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1,986 results for “valve”
Data from: Seeing the Invisible: On Aortic Valve Reconstruction in Non-Contrast CT
<p><strong>Abstract</strong></p> <p>In this dataset, we present supplementary material from the paper by Bujny et al. (2024). The material includes STL models of aorta segmented in contrast Computed Tomography (CT) scans by a medical expert and using the Machine Learning (ML) model described in the paper. A gallery of ML-based segmentations of the aortic root in non-contrast CT, with the corresponding scans and aortic valve meshes registered from contrast CT using the Iterative Closest Point (ICP) algorithm is provided, as well. Finally, we include the source code of the ICP-based accuracy evaluation method proposed in the paper, with an example in Jupyter Notebook. All of the data included in the dataset has been generated based on the CT scans from the openly available orCaScore dataset (Wolterink et al. 2016).</p> <p> </p> <p><strong>Dataset organization</strong></p> <p>The root folder contains 3 catalogs:</p> <ul> <li>contrast_aorta_stls – set of 19 Ground Truth (GT) segmentations of aorta in contrast CT, with the corresponding inferences of the contrast ML model described in the paper, for the scans from the open-source orCaScore dataset (Wolterink et al. 2016).</li> <li>icp_code – Python code of the ICP-based accuracy evaluation method proposed in the paper.</li> <li>icp_gallery – HTML gallery of aorta segmentations based on the non-contrast ML model described in the paper, with the corresponding CT scans and meshes of the aortic valves segmented in contrast CT, which were rigidly registered to the non-contrast scans using the proposed ICP-based approach. In the CT scans, blue and red contours were used to depict non-contrast-based and registered contrast-based ML segmentations, respectively.</li> </ul> <p> </p> <p><strong>References</strong></p> <p>M. Bujny, K. Jesionek, J. Nalepa, T. Bartczak, K. Miszalski-Jamka, M. Kostur, “Seeing the Invisible: On Aortic Valve Reconstruction in Non-Contrast CT,” 27th International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI), Marrakesh, Morocco, 2024 [accepted].</p> <p>J. M. Wolterink et al., “An evaluation of automatic coronary artery calcium scoring methods with cardiac CT using the orCaScore framework: Evaluation of cardiac CT-based automatic coronary calcium scoring,” Med. Phys., vol. 43, no. 5, pp. 2361–2373, 2016.</p>
Multi-modal phantom experiments, mimicking flow through the mitral heart valve
<p>In this repository all experimental data obtained from a phantom study on the left heart, including a deformable mitral valve, is reported. Using invasive catheter pressure measurements, magnetic resonance imaging and ultrasound imaging, several parameters relevant to diagnosing heart valve disease were measured on the phantom. The data is reported in MS excel files (xlsx format) and the geometry of the phantom is reported in STL and STEP file format, together with an exploded view, indicating how the parts are put together.</p>
Defining the role of the miR-145 – KLF4 – αSMA axis in mitral valvular interstitial cell activation in myxomatous mitral valve prolapse using the canine model
<p>Mitral valve prolapse (MVP) is a common valvular disease, affecting 2-3% of the adult human population and is a degenerative condition. 5-10% of the afflicted will develop severe mitral regurgitation, cardiac dysfunction, congestive heart failure, and sudden cardiac death. Naturally occurring myxomatous MVP in dogs closely resembles MVP in humans structurally, and functional consequences are similar. In both species, valvular interstitial cells (VICs) in affected valves exhibit phenotype consistent with activated myofibroblasts with increased αSMA expression. Using VICs collected from normal and MVP-affected valves of dogs, we analyzed the miRNA expression profile of the cells and their associated small extracellular vesicles (sEV) using RNA sequencing to understand the role of non-coding RNAs and sEV in MVP pathogenesis. miR-145 was shown to be upregulated in both the affected VICs and sEV, and overexpression of miR-145 by mimic transfection in quiescent VIC recapitulates the activated myofibroblastic phenotype. Concurrently, KLF4 expression was suppressed by miR-145, and KLF4 overexpression resulted in a decrease in αSMA expression, and its suppression resulted in an increase in αSMA expression, thus confirming the miR-145 – KLF4 – αSMA axis. Targeting this axis may serve as potential therapy in controlling pathologic abnormalities found in MVP valves.</p>
Data from: The classical and alternative circulating renin-angiotensin system in normal dogs and dogs with stage B1 and B2 myxomatous mitral valve disease
<p>The behavior of the comprehensive circulating renin‐angiotensin system (RAS) in dogs with myxomatous mitral valve disease (MMVD) before the onset of congestive heart failure remains largely unexplored.</p> <p>Hypothesis/Objectives: The classical and alternative RAS activity and aldosterone concentrations will be significantly higher in dogs with American College of Veterinary Internal Medicine (ACVIM) stage B2 MMVD compared to normal dogs and dogs with ACVIM stage B1 MMVD.</p> <p>Animals: One hundred seventeen client‐owned dogs (normal = 60; B1 = 31; B2 = 26).</p> <p>Methods: Prospective observational study. Angiotensin peptides (AP) and aldosterone concentrations were measured using liquid chromatography and mass spectrometry. Angiotensin converting enzymes 1 and 2 (ACE, ACE2) and renin activity surrogates were calculated from AP concentrations. Equilibrium dialysis (ED) and immediate protease inhibition (PI) methods of AP quantification were compared in 14 healthy dogs.</p> <p>Results: Core RAS activity and aldosterone concentrations did not differ among the 3 groups. However, the balance between the alternative and classical RAS differed, with dogs with stage B2 MMVD having significantly higher ACE2 activity surrogate (ACE2surr) when compared to normal dogs (adjusted P = .02; ratio of medians for ACE2surr [B2:normal], 1.89; 95% confidence interval [CI]: 1.4‐2.6). The ED and PI methods of AP quantification were highly correlated (AngI, r = .9, P < .0001; AngII, r = .8, P = .001).</p> <p>Conclusions and Clinical Importance: Circulating alternative RAS activity, specifically the surrogate measure of ACE2 activity, was increased in dogs with stage B2 MMVD as compared to normal dogs. Equilibrium dialysis results are analogous to immediate protease inhibition in dogs.</p>
Photoactive integrated microfluidic valves for on-chip fluid control
<p>This dataset is acompannying the publication: Photoactive integrated microfluidic valves for on-chip fluid control.</p>
Minimally Invasive Transaxillary Approach: Aortic Valve Replacement in a Patient with BMI >50 kg/m²
<p>This video demonstrates the successful application of the transaxillary MICLAT-S (<em>M</em>inimally <em>I</em>nvasive <em>C</em>ardiac <em>L</em>ateral <em>S</em>urgery) approach for aortic valve replacement (AVR) in a patient with a BMI >50 kg/m². The procedure showcases the feasibility and safety of the MICLAT-S technique in a high-risk, morbidly obese patient, a group traditionally considered challenging for minimally invasive surgery. By sparing the sternum and utilizing a lateral, transaxillary access route, the MICLAT-S method minimizes surgical trauma, reduces the risk of postoperative wound complications, and preserves thoracic stability, even in patients with extreme obesity.</p> <p>Despite the patient’s elevated BMI, the surgical team was able to maintain excellent access to the aortic valve, ensuring a smooth and efficient valve replacement. This video further supports the findings of our study, which demonstrate that the transaxillary concept of MICLAT-S is a viable alternative to traditional sternotomy, offering significant advantages, particularly in obese patients.</p> <p>This description complements the video by tying it to the findings of the paper and underlining the advantages of the transaxillary concept of MICLAT-S technique in this specific patient population.</p>
Data: Acoustic disturbance in blue mussels: sound-induced valve closure varies with pulse train speed but does not affect phytoplankton clearance rate
<p>Data abstract:</p> <p>Data on mussels' valve gape behaviour and phytoplankton clearance during sound exposure trials. We provide the raw data, processed data, scripts to process the raw data, make plots, and run the statistics.</p> <p> </p> <p>Paper abstract:</p> <p>Anthropogenic sound has increasingly become part of the marine soundscape and may negatively affect animals across all taxa. Invertebrates, including bivalves, received limited attention even though they make up a significant part of the marine biomass and are very important for higher trophic levels. Behavioural studies are critical to evaluate individual and potentially population-level impact of noise and can be used to compare the effects of different sounds. In the current study, we examined the effect of impulsive sounds with different pulse rates on the valve gape behaviour and phytoplankton clearance rate of blue mussels (<em>Mytilus</em> spp.<em>)</em>. We monitored the mussels’ valve gape using an electromagnetic valve gape monitor, and their clearance rate using spectrophotometry of phytoplankton densities in the water. We found that the mussels’ valve gape was positively correlated with their clearance rate, but the sound exposure did not significantly affect the clearance rate or reduce the valve gape of the mussels. They did close their valves upon the onset of a pulse train, but the majority of the individuals recovered to pre-exposure valve gape levels during the exposure. Individuals that were exposed to faster pulse trains returned to their baseline valve gape faster. Our results show that different sound exposures can affect animals differently, which should be taken into account for noise pollution impact assessments and mitigation measures.</p> <p> </p> <p>Paper reference:</p> <p>Hubert, J., Moens, R., Witbaard, R., Slabbekoorn, H. (2022). Acoustic disturbance in blue mussels: sound-induced valve closure varies with pulse train speed but does not affect phytoplankton clearance rate. <em>ICES Journal of Marine Science</em>. DOI: 10.1093/icesjms/fsac193.</p>
Data belonging to the paper "Experimental Investigations of Partially Valve-, Partially Displacement-Controlled Electrified Telehandler Implements"
<p>These are measured energy values of work cycle halves that are the basis for the analyses in the paper "Experimental Investigations of Partially Valve-, Partially Displacement-Controlled Electrified Telehandler Implements", which is currently under review at a journal.</p>
SIMCor - Clinically driven Virtual Cohort Generator for aortic valve geometries
<p>This video demonstrates the generator for virtual geometries of the aortic rude, including the aortic valve leaflets based on clinically driven features. Two clinically relevant features: the type of the left ventricular outlet (LVOT) shape, either convergent or divergent, as well as the angle between LVOT and the aorta can be specified. Based on a statistical shape model and appropriate filtering strategies, virtual patients featuring the specified anatomical characteristics are then generated.</p>
Dataset related to the article "Purinergic Receptor P2Y2 Stimulation Averts Aortic Valve Interstitial Cell Calcification and Myofibroblastic Activation"
<p>This record contains raw data related to the article "Purinergic Receptor P2Y2 Stimulation Averts Aortic Valve Interstitial Cell Calcification and Myofibroblastic Activation"</p> <p>Rationale-Calcific aortic valve stenosis (CAVS) is a pathological condition of the aortic valve with a prevalence of 3% in the general population. It is characterized by massive rearrangement of the extracellular matrix, mostly due to the accumulation of fibro-calcific deposits driven by valve interstitial cells (VIC), and no pharmacological treatment is currently available. The aim of this study was to evaluate the effects of P2Y2 receptor (P2RY2) activation on fibro-calcific remodeling of CAVS. Methods-We employed human primary VICs isolated from CAVS leaflets treated with 2-thiouridine-5'-triphosphate (2ThioUTP, 10 µM), an agonist of P2RY2. The calcification was induced by inorganic phosphate (2 mM) and ascorbic acid (50 µg/mL) for 7 or 14 days, while the 2ThioUTP was administered starting from the seventh day. 2ThioUTP was chronically administered for 5 days to evaluate myofibroblastic activation. Results-P2RY2 activation, under continuous or interrupted pro-calcific stimuli, led to a significant inhibition of VIC calcification potential (<em>p</em> < 0.01). Moreover, 2ThioUTP treatment was able to significantly reduce pro-fibrotic gene expression (<em>p</em> < 0.05), as well as that of protein α-smooth muscle actin (<em>p</em> = 0.004). Conclusions-Our data suggest that P2RY2 activation should be further investigated as a pharmacological target for the prevention of CAVS progression, acting on both calcification and myofibroblastic activation.</p>
Data from: Separate and combined effects of boat noise and a live crab predator on mussel valve gape behaviour
<p><strong>Data abstract:</strong></p> <p>Data on the valve gape of mussels and the behaviour of stimulus crabs during sound exposure trials. We provide the raw valve gape data, processed data, and scripts to process the raw data, make plots, and run the statistics.</p> <p><strong><span>Paper abstract:</span></strong></p> <p><span>Noisy human activities at sea are changing the acoustic environment, which has been shown to affect marine mammals and fishes. Invertebrates, such as bivalves, have so far received limited attention despite their important role in the marine ecosystem. Several studies have examined the impact of sound on anti-predator behaviour using simulated predators, but studies using live predators are scarce. In the current study, we examined the separate and combined effects of boat sound playback and predator cues from shore crabs (<em>Carcinus maenas</em>) on the behaviour of mussels (<em>Mytilus</em> spp.). We examined the behaviour of the mussels using a valve gape monitor and scored the behaviour from the crabs in one of two types of predator test conditions from video footage to control for effects from potential, sound-induced variation in crab behaviour. We found that mussels closed their valve gape during boat noise and with a crab in their tank, but also that the stimulus combination did not add up to an even smaller valve gape. The sound treatment did not affect the stimulus crabs, but the behaviour of the crabs did affect the valve gape of the mussels. Future research is needed to examine whether these results stand <em>in situ</em> and whether valve closure due to sound have fitness consequences for mussels. The effects on the well-being of individual mussels from anthropogenic noise may be relevant for population dynamics in the context of pressure from other stressors, their role as ecosystem engineers, and in the context of aquaculture.</span></p>
FIGURE 29. Apparent valve between abdominal segments, between A3 in COMPARATIVE ANATOMY OF THE INSECT TRACHEAL SYSTEM PART 1: INTRODUCTION, APTERYGOTES, PALEOPTERA, POLYNEOPTERA
FIGURE 29. Apparent valve between abdominal segments, between A3-DLT and A4-DLT.
FIGURE 37. Aeshnidae with valve. Direct screen capture from 3D in COMPARATIVE ANATOMY OF THE INSECT TRACHEAL SYSTEM PART 1: INTRODUCTION, APTERYGOTES, PALEOPTERA, POLYNEOPTERA
FIGURE 37. Aeshnidae with valve. Direct screen capture from 3D Slicer.
Data from: Effect of valve opening on starting performance of pump as turbine
<p><span>The study on transient characteristics of pump as turbines during atypical startup has not been deeply explored yet.</span> <span>In order to reveal the transient characteristics of a small centrifugal pump reversing as turbine during startup process in this paper, the transient hydraulic performance experiments are conducted for three steady rotational speed cases. Under the condition of each case, three, five, and three valve opening scenarios are completed to measure the performance. The dimensionless analysis are also employed so as to better reveal transient behavior of the pump as turbine during atypical startup. The results show that the rise rate of each performance parameter is different, wherein the shaft power and rotational speed have the fastest rising rate, followed by the flow rate, and the head rise is the slowest. It is clearly seen that the shock phenomenon in static pressure easily occurs at the outlet of pump as turbine. With the increase of valve opening, the dimensionless flow rate, head, and power coefficient all show the evolution trend of gradually increasing.</span></p>
EndoMAXX Endoluminal Valve Technology (EVT) Compared to EndoMAXX
ClinicalTrials.gov study NCT02159898. IPD Sharing: Not stated. Countries: 1. Publications: 1.
PROACT Xa - A Trial to Determine if Participants With an On-X Aortic Valve Can be Maintained Safely on Apixaban
ClinicalTrials.gov study NCT04142658. IPD Sharing: Not stated. Countries: 1. Publications: 21.
PARTNER II Trial: Placement of AoRTic TraNscathetER Valves II - S3 Intermediate
ClinicalTrials.gov study NCT03222128. IPD Sharing: NO. Countries: 1. Publications: 10.
HAART 200 Aortic Valve Annuloplasty Trial
ClinicalTrials.gov study NCT02071849. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Study on Safety and Performance of Medtentia Mitral Valve Repair System in Surgical Repair of Mitral Regurgitation
ClinicalTrials.gov study NCT01678144. IPD Sharing: NO. Countries: 1. Publications: 2.
Early Feasibility Study of the Neovasc Tiara™ Mitral Valve System
ClinicalTrials.gov study NCT02276547. IPD Sharing: NO. Countries: 3. Publications: 3.
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.