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39 results for “Cdc42”
Data from: Selectivity of Guanine Nucleotide Exchange Factor-mediated Cdc42 activation in primary human endothelial cells
<p>Data that was reported in "Selectivity of Guanine Nucleotide Exchange Factor-mediated Cdc42 activation in primary human endothelial cells" by </p> <p>Nathalie R. Reinhard<sup>1</sup>, Sanne van der Niet<sup>1</sup>, Anna Chertkova<sup>1</sup>, Marten Postma<sup>1</sup>, Theodorus W.J. Gadella Jr.<sup>1</sup>, Peter L. Hordijk<sup>1,2</sup>, and Joachim Goedhart<sup>1*</sup><br> </p> <p><strong>Affiliations:</strong></p> <p><sup>1 </sup>University of Amsterdam, Molecular Cytology, Swammerdam Institute for Life Sciences, van Leeuwenhoek Centre for Advanced Microscopy, Amsterdam, the Netherlands</p> <p><sup>2 </sup>Department of Physiology, Free University Medical Center, Amsterdam, The Netherlands</p> <p> </p> <p>*Correspondence to: j.goedhart@uva.nl</p>
Cdc42 couples T cell receptor endocytosis to GRAF1-mediated tubular invaginations of the plasma membrane
<p>This Dataset contains primary data used for the publication "Cdc42 couples T cell receptor endocytosis to GRAF1-mediated tubular invaginations of the plasma membrane" published online on 04. November 2019<br> doi:10.3390/cells8111388</p> <p><strong>Abstract:</strong> T cell activation is immediately followed by internalization of the T cell receptor (TCR).<br> TCR endocytosis is required for T cell activation, but the mechanisms supporting removal of TCR<br> from the cell surface remain incompletely understood. Here we report that TCR endocytosis is<br> linked to the clathrin-independent carrier (CLIC) and GPI-enriched endocytic compartments<br> (GEEC) endocytic pathway. We show that unlike the canonical clathrin cargo transferrin or the<br> adaptor protein Lat, internalized TCR accumulates in tubules shaped by the small GTPase Cdc42<br> and the Bin/amphiphysin/Rvs (BAR) domain containing protein GRAF1 in T cells. Preventing<br> GRAF1-positive tubules to mature into endocytic vesicles by expressing a constitutively active<br> Cdc42 impairs the endocytosis of TCR, while having no consequence on the uptake of transferrin.<br> Together, our data reveal a link between TCR internalization and the CLIC/GEEC endocytic route<br> supported by Cdc42 and GRAF1.</p> <p> </p> <p>Data are organised in compressed (.zip) folders entitled as the corresponding Figures in the publication.</p> <p>Programs we recommend to view the files are:<br> .fcs files: FlowJo software v10 (Tree Star, Ashland, OR, USA)<br> .lif files: LAS X v3 (Leica Microsystems, Wetzlar, Germany)<br> .pzfx files: Prism v7 software (GraphPad, San Diego, CA, USA)</p> <p> </p> <p>In case this Dataset is updated, new version will be available with doi:10.5281/zenodo.3545842</p>
Inhibition of Cdc42 activity extends lifespan and decreases circulating inflammatory cytokines in aged female C57BL/6 mice
<p>Cdc42 is a small RhoGTPase regulating multiple functions in eukaryotic cells. The activity of Cdc42 is significantly elevated in several tissues of aged mice, while the Cdc42 gain-of-activity mouse model presents with a pre-mature aging-like phenotype and with decreased lifespan. These data suggest a causal connection between elevated activity of Cdc42, aging and reduced lifespan. Here, we demonstrate that systemic treatment of aged (75-week old) female C57BL/6 mice with a Cdc42 activity specific inhibitor (CASIN) for 4 consecutive days significantly extends average and maximum lifespan. Moreover, aged CASIN-treated animals displayed a youthful level of the aging-associated cytokines IL-1b, IL-1a and INFg in serum and a significantly younger epigenetic clock as based on DNA methylation levels in blood cells. Overall, our data show that systemic administration of CASIN to reduce Cdc42 activity in aged mice extends murine lifespan.</p>
Inhibition of Cdc42 activity extends lifespan and decreases circulating inflammatory cytokines in aged female C57BL/6 mice
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Data from: Activity-dependent regulation of Cdc42 by Ephexin5 drives synapse growth and stabilization
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Study to Evaluate the Efficacy, Safety and Tolerability of MAS825 in Patients With Monogenic IL-18 Driven Autoinflammatory Diseases, Including NLRC4-GOF, XIAP Deficiency, or CDC42 Mutations
ClinicalTrials.gov study NCT04641442. IPD Sharing: YES. Countries: 7. Publications: 0.
Rpph1 regulated Cdc42 and modulated hippocampal pyramidal neurons by competing endogenous miR-330-5p
GEO Series GSE87550. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Ror2-mediated non-canonical Wnt signaling regulates Cdc42 and cell proliferation during root development
GEO Series GSE161395. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
CDC42 inhibitors regulate genes involved in skin vasculaization
GEO Series GSE298488. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Gene expression changes in REH following CDC42 inhibition
GEO Series GSE152836. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
TINCR lncRNA encodes a ubiquitin-like protein that activates CDC42, promotes epithelial differentiation and suppresses tumor growth
GEO Series GSE175463. Homo sapiens. 58 samples. Type: Expression profiling by high throughput sequencing.
Galactin-3 regulation of CDC42 promotes neuronal autophagy following spinal cord injury
GEO Series GSE274319. Rattus norvegicus. 6 samples. Type: Expression profiling by high throughput sequencing.
Impaired neurovascular remodeling mediated by Apelin signaling and Cdc42 activity in endothelial Rbpj deficient brain arteriovenous malformation [RNA-seq]
GEO Series GSE223531. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Overactivation of Cdc42 GTPase Impairs the Cytotoxic Function of NK Cells from Old Individuals towards Senescent Fibroblasts
GEO Series GSE313986. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
A DLG1-ARHGAP31-CDC42 axis regulates the Wnt response in intestinal stem cells
GEO Series GSE198573. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Studies of target genes for signal transduction pathways (using a Ras1-, a Cdc42- and a Gap1-mutant) in the basidiomycete Schizophyllum commune.
GEO Series GSE43965. Schizophyllum commune. 6 samples. Type: Expression profiling by array.
Transcriptomic profiling of thymocytes in CDC42-deficient and wild-type mice using single-cell RNA-seq
GEO Series GSE289949. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profiles of Treg cells lacking Cdc42 GTPase
GEO Series GSE181779. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
CDC42 controlled apical-basal polarity regulates intestinal stem cell to transit amplifying cell fate transition via YAP-EGF-mTOR signaling
GEO Series GSE166736. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
Desflurane Potentially Induces Postoperative Cognitive Dysfunction in Elderly Patients Undergoing Perioperative Procedures by Modulating Cdc42 and Clock Proteins
ClinicalTrials.gov study NCT06772558. IPD Sharing: YES. Countries: 1. Publications: 0.
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.