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FIGURE 7 in Morphological and molecular profiling of an entomopathogenic nematode Steinernema feltiae: Unlocking its biocontrol potential against vegetable insect pests
FIGURE 7. Median lethal concentration (LC50) of Steinernema feltiae in the larvae of different insect pests at different time intervals and at different nematode concentrations, respectively.
NanoString autoimmune profiling panel normalized linear counts and summary of statistical analyses
<p>Occupational exposure to respirable crystalline silica (cSiO<sub>2</sub>) is linked to the development of lupus. Preclinical studies have revealed weekly repeated intranasal exposure to 1 mg cSiO<sub>2</sub> in young (8-11 wk-old) female NZBWF1 lupus-prone mice, a life-stage equivalent to 12–20-yr-old humans, triggers autoimmunity in the lungs and kidneys that is prevented by dietary supplementation with the omega-3 fatty acid docosahexaenoic acid (DHA).</p> <p><strong>Methods</strong>: Here, we characterized cSiO<sub>2</sub>'s and DHA's effects in mature adult (16–19-wk-old) female NZBWF1 mice, an age period that coincides with the onset of immunological tolerance breach and that is more representative of the age (>20-yr-old) of cSiO<sub>2</sub>-exposed workers. We fed mice either a control diet (CON) or diet amended with DHA calorically equivalent to a human daily dose of 5 g. After 2 wk, we intranasally instilled them with either saline vehicle (VEH) or 1 mg of cSiO<sub>2</sub> weekly for 4 wk. Cohorts were terminated 1 and 5 wk after the final installation. Lungs were then analyzed for inflammatory cell counts, chemokines, histopathology, B-and T-cell infiltration, autoantibody profile, and inflammatory/autoimmune gene signatures and results further related to autoimmune glomerulonephritis onset.</p> <p><strong>Results</strong>: VEH/CON mice displayed no lung or kidney pathology at either time point. In contrast, cSiO<sub>2</sub>/CON mice exhibited mild ectopic lymphoid tissue (ELT) formation in the lungs at 1 wk, which increased significantly by 5 wk. Lungs from cSiO<sub>2</sub>/CON mice also showed elevations in BALF cellularity, chemokine production, CD3 + T-cells, CD45R + B-cells, IgG + plasma cells, inflammatory/autoimmune gene expression, IgG autoantibodies. cSiO<sub>2</sub>/CON mice had visible glomerular hypertrophy and IgG deposition. Dietary DHA supplementation suppressed all these endpoints.</p> <p><strong>Discussion</strong>: Consistent with young mice, intranasal cSiO<sub>2</sub> exposure in mature adult NZBWF1 lupusprone mice elicited early pulmonary inflammation that served as a nexus for autoimmunity, suggesting these life-stage differences are not critical for cSiO2-triggered autoimmune response in this preclinical model. DHA supplementation at a translationally relevant human dosage effectively mitigated cSiO<sub>2</sub>-induced inflammation/autoimmunity in mature adult mice, resembling the protective effects observed in young mice. Together these findings further highlight the therapeutic potential of omega-3 fatty acids in mitigating toxicant-triggered autoimmune responses.</p>
Multivariate GWAS of Alzheimer's disease CSF biomarker profiles implies GRIN2D in synaptic functioning: Summary statistics
<p>Summary statistics for a genome-wide association study (GWAS) of Alzheimer's disease CSF biomarkers principal components (PCs). This dataset accompanies the publication "Multivariate GWAS of Alzheimer’s disease CSF biomarker profiles implies GRIN2D in synaptic functioning". The article is currently in press at Genome Medicine. A link will be provided upon publication, but see the medRxiv preprint in the meantime:</p> <p>Neumann, A., Ohlei, O., Küçükali, F., Bos, I. J., Vos, S., Prokopenko, D., ... & Kristel Sleegers & Lars Bertram. (2022). Multivariate GWAS of Alzheimer’s disease CSF biomarker profiles implies GRIN2D in synaptic functioning. <em>medRxiv</em>, 2022-08. https://doi.org/10.1101/2022.08.02.22278185</p> <p>A GWAS was performed for five different PC biomarkers.</p> <p>PC1: Tau pathology/degeneration</p> <p>PC2: Aβ Pathology</p> <p>PC3: Injury/inflammation</p> <p>PC4: Non-AD inflammation</p> <p>PC5: Non-AD synaptic functioning</p> <p>Each GWAS was performed in either males and females ("all"), in females only ("female"), or in males only ("male"). In addition, we also ran an interaction model with sex as moderator ("interaction"). Each file includes output of the meta-analysis between the EMIF-AD study and ADNI.</p> <p>The files contain following columns:</p> <p>CHROM: Chromosome</p> <p>POS: Position according to Build 37</p> <p>ID: Chromosome:Position</p> <p>A1: Effect allele</p> <p>A2: Other allele</p> <p>BETA: Effect of one copy of the effect allele on biomarker PCs in SD. In case of sex interaction, the effect specific to females.</p> <p>SE: Standard Error</p> <p>P: p-value</p> <p>D: Direction in ADNI and EMIF-AD respectively</p> <p>Het: Heterogeneity statistics (I<sup>2</sup>, and corresponding χ<sup>2</sup>, degrees of freedom and p-value)</p>
Spatiotemporal Profiling Unveiling the Cellular Organization Patterns and Local Protumoral Immune Microenvironment Remodeling in Early Lung Adenocarcinoma Progression
<p>Spatial cellular organization patterns (COPs) in tumor microenvironment influence the tumor progression and therapeutic response, however, little is known about the cellular composition and functional potential of these multicellular structures during lung adenocarcinoma progression. Here, we integrate spatial transcriptomics with single cell RNA sequencing to characterize the local tumor and immunological landscape of samples from 8 patients with lung adenocarcinoma at different pathological stages. We identified ten COPs that show distinct associations with local immune states and clinical outcomes, including survival and therapy response. The local infiltration levels of regulatory and dysfunctional immune cells are increased with pathological progression. Cell-to-cell interactions between malignant cells and tumor microenvironment (TME) cells were involved in protumor immune state remodeling. Finally, we detected a group of malignant cells that were specifically located at the tumor boundary, representing a more aggressive state, were involved in the invasion of invasive adenocarcinoma (IAC). Altogether, these results can improve our understanding of the local microenvironment characteristics that underlie LUAD progression and may facilitate the identification of drug targets to prevent invasive progression and biomarkers for diagnosis.</p><p>If you're going to use this dataset, please cite 'Haojie Chen et al. 2023. Protumoral Immune Microenvironment Remodeling in Early Lung Adenocarcinoma Progression. bioRxiv. https://doi.org/10.1101/2023.10.29.564580'</p>
Data containing alitude profiles of Joule heating and Pedersen conductivity from EISCAT and TIE-GCM used for the research work "A comparative assessment of the distribution of Joule heating in altitude as estimated in TIE-GCM and EISCAT over one solar cycle"
<p>This archive contains the data used for the research work with title "A comparative assessment of the distribution of Joule heating in altitude as estimated in TIE-GCM and EISCAT over one solar cycle". The data represent Joule heating and Pedersen conductivity altitude profiles for the duration of the solar cycle 24 between the years 2009 and 2019. The information is separated by Magnetic Local Time, Kp index and altitude. There are data from the EISCAT incoherent scatter radar in Matlab format and from a TIE-GCM simulation executed at the Department of Electrical and Computer Engineering, Democritus University of Thrace in NetCDF format. </p>
Proximity labeling-based profiling reveals a central role of the nuclear pore in mRNA metabolism
<p>The dataset for '<strong>Proximity labeling-based profiling reveals a central role of the nuclear pore in mRNA metabolism'</strong></p><p>This repository contains 81 high-confidence heterodimer complexes discussed in the publication. </p>
Code for the article titled "A New Approach to Ozone Profiling Based on MAX-DOAS Observations and Stacking Machine Learning Models"
Open the record for dataset details and reuse information.
Receiver-function datasets of the passive-source seismic profiles in the northeastern Tibetan plateau contributed by LRC
Open the record for dataset details and reuse information.
Data: Two-sided profile-based optimality in the stable marriage problem
<p>This data corresponds to the data and experiments described in Section 5 of<br> the following paper:</p> <p>Two-sided profile-based optimality in the stable marriage problem<br> Authors: Frances Cooper and David Manlove</p> <ul> <li>The paper is located at: <a href="https://arxiv.org/abs/1905.06626">https://arxiv.org/abs/1905.06626</a></li> <li>The data is located at: <a href="https://doi.org/10.5281/zenodo.2542703">https://doi.org/10.5281/zenodo.2542703</a></li> <li>The software is located at: <a href="https://doi.org/10.5281/zenodo.1183221">https://doi.org/</a><a href="https://doi.org/10.5281/zenodo.2545798">10.5281/zenodo.2545798</a></li> </ul> <p>See the README for more information.</p> <p>Version 1.0.2 updates:</p> <p>* Updated README</p>
Metabolomic Profiling of Patients With Traumatic Brain Injury
ClinicalTrials.gov study NCT07292766. IPD Sharing: NO. Countries: 1. Publications: 3.
Taurine Effect on Glycemic, Lipidic and Inflammatory Profile in Individuals With Type 2 Diabetes
ClinicalTrials.gov study NCT04874012. IPD Sharing: NO. Countries: 1. Publications: 8.
Safety Profile Comparison of Undiluted Intracameral Moxifloxacin vs. Levofloxacin in Cataract Surgery
ClinicalTrials.gov study NCT05741632. IPD Sharing: NO. Countries: 1. Publications: 3.
Ex Vivo Drug Sensitivity Testing and Mutation Profiling
ClinicalTrials.gov study NCT03860376. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Blocking Blue Light in Pregnancy, Effects on Melatonin Profile and Sleep
ClinicalTrials.gov study NCT03114072. IPD Sharing: NO. Countries: 1. Publications: 24.
Prediction of Progression of Coronary Artery Disease (CAD) Using Vascular Profiling of Shear Stress and Wall Morphology
ClinicalTrials.gov study NCT01316159. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Coagulation Profile in Patients Undergoing Video Assisted Thorascopic Surgery (VATS) for Lung Cancer
ClinicalTrials.gov study NCT01741506. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Salivary Bacterial Profiles in Relation to Periodontal Treatment
ClinicalTrials.gov study NCT02913248. IPD Sharing: YES. Countries: 1. Publications: 2.
The Pharmacologic Profile of Sodium Thiosulfate in Renal Failure and Healthy Volunteers
ClinicalTrials.gov study NCT01008631. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Determine PK Profiles of Ozanimod and Its' Major Metabolites in Healthy Subjects
ClinicalTrials.gov study NCT06528665. IPD Sharing: NO. Countries: 1. Publications: 1.
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
ClinicalTrials.gov study NCT04278404. IPD Sharing: NO. Countries: 2. Publications: 11.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.