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1,952 results for “actionality”
NPJ Climate Action AR6 scenarios database submission histograms by model family and project
<p>Based on submissions to the IPCC AR6 Scenarios Database, this datasets uses the metadata to construct histograms of the submitted scenarios by model family and project, noting the total submissions, vetted scenarios, and climate assessed scenarios. A total of 2304 scenarios were submitted to the global emissions database, of these, 618 did not passing vetting for sufficiently consistency with historical energy and emissions data, and a further 484 did not have sufficient data to perform a climate assessment, leaving a total of 1202 used in the primary assessment of scenarios. </p> <p>The database based on the scenario metadata. The ‘model family’ was determined by removing version numbers from the full model name. The ‘project family’ was obtained using the ‘Scenario family’ variable in metadata, supplemented by manually checking against cited literature. The classification of vetted scenarios was based on the variable ‘Historical vetting’ and the climate assessment on the ‘Climate Category’.</p> <p>This version is based on version 1.0 of the AR6 scenarios database.</p>
Data from: Prospection of potential actions during visual working memory starts early, is flexible, and predicts behavior.
<p>Raw data (EEG and behavior) reported in the manuscript "Prospection of potential actions in visual working memory starts early, is flexible, and predicts behavior" by Rose Nasrawi, Sage E.P. Boettcher, and Freek van Ede</p>
Data for Progress on Climate Action: a Multilingual Machine Learning Analysis of the Global Stocktake
<p>Data to go with our submission to Climatic Change titled "Progress on Climate Action: a Multilingual Machine Learning Analysis of the Global Stocktake".</p> <p>Dataset contains the embeddings (.zip with pickles) as well as the associated document items (idem), the most-closely associated keywords and paragraphs per topic in the final model (.xlsx), the reduced 2d embeddings with all selected paragraphs (.csv utf-8 encoded), as well as an overview with the meta-data per source (.csv utf-8 encoded).</p>
The Dynamics of Collective Action Corpus
<p>This respository includes two datasets, a Document-Term Matrix and associated metadata, for 17,493 <em>New York Times</em> articles covering protest events, both saved as single R objects.</p> <p>These datasets are based on the original <a href="https://web.stanford.edu/group/collectiveaction/cgi-bin/drupal/">Dynamics of Collective Action (DoCA) dataset</a> (Wang and Soule 2012; Earl, Soule, and McCarthy). The original DoCA datset contains variables for protest events referenced in roughly 19,676 <em>New York Times</em> articles reporting on collective action events occurring in the US between 1960 and 1995. Data were collected as part of the Dynamics of Collective Action Project at Stanford University. Research assistants read every page of all daily issues of the <em>New York Times</em> to find descriptions of 23,624 distinct protest events. The text for the news articles were not included in the original DoCA data.</p> <p>We attempted to recollect the raw text in a semi-supervised fashion by matching article titles to create the <strong>Dynamics of Collective Action Corpus</strong>. In addition to hand-checking random samples and hand-collecting some articles (specifically, in the case of false positives), we also used some automated matching processes to ensure the recollected article titles matched their respective titles in the DoCA dataset. The final number of recollected and matched articles is 17,493.</p> <p>We then subset the original DoCA dataset to include only rows that match a recollected article. The "20231006_dca_metadata_subset.Rdata" contains all of the metadata variables from the original DoCA dataset (see <a href="https://web.stanford.edu/group/collectiveaction/cgi-bin/drupal/node/17">Codebook</a>), with the addition of "pdf_file" (used to link to original article pdfs) and "pub_title" (which is the title of the recollected article and may differ from the "title" variable in the original dataset), for a total of 106 variables and 21,126 rows (noting that a row is a distinct protest events and one article may cover more than one protest event).</p> <p>Once collected, we prepared these texts using typical preprocessing procedures (and some less typical procedures, which were necessary given that these were OCRed texts). We followed these steps in this order: We removed headers and footers that were consistent across all digitized stories and any web links or HTML; added a single space before an uppercase letter when it was flush against a lowercase letter to its right (e.g., turning "JohnKennedy'' into "John Kennedy''); removed excess whitespace; converted all characters to the broadest range of Latin characters and then transliterated to "Basic Latin'' ASCII characters; replaced curly quotes with their ASCII counterparts; replaced contractions (e.g., turned "it's'' into "it is''); removed punctuation; removed capitalization; removed numbers; fixed word kerning; applied a final extra round of whitespace removal.</p> <p>We then tokenized them by following the rule that each word is a character string surrounded by a single space. At this step, each document is then a list of tokens. We count each unique token to create a document-term matrix (DTM), where each row is an article, each column is a unique token (occurring at least once in the corpus as a whole), and each cell is the number of times each token occurred in each article. Finally, we removed words (i.e., columns in the DTM) that occurred less than four times in the corpus as a whole or were only a single character in length (likely orphaned characters from the OCRing process). The final DTM has 66,552 unique words, 10,134,304 total tokens and 17,493 documents. The "20231006_dca_dtm.Rdata" is a sparse matrix class object from the <a href="https://cran.r-project.org/web/packages/Matrix/index.html">Matrix R package</a>.</p> <p>In R, use the load() function to load the objects `dca_dtm` and `dca_meta`. To associate the `dca_meta` to the `dca_dtm` , match the "pdf_file" variable in`dca_meta` to the rownames of `dca_dtm`.</p> <p> </p>
Now or Never? Global Review of Reactive and Near Real-Time Conservation Actions For Cetaceans
<p><span>Table S1: Information on resulting publications (<em>n</em> = 64) reviewed in this study.</span></p>
Study of DS-1062a in Advanced or Metastatic Non-small Cell Lung Cancer With Actionable Genomic Alterations (TROPION-Lung05)
ClinicalTrials.gov study NCT04484142. IPD Sharing: YES. Countries: 10. Publications: 1.
Million Veteran Program Return of Actionable Results
ClinicalTrials.gov study NCT04178122. IPD Sharing: YES. Countries: 1. Publications: 2.
Respiratory Exacerbation Plans for Action and Care Transitions for Children With Severe CP
ClinicalTrials.gov study NCT05292365. IPD Sharing: YES. Countries: 1. Publications: 2.
Study of DS-1062a Versus Docetaxel in Previously Treated Advanced or Metastatic Non-small Cell Lung Cancer With or Without Actionable Genomic Alterations (TROPION-LUNG01)
ClinicalTrials.gov study NCT04656652. IPD Sharing: YES. Countries: 26. Publications: 2.
Data for: Selection on the joint action of pairs leads to divergent adaptation and coadaptation of care-giving parents during pre-hatching care
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Dorsal striatum coding for the timely execution of action sequences
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Data from: Learning of probabilistic punishment as a model of anxiety produces changes in action but not punisher encoding in the dmPFC and VTA
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Computational mechanisms underlying latent value updating of unchosen actions
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A "morphogenetic action" principle for 3D shape formation by the growth of thin sheets
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Dataset and R code: Genetic diversity of lion populations in Kenya: evaluating past management practices and recommendations for future conservation actions by Chege M et.al
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The stability implications of drag minimization by tail action modelled in the gliding barn owl (<em>Tyto alba</em>)
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Action potential evoked dendritic calcium signals in the medial superior olive (MSO) during development
<p>Dataset underlying the analysis of dendritic calcium signals evoked by somatic action potentials in MSO neurons during development (postnatal day 10 - 60). The data includes recordings from Mongolian gerbils (<em>Meriones unguiculatus</em>) raised in a normal acoustic environment and in omnidirectional white noise.</p> <p><strong>Linked paper:</strong> Franzen DL, Gleiss SA, Kellner CJ, Kladisios N, Felmy F. Activity-Dependent Calcium Signaling in Neurons of the Medial Superior Olive during Late Postnatal Development. J Neurosci. 2020 Feb 19;40(8):1689–700. <a href="https://doi.org/10.1523/JNEUROSCI.1545-19.2020">https://doi.org/10.1523/JNEUROSCI.1545-19.2020</a>.</p> <p><strong>Files included:</strong></p> <ul> <li> <p>A folder entitiled <em>data</em> containing:</p> <ul> <li>The imaging files (<code>.nix</code>) (1 file per imaged neuron). NIX files contain the kymograph data extracted from a ROI in the raw images along with the metadata. The imaging kymographs and associated <code>.nix</code> files were created with the <a href="https://zenodo.org/record/2575542#.XiYdAS2ZNo4">CaManager: ImageJ Plugin For Ca²⁺ Imaging</a>.</li> <li>An <code>excludes.csv</code> file that contains cells/trials to be excluded (e.g. recording error, movement, difficulty in tracing)</li> <li>A <code>Megatable_C.csv</code> file containing the electrophysiological data corresponding to imaged cells</li> </ul> </li> <li> <p>A <code>.nix</code> intermediate analysis file for <em>default parameters</em></p> </li> <li> <p>A <code>.csv</code> file with the combined electrophysiological and imaging data for <em>default parameters</em></p> </li> <li> <p>Several <code>.xlsx</code> files with the single cell data in Figures 2C, 2D, 2F.</p> </li> </ul> <p><strong>Jupyter notebook:</strong></p> <p>The <a href="https://github.com/delwen/CaJupyter">CaJupyter</a> GitHub repository contains a Jupyter notebook with a step-by-step guide of the analysis. It also allows for further exploration of the data.</p> <p><strong>See also:</strong></p> <ul> <li> <p>The original analysis code (without adaptations for the Jupyter notebook and Python 3) can be found at <a href="https://zenodo.org/record/2575675#.Xi%E2%80%A6">CaAnalysis: Analysis Toolbox for Ca²⁺ Imaging</a>.</p> </li> <li> <p>More information on NIX can be found at this <a href="https://g-node.github.io/nix/">link</a>.</p> </li> </ul>
Database of mechanism of action paths for selected drug-disease indications
<p>Mechanistic paths that lead from drug to disease in a heterogeneous network.</p> <p>Version 1.1.0 includes a new tab `metapaths_biolink` where the majority of node and edge types have been mapped to entities and relationship slots in the <a href="https://biolink.github.io/biolink-model/">biolink model.</a> Concepts unable to be mapped at this time are represented in ALL CAPS.</p> <p>JSON version of the paths available <a href="https://github.com/SuLab/indication_moa_db/tree/1.0">on GitHub</a></p>
Data from: Evaluation of a pharmacist-led actionable audit and feedback intervention for improving medication safety in primary care: an interrupted time series analysis
<p><strong>Background</strong>. We evaluated the impact of a pharmacist-led Safety Medication dASHboard (SMASH) intervention on medication safety in primary care.<br> <strong>Methods and findings</strong>. SMASH comprised: (1) training of clinical pharmacists to deliver the intervention; (2) a web-based dashboard providing actionable, patient-level feedback; and (3) pharmacists reviewing individual at-risk patients, and initiating remedial actions or advising general practitioners on doing so. It was implemented in forty-three general practices covering a population of 235,595 people in Salford (Greater Manchester), UK. All practices started receiving the intervention between 18 April 2016 and 26 September 2017. We used an interrupted time series analysis of rates of potentially hazardous prescribing and inadequate blood-test monitoring, comparing observed rates post-intervention to extrapolations from a 24-month pre-intervention trend. The number of people registered to participating practices and having one or more risk factors for being exposed to hazardous prescribing or inadequate blood-test monitoring at the start of the intervention was 47,413 (males: 23,073 [48.7%]; mean age: 60 [standard deviation: 21]). At baseline, 95% of practices had rates of potentially hazardous prescribing (composite of 10 indicators) between 0.88% and 6.19%. The prevalence of potentially hazardous prescribing reduced by 27.9% (95% confidence interval [CI], 20.3% to 36.8%) at 24 weeks and by 40.7% (95% CI, 29.1% to 54.2%) at twelve months after introduction of SMASH. The rate of inadequate blood-test monitoring (composite of 2 indicators) reduced by 22.0% (95% CI, 0.2% to 50.7%) at 24 weeks and by 23.5% (95% CI, -4.5% to 61.6%) at 12 months. After 12 months, 95% of practices had rates of potentially hazardous prescribing between 0.74% and 3.02%. We did not randomise practices but enrolled them in a naturalistic fashion. All our measurements were based on routinely kept electronic health records.<br> <strong>Conclusions</strong>. The SMASH intervention was associated with reduced rates of potentially hazardous prescribing and inadequate blood-test monitoring in general practices. This reduction was sustained over 12 months after start of the intervention for prescribing but not for monitoring of medication. There was a marked reduction in the variation in rates of high-risk prescribing between practices.</p>
Genetic algorithm-based personalized models of human cardiac action potential
<p>We present a novel modification of genetic algorithm (GA) which determines personalized parameters of cardiomyocyte electrophysiology model based on set of experimental human action potential (AP) recorded at different heart rates. In order to find the steady state solution, the optimized algorithm performs simultaneous search in the parametric and slow variables spaces. We demonstrate that several GA modifications are required for effective convergence. Firstly, we used a mutation operator, based on Cauchy amplitude distribution along with a random direction in the parametric space. Secondly, relatively large number of elite organisms (6-10 % of the population passed on to new generation) was required for effective convergence. Test runs with synthetic AP as input data indicate that algorithm error is low for high amplitude ionic currents (1.6±1.6% for IKr, 3.2±3.5% for IK1, 3.9±3.5% for INa, 8.2±6.3% for ICaL). Experimental signal-to-noise ratio above 28 dB was required for high quality GA performance. GA was validated against optical mapping recordings of human ventricular AP and mRNA expression profile of donor hearts. In particular, GA output parameters were rescaled proportionally to mRNA levels ratio between patients. We have demonstrated that mRNA-based models predict the AP waveform dependence on heart rate with high precision. The latter also provides a novel technique of model personalization that makes it possible to map gene expression profile to cardiac function. </p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.