence and clinical correlates of neurogenic heterotopic ossifications (NHO) in patients with prolonged disorder of consciousness (DoC).<strong>Design</strong>: multi-center cross-sectional observational study.<strong>Setting</strong>: 23 intensive neurorehabilitation units.<strong>Subjects</strong>: 287 patients with prolonged disorder of consciousness (DoC; 150 in vegetative state, VS, and 128 in minimally conscious state, MCS) of different etiology (vascular = 125, traumatic = 83, anoxic = 56, others = 14).<strong>Main Measures</strong>: clinical evidence of NHO confirmed by standard radiological and/or sonographic evaluation; Coma Recovery Scale-Revised; Disability Rating Scale (DRS); Early Rehabilitation Barthel Index; presence of ventilator support, spasticity, bone fractures and paroxysmal sympathetic hyperactivity.<strong>Results</strong>: 31 patients (11.2%) presented NHO. Univariate analyses showed that NHO was associated with VS diagnosis, traumatic etiology, high DRS category and total score, and high occurrence of limb spasticity and bone fractures. A cluster-corrected binary logistic regression model (excluding spasticity available in a subset of patients) showed that only lower DRS total score and presence of bone fractures were independently associated with NHO.<strong>Conclusions</strong>: NHO are relatively frequent in patients with DoC, and are independently associated with functional disability, bone fractures and spasticity. These findings contribute to identifying patients with DoC prone to develop NHO and requiring special interventions to improve functional recovery.</p>
"Early COVID-related Acute Kidney Injury Recovery May Course with Hydroelectrolytic Disorders in Patients With High Risk of Insensible Fluid Loss" dataset
<p>The dataset used and analyzed during the study "<strong>Early COVID-related Acute Kidney Injury Recovery May Course with Hydroelectrolytic Disorders in Patients With High Risk of Insensible Fluid Loss"</strong></p>
Comorbid-phenome prediction and phenotype risk scores enhance gene discovery for generalized anxiety disorder and posttraumatic stress disorder
<p>GWAS summary statistics. See ReadMe for column descriptions.</p>
Hard X-ray helical dichroism of disordered molecular media
<p>Ptychographic reconstruction of X-ray OAM beams and X-ray absorption spectra recorded on [Fe(4,4′-diMebpy)3]2+. Data associated with the publication "Hard X-ray helical dichroism of disordered molecular media", Nature Photonics (2022).</p>
CG molecular dynamics simulations. Supporting data for "Improving Martini 3 for Disordered and Multidomain Proteins".
<pre>Coarse-grained molecular dynamics simulations with Martini 3 with varying rescaling of protein-water interactions. Supporting data for "Improving Martini 3 for Disordered and Multidomain Proteins".</pre>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.