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7 results for “Cerebral Blood Volume”
Data underpinning "Coupling between cerebral blood flow and cerebral blood volume: Contributions of different vascular compartments"
<p>The data in this archive was acquired to investigate the coupling between cerebral blood flow and cerebral blood volume across different vascular compartments. These results will form the basis of a forthcoming publication. Please reference this dataset (version v1.1.0) if you use it in your work. Wesolowski R, Blockley NP, Driver ID, Francis ST, Gowland PA. Data underpinning "Coupling between cerebral blood flow and cerebral blood volume: Contributions of different vascular compartments". Zenodo 2018. doi: 10.5281/zenodo.1411018. </p> <p>This dataset contains measurements of the haemodynamic responses of different compartments to a visual stimulus (8Hz red LED goggles, 19.2s ON, 40.8s OFF). Time course data are cycle averaged for the following haemodynamic properties;</p> <ol> <li>Arterial cerebral blood volume (CBVa) measured using Look-Locker Flow-sensitive Alternating Inversion Recovery (LL-FAIR) sensitised to CBVa.</li> <li>Cerebral blood flow (CBF) measured using Look-Locker Flow-sensitive Alternating Inversion Recovery (LL-FAIR) sensitised to CBF.</li> <li>Total cerebral blood volume (CBVtot) measured using bolus injections of a Gadolinium based contrast agent combined with T2* weighed gradient echo EPI.</li> </ol> <p>In addition, weighted mean and standard deviation of the changes in these parameters are presented using time windows of 9.6–19.2s and 40.8–60s for ON and OFF, respectively. Weighting is performed with respect to the number of voxels present in each of the subjects regions of interest.</p> <p>Time course data were extracted from two different regions of interest;</p> <ol> <li>ROI<sub>CBF</sub>: defined using a CBF localiser</li> <li>ROI<sub>COMMON</sub>: defined using the overlap of CBF, CBV<sub>a</sub> and CBV<sub>tot</sub> localisers</li> </ol> <p>Furthermore, the transit times for CBF and CBVa were estimated for an average stimulus cycle and mean values extracted using time windows of 9.6–19.2s and 40.8–60s for ON and OFF, respectively. These data were extracted from ROI<sub>CBF</sub>.</p> <p>Changes</p> <p>- Addition of propagation of uncertainty for CBVv and the Grubb constants alpha_tot and alpha_a.</p> <p> </p>
Comparison of Pain-Related Changes in Cerebral Blood Volume in Burn Patients With Neuropathic Pain
ClinicalTrials.gov study NCT04125576. IPD Sharing: NO. Countries: 1. Publications: 2.
Data from: Comparison of cerebral blood volume and plasma volume in untreated intracranial tumors
Purpose: Plasma volume and blood volume are imaging-derived parameters that are often used to evaluation intracranial tumors. Physiologically, these parameters are directly related, but their two different methods of measurements, T1-dynamic contrast enhanced (DCE)- and T2-dynamic susceptibility contrast (DSC)-MR utilize different model assumptions and approaches. This poses the question of whether the interchangeable use of T1-DCE-MRI derived fractionated plasma volume (vp) and relative cerebral blood volume (rCBV) assessed using DSC-MRI, particularly in glioblastoma, is reliable, and if this relationship can be generalized to other types of brain tumors. Our goal was to examine the hypothetical correlation between these parameters in three most common intracranial tumor types. Methods: Twenty-four newly diagnosed, treatment naïve brain tumor patients, who had undergone DCE- and DSC-MRI, were classified in three histologically proven groups: glioblastoma (n=7), meningioma (n=9), and intraparenchymal metastases (n=8). The rCBV was obtained from DSC after normalization with the normal-appearing anatomically symmetrical contralateral white matter. Correlations between these parameters were evaluated using Pearson (r), Spearman's (ρ) and Kendall's tau-b (τB) rank correlation coefficient. Results: The Pearson, Spearman and Kendall's correlation between vp with rCBV were r=0.193, ρ=0.253 and τB=0.33 (p-Pearson=0.326, p-Spearman=0.814 and p-Kendall=0.823) in glioblastoma, r=-0.007, ρ=0.051 and τB=0.135 (p-Pearson=0.970, p-Spearman=0.765 and p-Kendall=0.358) in meningiomas, and r= 0.289, ρ=0.228 and τB= 0.239 (p-Pearson=0.109, p-Spearman=0.210 and p-Kendall=0.095) in metastasis. Conclusion: Results indicate that no correlation exists between vp with rCBV in glioblastomas, meningiomas and intraparenchymal metastatic lesions. Consequently, these parameters, as calculated in this study, should not be used interchangeably in either research or clinical practice.
Data from: Comparison of cerebral blood volume and plasma volume in untreated intracranial tumors
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Effect of Volume Guarantee-High Frequency Oscillatory Ventilation on Cerebral Blood Flow in Neonates
ClinicalTrials.gov study NCT05592431. IPD Sharing: NO. Countries: 1. Publications: 0.
Study of Regional Cerebral Oxygenation and Brain Blood Volume Changes During Carotid Endarterectomy Using the NeurOS System
ClinicalTrials.gov study NCT03981757. IPD Sharing: NO. Countries: 1. Publications: 0.
Regional Cerebral Oxygenation and Brain Blood Volume During Cardiac Surgery Using the NeurOS System
ClinicalTrials.gov study NCT03969836. IPD Sharing: NO. Countries: 1. Publications: 0.
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