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524 results for “GI”
Brewer Global Iradiance (GI) total ozone data at two Norwegian sites (2000 to 2020)
<p>Total column ozone (TCO) derived from Global Irradiance (GI) measurements from the Brewer instruments B042 in Oslo (Norway) and B104 in Andøya (Norway) from 01-01-2000 to 31-12-2020.</p> <p>The data consist of daily values averaged +/-2 hours around local noon.</p> <p>GI calibrations where performed with a clear sky direct sun (DS) measurements in 06-2001, 08-2014, 08-2016, 08-2018, and 08-2019 at Andøya, and in 08-2005, 06-2019, and 08-2019 at Oslo. The data has been calibrated with standard lamp measurements and have been homogenized with DS measurements as a function of clouds and solar zenith angle.</p> <p>The method, calibration, and homogenization is described by Bernet et al. (2022) (Appendix A).</p> <p>Responsible institute: NILU - Norwegian Institute for Air Research</p> <p>Funded by the Swiss National Science Foundation and the Norwegian Environment Agency</p> <p>Bernet, L., Svendby, T., Hansen, G., Orsolini, Y., Dahlback, A., Goutail, F., Pazmiño, A., Petkov, B., and Kylling, A., Total ozone trends at three northern high-latitude stations, 2022.</p>
Astrocytic Gi-GPCR activation enhances stimulus-evoked extracellular glutamate
<p>Astrocytes perform critical functions in the nervous system, many of which are dependent on neurotransmitter-sensing through G protein-coupled receptors (GPCRs). However, whether specific astrocytic outputs follow specific GPCR activity remains unclear, and exploring this question is critical for understanding how astrocytes ultimately influence brain function and behavior. Here, we investigate the outputs of astrocytic Gi-GPCRs, a family of GPCRs which we previously showed is sufficient to increase slow-wave neural activity (SWA) during sleep when activated in cortical astrocytes<sup>1</sup>. We focus on two putative outputs by astrocytes <em>in vivo</em>, the regulation of extracellular glutamate and GABA, by combining fiber photometry recordings of the extracellular indicators iGluSnFR and iGABASnFR with astrocyte-specific chemogenetic Gi-GPCR activation. We find that Gi-GPCR activation does not change spontaneous dynamics of extracellular glutamate or GABA. However, Gi-GPCR activation does specifically increase visual stimulus-evoked extracellular glutamate. Together, these data point towards a complex relationship between astrocytic inputs and outputs <em>in vivo </em>that may depend on behavioral context. Further, they suggest an extracellular glutamate-specific mechanism underlying some astrocytic Gi-GPCR-dependent behaviors, including the regulation of sleep SWA.</p>
Fig. 4 in M Or P Ho L O Gi Ca L Va R Iati On An D P Op U Lat Io N Structure Of The Natterjack Toad, Epidalea Calamita, In Northern Part Of The Range In Belarus
Fig. 4. Variation of the ratios males and females in the Natterjack toad Epidalea calamita population during the activity season in Belarus.
Fig. 3 in M Or P Ho L O Gi Ca L Va R Iati On An D P Op U Lat Io N Structure Of The Natterjack Toad, Epidalea Calamita, In Northern Part Of The Range In Belarus
Fig. 3. The color differences of males and females Natterjack toad Epidalea calamita in population of Belarus.
Fig. 3 in M Or P Ho L O Gi Ca L Va R Iati On An D P Op U Lat Io N Structure Of The Natterjack Toad, Epidalea Calamita, In Northern Part Of The Range In Belarus
Fig. 3. The color differences of males and females Natterjack toad Epidalea calamita in population of Belarus.
DDISH-GI: Dynamic Distributed Spherical Harmonics Global Illumination - Supplementary Video
<p>A supplementary video for the upcoming publication "DDISH-GI: Dynamic Distributed Spherical Harmonics Global Illumination". The video includes a comparison to a state-of-the-art method and also to the path traced ground truth. Limitations of the proposed method are also shown.</p>
A Study of TAK-164 in Participants With Advanced Gastrointestinal (GI) Cancer Expressing Guanylyl Cyclase C (GCC)
ClinicalTrials.gov study NCT03449030. IPD Sharing: YES. Countries: 1. Publications: 2.
Everolimus Plus Best Supportive Care vs Placebo Plus Best Supportive Care in the Treatment of Patients With Advanced Neuroendocrine Tumors (GI or Lung Origin)
ClinicalTrials.gov study NCT01524783. IPD Sharing: YES. Countries: 25. Publications: 5.
Astrocytic Gi-GPCR activation enhances stimulus-evoked extracellular glutamate
Open the record for dataset details and reuse information.
Confocal stacks of Cii_beta gamma crystalin_hM4D(Gi)_mCherry transgenic Ciona Larvae
<p>Confocal stacks of Cii_beta gamma crystalin_hM4D(Gi)_mCherry transgenic Ciona Larvae used to generate the panels of Hoyer et al.</p>
CB2 Receptor Signaling Complexes with Beta-Arrestin-2 and Gi Protein
<p>CB2 receptor signaling complexes with beta-arrestin-2 and Gi protein<br>Eun Ha Heo and Ravinder Abrol (CSUN)<br>11/27/2024 (Zenodo)</p> <p>System names as filename prefixes:</p> <p>CB2R-WT-NoPhosphoC_BARR2_*: wildtype CB2 receptor without phosphorylated C-terminus bound to beta-arrestin-2.<br> <br>CB2R-WT-NoPhosphoC_Gi-Empty_*: wildtype CB2 receptor without phosphorylated C-terminus bound to nucleotide-free Gi protein (no GDP).<br> <br>CB2R-WT-NoPhosphoC_Gi-GDP_*: wildtype CB2 receptor without phosphorylated C-terminus bound to Gi-GDP.<br> <br>CB2R-WT-PhosphoC_BARR2_*: wildtype CB2 receptor with a phosphorylated C-terminus bound to beta-arrestin-2. </p> <p>CB2R-Q63R-NoPhosphoC_BARR2_*: CB2 receptor mutant Q63R without phosphorylated C-terminus bound to beta-arrestin-2.</p> <p>CB2R-Q63R-NoPhosphoC_Gi-Empty_*: CB2 receptor mutant Q63R without phosphorylated C-terminus bound to nucleotide-free Gi protein (no GDP).</p> <p>CB2R-Q63R-NoPhosphoC_Gi-GDP_*: CB2 receptor mutant Q63R without phosphorylated C-terminus bound to Gi-GDP.</p> <p>CB2R-Q63R-PhosphoC_BARR2_*: CB2 receptor mutant Q63R with a phosphorylated C-terminus bound to beta-arrestin-2. </p> <p>CB2R-L133I-NoPhosphoC_BARR2_*: CB2 receptor mutant L133I without phosphorylated C-terminus bound to beta-arrestin-2.</p> <p>CB2R-L133I-NoPhosphoC_Gi-Empty_*: CB2 receptor mutant L133I without phosphorylated C-terminus bound to nucleotide-free Gi protein (no GDP). </p> <p>CB2R-L133I-NoPhosphoC_Gi-GDP_*: CB2 receptor mutant L133I without phosphorylated C-terminus bound to Gi-GDP. </p> <p>CB2R-L133I-PhosphoC_BARR2_*: CB2 receptor L133I mutant with a phosphorylated C-terminus bound to beta-arrestin-2. </p> <p><br>Different file types in following folders when uncompressed:</p> <p>Folder: PDB files for signaling complex starting and average structures<br>*_md.pdb: Solvated complex structures used as starting geometries.<br>*_avgframe#.pdb: PDB file of average frame given by #.</p> <p>Folder: MD simulation input files for Amber MD<br>*_md.inpcrd: input coordinates file for MD job<br>*_md.prmtop: parameter and topology file for MD job<br>Step1_mini_solv.in: mdin file for energy minimization of solvent keeping protein fixed.<br>Step2_equi_solv.in: mdin file for NPT equilibration of solvent while keeping protein fixed.<br>Step3_mini_full.in: mdin file for energy minimization of whole system.<br>Step4_heat_full.in: mdin file for heating system under NPT of whole system.<br>Step5_equi_full.in: mdin file for NPT equilibration of whole system.<br>Step6_prod_full.in: mdin file for 100ns production NPT equilibration of whole system. <br>Step7a_prod_full.in: mdin file for 500ns production NPT equilibration of whole system.<br>Step7b_prod_full.in: mdin file for 500ns production NPT equilibration of whole system.<br>Step7c_prod_full.in: mdin file for 500ns production NPT equilibration of whole system.<br>Step7d_prod_full.in: mdin file for 500ns production NPT equilibration of whole system.</p> <p>Folder: MD trajectories<br>*_step7_ai_stride100.xtc: Trajectory file in Gromacs xtc format.</p>
Fig. 1 in M Or P Ho L O Gi Ca L Va R Iati On An D P Op U Lat Io N Structure Of The Natterjack Toad, Epidalea Calamita, In Northern Part Of The Range In Belarus
Fig. 1. Natterjack toad Epidalea calamita in Belarus.
Acupuncture and Relaxation Response for GI Symptoms and HIV Medication Adherence
ClinicalTrials.gov study NCT00545623. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study of IL-22 IgG2-Fc (F-652) for Subjects With Grade II-IV Lower GI aGVHD
ClinicalTrials.gov study NCT02406651. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Real World Data on Gi(l)Otrif® Dose Adjustment
ClinicalTrials.gov study NCT02751879. IPD Sharing: Not stated. Countries: 13. Publications: 1.
GI-Reasons- A Trial Of GI Safety Of Celecoxib Compared With Non-Selective Nonsteroidal Antiinflammatory Drugs (NSAIDS)
ClinicalTrials.gov study NCT00373685. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Dose-Finding Safety Study Evaluating Remimazolam (CNS 7056) in Patients Undergoing Diagnostic Upper GI Endoscopy
ClinicalTrials.gov study NCT00869440. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Detection of Upper Gastrointestinal (GI) Bleeding With a Novel Bleeding Sensor Capsule [DING]
ClinicalTrials.gov study NCT03176407. IPD Sharing: NO. Countries: 1. Publications: 1.
Assessing the PK and Effect on Glucose and GI Hormone Concentrations of Metformin Delayed-Release in Subjects With T2DM
ClinicalTrials.gov study NCT01677299. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effects of ROSE-010 on GI Transit in Constipation Predominant Irritable Bowel Syndrome (C-IBS) Patients
ClinicalTrials.gov study NCT01056107. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.