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1,723 results for “Reactivation”
Transcriptional response to tetanus toxoid in pigs with divergent temperament (High-Reactive vs. Low-Reactive) [day 14]
GEO Series GSE55413. Sus scrofa. 46 samples. Type: Expression profiling by array.
Elevated C-reactive protein levels across diagnoses: The first comparison among inpatients with major depressive disorder, bipolar disorder, or obsessive–compulsive disorder
<p>Elevated C-reactive protein levels across diagnoses: The first comparison among inpatients with major depressive disorder, bipolar disorder, or obsessive–compulsive disorder</p> <p>Objective: We addressed elevated C-reactive protein level (eCRP) specificity comparing, for the first time, eCRP (i.e., serum CRP > 3 and ≤10 mg/L) in patients with major depressive disorder (MDD), bipolar disorder (BD), or obsessive–compulsive disorder (OCD). We also assessed to what extent multiple variables that can potentially increase inflammation may have influenced eCRP in our sample.<br> Methods: We performed a retrospective, observational, cross-sectional study using information documented in the electronic medical records (EMRs) of patients hospitalized for a 4-week psychiatric rehabilitation program. We collected all information according to the standardized procedures of the hospital’s clinical practice and applied a logistic regression model (α = 0.05).<br> Results: We included 388 inpatients, that is, 156 (40.2%) with MDD, 135 (34.8%) with BD, and 97 (25.0%) with OCD, and found considerable eCRP rates among them (36.5%, 47.4%, and 29.9% in MDD, BD, and OCD, respectively) but without significant differences across groups. In the whole sample, eCRP variations were only partially attributable (approximately for one-third) to potential confounders. All groups presented considerable rates of cardiovascular risk factors, and we classified most patients as having medium or high CRP-based cardiovascular risk.<br> Conclusion: This first study comparing eCRP in MDD, BD, and OCD suggests that eCRP may be a transdiagnostic feature of different psychiatric disorders, and other mechanisms beyond the effects of multiple confounders may explain the presence of eCRP in a substantial portion of psychiatric patients. Therefore, we encourage the routine measurement of CRP in psychiatric clinical practice.</p> <p> </p>
Ozone formation sensitivity study using machine learning coupled with the reactivity of volatile organic compound species
<p>Ozone formation sensitivity study using machine learning coupled with the reactivity of volatile organic compound species</p>
LAG-3 blockade reactivates the CD8+ T cell expansion program to re-expand contracted clones in the tumor
<p>Additional data</p>
Dataset French version of reactive-proactive aggression questionnaire: Assessment of psychometrics properties in adolescent samples
<p>This dataset is related to French version of reactive-proactive aggression questionnaire: Assessment of psychometrics properties in adolescent samples (Suter M., Pihet S., Urben S.)</p>
Total OH reactivity measured around the Arabian Peninsula July-August 2017
<p>Total OH reactivity measured by the Comparative Reactivity Method in July and August 2017 during the Air Quality and Climate Change in the Arabian Basin (AQABA) Campaign. The data are available upon request to all scientists agreeing to the AQABA protocol after August 2019 (eva.pfannerstill@mpic.de). Data is in 5 min resolution and measurements influenced by own ship exhaust are excluded.</p>
LAG-3 blockade reactivates the CD8+ T cell expansion program to re-expand contracted clones in the tumor
<p>Code and data for review of manuscript</p>
Dataset related to the article "Enduring Reactive Oxygen Species Emission Causes Aberrant Protein S-Glutathionylation Transitioning Human Aortic Valve Cells from a Sclerotic to a Stenotic Phenotype"
<p>This record contains raw data related to the article "Enduring Reactive Oxygen Species Emission Causes Aberrant Protein S-Glutathionylation Transitioning Human Aortic Valve Cells from a Sclerotic to a Stenotic Phenotype"</p> <p><strong><em>Aims:</em></strong> During calcific aortic valve stenosis (CAVS) progression, oxidative stress and endothelial dysfunction mark the initial pathogenic steps with a parallel dysregulation of the antioxidant systems. Here, we tested whether oxidation-induced protein S-glutathionylation (P-SSG) accounts for a phenotypic switch in human aortic valvular tissue, eventually leading to calcium deposition. Next, we tested whether countering this reactive oxygen species (ROS) surge would prevent these perturbations. <strong><em>Results:</em></strong> We employed state-of-the-art technologies, such as electron paramagnetic resonance (EPR), liquid chromatography-tandem mass spectrometry, imaging flow-cytometry, and live-cell imaging on human excised aortic valves and primary valve endothelial cells (VECs). We observed that a net rise in EPR-detected ROS emission marked the transition from fibrotic to calcific in human CAVS specimens, coupled to a progressive increment in P-SSG deposition. In human VECs (hVECs), treatment with 2-acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylthiocarbonylamino)phenylthiocarbamoylsulfanyl]propionic acid triggered highly oxidizing conditions prompting P-SSG accumulation, damaging mitochondria, and inducing endothelial nitric oxide synthase uncoupling. All the events conjured up in morphing these cells from their native endothelial phenotype into a damaged calcification-inducing one. As proof of principle, the use of the antioxidant N-acetyl-L-cysteine prevented these alterations. <strong><em>Innovation:</em></strong> Borne as a compensatory system to face excessive oxidative burden, with time, P-SSG contributes to the morphing of hVECs from their innate phenotype into a damaged one, paving the way to calcium deposition. <strong><em>Conclusion:</em></strong> Our data suggest that, in the human aortic valve, unremitted ROS emission along with a P-SSG build-up occurs and accounts, at least in part, for the morphological/functional changes leading to CAVS.</p>
Human Sarcopenic Myoblasts Can Be Rescued by Pharmacological Reactivation of HIF-1α
<p>Cirillo F, Mangiavini L, La Rocca P, Piccoli M, Ghiroldi A, Rota P, Tarantino A, Canciani B, Coviello S, Messina C, Ciconte G, Pappone C, Peretti GM, Anastasia L. Human Sarcopenic Myoblasts Can Be Rescued by Pharmacological Reactivation of HIF-1α. Int J Mol Sci. 2022 Jun 26;23(13):7114. doi: 10.3390/ijms23137114. PMID: 35806119; PMCID: PMC9267002.</p> <p>Abstract</p> <p>Sarcopenia, an age-related decline in muscle mass and strength, is associated with metabolic disease and increased risk of cardiovascular morbidity and mortality. It is associated with decreased tissue vascularization and muscle atrophy. In this work, we investigated the role of the hypoxia inducible factor HIF-1α in sarcopenia. To this end, we obtained skeletal muscle biopsies from elderly sarcopenic patients and compared them with those from young individuals. We found a decrease in the expression of HIF-1α and its target genes in sarcopenia, as well as of <em>PAX7</em>, the major stem cell marker of satellite cells, whereas the atrophy marker MURF1 was increased. We also isolated satellite cells from muscle biopsies and cultured them in vitro. We found that a pharmacological activation of HIF-1α and its target genes caused a reduction in skeletal muscle atrophy and activation of <em>PAX7</em> gene expression. In conclusion, in this work we found that HIF-1α plays a role in sarcopenia and is involved in satellite cell homeostasis. These results support further studies to test whether pharmacological reactivation of HIF-1α could prevent and counteract sarcopenia.</p> <p> </p>
Single Patient Protocol: A Phase II Study Using the Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Mutated Neoantigens in a Patient With Metas
ClinicalTrials.gov study NCT04135092. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Nutrient-Delivery and Metabolism Reactivation Therapy for Melanoma
GEO Series GSE263479. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
A specific protective mechanism against chloroplast photo-reactive oxygen species in phosphate-starved rice plants
GEO Series GSE225478. Oryza sativa. 16 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Mesenchymal transition and acquired therapy resistance of glioblastoma cells is connected to astrocyte reactivity
GEO Series GSE122809. Homo sapiens. 38 samples. Type: Expression profiling by array; Methylation profiling by genome tiling array.
ERV reactivation in Daxx knock-out embryonic stem cells
GEO Series GSE70965. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
S-lactoyl modification of KEAP1 by a reactive glycolytic metabolite activates NRF2 signaling
GEO Series GSE230577. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Reactivation of an Embryonic Cardiac Neural Crest Transcriptional Subcircuit During Zebrafish Heart Regeneration [bulk ATAC-seq]
GEO Series GSE287813. Danio rerio. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Gene reactivation upon erosion of X-chromosome inactivation in female hiPSCs is predictable yet variable and persists through differentiation
GEO Series GSE262239. Homo sapiens. 39 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other.
Dataset related to the article "High sensitivity C-reactive protein and acute kidney injury in patients wit acute myocardial infarction: a prospective observational study"
<p>This record contains raw data related to the article "High sensitivity C-reactive protein and acute kidney injury in patients wit acute myocardial infarction: a prospective observational study"</p> <p><strong>Abstract:</strong> Background. Accumulating evidence suggests that inflammation plays a key role in acute<br> kidney injury (AKI) pathogenesis. We explored the relationship between high-sensitivity C-reactive<br> protein (hs-CRP) and AKI in acute myocardial infarction (AMI). Methods. We prospectively included<br> 2,063 AMI patients in whom hs-CRP was measured at admission. AKI incidence and a clinical<br> composite of in-hospital death, cardiogenic shock, and acute pulmonary edema were the study<br> endpoints. Results. Two-hundred-thirty-four (11%) patients developed AKI. hs-CRP levels were<br> higher in AKI patients (45 87 vs. 16 41 mg/L; p < 0.0001). The incidence and severity of AKI, as well<br> as the rate of the composite endpoint, increased in parallel with hs-CRP quartiles (p for trend <0.0001<br> for all comparisons). A significant correlation was found between hs-CRP and the maximal increase<br> of serum creatinine (R = 0.23; p < 0.0001). The AUC of hs-CRP for AKI prediction was 0.69 (p < 0.001).<br> At reclassification analysis, addition of hs-CRP allowed to properly reclassify 14% of patients when<br> added to creatinine and 8% of patients when added to a clinical model. Conclusions. In AMI,<br> admission hs-CRP is closely associated with AKI development and severity, and with in-hospital<br> outcomes. Future research should focus on whether prophylactic renal strategies in patients with<br> high hs-CRP might prevent AKI and improve outcome.</p>
Telomere length and salivary cortisol stress reactivity in very preterm infants
<p>Raw data of the study "Telomere length and salivary cortisol stress reactivity in very preterm infants" In this study, we prospectively examined the relationship between NICU pain-related stress and HPA axis reactivity to an age-appropriate socio-emotional condition (i.e., the Still-Face Procedure, SFP) in healthy VPT infants at 3-month corrected age. NICU pain-related stress was computed as the ratio between the number of skin-breaking procedures and length of NICU stay. A differential score (i.e., ∆TL) was obtained subtracting TL at birth from TL at discharge. A normalized (log10) cortisol reactivity index (CRI) was obtained by averaging post-stress (20 min after SFP) salivary cortisol sample on baseline value. A regression model controlling for neonatal and socio-demographic confounders showed that ∆TL was the only significant predictor of CRI. Although preliminary, these findings contribute to our knowledge of the mechanisms linking early exposures to adversity and later in life regulation of the HPA axis in VPT infants.</p>
Data set from Ranucci M, Aloisio T, Di Dedda U, Menicanti L, de Vincentiis C, Baryshnikova E; Surgical and Clinical Outcome REsearch (SCORE) group. Gender-based differences in platelet function and platelet reactivity to P2Y12 inhibitors. PLoS One. 2019 Nov 27;14(11):e0225771. doi: 10.1371/journal.pone.0225771. PMID: 31774869; PMCID: PMC6881030.
<p>Data set from Ranucci M, Aloisio T, Di Dedda U, Menicanti L, de Vincentiis C, Baryshnikova E; Surgical and Clinical Outcome REsearch (SCORE) group. Gender-based differences in platelet function and platelet reactivity to P2Y12 inhibitors. PLoS One. 2019 Nov 27;14(11):e0225771. doi: 10.1371/journal.pone.0225771. PMID: 31774869; PMCID: PMC6881030.</p> <p>This is the article:</p> <p><strong>Background: </strong> Gender influences platelet biology. Women have a larger platelet count, but gender-based differences in platelet function remain debated. We performed a study addressing gender-based differences in platelet function using point-of-care platelet function tests (PFT).</p> <p><strong>Methods: </strong> The patient population consisted of 760 cardiac surgery patients where preoperative PFT (multiple-electrode aggregometry [MEA]) were available. Platelet count and function at the ADPtest and TRAPtest were compared in the overall population and separately in patients with or without residual effects of P2Y12 inhibitors.</p> <p><strong>Results: </strong> Women had a significantly (P = 0.001) higher platelet count but a non-significantly higher platelet reactivity to ADP. In clopidogrel-treated patients, the platelets ADP reactivity was significantly (P = 0.031) higher in women, and platelet count was the main determinant of platelet hyper-reactivity. Within patients under full clopidogrel effects, women with a platelet count ≥ 200,000 cells/μL had a significantly (P = 0.023) higher rate of high-on-treatment platelet reactivity (HTPR, 45.5%) with respect to males with a platelet count < 200,000 cells/μL (11.9%), with a relative risk of 6.2 (95% confidence interval 1.4-29).</p> <p><strong>Conclusions: </strong> Our findings confirm that women have a larger platelet count than men, and that this is associated to a trend towards a higher platelet reactivity. HTPR is largely represented in women with a high platelet count. This generates the hypothesis that women requiring P2Y12 inhibitors could potentially benefit from larger doses of drug or should be treated with anti-platelet agents with a low rate of HTPR.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.