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1,742 results for “Activity data”
Histone H3K27ac separates active from poised enhancers and predicts developmental state (gene expression data)
GEO Series GSE23907. Mus musculus. 8 samples. Type: Expression profiling by array.
Systematic comparison of experimental and human obstructive cholestasis reveals conservation of canonical pathway activation and biomarkers relevant for cholestatic liver disease [human data set]
GEO Series GSE183754. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
LINC00261 is an epigenetically-regulated tumor suppressor that is essential for activation of the DNA damage response (AEC/LUAD RNA-seq data set)
GEO Series GSE110024. Homo sapiens. 19 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Inferring secretory and metabolic pathway activity from omic data with secCellFie
GEO Series GSE248376. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Experimental raw data for "Specific adsorption sites and conditions derived by thermal decomposition of activated carbons and adsorbed carbamazepine"
<p>LICENSE: These data are made available under the Public Domain Dedication and License v1.0 whose full text can be found at: http://opendatacommons.org/licenses/pddl/1.0/</p> <p><br> This is the repository of all experimental raw data used in the Scientific Reports publication "Specific adsorption sites and conditions derived by thermal decomposition of activated carbons and adsorbed carbamazepine" by Daniel Dittmann, Paul Eisentraut, Caroline Goedecke, Yosri Wiesner, Martin Jekel, Aki Sebastian Ruhl, and Ulrike Braun.</p> <p>It includes<br> - overview_measurements.xlsx and overview_measurements.ods containing a list of all TGA experiments (TGA, TGA-FTIR, TED-GC-MS, and ramp-kinetics)<br> - TED-GC-MS.zip containing gas chromatography-mass spectrometry experimtent files for the Chemstation and OpenChrom<br> - TGA.zip containing thermogravimetric analyses raw data on evolved gas analyses experiments (TGA-FTIR and TED-GC-MS)<br> - TGA_kinetics.zip containing thermogravimetric analyses raw data on decomposition kinetic experiments (ramp-kinetics)<br> - TGA-FTIR.zip containing Fourier-transform infrared spectroscopy series files for OMNIC<br> - XRF.zip containing x-ray flourescence data on elemental composition</p>
Phonological activation in Cantonese reading: Data and R scripts
<p>Data and R scripts from a 2017 error disruption study on Cantonese readers.</p>
Data from: Differential sensitivity to in vitro inhibition of cytochrome P450 aromatase (CYP19) activity among 18 freshwater fishes
There is significant concern regarding potential impairment of fish reproduction associated with endocrine disrupting chemicals. Aromatase (CYP19) is a steroidogenic enzyme involved in the conversion of androgens to estrogens. Inhibition of aromatase by chemicals can result in reduced concentrations of estrogens leading to adverse reproductive effects. These effects have been extensively investigated in a small number of laboratory model fishes, such as fathead minnow (Pimephales promelas), Japanese medaka (Oryzias latipes), and zebrafish (Danio rerio). But, differences in sensitivity among species is largely unknown. Therefore, this study took a first step towards understanding potential differences in sensitivity to aromatase inhibitors among fishes. Specifically, a standard in vitro aromatase inhibition assay using subcellular fractions of whole tissue homogenates was used to evaluate the potential sensitivity of eighteen phylogenetically diverse species of freshwater fish to the nonsteroidal aromatase inhibitor fadrozole. Sensitivity to fadrozole ranged by more than 52-fold among these species. Five species were further investigated for sensitivity to up to four additional nonsteroidal aromatase inhibitors, letrozole, imazalil, prochloraz, and propiconazole. Potencies of each of these chemicals relative to fadrozole ranged by up to two orders of magnitude among the five species. Fathead minnow, Japanese medaka, and zebrafish were among the least sensitive to all the investigated chemicals; therefore, ecological risks of aromatase inhibitors derived from these species might not be adequately protective of more sensitive native fishes. This information could guide more objective ecological risk assessments of native fishes to chemicals that inhibit aromatase.
Data from: Microparticle-mediated VZV propagation and endothelial activation: mechanism of VZV vasculopathy
Objective: Varicella zoster virus (VZV) can spread anterogradely and infect cerebral arteries causing VZV vasculopathy and arterial ischaemic stroke (AIS). In this study we tested the hypothesis that virus-infected cerebrovascular fibroblasts undergo phenotypic changes that promote vascular remodeling and facilitate virus transmission in an in vitro model of VZV vasculopathy. The aims of this project were therefore: (i) to examine the changes that virus-infected Human brain adventitial vascular fibroblasts (HBVAF) undergo in an in vitro model of VZV vasculopathy; and to (ii) identify disease biomarkers relating to VZV related vasculopathy. Methods: HBVAF were infected with VZV, and their ability to migrate, proliferate, transdifferentiate and interact with endothelial cells was studied with flow cytometry. Microparticles (MP) released from these cells were isolated, and imaged with transmission electron microscopy; and their protein content analysed with mass spectrometry. Circulating MP profiles were also studied in children with VZV and non-VZV vasculopathy and compared with controls. Results: VZV-infected HBVAF transdifferentiated into myofibroblasts with enhanced proliferative and migratory capacity. Interaction of VZV-infected HBVAF with endothelial cells resulted in endothelial dysfunction. These effects were, in part, mediated by the release of MP from VZV infected HBVAF. These MP contained VZV virions that could transmit VZV to neighbouring cells, highlighting a novel model of VZV cell-to-cell viral dissemination. MP positive for VZV were significantly higher in children with VZV-related vasculopathy compared to children with non-VZV vasculopathy (p=0.01), and controls (p=0.007). Conclusions: VZV infected HBVAF promote vascular remodeling and facilitate virus transmission. These effects were mediated by the release of apoptotic MP that could transmit VZV infection to neighbouring cells, through a "Trojan Horse" means of productive viral infection. VZV+MP may represent a disease biomarker worthy of further study.
Data for: "Random forest algorithms for recognizing daily life activities using plantar pressure information: A smart-shoe study"
<p>Data and software related to the manuscript "Random forest algorithms for recognizing daily life activities using plantar pressure information: A smart-shoe study" (2020). </p> <p>========</p> <p>Typo in README_DataRep.txt:</p> <p>' 2) "one_config" [...] Selected results requiring these data are shown in Fig. <strong>13</strong>'<strong> </strong>(not 11).</p>
How do table shape, group size, and gender affect on-task actions in collaborative learning activities? - Qualitative data
<p>Qualitative data set for the ijCSCL journal paper " <strong>How do table shape, group size, and gender affect on-task actions in collaborative learning activities?</strong> "</p>
Data analyses of Co-evaluation Activity 1
<p>The data retrieved from Groups 1 and 2 of Co-evaluation Activity 1. Feedback from doctors and nurses who had been engaged in type 2 diabetes treatments were coded into 1) satisfactions, 2) suggestions for changes, 3) preferences, and 4) concerns.</p>
Data analysis on the design requirements of the app for communication bridging as part of Co-design Activity 1
<p>This dataset includes the analyses of the participants' statements and drawing toward the design requirements of the app for communication bridging.</p>
Data analysis of the health contents to be available on the conceptual design of the app as part of Co-design Activity 1
<p>This dataset presents the analysis of the health contents to be available on the conceptual design of the app.</p>
Data analyses of Co-exploration Activity 1
<p>These datasets are the appendices of the analyses for Co-exploration Activity 1 of Chininthorn's Ph.D. thesis. </p>
Cytosplore-Transcriptomics: a scalable inter-active framework for single-cell RNA sequenc-ing data analysis
<p>Allen institute 10X mouse data (<a href="https://portal.brain-map.org/atlases-and-data/rnaseq/mouse-whole-cortex-and-hippocampus-10x">https://portal.brain-map.org/atlases-and-data/rnaseq/mouse-whole-cortex-and-hippocampus-10x</a>) converted into h5 format including metadata, to be easily uploaded in Cytosplore-Transcriptomics.</p>
Data from: Imbalance in individual researcher's peer review activities quantified for four British Ecological Society Journals, 2003-2010
Researchers contribute to the scientific peer review system by providing reviews, and "withdraw" from it by submitting manuscripts that are subsequently reviewed. So far as we are aware, there has been no quantification of the balance of individual's contributions and withdrawals. We compared the number of reviews provided by individual researchers (i.e., their contribution) to the number required by their submissions (i.e. their withdrawals) in a large and anonymised database provided by the British Ecological Society. The database covered the Journal of Ecology, Journal of Animal Ecology, Journal of Applied Ecology, and Functional Ecology from 2003–2010. The majority of researchers (64%) did not have balanced contributions and withdrawals. Depending on assumptions, 12% to 44% contributed more than twice as much as required; 20% to 52% contributed less than half as much as required. Balance, or lack thereof, varied little in relation to the number of years a researcher had been active (reviewing or submitting). Researchers who contributed less than required did not lack the opportunity to review. Researchers who submitted more were more likely to accept invitations to review. These finding suggest overall that peer review of the four analysed journals is not in crisis, but only due to the favourable balance of over- and under-contributing researchers. These findings are limited to the four journals analysed, and therefore cannot include researcher's other peer review activities, which if included might change the proportions reported. Relatively low effort was required to assemble, check, and analyse the data. Broader analyses of individual researcher's peer review activities would contribute to greater quality, efficiency, and fairness in the peer review system.
Data from: Invertebrate community response to fire and rodent activity in the Mojave and Great Basin Deserts
Recent increases in the frequency and size of desert wildfires bring into question the impacts of fire on desert invertebrate communities. Furthermore, consumer communities can strongly impact invertebrates through predation and top‐down effects on plant community assembly. We experimentally applied burn and rodent exclusion treatments in a full factorial design at sites in both the Mojave and Great Basin deserts to examine the impact that fire and rodent consumers have on invertebrate communities. Pitfall traps were used to survey invertebrates from April through September 2016 to determine changes in abundance, richness, and diversity of invertebrate communities in response to fire and rodent treatments. Generally speaking, rodent exclusion had very little effect on invertebrate abundance or ant abundance, richness or diversity. The one exception was ant abundance, which was higher in rodent access plots than in rodent exclusion plots in June 2016, but only at the Great Basin site. Fire had little effect on the abundances of invertebrate groups at either desert site, with the exception of a negative effect on flying‐forager abundance at our Great Basin site. However, fire reduced ant species richness and Shannon's diversity at both desert sites. Fire did appear to indirectly affect ant community composition by altering plant community composition. Structural equation models suggest that fire increased invasive plant cover, which negatively impacted ant species richness and Shannon's diversity, a pattern that was consistent at both desert sites. These results suggest that invertebrate communities demonstrate some resilience to fire and invasions but increasing fire and spread of invasive due to invasive grass fire cycles may put increasing pressure on the stability of invertebrate communities.
Data from: Diel activity, frequency and visit duration of pollinators in focal plants: in situ automatic camera monitoring and data processing
Data collection on interactions between organisms and their environment has traditionally been conducted by on-site human observations, a time-consuming enterprise that could explain the shortage of around-the-clock observations of free-ranging wild animals. In this paper, I outline a time-efficient procedure to collect data on flower-visiting animals. The objectives were, first, to model diel activity rhythms by using cosine-based mixed-effects regression models (cosinor method) on data from an established automatic video monitoring system and, secondly, to test the use of a cheap off-the-shelf digital camera modified for automated monitoring of flower visitors. Two different model systems were studied: foraging bumblebees visiting focal white clovers, monitored around-the-clock (193 h) to model diel activity; and honeybees visiting thistles, monitored over a shorter period (5 h) to test the applicability and reliability of a new method for monitoring pollinators. The data were automatically entered and processed using R-scripts after manual filtering of the images, obviating the need for manual data entry prior to analysis. For diel activity in bumblebees, the model that gave the best fit included the 24-h fundamental period and one harmonic, a 12-h period to modulate the signal, together with temperature. The bumblebees were exclusive diurnal, with activity starting about 5 h after sunrise, peaking sharply in the afternoon and ending about 1 h before sunset. In addition to time of day, activity also increased with temperature. The off-the-shelf digital camera, Canon PowerShot®, with motion detection script, was triggered by every flower-visiting honeybee. In addition to recorded visitor frequency and visitor duration, it enabled high-resolution images, which could be important for species identification. Automatic camera recording is advantageous for close-up monitoring, compared with continuous video recording, because the latter demands more time and effort in reviewing the material. It could be used to study a range of different species such as pollinators, on-plant behaviour of herbivorous animals, cavity dwellers or cavity breeders. Moreover, the procedures for automatic data entry, data processing and statistical analysis for modelling diel activity rhythms could have great relevance for researchers using other types of camera monitoring systems operating 24 h per day.
Data from: Preparation, characterisation and antioxidant activities of rutin-loaded zein-sodium caseinate nanoparticles
Novel rutin-loaded zein-sodium caseinate nanoparticles (ZP) that release slowly in simulated gastric/intestinal solutions with antioxidant activity in aqueous medium were investigated. The results showed that the sodium caseinate concentrations, dosages of rutin and ethanol volume fractions significantly affected the zein nanoparticles' characteristics. A slower rutin cumulative release (14.8-19.8%) in simulated gastric solutions and a relatively faster one (19.8-26.1%) in simulated intestinal solutions for 3 h from rutin loaded ZP with different dosages (0.05-0.20 g) were observed. Concerning the antioxidant properties, the highest values of rutin loaded ZP obtained using 2, 2-diphenyl-1-picrylhydrazyl scavenging and 2 and 2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) decolourisation assays were 52.7% and 71.2%, respectively, and the total antioxidant capacity was 0.40nmol g-1. The results suggest that zein-sodium caseinate nanoparticles can be used as a new nano delivery system for rutin or other water insoluble active ingredients for a controlled release.
Data from: Activation recovery interval imaging of premature ventricular contraction
Dispersion of ventricular repolarization due to abnormal activation contributes to the susceptibility to cardiac arrhythmias. However, the global pattern of repolarization is difficult to assess clinically. Activation recovery interval (ARI) has been used to understand the properties of ventricular repolarization. In this study, we developed an ARI imaging technique to noninvasively reconstruct three-dimensional (3D) ARI maps in 10 premature ventricular contraction (PVC) patients and evaluated the results with the endocardial ARI maps recorded by a clinical navigation system (CARTO). From the analysis results of a total of 100 PVC beats in 10 patients, the average correlation coefficient is 0.86±0.05 and the average relative error is 0.06±0.03. The average localization error is 4.5±2.3 mm between the longest ARI sites in 3D ARI maps and those in CARTO endocardial ARI maps. The present results suggest that ARI imaging could serve as an alternative of evaluating global pattern of ventricular repolarization noninvasively and could assist in the future investigation of the relationship between global repolarization dispersion and the susceptibility to cardiac arrhythmias.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.