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137 results for “Carcinogens”
Datasets of the proposed models for carcinogenicity assessment based on slope factor.
<p>Datasets of the classification and regression models for carcinogenicity proposed in the paper "QSAR models for the human carcinogenicity: an assessment based on oral and inhalation slope factors" by Cosimo Toma<sup>1,2</sup>, Alberto Manganaro<sup>3</sup>, Giuseppa Raitano<sup>1</sup>, Marco Marzo<sup>1</sup>, Domenico Gadaleta<sup>1</sup>, Diego Baderna<sup>1</sup>*, Alessandra Roncaglioni<sup>1</sup>, Nynke Kramer<sup>2</sup>, Emilio Benfenati<sup>1</sup>*</p> <p><sup>1</sup> Laboratory of Chemistry and Environmental Toxicology, Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, 20156 Milan, Italy</p> <p><sup>2</sup> Institute for Risk Assessment Sciences (IRAS), Utrecht University, PO Box 80177, 3508 TD Utrecht, the Netherlands</p> <p><sup>3</sup> Kode Chemoinformatics s.r.l., Pisa, Italy</p> <p><strong>*</strong> Correspondence: diego.baderna@marionegri.it</p> <p>Paper is now published on Molecules by MDPI and it is available here DOI:10.3390/molecules26010127</p> <p>S5 dataset for models based on Oral Slope Factor and S5 dataset for models based on Inhalation Slope Factor.</p> <p><strong>Models were developed under the framework of LIFE-VERMEER project (LIFE 16ENV/IT7000167).</strong></p>
Microscopy images - "An elevated rate of whole-genome duplications associated with carcinogen exposure in Black cancer patients"
<p>This repository contains microscopy data from the manuscript "An elevated rate of whole-genome duplications associated with carcinogen exposure in Black cancer patients" by Leanne M. Brown, Ryan A. Hagenson, Tilen Koklič, Iztok Urbančič, Janez Strancar, and Jason M. Sheltzer (preprint: 10.1101/2023.11.10.23298349; accepted for publication in Nature Communications).</p> <p> </p> <p>Each zip contains the set of images from individual multi-channel multi-position time-lapse experiment with different combinations of cells exposed to one nanomaterial. Files are named as: IMGxxxx_[ExperimentCode]_ROIxx_tile[TileNumber]_[Channel]_[CellType]_t[Timepoint].tif, where each of the varying elements in [..] denotes the following:</p> <ul> <li>[ExperimentCode]: tells which material the cells were exposed to - see decoding table in the file "material-codes.xlsx"</li> <li>[TileNumber]: two xy-tiles per condition</li> <li>[Channel]: cytoplasm of epi cells (LA4), membrane (MEM), cytoplasm of imu cells and tubulin (MHSTUB), nanomaterial (NANO)</li> <li>[CellType]: mono-culture of lung epithelial cells (epi), their coculture with macrophages (epiimu)</li> <li>[Timepoint]: consecutive number of the frame in the time-lapse</li> </ul> <p> </p>
Clinical Trial of Two Study Drinks in Detoxification of Environmental Toxicants and Carcinogens
ClinicalTrials.gov study NCT03978117. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Simultaneous estimation of troxerutin and calcium dobesilate in presence of the carcinogenic hydroquinone using green spectrofluorimetric method
<p>In the present study, we conducted two facile and highly sensitive spectrofluorimetric approaches in order to quantify the vasoprotective agents; troxerutin (TROX) and calcium dobesilate (DOB) in the presence of hydroquinone (HQ) (as a highly toxic impurity and potential degradation product of DOB) in commercial formulations and human plasma. The first approach relies simply on using ethanol as an eco-friendly solvent for the estimation of DOB at 345 nm after being excited at 305 nm. The linearity was carefully investigated between DOB concentration and the relative fluorescence intensity in the range of 0.05-0.8 µg/mL. Due to the method's high simplicity and sensitivity, applying the first approach to quality control analysis and spiked human plasma samples with mean % recoveries 100.74 ± 3.71 adds another merit. The second approach involved rapid conventional fluorometric estimation of TROX ethanolic solution in TROX/DOB combined dosage forms at 455/350 nm (emission/excitation) with a linear calibration chart covering the range of 0.1–1.2 µg/mL. Moreover, the second approach involved a comprehensive study in a trial to solve the problem of superposition of DOB and HQ graph adopting the first derivative synchronous fluorimetric mechanism in ethanol at Δ λ=60 nm. Therefore, DOB was measured at 286 nm and 323 nm, while HQ could be quantitated at 301 nm. Beer's-Lambert law has complied over the ranges of 0.1- 1.0 µg/mL and 0.02-0.4 μg/mL for DOB and HQ, respectively. Guidelines adopted by the International Council of Harmonization (ICH) were used to validate the target approaches. They were more convenient for routine quality control laboratory instead of the time-consuming and sophisticated reported techniques. Moreover, different aspects of evaluating the proposed approaches' greenness were conducted to have a complete image of their environmental impact.</p>
Assessing the Link Between Smoke Carcinogen Biomarkers and Lung Cancer Risk - 1
ClinicalTrials.gov study NCT00218179. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Dosing of Carcinogenic Complexes After Anesthesia With Intrathecal Hyperbaric Prilocaine.
ClinicalTrials.gov study NCT03642301. IPD Sharing: NO. Countries: 1. Publications: 6.
Lung Cancer Screening in a Population Exposed to Occupational Lung Carcinogens
ClinicalTrials.gov study NCT03562052. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Simultaneous estimation of troxerutin and calcium dobesilate in presence of the carcinogenic hydroquinone using green spectrofluorimetric method
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Segmentations of carcinogenic DNA damages in WSI
<p>The dataset includes patches from WSI images of the carcinogenic DNA damages caused by ultraviolet (UV) radiation on excised abdominal human skin, excised porcine skin and in vitro skin models with different melanin indices. Two predominant types of DNA damage are featured in this dataset: Cyclobutane pyrimidine dimers (CPD) and pyrimidine (6-4) pyrimidone photoproducts (6-4PP). The dataset spans 804 patches.</p> <p>A regression score, concerning the relative amount of damaged nuclei was annotated for all samples, segmentation maps were annotated for a subset of 202 samples. All files were anonymized and processed in accordance with the institutional guidelines and cannot be traced back to an individual person.</p>
Prevention of UV-induced Carcinogenic Skin Alterations in Immunosuppressed Solid Organ Transplanted Patients
ClinicalTrials.gov study NCT01532453. IPD Sharing: Not stated. Countries: 9. Publications: 0.
Study of Lung Cancer in Appalachian Kentucky: The Role of Environmental Carcinogens
ClinicalTrials.gov study NCT01648166. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Data from: Derivation of occupational thresholds of toxicological concern for airborne systemically-acting non-carcinogenic organic chemicals
Open the record for dataset details and reuse information.
Polycyclic aromatic hydrocarbons as skin carcinogens: Comparison of benzo[a]pyrene, dibenzo[def,p]chrysene and three environmental mixtures in the FVB/N mouse
GEO Series GSE39455. Mus musculus. 25 samples. Type: Expression profiling by array.
Control of alveolar macrophage differentiation by Siah1a/2 ubiquitin ligases limits carcinogen-induced lung adenocarcinoma [scRNA-seq]
GEO Series GSE215992. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Control of alveolar macrophage differentiation by Siah1a/2 ubiquitin ligases limits carcinogen-induced lung adenocarcinoma [Bulk RNA-seq]
GEO Series GSE215920. Mus musculus. 7 samples. Type: Expression profiling by high throughput sequencing.
Time course effects of a latent carcinogen in mice
GEO Series GSE86065. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
Global gene expression analysis in cord blood reveals gender-specific differences in response to carcinogenic exposure in utero
GEO Series GSE31836. Homo sapiens. 111 samples. Type: Expression profiling by array.
Hepatic premalignant alterations triggered by human carcinogen aristolochic acid I in canines
GEO Series GSE75474. Canis lupus familiaris; synthetic construct. 8 samples. Type: Non-coding RNA profiling by array.
Persistent gene expression and DNA methylation alterations linked to carcinogenic effects of dichloroacetic acid [RNA-seq]
GEO Series GSE242661. Mus musculus. 78 samples. Type: Expression profiling by high throughput sequencing.
Nitroparaffin Transcriptional Profiles and Toxicokinetics Support Chemical-Specific Carcinogenicity Assessment
GEO Series GSE310151. Rattus norvegicus. 105 samples. Type: Expression profiling by high throughput sequencing.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.