Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
23
datasets available to search
ShareScore release 0.9.0
Dataset results
23 results for “Clinical chemistry”
Fig. 16 in Stilbenes: Source plants, chemistry, biosynthesis, pharmacology, application and problems related to their clinical Application-A comprehensive review
Fig. 16. Biological activities of stilbenes and their action mechanisms: The major biological activities of stilbenes are anticancer (through inhibiting β-hexosaminidase, DNA topoisomerase, expression of cylin B1 & D1, and NOR 1 activity); anti-inflammatory (through inhibition of expression of proinflammatory cytokines such as Tumor necrosis factor-alpha (TNF-α) and Interleukin-1 (IL-1)); regulation of Nrf2/HO-1 and NF-kB/ TGF-β pathway as well as inhibiting direct binding between siCAM-1 and LFA-1); antimicrobial (by damaging microbial cell wall and cell membrane damage, condensation of cytoplasm, perturbation of membrane potential, interacting with the conserved ubiquitin-specific protease residues of PLpro), and down-regulation of ergosterol biosynthesis and Camp/Ras pathway; antidiabetic (through inhibiting TNF-α, α-glucosidase, intestinal sucrose transfer, elevation of blood glucose as well as inducing/ increasing PPAR gamma 2 and GLUT4); antioxidant (through inhibiting lipid peroxidation, NO production, NOS activity, and increasing SOD activity); and neuroprotective (by inhibiting NOS activity, NO production, and HO-1 expression) activities.
Fig. 12 in Stilbenes: Source plants, chemistry, biosynthesis, pharmacology, application and problems related to their clinical Application-A comprehensive review
Fig. 12. Biosynthesis of stilbenes in microbes: For high production of stilbenes in microbes such as E. coli, the metabolic pathway of malonyl-CoA, the major and common extender substrate during conversion of coumaroyl, cinnamyl, and caffeoyl-CoAs to their respective monomeric stilbenes, is mainly manipulated. Enzymes of side pathways leading to the synthesis of fatty acids and acetate from acetyl-CoA, the direct precursor of malonyl-CoA, are inhibited, or their encoding enzymes are down-regulated or knocked out. For more efficient and high production of the stilbenes, there is also host, pathway, and enzyme engineering in the pathway of converting coumaroyl, cinnamyl, and caffeoyl- CoAs to monomeric stilbenes using STS.
Fig. 15 in Stilbenes: Source plants, chemistry, biosynthesis, pharmacology, application and problems related to their clinical Application-A comprehensive review
Fig. 15. Chemical synthesis of resveratrol derivatives: The derivatives 3,4′,5-trimethoxy-cis-stilbene (b), 3,4′,5-trimethoxy-trans-stilbene (c), 3,4,4′,5-tetramethoxytrans-stilbene (DMU-212, d), 2,3′,4,4′,5′-pentamethoxy-trans-stilbene (PMS, e), and 2′,3,4′,5-tetramethoxy (TMS; f) are synthesized by methoxylation of the central resveratrol (a), while the synthetic analogs 3′,4′,3,5-tetrahydroxy-trans-stilbene (piceatannol); (g) and 3,3′,4,4′,5,5′-hexahydroxy-trans-stilbene (h) are produced by hydroxylation of (a). The result of fluorination and esterification is 3,4-difluoro-4′-acetoxy-trans-stilbene (i), while bromination and methoxylation give 3,4,5-trimethoxy-4′-bromostilbene (j). The analogous 2,3-thiazolidin-4-one RSV derivatives (l and k) are synthesized through replacement of the olefinic group of (a) by heterocyclic compounds.
Fig. 1 in Stilbenes: Source plants, chemistry, biosynthesis, pharmacology, application and problems related to their clinical Application-A comprehensive review
Fig. 1. Phylogenetic tree of known stilbene-producing plants: Each family was marked with a different color in the figure. The circle-marked species are capable of producing stilbenes. Kappaphycus striatum (JN897024.1) and Silvetia siliquosa (JF718409.1) are included as out-groups. The phylogenetic tree was constructed using the ITS2 (ribosomal internal transcribed spacer 2) genus sequence. ITS2 sequences were obtained from NCBI (National Center for Biotechnology Information) (https://www.ncbi.nlm.nih.gov/). Some unannotated sequences were identified and delimited based on Hidden Markov models (HMMs), which was performed through the online website-ITS2 Database (http://its2.bioapps.biozentrum.uni-wuerzburg.de/). The MUSCLE program in MEGA6.0 software was used to perform multiple sequence alignments, and the neighbor-joining (NJ) method was used to construct phylogenetic trees with 1000 bootstrap replicates. The kimura-2- parameter substitution model was also employed, and the confidence interval was 95%. The evolutionary tree is visualized and beautified by the online software iTOL (https://itol.embl.de/). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
Fig. 11 in Stilbenes: Source plants, chemistry, biosynthesis, pharmacology, application and problems related to their clinical Application-A comprehensive review
Fig. 11. Biosynthesis of stilbenes in plant suspension cell culture: plants with a high stilbene content will be cut to a specific size. These will be incubated in agarized medium (Murashige and Skoog (MS) medium or CHU (N6) medium or Gamborg's B5 medium (B5)) with supplements such as 6-benzyl amino purine (6-BA), kinetin (KT), Naphthalene acetic acid (NAA), and 2,4-Dichlorophenoxyacetic acid (2,4-D). After some specific days, friable cells will be produced in the medium, and these cells are then transferred into a new fresh medium with the specific supplements. Finally, elicitors such as 12-oxo-phytodienoic acid (OPDA), cornatine (COR), jasmonic acid (JA), methyl jasmonate (MeJA), salicylic acid (SA), ethylene (ET), abscisic acid (ABA), and reactive oxygen species (ROS) will be added for high production of stilbenes.
Fig. 14 in Stilbenes: Source plants, chemistry, biosynthesis, pharmacology, application and problems related to their clinical Application-A comprehensive review
Fig. 14. Synthetic derivatives of CA-4 (1): These are produced by replacement, substitution, and modification at both the cis-olefinic bond and the aromatic rings of 1. N-acyl hydrazone CA-4 (4), azo CA-4 (3), 1, 3, 4, oxadiazole CA-4 (9), benzoxazole CA-4 (8) which are produced by replacement and modifications at the olefinic group. Through modifications to the cis-olefinic bond and aromatic rings of CA-4, analogs such as 2 and 7 (benzothiazole derivatives of CA-4 with fluorine), 5 and 6 (imidazole and indole derivatives of CA-4) are also synthesized.
Influence of Rapydan on Clinical Chemistry and Hematology Measurements
ClinicalTrials.gov study NCT00765934. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Fig. 17 in Stilbenes: Source plants, chemistry, biosynthesis, pharmacology, application and problems related to their clinical Application-A comprehensive review
Fig. 17. Synthetic non-steroidal estrogens derived from synthetic trans- resveratrol derivatives.
Fig. 13. Combretastatin A in Stilbenes: Source plants, chemistry, biosynthesis, pharmacology, application and problems related to their clinical Application-A comprehensive review
Fig. 13. Combretastatin A (CA-4) and its potential anticancer synthetic derivatives.
Fig. 9 in Stilbenes: Source plants, chemistry, biosynthesis, pharmacology, application and problems related to their clinical Application-A comprehensive review
Fig. 9. Photochemical behavior of stilbenes.
Fig. 6 in Stilbenes: Source plants, chemistry, biosynthesis, pharmacology, application and problems related to their clinical Application-A comprehensive review
Fig. 6. Structures of representative tetrameric stilbenes.
Fig. 5 in Stilbenes: Source plants, chemistry, biosynthesis, pharmacology, application and problems related to their clinical Application-A comprehensive review
Fig. 5. Structures of representative trimeric stilbenes.
Fig. 3 in Stilbenes: Source plants, chemistry, biosynthesis, pharmacology, application and problems related to their clinical Application-A comprehensive review
Fig. 3. Structures of representative monomeric stilbenes.
Fig. 2 in Stilbenes: Source plants, chemistry, biosynthesis, pharmacology, application and problems related to their clinical Application-A comprehensive review
Fig. 2. Basic structures of stilbenes.
Fig. 7 in Stilbenes: Source plants, chemistry, biosynthesis, pharmacology, application and problems related to their clinical Application-A comprehensive review
Fig. 7. Structures of representative pentameric and hexameric stilbenes.
Fig. 4 in Stilbenes: Source plants, chemistry, biosynthesis, pharmacology, application and problems related to their clinical Application-A comprehensive review
Fig. 4. Structures of representative dimeric stilbenes.
Fig. 8 in Stilbenes: Source plants, chemistry, biosynthesis, pharmacology, application and problems related to their clinical Application-A comprehensive review
Fig. 8. Structures of representative heptameric and octameric stilbenes.
An Open Label Study to Assess the Effect of BLI800 on Safety and Clinical Chemistry Parameters
ClinicalTrials.gov study NCT00583713. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Clinical Performance of Capillary Blood Samples Collected Using the Tasso+ Serum Gel Capillary Blood Collection System for Clinical Chemistry Testing of 14 Analytes on an Abbott Alinity Analyzer
ClinicalTrials.gov study NCT07260799. IPD Sharing: NO. Countries: 1. Publications: 0.
Fig. 10 in Stilbenes: Source plants, chemistry, biosynthesis, pharmacology, application and problems related to their clinical Application-A comprehensive review
Fig. 10. Biosynthesis pathway of stilbenes in plants: Phenylalanine and tyrosine amino acids are produced through the shikimate pathway. Both amino acids are converted to cinnamic acid and coumaric acid using phenylalanine ammonia-lyase (PAL) and tyrosine ammonia-lyase (TAL). Both acids are changed to their respective CoA products using the CoA ligase enzyme. Cinnamyl-CoA and coumaroyl-CoA are then converted to the monomeric stilbenes pinosylvin and resveratrol using stilbene synthase (STS). Both stilbenes are used as the precursors of several types of stilbenes by modifications such as methylation, hydroxylation, glycosylation, isomerization, and oligomerization. Using similar enzymes, caffeic acid is also used as the precursor of piceatannol, an additional monomeric origin of some stilbenes. Cinnamic acid can also be converted to coumaric using coumarate-4-hydroxylase, giving resveratrol through coumaroyl-CoA. Optionally, HpaBC is used to convert resveratrol to piceatannol.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.