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21 results for “Enterococcus faecium”
Diet-induced changes in the jejunal microbiota of developing broilers reduce the abundance of Enterococcus hirae and Enterococcus faecium
<p>This ready to load <strong>phyloseq </strong>R S4 object contains the OTU table, taxonomy table and sample metadata. This data was build using kraken v2.1.2, kraken-biom v1.0.1 and phyloseq version 1.4. Sequencing data is deposited at NCBI-SRA under BioProject: PRJNA952340. </p><p> </p><p><strong>Study abstract</strong></p><p>Paul B. Stege, Dirkjan Schokker, Frank Harders, Soumya K. Kar, Norbert Stockhofe, Vera Perricone, Johanna M. J. Rebel, Ingrid C. de Jong, Alex Bossers </p><p> </p><p>Modern broiler breeds allow for high feed efficiency and rapid growth, which come at a cost of increased susceptibility to pathogens and disease. Broiler growth rate, feed efficiency, and health are affected by the composition of the gut microbiota, which in turn is influenced by diet. In this study, we therefore assessed how diet composition can affect the broiler jejunal gut microbiota. A total of 96 broiler chickens were divided into four diet groups: control, coated butyrate supplementation, medium-chain fatty acid supplementation, or a high-fibre low-protein content. Diet groups were sub-divided into age groups (4, 12 and 33 days of age) resulting in groups of 8 broilers per diet per age. The jejunum content was used for metagenomic shotgun sequencing to determine the microbiota taxonomic composition at species level. The composed diets resulted in a total of 104 differentially abundant bacterial species. Most notably were the butyrate-induced changes in the jejunal microbiota of broilers 4 days post-hatch, resulting in the reduced relative abundance of mainly <i>Enterococcus</i> <i>faecium</i> and the opportunistic pathogen <i>Enterococcus</i> <i>hirae</i>, when compared to the control diet. This effect takes place during early broiler development, which is critical for broiler health, thus exemplifying the importance of how diet can influence the microbiota composition and its relation to broiler health. Future studies should therefore elucidate how diet can be used to promote a beneficial microbiota in the early stages of broiler development.</p>
Draft Genome Sequences of Two Bacteriocin-Producing Enterococcus faecium Strains Isolated from Nonfermented Animal Foods in Spain
<p>Raw sequences of two bacteriocin-producing Enterococcus faecium.</p> <p> </p>
Figure 6: Theoretical Prediction of Ampicillin Resistance in Enterococcus faecium (2020-2030)
<p><strong>Figure 6: Theoretical Prediction of Ampicillin Resistance in Enterococcus faecium (2020-2030)</strong></p> <p> </p>
Oral cholestyramine prevents the enrichment of diverse daptomycin-resistance mutations in intestinal Enterococcus faecium populations
<p><em><strong>Background and Objectives</strong></em>: Previously, we showed proof-of-concept in a mouse model that oral administration of cholestyramine prevented enrichment of daptomycin-resistant <em>Enterococcus faecium</em> in the gastrointestinal (GI) tract during daptomycin therapy. Cholestyramine binds daptomycin in the gut, which removes daptomycin selection pressure and so prevents the enrichment of resistant clones. Here, we investigated two open questions related to this approach: 1) can cholestyramine prevent the enrichment of diverse daptomycin mutations emerging <em>de novo</em> in the gut? 2) how does the timing of cholestyramine administration impact its ability to suppress resistance?</p> <p><em><strong>Methodology</strong></em>: Mice with GI <em>E. faecium</em> were treated with daptomycin with or without cholestyramine, and <em>E. faecium</em> was cultured from feces to measure changes in daptomycin susceptibility. A subset of clones was sequenced to investigate the genomic basis of daptomycin resistance.</p> <p><em><strong>Results</strong></em>: Cholestyramine prevented the enrichment of diverse resistance mutations that emerged de novo in daptomycin-treated mice. Whole-genome sequencing revealed that resistance emerged through multiple genetic pathways, with most candidate resistance mutations observed in the clsA gene. Additionally, we observed that cholestyramine was most effective when administration started prior to the first dose of daptomycin. However, beginning cholestyramine after the first daptomycin dose reduced the frequency of resistant <em>E. faecium</em> compared to not using cholestyramine at all.</p> <p><em><strong>Conclusions and Implications</strong></em>: Cholestyramine prevented the enrichment of diverse daptomycin-resistance mutations in intestinal <em>E. faecium</em> populations during daptomycin treatment, and it is a promising tool for managing transmission of daptomycin-resistant <em>E. faecium</em>.</p>
Figure 4: Antibiotic sensitivity and resistance pattern of Enterococcus faecium
<p><strong>Figure 4: Antibiotic sensitivity and resistance pattern of Enterococcus faecium</strong></p>
Figure 5: Theoretical Prediction of Vancomycin Resistance in Enterococcus faecium(2020-2030)
<p><strong>Figure 5: Theoretical Prediction of Vancomycin Resistance in Enterococcus faecium(2020-2030)</strong></p> <p> </p>
Data from: Prevalence of vancomycin-variable Enterococcus faecium (VVE) among vanA-positive sterile site isolates and patient factors associated with VVE bacteremia
Open the record for dataset details and reuse information.
Oral cholestyramine prevents the enrichment of diverse daptomycin-resistance mutations in intestinal Enterococcus faecium populations
Open the record for dataset details and reuse information.
The regulatory RNA Ern0160 is involved in pathogenicity of Enterococcus faecium
GEO Series GSE239910. Enterococcus faecium Aus0004. 8 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide identification of small RNAs expressed in multidrug-resistant Enterococcus faecium and their implications in daptomycin resistance
GEO Series GSE94924. Enterococcus faecium Aus0004. 4 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Brucker Maldi-TOF custom database for differentiating Enterococcus faecium clades A1/A2 from B
<p>This custom database has been constructed using MBT explorer software (Bruker ®) and the Maldi Biotyper (Bruker). Protein extraction were performed according to the MSP Creation protocol (V1.1, Bruker ®) and mass spectra were obtained following the Maldi Biotyper protocol (V.2.4, Bruker ®). The resulting spectra were carefully inspected using flexAnalysis software (V3.4, Bruker ®). After elimination of spectra with mass peak deviation > 0.05%, outlier peaks or flatline, the remaining spectra were combined to generate a single mass spectrum for each strain onto the MALDI Biotyper software (V4.1, Bruker ®), with default parameters. The mass spectra were used to generate this new database, available on the MBT Compass RUO software (RevC Version, Bruker ®). </p> <p>The individual spectra are available as well as the MSP (Mass Spectrum Profile) for each strains.</p>
Phage Therapy for the Treatment of a Chronic Enterococcus Faecium Periprosthetic Joint Infection
ClinicalTrials.gov study NCT06942624. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Transcriptome mapping of Enterococcus faecalis and Enterococcus faecium
GEO Series GSE115009. Enterococcus faecium Aus0004; Enterococcus faecalis V583. 12 samples. Type: Expression profiling by high throughput sequencing.
Emergence of cephalosporin resitance in cephalosporin-sensitive class A penicillin binding protein mutants in Enterococcus faecium
GEO Series GSE77436. Enterococcus faecium. 6 samples. Type: Expression profiling by array.
Figure 4: Antibiotic sensitivity and resistance pattern of Enterococcus faecium.
<p><strong>Figure 4: Antibiotic sensitivity and resistance pattern of Enterococcus faecium. </strong></p>
Allele-Specific Effects of Mutations in the Rifampin Resistance-Determining Region (RRDR) of RpoB on Physiology and Antibiotic Resistance in Enterococcus faecium
GEO Series GSE302807. Enterococcus faecium. 20 samples. Type: Expression profiling by high throughput sequencing.
Unexpected bactericidal activity of caspofungin against Enterococcus faecium
GEO Series GSE100091. Enterococcus faecium. 4 samples. Type: Expression profiling by high throughput sequencing.
A dual T-box riboswitch in Enterococcus faecium binds two tRNAs
GEO Series GSE161499. Enterococcus faecium. 8 samples. Type: Expression profiling by high throughput sequencing.
Enterococcus faecium activates BMP/SMAD-mediated osteoblastogenesis and Wnt mediated neurogenesis while inhibiting PD
GEO Series GSE284676. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
Subinhibitory concentrations of ciprofloxacin enhance antimicrobial resistance and pathogenicity of Enterococcus faecium
GEO Series GSE94507. Enterococcus faecium Aus0004. 4 samples. Type: Expression profiling by high throughput sequencing.
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The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
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