Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
38
datasets available to search
ShareScore release 0.9.0
Dataset results
38 results for “Antioxidant system”
Data from: Hypoxia blunts angiogenic signaling and upregulates the antioxidant system in elephant seal endothelial cells
<p><strong><em>Background</em></strong></p> <p>Elephant seals exhibit extreme hypoxemic tolerance derived from repetitive hypoxia/reoxygenation episodes they experience during diving bouts. Real-time assessment of the molecular changes underlying protection against hypoxic injury in seals remains restricted by their at-sea inaccessibility. Hence, we developed a proliferative arterial endothelial cell culture model from elephant seals and used RNA-seq, functional assays, and confocal microscopy to assess the molecular response to prolonged hypoxia.</p> <p><strong><em>Results</em></strong></p> <p>Seal and human endothelial cells exposed to 1% O<sub>2</sub> for up to 6 h respond differently to acute and prolonged hypoxia. Seal cells decouple stabilization of the hypoxia-sensitive transcriptional regulator HIF-1α from angiogenic signaling. Rapid upregulation of genes involved in glutathione (GSH) metabolism supports the maintenance of GSH pools, and intracellular succinate increases in seal but not human cells. High maximal and spare respiratory capacity in seal cells after hypoxia exposure occurs in concert with increasing mitochondrial branch length and independent from major changes in extracellular acidification rate, suggesting that seal cells recover oxidative metabolism without significant glycolytic dependency after hypoxia exposure.</p> <p><strong><em>Conclusions</em></strong></p> <p>We found that the glutathione antioxidant system is upregulated in seal cells during hypoxia, while this system remains static in comparable human cells. Furthermore, we found that in contrast to human cells, hypoxia exposure rapidly activates HIF-1 in seal cells, but this response is decoupled from the canonical HIF-angiogenesis pathway. These results highlight the unique mechanisms that confer extraordinary tolerance to limited oxygen availability in a champion diving mammal.</p>
Figure 1. Standard curve for gallic acid y in Effect of extraction solvent system on the antimicrobial, antioxidant and total polyphenol content of the bark of Pistacia chinensis
Figure 1. Standard curve for gallic acid y = absorbance, x = concentration of Gallic Acid, R2 = correlation coefficient.
Figure 2 in Exogenously applied nutrients can improve the chickpea productivity under water stress conditions by modulating the antioxidant enzyme system
Figure 2. Effect of foliar application of nutrients on relative growth rate (g g-1 day-1) of chickpea genotypes in Bahawalpur (a) and Cholistan (b). Whereas D1= well watered; D2= Drought at flowering+ pod formation + grain filling stage; D3= Drought at flowering stage; DAS= days after sowing.
Figure 1 in Exogenously applied nutrients can improve the chickpea productivity under water stress conditions by modulating the antioxidant enzyme system
Figure 1. Effect of foliar application of nutrients on crop growth rate (g m-2 day-1) of chickpea genotypes in Bahawalpur (a) and Cholistan (b). Whereas D1= well watered; D2=Drought at flowering+ pod formation + grain filling stage; D3= Drought at flowering stage; DAS= days after sowing.
Data from: Hypoxia blunts angiogenic signaling and upregulates the antioxidant system in elephant seal endothelial cells
Open the record for dataset details and reuse information.
Lipoic acid protects the central nervous system by immunomodulation and antioxidation
<p>Lipoic acid protects the central nervous system by immunomodulation and antioxidation. In the periphery, LA prevents inflammatory cells from crossing the BBB and protects brain endothelial cells. In the CNS, LA inhibits the activity of T cells/microglia, decreases the expression of TNF-α and IFN-γ, and neutralizes ROS and NO.</p>
Season, anthocyanin supplementation, and flight training have mixed effects on the antioxidant system of migratory European starlings (Sturnus vulgaris)
<p>Migratory birds engage in two periods of endurance flight annually as they travel between summer breeding and overwintering grounds, and such endurance flights likely incur oxidative costs. These costs may differ between fall and spring migration, especially for females who must prepare for breeding and egg laying in spring. The objective of this study of a migratory bird was to test proposed hypotheses about how key components of the female's antioxidant system differ in response to flight training in the fall and spring and to dietary antioxidant supplementation. We hand-raised female European starlings (<i>Sturnus vulgaris</i>) and then fed them either a diet supplemented with dietary anthocyanins or a diet without added anthocyanins. <a name="_Hlk53656115">We then flew females in a windtunnel for 15 days during fall and spring migration seasons and measured over time oxidative damage (d-ROMs) and three components of the antioxidant system</a>—non-enzymatic antioxidant capacity (OXY), uric acid, and glutathione peroxidase (GPx) activity. Prior to flight training, non-enzymatic antioxidant capacity and oxidative damage were lower in females during spring compared to fall, and females fed a low-antioxidant diet had consistently higher circulating uric acid. GPx activity decreased more in spring immediately after a long-duration flight. Females fed a high-antioxidant diet had a greater decrease in non-enzymatic antioxidant capacity after the 15-day flight training. <a name="_Hlk53656268">Flight-trained females had higher circulating uric acid than untrained females immediately after the longest-duration flight</a>, and decreased GPx activity after the 15-day flight training. In sum, females upregulated enzymatic and non-enzymatic endogenous antioxidants in spring, and females fed a diet with less antioxidants appear to compensate by increasing circulating uric acid. Our findings emphasize the important role of dietary antioxidants for birds during migration, <a name="_Hlk53656372">and that similar flights in fall and spring likely represent distinct oxidative challenges in the life history of female birds.</a></p>
Development of innovative antioxidant food packaging systems based on natural extracts from food industry waste and Moringa oleifera leaves
<p>This is the dataset of "Development of innovative antioxidant food packaging systems based on natural extracts from food industry waste and Moringa oleifera leaves"</p> <p> </p> <p><span>This research is funded by the project 21GRD07 PlasticTrace. This project has received funding from the European Partnership on Metrology, co-financed from the European Union’s Horizon Europe Research and Innovation Programme and by the Participating States.</span></p> <p><span>Funder name: European Partnership on Metrology<br>• Funder ID: 10.13039/100019599<br>• Grant number: 21GRD07 PlasticTrace</span></p>
Data from: Flying stimulates the antioxidant system and protects against oxidative damage in a migratory songbird, yet diet quality has little effect
Open the record for dataset details and reuse information.
Season, anthocyanin supplementation, and flight training have mixed effects on the antioxidant system of migratory European starlings (Sturnus vulgaris)
Open the record for dataset details and reuse information.
Effect of heat shock and competition on the antioxidant system of round goby
<p><span><span><span><span><span><span><span><span><span><span><span>Monitoring oxidative stress biomarkers has become a powerful and common tool to estimate organismal condition and response to endogenous and environmental factors. In the present study, we used round goby (<i>Neogobius melanostomus</i>) from non-native European populations, as a model species to test sex differences in oxidative stress biomarkers. Considering sex differences in reproductive investment, we hypothesized that males would display lower resistance to abiotic stress. Fish were exposed to a heat shock (temperature elevated by 10°C) for 1h, 6h, and 12h and catalase activity (CAT), reduced glutathione (GSH), total antioxidant capacity (TAC) and lipid peroxidation (LPO) were measured in liver and muscle tissues. Liver of males was significantly more responsive compared to liver of females in all tested parameters. GSH was found to be the most responsive to heat stress exposure in both sexes. The results supported our hypothesis that male reproductive investment (territoriality, courtship, and brood care) and likelihood of only a single spawning period in their lifetime influenced on higher sensitivity of their antioxidant defence. On the other hand, for females antioxidant defence is considered more important to survive the environmental changes and successfully reproduce in the next season. Our experiments exposed fish to acute thermal stress. Further research should determine the effects of exposure to chronic thermal stress to corroborate our understanding on sex differences in antioxidant defence in the round goby.</span></span></span></span></span></span></span></span></span></span></span></p>
Prebiotic Systems Containing Anthocyanin-Rich Pomegranate Flower Extracts with Antioxidant and Antidiabetic Effects
<p>Publication and related data</p>
Fig. 8 in Rosmarinic acid and hesperidin regulate gas exchange, chlorophyll fluorescence, antioxidant system and the fatty acid biosynthesis-related gene expression in Arabidopsis thaliana under heat stress
Fig. 8. The changes of the relative expression of WRI1 (A), BCCP2 (B), FAD2 (C), FAD3 (D) genes encoding after rosmarinic acid (RA, 100 μM) and/or hesperidin (HP, 100 μM) with/without heat stress (38 ◦C) in A. thaliana leaves. Multivariate data analyses of gene expression analysis under investigation.
Fig. 5 in Rosmarinic acid and hesperidin regulate gas exchange, chlorophyll fluorescence, antioxidant system and the fatty acid biosynthesis-related gene expression in Arabidopsis thaliana under heat stress
Fig. 5. The changes of the relative band intensity of different types of glutathione S-transferase activity isoenzymes (GST, A) and GST activity (B), and glutathione peroxidase activity (GPX, C) after rosmarinic acid (RA, 100 μM) and/or hesperidin (HP, 100 μM) with/without heat stress (38 ◦C) in A. thaliana leaves.
Fig. 1 in Rosmarinic acid and hesperidin regulate gas exchange, chlorophyll fluorescence, antioxidant system and the fatty acid biosynthesis-related gene expression in Arabidopsis thaliana under heat stress
Fig. 1. The average absorption per active reaction center (ABS/RC), the electron transport flux per active reaction center (ETo/RC), the flux of trapped exciton per active reaction center (TRo/RC), and the energy flow on the acceptor side of PSI ((Ro), The number of QA-reducing reaction centers per PSII antenna chlorophyll ((ΦPo/(1-ΦPo)), the efficiency with which a trapped exciton transfers an electron to the photosynthetic electron transfer chain ((ΨEo/(1-ΨEo)), the number of QA- reducing reaction centers per PSII antenna chlorophyll (γRC/(1-γRC)), the ratio of total dissipation to the number of active reaction centers (DIo/RC). The relative variable fluorescence intensity at J (VJ) and I step (VI), the performance index based on light absorption (PIABS), and the performance index (potential) for energy conservation from exciton to PSI and acceptor reduction (PItotal) were determined in A. thaliana leaves following treatment with rosmarinic acid (RA, 100 μM) and/or hesperidin (HP, 100 μM) with/without heat stress (38 ◦ C).
Fig. 7 in Rosmarinic acid and hesperidin regulate gas exchange, chlorophyll fluorescence, antioxidant system and the fatty acid biosynthesis-related gene expression in Arabidopsis thaliana under heat stress
Fig. 7. The changes of monodehydroascorbate reductase activity (MDHAR, A), dehydroascorbate reductase activity (DHAR, B), ascorbate content (AsA, C), dehydroascorbate content (DHA, D), glutathione content (GSH, E), oxidized glutathione content (GSSG, F), AsA/DHA (G), GSH/GSSG (H) and GSH redox state (I) after rosmarinic acid (RA, 100 μM) and/or hesperidin (HP, 100 μM) with/without heat stress (38 ◦C) in A. thaliana leaves.
Fig. 4 in Rosmarinic acid and hesperidin regulate gas exchange, chlorophyll fluorescence, antioxidant system and the fatty acid biosynthesis-related gene expression in Arabidopsis thaliana under heat stress
Fig. 4. The changes of the relative band intensity of different types of peroxidase isoenzymes (POX, A) and POX activity (B), relative band intensity of different types of NADPH oxidase isoenzymes (NOX, C) and NOX activity (D) after rosmarinic acid (RA, 100 μM) and/or hesperidin (HP, 100 μM) with/without heat stress (38 ◦C) in A. thaliana leaves.
Fig. 3 in Rosmarinic acid and hesperidin regulate gas exchange, chlorophyll fluorescence, antioxidant system and the fatty acid biosynthesis-related gene expression in Arabidopsis thaliana under heat stress
Fig. 3. The changes of the relative band intensity of different types of superoxide dismutase isoenzymes (SOD, A) and SOD activity (B), the relative band intensity of different types of catalase isoenzymes (CAT, C) and CAT activity (D) after rosmarinic acid (RA, 100 μM) and/or hesperidin (HP, 100 μM) with/without heat stress (38 ◦C) in A. thaliana leaves.
Fig. 2 in Rosmarinic acid and hesperidin regulate gas exchange, chlorophyll fluorescence, antioxidant system and the fatty acid biosynthesis-related gene expression in Arabidopsis thaliana under heat stress
Fig. 2. The changes of hydrogen peroxide content (H O, A), lipid peroxidation (TBARS content, B), histochemical staining for O • accumulation (C), histochemical 2 2 2 staining for H2O2 determination (D), histochemical staining for plasma membrane integrity (E) and histochemical staining for lipid peroxidation (F) after rosmarinic acid (RA, 100 μM) and/or hesperidin (HP, 100 μM) with/without heat stress (38 ◦C) in A. thaliana leaves.
Fig. 6 in Rosmarinic acid and hesperidin regulate gas exchange, chlorophyll fluorescence, antioxidant system and the fatty acid biosynthesis-related gene expression in Arabidopsis thaliana under heat stress
Fig. 6. The changes of the relative band intensity of different types of ascorbate glutathione isoenzymes (APX, A) and APX activity (B), and glutathione reductase activity (GR, C) after rosmarinic acid (RA, 100 μM) and/or hesperidin (HP, 100 μM) with/without heat stress (38 ◦C) in A. thaliana leaves.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.