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192 results for “glycosylation”
Dataset related to the article: "Cyclooxygenase-2 Glycosylation Is Affected by Peroxynitrite in Endothelial Cells: Impact on Enzyme Activity and Degradation"
<p>This record containsraw data related to the article: "Cyclooxygenase-2 Glycosylation Is Affected by Peroxynitrite in Endothelial Cells: Impact on Enzyme Activity and Degradation"</p> <p>Abstract: The exposure of human endothelial cells to 3-morpholinosydnonimine (SIN-1) induced the<br> expression of cyclooxygenase-2 (COX-2) in a dose- and time-dependent manner. Interestingly, after a<br> prolonged incubation (>8 h) several proteoforms were visualized by Western blot, corresponding<br> to different states of glycosylation of the protein. This effect was specific for SIN-1 that generates<br> peroxynitrite and it was not detected with other nitric oxide-donors. Metabolic labeling experiments<br> using 35S or cycloheximide suggested that the formation of hypoglycosylated COX-2 was dependent<br> on de novo synthesis of the protein rather than the deglycosylation of the native protein. Moreover,<br> SIN-1 reduced the activity of the hexokinase, the enzyme responsible for the first step of glycolysis.<br> The hypoglycosylated COX-2 induced by SIN-1 showed a reduced capacity to generate prostaglandins<br> and the activity was only partially recovered after immunoprecipitation. Finally, hypoglycosylated<br> COX-2 showed a more rapid rate of degradation compared to COX-2 induced by IL-1a and an<br> alteration in the localization with an accumulation mainly detected in the nuclear membrane. Our<br> results have important implication to understand the effect of peroxynitrite on COX-2 expression<br> and activity, and they may help to identify new pharmacological tools direct to increase COX-2<br> degradation or to inhibit its activity.</p>
Fig. 4 in Glycosylated constituents isolated from the trunk of Abies holophylla and their anti-inflammatory and neurotrophic activity
Fig. 4. Zoomed-in region (7.0–8.0 ppm) of 1H NMR of 6 (top) and 15 (bottom).
Fig. 2 in Molecular networking-driven isolation of 8 -Glycosylated biscoumarins from Cruciata articulata
Fig. 2. Chemical structures of compounds 1–7.
Disruption of the epigenetic regulator BAP1 drives chromatin remodeling leading to the emergence of cells with breast cancer stem cell properties and aberrant glycosylation [RNAseq_2D]
GEO Series GSE271680. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Mechanism of OGT-mediated FASN glycosylation regulating JNK/ICAM1 pathway in Liver cancer stem cell metastasis
GEO Series GSE269783. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
The use of the glycoarray chip to investigate VHL-dependent protein glycosylation changes in renal cancer Renal cell carcinoma (RCC)
GEO Series GSE30491. Homo sapiens. 18 samples. Type: Expression profiling by array.
Glycosyl-T expression in NB cells
GEO Series GSE26481. Homo sapiens; Mus musculus. 18 samples. Type: Expression profiling by array.
O-glycosylation inhibition and O-glycosylation mutants
GEO Series GSE12197. Schizosaccharomyces pombe; Saccharomyces cerevisiae. 15 samples. Type: Expression profiling by array.
Profound effect of asparagine-linked glycosylation protein 11 (TgALG11) on genomic expression of Toxoplasma gondii
GEO Series GSE303275. Toxoplasma gondii. 6 samples. Type: Expression profiling by high throughput sequencing.
Glycosylation change in mouse CD8 T cells during development
GEO Series GSE26012. Mus musculus; Homo sapiens. 7 samples. Type: Expression profiling by array.
Gene microarray screening to identify glycosylation genes that are regulated during the formation of osteoclast cells
GEO Series GSE28937. Mus musculus. 6 samples. Type: Expression profiling by array.
Microarray analysis of RNA of TCR transgenic CD8 T cells to assess the role of protein glycosylation in the decision between deletion vs. anergy in immune tolerance
GEO Series GSE31987. Mus musculus. 9 samples. Type: Expression profiling by array.
Elucidating mechanisms by which regulated expression of proteoglycans and glycosylation-related genes in the striatum contribute to Huntington disease
GEO Series GSE27588. Homo sapiens; Mus musculus. 12 samples. Type: Expression profiling by array.
To investigate how the glycosylation of podocyte proteins changes during diabetic kidney disease
GEO Series GSE32553. Homo sapiens. 32 samples. Type: Expression profiling by array.
Glycosylation-related gene expression in the mucous-secreting gastrointestinal cell line HT29-MTX-E12 in response to infection by Campylobacter jejuni
GEO Series GSE107565. Homo sapiens. 5 samples. Type: Expression profiling by array.
To identify glycosylation-specific targets contributing to the interferon gamma-dependent upregulation of sialylated CD44v6 in certain types of intestinal epithelial cells
GEO Series GSE31937. Homo sapiens. 9 samples. Type: Expression profiling by array.
Profound effect of asparagine-linked glycosylation protein 11 (TgALG11) on genomic expression of Toxoplasma gondii II
GEO Series GSE314937. Toxoplasma gondii. 6 samples. Type: Expression profiling by high throughput sequencing.
Examine how the absence of prion protein expression could affect the cellular glycosylation enzymes during development
GEO Series GSE28935. Mus musculus. 12 samples. Type: Expression profiling by array.
Continued studies the glycosylation changes in a cell line model of embryo implantation of steroid-exposed and control Ichikawa cells
GEO Series GSE29940. Homo sapiens. 12 samples. Type: Expression profiling by array.
To identify the deficient enzyme(s) in the glycosylation pathway that yield incomplete maturation of (uPAR) protein
GEO Series GSE31929. Homo sapiens. 6 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.