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205 results for “Dose-response”
CurveCurator: A recalibrated F-statistic to assess, classify, and explore significance of dose-response curves - Example Datasets
<p>CurveCurator is an open-source analysis platform for any dose-dependent data. It fits a classical 4-parameter equation to estimate effect potency, effect size, and the statistical significance of the observed response. 2D-thresholding efficiently reduces false positives in high-throughput experiments and separates relevant from irrelevant or insignificant hits in an automated and unbiased manner. An interactive dashboard allows users to quickly explore data locally.</p> <p><br> Here, we store example dose-dependent data, parameter files, and the corresponding CurveCurator pipeline outputs (v.0.2.0). Example data sets include Kinobeads Drug-binding data (1), CTRP Viability data sets (2), and deryptM Proteomics data sets (3). The F-value matrices for developing the CurveCurator tools are deposited as well.</p> <p>Original data sources:</p> <p>(1)<a href="https://doi.org:10.1126/science.aan4368"> https://doi.org:10.1126/science.aan4368</a></p> <p>(2) <a href="https://doi.org:10.1158/2159-8290.CD-15-0235">https://doi.org:10.1158/2159-8290.CD-15-0235</a></p> <p>(3) <a href="https://doi.org:10.1126/science.ade3925">https://doi.org:10.1126/science.ade3925</a></p> <p> </p>
Figure 5.(a)Linear (y=0.45x + 57.74) dose-response relationship between plasma propranolol to % β- adrenergeric blockade derived from healthy study participants and translate into patients with angina pectoris. This image has been adapted from(Pine et al., 1975).-The Brain and Propranolol Pharmacokinetics in the Elderly
<p>Apharmacodynamic model,with parameters in the table below, may be used to visualize the<br> propranolol concentration-effect (β-blockade) relationship in patients suffering from angina pectoris.<br> These results have been adapted from the Pine et al article published in Circulation in 1975 which<br> identified a linear relationship plasma Propranolol (ng/mL) to an effect of % β-Adrenergic Blockade<br> in a single-oral dose of 40mg Propranolol in exercising individuals (Pine et al., 1975).</p>
Data from 90-day quantitative inhalation toxicology study evaluating the dose-response and fate in the lung and pleura of chrysotile-containing brake dust
<p>The final results from this multi-dose, 90-day inhalation toxicology study in the rat with life-time post-exposure observation have shown a significant fundamental difference in pathological response and tumorgenicity between brake dust generated from brake pads manufactured with chrysotile or from chrysotile alone in comparison to the amphiboles, crocidolite and amosite asbestos.</p> <p>The groups exposed to brake dust showed no significant pathological or tumorigenic response in the respiratory track compared to the air control group at exposure concentrations and deposited doses well above those at which humans have been exposed. Slight alveolar/interstitial macrophage accumulation of particles was noted. Wagner grades were 1–2 (1 = control group), similar to the TiO2 particle control group. Chrysotile was not biopersistent, exhibiting in the lung a deterioration of its matrix which results in breakage into particles and short fibers which can be cleared by alveolar macrophages and which can continue to dissolve. Particle-laden macrophage accumulation was observed, leading to a very-slight interstitial inflammatory response (Wagner grade 1–3). There was no peribronchiolar inflammation, occasional very-slight interstitial fibrosis (Wagner grade 4), and no exposure-related tumorigenic response.</p> <p>The pathological response of crocidolite and amosite compared to the brake dust and chrysotile was clearly differentiated by the histopathology and the confocal analysis. Crocidolite and amosite induced persistent inflammation, microgranulomas, persistent fibrosis (Wagner grades 4), and a dose-related lung tumor response. Confocal microscopy quantified extensive inflammatory response and collagen development in the lung, visceral and parietal pleura as well as pleural adhesions.</p> <p>These results provide a clear foundation for differentiating the innocuous effects of brake dust exposure from the adverse effects following amphibole asbestos exposure.</p>
EXPAREL Dose-Response for Single-Injection Femoral Nerve Blocks
ClinicalTrials.gov study NCT01349140. IPD Sharing: NO. Countries: 1. Publications: 3.
Dose-response Study of Efficacy and Safety of Botulinum Toxin Type A to Treat Spasticity of the Leg(s) in Cerebral Palsy
ClinicalTrials.gov study NCT01893411. IPD Sharing: Not stated. Countries: 14. Publications: 2.
Influenza Vaccine Dose-Response in Infants and Toddlers: Immunogenicity and Reactogenicity
ClinicalTrials.gov study NCT00710866. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Dose-response of Albuterol in Asthmatics
ClinicalTrials.gov study NCT00940927. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Dose-response Trial Using rFSH FE 999049 in Women Undergoing IVF/ICSI Treatment
ClinicalTrials.gov study NCT01426386. IPD Sharing: Not stated. Countries: 4. Publications: 2.
Dose-response Study of Efficacy and Safety of Botulinum Toxin Type A to Treat Spasticity of the Arm(s) or of Arm(s) and Leg(s) in Cerebral Palsy
ClinicalTrials.gov study NCT02002884. IPD Sharing: NO. Countries: 6. Publications: 2.
Dose-Response Study of MDMA-assisted Psychotherapy in People With PTSD
ClinicalTrials.gov study NCT01793610. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Safety, Tolerability, Efficacy and Dose-response of GSK2831781 in Ulcerative Colitis
ClinicalTrials.gov study NCT03893565. IPD Sharing: YES. Countries: 15. Publications: 1.
Dose-Response and Pharmacokinetics of Gabapentin Enacarbil (GEn [XP13512 / GSK1838262]) in Restless Legs Syndrome
ClinicalTrials.gov study NCT01332305. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Establishing a Dose-response Relationship With Accelerated Transcranial Magnetic Stimulation
ClinicalTrials.gov study NCT04243798. IPD Sharing: NO. Countries: 1. Publications: 16.
Dose-response Effect of Dietary Nitrate on Muscle Function in Older Individuals
ClinicalTrials.gov study NCT03595774. IPD Sharing: NO. Countries: 1. Publications: 6.
Dose-Response Relationships for Hemidiaphragmatic Paresis Following Ultrasound-Guided Supraclavicular Block
ClinicalTrials.gov study NCT03138577. IPD Sharing: NO. Countries: 1. Publications: 11.
Dose-response Study of Sodium Nitroprusside in Children Requiring Controlled Hypotension in the Operating Room
ClinicalTrials.gov study NCT00135668. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Dose-response of Inhaled Formoterol Using Methacholine Challenge as a Bioassay
ClinicalTrials.gov study NCT00643578. IPD Sharing: Not stated. Countries: 1. Publications: 9.
Efficacy, Safety and Dose-Response Study Followed by Open-Label Study of Lofexidine Treatment of Opioid Withdrawal
ClinicalTrials.gov study NCT01863186. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Dose-Response of Gonadal Steroids and Bone Turnover in Older Men
ClinicalTrials.gov study NCT00114114. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Maple Syrup Carbohydrate Dose-Response on 20-km Cycling Time-Trial Performance
ClinicalTrials.gov study NCT07389837. IPD Sharing: YES. Countries: 1. Publications: 8.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.