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1,265 results for “Atopic Dermatitis”
Preprocessed and Harmonised Transcriptomics Datasets for Psoriasis and Atopic Dermatitis
<p>The datasets uploaded within this record contain transcriptomics data of psoriasis and atopic dermatitis patients retrieved from the NCBI Gene Expression Omnibus and EBI ArrayExpress repositories. Overall, we retrieved 39 transcriptomics datasets, produced through both DNA microarrays and RNA-Sequencing technologies, along with relative meta-data tables. After data collection, each dataset was quality checked and preprocessed in order to obtain a harmonised source of data, ready-to-use for the research community. Beside, a thorough quality check was carried out on the retrieved meta-data, and data dictionaries were created (both for DNA microarry and RNA-Seq datasets) in order to homogenise the phenotypic data, enabling the comparability across the datasets. </p>
A combination of HLA-DP α and β chain polymorphisms paired with a SNP in the DPB1 3' UTR region, denoting expression levels, are associated with Atopic Dermatitis
<p>The publication "A combination of HLA-DP α and β chain polymorphisms paired with a SNP in the DPB1 3’ UTR region, denoting expression levels, are associated with Atopic Dermatitis" contains analysis from two different cohorts: Genetics in Atopic Dermatitis (GAD), which is the main dataset, and Pediatric Eczema Elective Registry (PEER), which is the replication cohort. Included herein are the HLA Class II genotypes for both the GAD and PEER cohorts at 2-field resolution, which forms the basis for the analysis included in the publication. (DOI: 10.3389/fgene.2023.1004138)</p>
A Study to Assess the Efficacy and Safety of Ruxolitinib Cream in Children With Atopic Dermatitis (TRuE-AD3)
ClinicalTrials.gov study NCT04921969. IPD Sharing: YES. Countries: 2. Publications: 0.
Dupilumab-PEdiatric Skin Barrier Function and LIpidomics STudy in Patients With Atopic Dermatitis
ClinicalTrials.gov study NCT04718870. IPD Sharing: YES. Countries: 2. Publications: 0.
A Study to Evaluate Risankizumab in Adults and Adolescents With Moderate to Severe Atopic Dermatitis
ClinicalTrials.gov study NCT03706040. IPD Sharing: YES. Countries: 5. Publications: 1.
Study of Ruxolitinib Cream in Adolescents With Atopic Dermatitis
ClinicalTrials.gov study NCT05456529. IPD Sharing: YES. Countries: 3. Publications: 0.
Treatment of Alopecia Areata (AA) With Dupilumab in Patients With and Without Atopic Dermatitis (AD)
ClinicalTrials.gov study NCT03359356. IPD Sharing: NO. Countries: 1. Publications: 1.
Evaluation of Dupilumab in Chinese Adult Patients With Moderate to Severe Atopic Dermatitis
ClinicalTrials.gov study NCT03912259. IPD Sharing: YES. Countries: 1. Publications: 1.
Ruxolitinib Cream in Participants With Facial and/or Neck Atopic Dermatitis Involvement
ClinicalTrials.gov study NCT05127421. IPD Sharing: YES. Countries: 1. Publications: 1.
A Study to Compare Safety and Efficacy of Upadacitinib to Dupilumab in Adult Participants With Moderate to Severe Atopic Dermatitis
ClinicalTrials.gov study NCT03738397. IPD Sharing: YES. Countries: 23. Publications: 3.
Study Testing Response Effect of KY1005 Against Moderate-to-Severe Atopic Dermatitis, The STREAM-AD Study
ClinicalTrials.gov study NCT05131477. IPD Sharing: YES. Countries: 12. Publications: 3.
Evaluating the Impact of Triple Compound Therapy on Relapse Frequency and Quality of Life in Children with Severe Atopic Dermatitis: A Phase II Randomised Clinical Trial
<p>Datasets and analysis from A multi-centre, randomized controlled trial, on pediatric Atopic Dermatitis, conducted at Red Cross and Walter Sisulu Hospitals. The study is entitled Evaluating the Impact of Triple Compound Therapy on Relapse Frequency and Quality of Life in Children with Severe Atopic Dermatitis: A Phase II Randomised Clinical Trial.</p>
Network pharmacology and UPLC-Q-TOF-MS-based method to explore the underlying mechanism of Shaoyao–Gancao decoction acting on atopic dermatitis
<p>This study aimed to investigate the immunomodulation and anti-inflammatory effects of SGD and further explore its pharmacodynamics material basis and potential molecular mechanisms on atopic dermatitis (AD) disorder.</p>
Atopic dermatitis and DNA methylation at birth: findings from epigenome-wide meta-analyses
<p>Meta-analyses results from "Atopic dermatitis and DNA methylation at birth: findings from epigenome-wide meta-analyses". This data contains summary statistics from 12 meta-analyses of EWAS of atopic dermatitis (AD) using DNA methylation measured using the Illumina Infinium HumanMethylation450 BeadChip. Details on the analyses can be found in the paper. </p> <p>Each of the files are tab-separated with the following column names (description in brackets):</p> <ul> <li>CpG</li> <li>Beta (the effect estimate)</li> <li>SE (standard error)</li> <li>P (P value)</li> <li>Direction (Direction of effect within each cohort)</li> <li>Het_ISq (I2 value of heterogeneity)</li> <li>Het_P (P value from Cochran’s Q-test for heterogeneity)</li> </ul> <p>The files are named in the following way: `AD-PHENOTYPE_MODEL_COHORT-STRAT.tsv`</p> <p>AD-PHENOTYPE: childhood, early-onset, or persistent.<br> MODEL: Model A, B, or C (see paper for details)<br> COHORT-STRAT: If the cohorts were stratified in anyway here is where it will be indicated. DD = AD was defined by doctor diagnosis only, DD-R = AD was defined by doctor diagnosis and/or rash symptoms, HR = AD was defined using the Hanifin-Rajka criteria. </p> <p>For example, the file `childhood_model-C_DD.tsv` contains the summary statistics from the meta-analysis of EWAS of AD within cohorts that defined AD using doctor diagnosis only. </p>
Atopic Dermatitis Research Network (ADRN) Influenza Vaccine Study
ClinicalTrials.gov study NCT01737710. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Study of Dupilumab Administered to Adult Patients With Moderate-to-Severe Atopic Dermatitis
ClinicalTrials.gov study NCT01859988. IPD Sharing: Not stated. Countries: 7. Publications: 6.
Safety and Efficacy of Lebrikizumab (LY3650150) in Combination With Topical Corticosteroid in Moderate-to-Severe Atopic Dermatitis.
ClinicalTrials.gov study NCT04250337. IPD Sharing: YES. Countries: 4. Publications: 1.
Safety and Efficacy of AN2728 Topical Ointment, 2% in Children, Adolescents, and Adults (Aged 2 Years and Older) With Atopic Dermatitis
ClinicalTrials.gov study NCT02118792. IPD Sharing: Not stated. Countries: 1. Publications: 8.
The Efficacy of 3% Kanuka Oil Versus 1% Hydrocortisone Cream in Patients With Atopic Dermatitis
ClinicalTrials.gov study NCT06488742. IPD Sharing: NO. Countries: 1. Publications: 1.
A Dose-Finding Study of GSK2894512 Cream in Subjects With Atopic Dermatitis (AD)
ClinicalTrials.gov study NCT02564055. IPD Sharing: Not stated. Countries: 3. Publications: 0.
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