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Data from: Limits on information transduction through amplitude and frequency regulation of transcription factor activity
Signaling pathways often transmit multiple signals through a single shared transcription factor (TF) and encode signal information by differentially regulating TF dynamics. However, signal information will be lost unless it can be reliably decoded by downstream genes. To understand the limits on dynamic information transduction, we apply information theory to quantify how much gene expression information the yeast TF Msn2 can transduce to target genes in the amplitude or frequency of its activation dynamics. We find that although the amount of information transmitted by Msn2 to single target genes is limited, information transduction can be increased by modulating promoter cis-elements or by integrating information from multiple genes. By correcting for extrinsic noise, we estimate an upper bound on information transduction. Overall, we find that information transduction through amplitude and frequency regulation of Msn2 is limited to error-free transduction of signal identity, but not signal intensity information.
Data from: DG-CA3 circuitry mediates hippocampal representations of latent information
<p>Survival in complex environments necessitates a flexible navigation system that incorporates memory of recent behavior and associations. Yet, how the hippocampal spatial circuit represents latent information independent of sensory inputs and future goals has not been determined. To address this, we imaged the activity of large ensembles in subregion CA1 via wide-field fluorescent microscopy during a novel behavioral paradigm. Our results demonstrated that latent information is represented through reliable firing rate changes during unconstrained navigation. We then hypothesized that the representation of latent information in CA1 is mediated by pattern separation/completion processes instantiated upstream within the dentate gyrus (DG) and CA3 subregions. Indeed, CA3 ensemble recordings revealed an analogous code for latent information. Moreover, selective chemogenetic inactivation of DG-CA3 circuitry completely and reversibly abolished the CA1 representation of latent information. These results reveal a causal and specific role of DG-CA3 circuitry in the maintenance of latent information within the hippocampus.</p> <p> </p>
Supplemental information, code, and data for the MS: Defaunation impacts carbon storage in tropical forests.
<p># MS_Carbon<br /> Supplemental information, code, and data for the MS: <br /> Carolina Bello, Mauro Galetti, Marco A. Pizo, Luiz Fernando S. Magnago, Mariana Ferreira Rocha, Renato A. F. Lima, Carlos A. Peres, Otso Ovaskainen, and Pedro Jordano (2015). Defaunation impacts carbon storage in tropical forests.</p> <p> </p> <p>*Summary*:<br /> Carbon storage is widely acknowledged as one of the most valuable forest ecosystem services. Deforestation, logging, fragmentation and climate change have significant impacts on tropical carbon stocks, however an elusive and yet undetected decrease in carbon storage may be due to defaunation of large seed dispersers. Many large tropical trees with sizeable contributions to carbon stock rely on large vertebrates for seed dispersal and regeneration, yet many of these frugivores are threatened by hunting, illegal trade and habitat loss. We used a large dataset on tree species composition and abundance, seed, fruit and carbon related traits, and plant-animal interactions to estimate the loss of carbon storage capacity of tropical forests in defaunated scenarios. By simulating the local extinction of trees that depend on large frugivores at 31 Atlantic Forest communities, we found that defaunation has the potential to significantly erode carbon storage even when only a small proportion (10%) of large-seeded trees are extirpated.</p> <p> </p>
Supplemental Information: Cooperative Coevolution of Control for a Real Multirobot System
<p>Supplemental information for the paper "Cooperative Coevolution of Control for a Real Multirobot System".</p> <p>[real_logs.csv] Position (from GPS) and orientation (from compass) logs of the robots in the real-robot experiments.</p> <p>[camera_video.mp4] Video recorded in one of the experimental trials, showing the real robots and the environment.</p> <p>[traces_all_trials.pdf] Images with the traces of the robots in all real-robot experiments.</p> <p>[video_CONTROLLER_TRIAL] Videos of the traces of the robots in the real-robot experiments.</p> <p> </p> <p>The source code for the evolutionary process can be found here: https://github.com/jorgemcgomes/mase</p> <p>And the simulation environment here: https://github.com/BioMachinesLab/drones</p>
Economic and financial barriers to delivering mental health services in Georgia: Informing policy and acting on evidence
<p>Dataset includes qualitative data for the manuscript entitled "Economic and financial barriers to delivering mental health services in Georgia: Informing policy and acting on evidence".</p>
Informative data about the biological sample studied in the article "Nineteenth century French rose (Rosa sp.) germplasm shows a shift over time from a European to an Asian genetic background"
<p>Informative data about the biological sample studied in the article "Nineteenth century French rose (<em>Rosa </em>sp.) germplasm shows a shift over time from a European to an Asian genetic background" published in Journal of Experimental Botany (https://doi.org/10.1093/jxb/erw269)</p>
FIGURE 1 in Description of the final instar larva of Acrogomphus jubilaris Lieftinck, 1964 (Odonata, Gomphidae), with information on the distribution of Acrogomphus in Borneo
FIGURE 1. Distribution map of A. jubilaris (red triangles) and locations where larvae of Acrogomphus have been found (white squares).
FIGURE 2. A in Description of the final instar larva of Acrogomphus jubilaris Lieftinck, 1964 (Odonata, Gomphidae), with information on the distribution of Acrogomphus in Borneo
FIGURE 2. A. jubilaris habitat, larva and adult. A Habitat of A. jubilaris larvae, forest stream in Garden of Eden area, Gunung Mulu National Park. B Habitat of A. jubilaris larvae, forest streamlet, Bat Cave area, Gunung Mulu National Park. C A. jubilaris freshly emerged adult Ƌ, reared from larva. D A. jubilaris larva in life, reared out in the laboratory.
FIGURE 4 in Description of a new species of Lutosa Walker, 1869 (Orthoptera: Anostostomatidae: Lutosinae) from the Brazilian Atlantic Forest, with biological and behavioral information
FIGURE 4. Lutosa horribilis sp. nov. alive specimens. A) male in dorsolateral view; B) female in lateral view.
FIGURE 5 in Description of a new species of Lutosa Walker, 1869 (Orthoptera: Anostostomatidae: Lutosinae) from the Brazilian Atlantic Forest, with biological and behavioral information
FIGURE 5. Lutosa horribilis sp. nov. live specimens. A) male nymph foraging on a leaf; B) male adult eating a dead stick insect.
FIGURE 3 in Description of a new species of Lutosa Walker, 1869 (Orthoptera: Anostostomatidae: Lutosinae) from the Brazilian Atlantic Forest, with biological and behavioral information
FIGURE 3. Lutosa horribilis sp. nov. paratype ♀. A) habitus in dorsal view; B) same in lateral view; C) apex of abdomen in posterodorsal view; D) same in ventral view; E) same in lateral view.
FIGURE 2 in Description of a new species of Lutosa Walker, 1869 (Orthoptera: Anostostomatidae: Lutosinae) from the Brazilian Atlantic Forest, with biological and behavioral information
FIGURE 2. Genitalia of Lutosa horribilis sp. nov. Ƌ. A) dorsal view; B) ventral view; C) lateral view. Abbreviations: LS = lateral sclerite of titillator, ti = titillator process, TS = titillator's sclerite.
FIGURES 59–68. Forewing. 59 in The Neotropical genus Klyngon Hansson (Hymenoptera: Eulophidae), with new species and biological information
FIGURES 59–68. Forewing. 59. Klyngon albicornis sp. nov., female. 60. K. brasilense sp. nov., female. 61. K. aulacis sp. nov., female. 62. K. copaiferae sp. nov., female. 63. K. costalimai sp. nov., female. 64. K. hortense sp. nov., male. 65. K. pegosoma sp. nov., female. 66. K. petalon sp. nov., female. 67. K. guimaraesi sp. nov., female. 68. K. serjaniae sp. nov., female.
FIGURES 69–86. Flagellum. 69 in The Neotropical genus Klyngon Hansson (Hymenoptera: Eulophidae), with new species and biological information
FIGURES 69–86. Flagellum. 69. Klyngon albicornis sp. nov., female. 70. K. brasilense sp. nov., female. 71. K. aulacis sp. nov., female. 72. K. brasilense, male. 73. K. copaiferae sp. nov., female. 74. K. costalimai sp. nov., female. 75. K. costalimai, male. 76. K. gibberum sp. nov., female. 77. K. hortense sp. nov., male. 78. K. pegosoma sp. nov., female. 79. K. petalon sp. nov., female. 80. K. guimaraesi sp. nov., female. 81. K. guimaraesi, male. 82. K. serjaniae sp. nov., female. 83. K. serjaniae, male. 84. K. jimenezi Hansson, female. 85. K. bouceki Hansson, female. 86. K. jimenezi, male.
FIGURES 44–47. Thoracic dorsum. 44 in The Neotropical genus Klyngon Hansson (Hymenoptera: Eulophidae), with new species and biological information
FIGURES 44–47. Thoracic dorsum. 44. Klyngon petalon sp. nov., female. 45. K. guimaraesi sp. nov., female. 46. K. serjaniae sp. nov., female. 47. K. bouceki Hansson, female.
FIGURES 3–8. Head, frontal. 3 in The Neotropical genus Klyngon Hansson (Hymenoptera: Eulophidae), with new species and biological information
FIGURES 3–8. Head, frontal. 3. Klyngon albicornis sp. nov., female. 4. K. aulacis sp. nov., female. 5. K. brasilense sp. nov., female. 6. K. brasilense, male. 7. K. copaiferae sp. nov., female. 8. K. copaiferae, male.
FIGURES 28–35. 28–34. Vertex. 28 in The Neotropical genus Klyngon Hansson (Hymenoptera: Eulophidae), with new species and biological information
FIGURES 28–35. 28–34. Vertex. 28. Klyngon hortense sp. nov., male. 29. K. pegosoma sp. nov., female. 30. K. petalon sp. nov., female. 31. K. guimaraesi sp. nov., female. 32. K. serjaniae sp. nov., female. 33. K. bouceki Hansson, female. 34. K. jimenezi Hansson, female. 35. K. costalimai sp. nov., female, part of mesoscutum and scutellum, arrows point at scuto-scutellar slit.
FIGURES 9–14. Head, frontal. 9 in The Neotropical genus Klyngon Hansson (Hymenoptera: Eulophidae), with new species and biological information
FIGURES 9–14. Head, frontal. 9. Klyngon costalimai sp. nov., female. 10. K. costalimai, male. 11. K. gibberum sp. nov., female. 12. K. hortense sp. nov., male. 13. K. pegosoma sp. nov., female. 14. K. petalon sp. nov., female.
FIGURES 40–43. Thoracic dorsum. 40 in The Neotropical genus Klyngon Hansson (Hymenoptera: Eulophidae), with new species and biological information
FIGURES 40–43. Thoracic dorsum. 40. Klyngon costalimai sp. nov., female. 41. K. gibberum sp. nov., female. 42. K. hortense sp. nov., male. 43. K. pegosoma sp. nov., female.
FIGURES 51–58. 51–56. Gaster, female. 51 in The Neotropical genus Klyngon Hansson (Hymenoptera: Eulophidae), with new species and biological information
FIGURES 51–58. 51–56. Gaster, female. 51. Klyngon brasilense sp. nov. 52. K. copaiferae sp. nov. 53. K. pegosoma sp. nov. 54. K. jimenezi Hansson, female. 55. K. serjaniae sp. nov. 56. K. guimaraesi sp. nov. 57–58. Forewing, female. 57. K. bouceki Hansson. 58. K. jimenezi Hansson.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.