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1,923 results for “Compound”
USP5 Zf-UBD Co-Crystal Structure with Compound XSR00035795a & Testing Selectivity
<p>Growth of well-diffracting co-crystals of USP5 zinc finger ubiquitin binding domain (Zf-UBD) and compound XSR00035795a to solve the structure to determine ligand interactions in the binding pocket. A surface plasmon resonance assay was used to determine if methyl group on carboxylic chain of compound XSR00035795a confers selectivity to USP5 versus HDAC6. </p>
Can metal organic frameworks outperform adsorptive removal of harmful phenolic compound 2-chlorophenol by activated carbon?
<p>Dataset supporting publication. High resolution images, and full data set as produced in manuscript figures.</p> <p><strong>Preprint</strong>: <a href="https://doi.org/10.26434/chemrxiv.10320752.v1">https://doi.org/10.26434/chemrxiv.10320752.v1 </a></p> <p><strong>Published article:</strong> <a href="https://doi.org/10.1016/j.cherd.2020.03.017">https://doi.org/10.1016/j.cherd.2020.03.017 </a></p> <p><strong>Abstract:</strong> Removal of persistent organic compounds from aqueous solutions is generally achieved using adsorbent like activated carbon (AC) but it suffers from limited adsorption capacity due to low surface area. This paper describes a pioneering work on the adsorption of an organic pollutant, 2-chlorophenol (2-CP) by two MOFs with high surface area and water stability; MIL-101 and its amino-derivative, MIL-101-NH<sub>2</sub>. Although MOFs have higher surface area than AC, the latter was proven better having the highest equilibrium 2-CP uptake (345 mg.g<sup>-1</sup>), followed by MIL-101 (121 mg.g<sup>-1</sup>) and MIL-101-NH<sub>2</sub> (84 mg.g<sup>-1</sup>). Used MIL-101 could be easily regenerated multiple times by washing with ethanol and even showed improved adsorption capacity after each washing cycle. These results can open the doors to meticulous adsorbent selection for treating 2-CP-contaminated water. </p>
Antileishmanial compounds isolated from Psidium guajava L. using a metabolomic approach
<p>With an estimated annual incidence of 1 million cases, leishmaniasis is one of the top five vector-borne diseases. Currently available treatments involve side effects, including toxicity, non-specific targeting, and resistance development. Thus, new antileishmanial chemical entities are of the utmost interest to fight against this disease. The aim of this study was to obtain potential antileishmanial natural products from <em>Psidium guajava</em> leaves using a metabolomic workflow. Several crude extracts from <em>P. guajava</em> leaves harvested from different locations Lao People’s Democratic Republic (Lao PDR) were profiled by liquid chromatography coupled to high-resolution mass spectrometry and evaluated for their antileishmanial activities. The putative active compounds were highlighted by multivariate correlation analysis between the antileishmanial response and chromatographic profiles of <em>P. guajava</em> mixtures. The results showed that the pooled apolar fractions from <em>P. guajava</em> were the most active (IC<sub>50</sub> = 1.96±0.47 µg/mL). Multivariate data analysis of the apolar fractions highlighted a family of triterpenoid compounds, including jacoumaric acid (IC<sub>50</sub> = 1.318±0.59 µg/mL) and corosolic acid (IC<sub>50</sub> = 1.01±0.06 µg/mL). Our approach allowed the identification of antileishmanial compounds from the crude extracts in only a small number of steps steps and can be easily adapted for use in the discovery workflows of several other natural products.</p>
Fig. 2 in Variation of cuticular chemical compounds in three species of Mischocyttarus (Hymenoptera: Vespidae) eusocial wasps
Fig. 2. Relative proportions (A) and numbers in percentage terms (B) of the compounds identified in the three social wasp species of the genus Mischocyttarus: Mischocyttarus consimilis, Mischocyttarus bertonii, and Mischocyttarus latior.
Fig. 1 in Variation of cuticular chemical compounds in three species of Mischocyttarus (Hymenoptera: Vespidae) eusocial wasps
Fig. 1. Representative chromatograms for three species of social wasps of the genus Mischocyttarus, indicating the 10 compounds common to all of them. 1 = 3-methyloctadecane; 2 = pentacosane; 3 = heptacosane; 4 = 3-methylheptacosane; 5 = octacosane; 6 = X-methyloctacosane; 7 = 3-methyloctacosane; 8 = nonacosane; 9 = 13-methylnonacosane; 10 = 3-methyltriacontane.
Figures 4a-4c in Bioacoustic analysis of a compound sound with stridulation and forced air produced by the larva of Phileurus valgus (Olivier, 1789) (Coleoptera: Scarabaeidae: Dynastinae: Phileurini)
Figures 4a-4c. Oscillograms (above) and spectrograms (down) of sounds emitted by Phileurus valgus larvae. a) Bioacoustic stridulation (isolated) patterns. b) Bioacoustic sound patterns of compound sound (stridulatory + forced air). c) Bioacoustic pattern of compound sound pulse and some forced air sound pulses (6 pulses after the compound sound). / Oscilogramas (arriba) y espectrogramas (abajo) de los sonidos emitidos por las larvas de Phileurus valgus. a) Patrones bioacústicos de estridulación (aislada). b) Patrones bioacústicos de sonido compuesto (estridulación + aire forzado). c) Patrón bioacústico de pulso de sonido compuesto y algunos pulsos de sonido de aire forzado (6 pulsos después del sonido compuesto).
Figures 3a-3b in Bioacoustic analysis of a compound sound with stridulation and forced air produced by the larva of Phileurus valgus (Olivier, 1789) (Coleoptera: Scarabaeidae: Dynastinae: Phileurini)
Figures 3a-3b. Comparison of oscillogram and spectrogram of forced air sound pulse. a. Phileurus valgus. b. Phileurus didymus. / Comparación del oscilograma y el espectrograma del pulso sonoro de aire forzado. a. Phileurus valgus. b. Phileurus didymus.
Figures 1a-1d in Bioacoustic analysis of a compound sound with stridulation and forced air produced by the larva of Phileurus valgus (Olivier, 1789) (Coleoptera: Scarabaeidae: Dynastinae: Phileurini)
Figures 1a-1d. Diagrams of the experiments. a-c) Direct interaction (larva-larva) and response experiment. d) Direct manipulation experiment. / Diagramas de los experimentos. a-c) Experimento de interacción directa (larva-larva) y respuesta. d) Experimento de manipulación directa.
Figures 2a-2c in Bioacoustic analysis of a compound sound with stridulation and forced air produced by the larva of Phileurus valgus (Olivier, 1789) (Coleoptera: Scarabaeidae: Dynastinae: Phileurini)
Figures 2a-2c. Comparison of numbers of pulses in stridulation, oscillogram (above). Spectrogram (down). a) 4 pulses. b) 10 pulses. c) 12 pulses. / Comparación del número de pulsos en la estridulación, oscilograma (arriba). Espectrograma (abajo). a) 4 pulsos. b) 10 pulsos. c) 12 pulsos.
Figure 3 in Partially purified Glycine max proteinase inhibitors: potential bioactive compounds against tobacco cutworm, Spodoptera litura (Fabricius, 1775) (Lepidoptera: Noctuidae)
Figure 3. Food assimilation (in mg) with respect to control when second-instar larvae of S. litura were given different concentrations of soybean PIs. Columns and bars represent the mean ± SE. Different letters above the columns representing each concentration indicate significant differences with Tukey's test at P ≤ 0.05.
Figure 2 in Partially purified Glycine max proteinase inhibitors: potential bioactive compounds against tobacco cutworm, Spodoptera litura (Fabricius, 1775) (Lepidoptera: Noctuidae)
Figure 2. Percentage survival of adults when second-instar larvae of S. litura were given different concentrations of soybean PIs. Columns and bars represent the mean ± SE. Different letters above the columns representing each concentration indicate significant differences with Tukey's test at P ≤ 0.05.
Figure 1 in Partially purified Glycine max proteinase inhibitors: potential bioactive compounds against tobacco cutworm, Spodoptera litura (Fabricius, 1775) (Lepidoptera: Noctuidae)
Figure 1. (A) Normal S. litura adult, (B–D) abnormality in adults observed at 100 µg/mL concentration of soybean PIs.
Figure 4 in Partially purified Glycine max proteinase inhibitors: potential bioactive compounds against tobacco cutworm, Spodoptera litura (Fabricius, 1775) (Lepidoptera: Noctuidae)
Figure 4. Trypsin activity in larvae of S. litura at different time intervals under the influence of partially purified soybean PIs.
Figure 3 in Earthworm, a novel in vivo system to validate antimitotic compounds
Figure 3. Microscopy analysis of blastema development. Worms treated with water showed development of blastema 3 days after amputation (A), whereas wound healing alone was observed in worms treated with colchicine (B) or aqueous extract of A. calamus (C). Healed wounds are indicated by arrows. Histological studies show the regenerating budding tissue in water-treated worms (D), healed wounds alone in colchicine-treated worms (E), or aqueous extract of A. calamus (F). All tissues (D, E, and F) were stained with hematoxylin and eosin and were photographed with 4× magnification using a light microscope. The arrows in panels D, E, and F indicate the borders of the lesion. rb - regenerating blastema, wh - wound healing, ECL - epithelial cell layer, CML - circular muscle layer, LCL - longitudinal cell layer. Scale bar equals 50 µm.
Figure 2 in Earthworm, a novel in vivo system to validate antimitotic compounds
Figure 2. Inhibition of blastema development in Eudrilus eugeniae by colchicine and aqueous extract of Acorus calamus. A) The adult earthworm, E. eugeniae, is marked to show anterior (ar), clitellum (cl), and posterior (pr) regions. The control worms were injected with distilled water every 24 h for a period of 7 days, and the development of the blastema was observed after day 3 (B), day 5 (C), or day 7 (D). Colchicine was injected similarly for 7 consecutive days and the development of blastema was not observed after day 3 (E), day 5 (F). or day 7 (G). Aqueous extract of A. calamus rhizomes was injected every 24 h for a period of 7 days and the development of blastema was not observed after day 3 (H), day 5 (I), or day 7 (J). rb - regenerating blastema, wh - wound healing.
Figure 1 in Earthworm, a novel in vivo system to validate antimitotic compounds
Figure 1. Inhibition of cell division in AllIum cepa root tips by colchicine and water extract of Acorus calamus. All root tips were incubated with respective samples for 16 h before the processing. A) Different stages of mitosis of roots treated with distilled water, observed with a 40× objective lens; B) the arrest of cell division predominantly in metaphase by colchicine (100 µg/mL); C) more prophases compared to the stages of metaphase and anaphase in samples treated with Acorus calamus (1 mg/mL); D) magnified images of all 4 phases of mitosis (prophase, metaphase, anaphase, and telophase) in water-treated samples; E) the magnified images of 6 metaphases and 1 anaphase in colchicine-treated samples; F) the magnified images of metaphase, anaphase, and prophase. The graph (G) shows the % of cells observed in different phases of mitotic cell division with mean ± SEM bar and P-value (***: P <0.05). Marked circles indicate the different phases of cell division.
Fig. 1 in Effect of storage of pheromone lures for Amyelois transitella: field performance and compound ratios
Fig. 1. Cumulative total of males (mean and SE, n = 4) captured by Suterra NOW Biolure acquired in 2013, 2014, or 2015, or by Trécé NOW-L2L or NOWL2H during 4-week periods between lure change. Sets of lures were tested during Mar through Jun of 2015 as follows: (a) 1 Mar to 26 Mar; (b) 26 Mar to 23 Apr; (c) 23 Apr to 21 May; and (d) 21 May to 25 Jun. Means with different super- scripts are significantly different (ANOVA, experiment-wise P <0.05).
Fig. 2 in Effect of storage of pheromone lures for Amyelois transitella: field performance and compound ratios
Fig. 2. Effect of time of storage on emission of C23 pentaene by NOW Biolure. Emission rate of pheromone components was evaluated by GC-MS in Jun 2015 for lures purchased prior to the field season in 2013,2014, and 2015. Lures were stored at –20 °C prior to analysis. The rate of pentaene emission is expressed as a percentage of the rate of emission of Z11,Z13-16:Ald. Means with different letters are significantly different (ANOVA, P <0.05).
Fig. 1 in Volatile compounds emitted by the stink bug Antiteuchus innocens (Hemiptera: Pentatomidae)
Fig. 1. Typical gas chromatograms of volatile compounds released by disturbed females (A) and fifh instar nymphs (B), or produced by the dorsal gland of fifh instar nymphs (C). For an explanation of peak numbers see Tables 1 and 2.
Fig. 8. Compound chondrichthyan scales Type 1 in Givetian (Middle Devonian) sharks from Cairo, New York (USA): Evidence of early cosmopolitanism
Fig. 8. Compound chondrichthyan scales Type 1 sensu Liao et al. (2007), attributed to Wellerodus priscus, from the Givetian of the Cairo quarry, New York. A. NYSM 17785 in dorsal view. B. NYSM 17782 in dorsal (under BES mode) (B1) and dorso-lateral (B2) views. C. NYSM 17787 in dorsal view. D. NYSM 17783 in dorsal view (under BES mode). E. NYSM 17786 in rostral (E1), caudal (E2), and basal (E3) views (under BES mode).
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.