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30,817 results for “type”
In vivo screening of Lrp-type transcription factors in Escherichia coli
<p>This dataset contains the raw data that lie at the basis of the results discussed in <strong>Chapter 4: <em>In vivo</em> screening of Lrp-type transcription factors in <em>Escherichia coli</em></strong><strong> </strong>of the PhD thesis of Amber Bernauw. The README.txt file provides more information on the different data files.</p>
A telencephalon cell type atlas for goldfish reveals diversity in the evolution of spatial structure and cell types
<p class="MsoNormal"><span>Teleost fish form the largest group of vertebrates, making them critically important for the study on the</span> <span>mechanisms of brain evolution. In fact, teleosts show a tremendous variety of adaptive behaviors similar</span> <span>to birds and mammals, however, the neural basis mediating these behaviors remains elusive. We</span> <span>performed a systematic comparative survey of the goldfish telencephalon: the seat of plastic behavior,</span> <span>learning, and memory in vertebrates. We delineated and mapped goldfish telencephalon cell types using</span> <span>single-cell RNA-seq and spatial transcriptomics, resulting in de novo molecular neuroanatomy</span> <span>parcellation. Glial cells were highly conserved across 450 million years of evolution separating mouse</span> <span>and goldfish, while neurons showed diversity and modularity in gene expression. Specifically,</span> <span>somatostatin (SST) interneurons, famously interspersed in the mammalian isocortex for local inhibitory</span> <span>input, were curiously aggregated in a single goldfish telencephalon nucleus, but molecularly conserved.</span> <span>Cerebral nuclei including the striatum, a hub for motivated behavior in amniotes, had molecularly conserved goldfish homologs. We further suggest different elements of a hippocampal formation across</span> <span>the goldfish pallium. Finally, aiding study of the teleostan everted telencephalon, we describe substantial</span> <span>molecular similarities between the goldfish and zebrafish neuronal taxonomies. Together, our atlas</span> <span>provides new insights into organization and evolution of vertebrate forebrains and may serve as a resource</span> <span>for the functional study underlying cognition in teleost fish.</span></p>
RNA-seq based analysis of gene expression in thyroids of wild-type and Keap1 knockdown mice after exposure to excess iodide.
<p>C57BL/6J Keap1flox/flox mice were developed by Prof. Masayuki Yamamoto (DOI: 10.1016/j.bbrc.2005.10.185). These mice express lower levels of Keap1 because of the loxP site insertions (DOI: 10.1128/MCB.01591-09) and are designated as Keap1KD. 3-4 months old WT and Keap1KD mice fed a standard diet (KLIBA NAFAG 3242, Switzerland) containing 1.5 mg/kg sodium iodine were given normal tap water with or without 0.05% sodium iodide (Sigma, St Louis, MO, USA) for 7 days. Hence, the following groups of mice were included:</p> <p>WT mice on control water (n=8)-designated as wt in the file</p> <p>WT mice exposed to excess iodide (WT-IOD, n=6)- designated as wti in the file</p> <p>Keap1KD mice on control water (n=8)- designated as kp in the file</p> <p> and Keap1KD mice exposed to excess iodide (Keap1KD-IOD, n=6)- designated as kpI in the file. </p> <p> Mice were maintained in the animal facility of the Department of Physiology at the University of Lausanne in temperature-, light-, and humidity-controlled rooms with a 12-hour light/dark cycle. All animal procedures were in accordance with Swiss legislature and the study was approved by the Canton of Vaud SCAV.</p> <p>RNA from individual mouse thyroids was prepared as previously described (DOI: 10.1007/978-1-4939-3756-1_25) and was submitted to Alithea Genomics (Switzerland). The bulk RNA barcoding and sequencing (BRB-seq) libraries were generated and sequenced as described previously (DOI: 10.1186/s13059-019-1671-x) to a depth of approximately 1.2 million raw reads per sample.</p> <p>This research was funded by the Swiss National Science Foundation Research Grants 310030_212558, IZCOZ0_205415 and IZCOZ0_177070</p> <p></p> <p></p>
Regression Datasets: Strength as a Function of Liquid Water Content in Different Snow Types
<p>This repository contains two datasets used for determining the shear strength of different snow types as a function of liquid water content. It also contains one dataset with additional information pertaining to our experiment, including site and condition details. <strong>Please read the 'Read me.txt' file before using these datasets.</strong></p>
Progenitor like cell type of an MLL-EDC4 fusion in acute myeloid leukemia
<p>Transcriptome analysis by single cell sequencing provides valuable information on intratumor heterogeneity and developmental stages of acute myeloid leukemia (AML) as well as interactions of tumor cells with the microenvironment. However, it has been hardly applied to the subgroup of cases with translocations of the mixed lineage leukemia (<i>MLL</i>) gene for which the enhancer of mRNA decapping 4 (<i>EDC4</i>) gene was recently identified as a novel fusion partner <i>(MLL-EDC4</i>). In our study published in Blood Advances (Schuster et al., 2023; https://doi.org/10.1182/bloodadvances.2022009096), we compared different <i>MLL</i> translocations by single cell RNA sequencing of cells derived from peripheral blood or bone marrow. The <i>MLL</i>-<i>EDC4</i> positive cells almost exclusively showed a transcriptional profile of hematopoietic progenitor cells while leukemic cells of <i>MLL-MLLT3</i> and <i>MLL-ELL</i> fusions exhibited a more differentiated phenotype. The <i>MLL</i>-<i>EDC4</i> progenitor state was characterized by the upregulation of key transcriptional regulators in AML (<i>RUNX1, SOX4, HOPX</i>), target genes of <i>MYC</i> and interferon signaling as well as other genes known to play a critical role in hematopoiesis or leukemic stem cell activation (<i>CDK6, FLT3, NPM1</i>). Here, the scRNA-seq dataset of our study is provided. It contains six scRNA-seq read count matrices of the AML samples with MLL fusions as described in the table scRNA-seq_samples.xlsx. Further details are given in the publication associated with this dataset. </p>
Linked collectors and determiners for: Type specimen collections of Turku University.
Natural history specimen data linked to collectors and determiners held within, "Type specimen collections of Turku University". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/aabcc8c1-ed59-4f3f-81db-948c9952503d">https://bionomia.net/dataset/aabcc8c1-ed59-4f3f-81db-948c9952503d</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/aabcc8c1-ed59-4f3f-81db-948c9952503d">https://gbif.org/dataset/aabcc8c1-ed59-4f3f-81db-948c9952503d</a>. Formatted as a Frictionless Data package.
Composite activity type and stride-specific energy expenditure estimation model for thigh-worn accelerometry
<p>This repository contains code and data for the research project 'Estimation of activity induced energy expenditure using thigh-worn accelerometry and machine learning approaches'.</p> <ul> <li>The <strong>code </strong>subfolder contains Jupyter Notebooks and a Python file with helper functions. Further, the models subfolder contains the trained models.</li> <li>The <strong>data </strong>subfolder contains the raw accelerometer files (AX) as well as the raw data from the indirect calorimetry (CPET). Further, different processing files can be found here. The file log_master.csv contains the sociodemographic and timestamp data.</li> <li>The <strong>figures</strong> subfolder contains all relevant figures, which are created as part of running the Jupyter Notebooks. These figures are also part of the research publication.</li> </ul>
Efficacy and Safety Study of DX-2930 to Prevent Acute Angioedema Attacks in Patients With Type I and Type II HAE
ClinicalTrials.gov study NCT02586805. IPD Sharing: YES. Countries: 7. Publications: 4.
Safety, Pharmacokinetics and Efficacy of Bimagrumab in Overweight and Obese Patients With Type 2 Diabetes
ClinicalTrials.gov study NCT03005288. IPD Sharing: YES. Countries: 2. Publications: 1.
Comparison of the Safety and Efficacy of HOE901-U300 With Lantus in Children and Adolescents With Type 1 Diabetes Mellitus
ClinicalTrials.gov study NCT02735044. IPD Sharing: YES. Countries: 24. Publications: 1.
EValuating trEatment RESponses of Dupilumab Versus Omalizumab in Type 2 Patients
ClinicalTrials.gov study NCT04998604. IPD Sharing: YES. Countries: 17. Publications: 2.
Comparison of SAR341402 to NovoLog in Adult Patients With Type 1 Diabetes Mellitus Also Using Insulin Glargine
ClinicalTrials.gov study NCT03874715. IPD Sharing: YES. Countries: 1. Publications: 2.
"MyPlan" - Individualized Planned Eating Patterns for Adolescents With Type 1 Diabetes
ClinicalTrials.gov study NCT05147324. IPD Sharing: YES. Countries: 1. Publications: 20.
Comparison of a New Formulation of Insulin Glargine With Lantus in Patients With Type 2 Diabetes Mellitus on Basal Plus Mealtime Insulin
ClinicalTrials.gov study NCT01499082. IPD Sharing: YES. Countries: 13. Publications: 3.
An Open Label Study of LMI070 (Branaplam) in Type 1 Spinal Muscular Atrophy (SMA)
ClinicalTrials.gov study NCT02268552. IPD Sharing: UNDECIDED. Countries: 7. Publications: 1.
A Study of TAK-994 in Adults With Type 1 and Type 2 Narcolepsy
ClinicalTrials.gov study NCT04096560. IPD Sharing: YES. Countries: 12. Publications: 1.
Efficacy and Safety of the Insulin Glargine/Lixisenatide Fixed Ratio Combination (FRC) Versus GLP-1 Receptor Agonist in Patients With Type 2 Diabetes, With a FRC Extension Period
ClinicalTrials.gov study NCT02787551. IPD Sharing: YES. Countries: 9. Publications: 5.
Pivotal Study to Assess the Efficacy, Safety and Tolerability of Dupilumab in Patients With Moderate-to-severe COPD With Type 2 Inflammation
ClinicalTrials.gov study NCT03930732. IPD Sharing: YES. Countries: 24. Publications: 5.
Study of SAR421869 in Participants With Retinitis Pigmentosa Associated With Usher Syndrome Type 1B
ClinicalTrials.gov study NCT01505062. IPD Sharing: YES. Countries: 2. Publications: 1.
Effect of Sotagliflozin on Cardiovascular Events in Participants With Type 2 Diabetes Post Worsening Heart Failure (SOLOIST-WHF Trial)
ClinicalTrials.gov study NCT03521934. IPD Sharing: YES. Countries: 32. Publications: 6.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.