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176 results for “Multidrug resistance”
Figure 2 in Antiadhesion and antibiofilm potential of Fagonia indica from Cholistan desert against clinical multidrug resistant bacteria
Figure 2. Effect of sub-inhibitory concentrations of chloroform extract of Fagonia indica on bacterial attachment to polystyrene surfaces. Cells grown in the absence of extract served as control. Values are presented as mean + SE.
Figure 1 in Antiadhesion and antibiofilm potential of Fagonia indica from Cholistan desert against clinical multidrug resistant bacteria
Figure 1. Effect of chloroform extract of Fagonia indica on membrane protein leakage. Bradford method was used to monitor the effect of various concentrations on leakage of protein. Values are presented as mean + SE.
Personalized aerosolised bacteriophage treatment of a chronic lung infection due to multidrug-resistant Pseudomonas aeruginosa
<p>Bacteriophage therapy has been suggested as an alternative or complementary strategy for the treatment of multidrug resistant (MDR) bacterial infections. Here, we report the favourable clinical evolution of a 41-year-old male patient with a Kartagener syndrome complicated by a life-threatening MDR <em>Pseudomonas aeruginosa </em>infection, who was treated successfully with iterative aerosolized phage treatments specifically directed against the patient’s isolate. We followed the longitudinal evolution of both phage and bacterial loads during and after phage administration in respiratory samples. Phage titres in consecutive sputum samples showed <em>in patient</em> phage replication. Phenotypic analysis and whole genome sequencing of sequential bacterial isolates revealed a clonal, but phenotypically diverse population of hypermutator strains. The MDR phenotype in the collected isolates was multifactorial and mainly due to spontaneous chromosomal mutations. All isolates recovered after phage treatment remained phage susceptible. These results demonstrate that clinically significant improvement is achievable by personalised phage therapy even in the absence of complete eradication of <em>P. aeruginosa</em> lung colonization.</p>
Drug sensitive and multidrug-resistant Mycobacterium tuberculosis genotypes from Bulgaria
<p>Dataset of drug sensitive and multidrug-resistant Mycobacteium tuberculosis spoligo- and MIRU-VNTR genotypes from Bulgaria collected between 2008 till 2019.</p>
Computational Data for Weaker interdomain interactions in FimH30 from multidrug-resistant Escherichia coli ST131 mediate longer lasting interactions with mannose and enhanced adhesin function
<p>Input files for the MD simulations and the resulting trajectories. A representative trajectory is provided for the R and T state of each allele. </p>
Supervised Molecular Dynamics Movies from: Deciphering the molecular recognition mechanism of multidrug resistance Staphylococcus aureus NorA efflux pump using a Supervised Molecular Dynamics approach
<p>Molecular Recognition pathway of Supervised molecular dynamic simulations of MdfA-CLM NorA-CPX and NorA-CPX.</p>
Deciphering the molecular recognition mechanism of multidrug resistance Staphylococcus aureus NorA efflux pump using a Supervised Molecular Dynamics approach.
<p><strong>Legend of Movie-S1</strong></p> <p>The Movie is composed by four synchronized and animated panels that show different aspects of the SuMD simulation. The time evolution is reported in nanosecond. In the first panel (upper left), the molecular representation of the system is shown. The MdfA backbone is represented by the new cartoon style (cyan). The CLM is shown in yellow and by a transparent surface. The protein residues within 3 Å from the ligand are made explicit by a stick representation.</p> <p>In the second panel (upper-right), the CM-distance between the protein and the ligand centers of mass is reported.</p> <p>In the third panel (lower left), the MMGBSA energy profile is reported.</p> <p>In the fourth panel (lower-right) cumulative electrostatic interactions are reported for the 15 MdfA residues most contacted by CLM during the whole simulation.</p> <p> </p> <p><strong>Legend of Video-S2</strong></p> <p>The Movie shows the SuMD trajectory of CLM on MdfA compared to the CLM crystallographic pose. MdfA is represented in cyan new cartoon transparency. The crystallographic pose is showed in yellow while the experimental one in light green. At 16.69 ns a RMSD value of 1.77 Å is highlighted.</p> <p> </p> <p><strong>Legend of Video-S3</strong></p> <p>The Movie is composed by four synchronized and animated panels that show different aspects of the SuMD simulation. The time evolution is reported in nanosecond. In the first panel (upper left), the system is shown. The NorA backbone is represented by the new cartoon style (red) and the protein residues within 3 Å of CPX are showed in stick. CPX is rendered by a green stick.</p> <p>In the second panel (upper-right), the distance between the centre of mass of the ligand and the protein during the trajectory is reported.</p> <p>In the third panel (lower left), the MMGBSA energy profile is reported. In the fourth panel (lower-right) cumulative electrostatic interactions are reported for the 15 NorA residues most contacted by CPX during the whole SuMD trajectory.</p> <p>It is important to note that the following video has a duration that is half of the simulation of SuMD. However, this straid does not alter the description of the trajectory performed by the ligand.</p> <p> </p> <p><strong>Legend of Video-S4</strong></p> <p>The Movie depicts the clustering analysis of CPX during the whole SuMD simulation. The NorA protein is shown in red new cartoon transparency. CPX is rendered by a light-green stick and by a transparent surface. The spheres are shown in 7 different colours, according to the different clusters. Each sphere dimension is in according to the cluster dimensions. After a first recognition site, the ligand conformations are clustered in different sites of the NorA channel. It is important to note that the following video has a duration that is half of the simulation of SuMD. However, this straid does not alter the description of the trajectory performed by the ligand.</p>
Klebsiella pneumonia in Sudan: Multidrug Resistance, Poly-clonal Dissemination and Virulence
<p>Minimum spanning tree (MST) of 84 <em>K. pneumoniae</em> by hospital information. Ridom SeqSphere+ MST for 84 samples based on 2358 columns, pairwise ignoring missing values, logarithmic scale. Cluster distance threshold: 15. Isolates grouped by colour indicating the different hospitals . Samples were collected from five different hospitals, 37 different STs were identified, in addition to 14 transmission clusters, represented by shaded nodes and arrows. Numbers between the nodes indicate the number of allelic differences.</p>
Randomized Evaluation of Strategic Intervention in Multidrug Resistant Patients With Tipranavir (RESIST)
ClinicalTrials.gov study NCT00054717. IPD Sharing: Not stated. Countries: 4. Publications: 1.
A Trial to Evaluate OPC 67683 in Participants With Pulmonary Sputum Culture-positive, Multidrug-resistant Tuberculosis (TB)
ClinicalTrials.gov study NCT00685360. IPD Sharing: YES. Countries: 9. Publications: 1.
Safety and Efficacy Trial of Delamanid for 6 Months in Participants With Multidrug-resistant Tuberculosis
ClinicalTrials.gov study NCT01424670. IPD Sharing: Not stated. Countries: 7. Publications: 1.
A 6-Month Safety, Efficacy, and Pharmacokinetic (PK) Trial of Delamanid in Pediatric Participants With Multidrug Resistant Tuberculosis (MDR-TB)
ClinicalTrials.gov study NCT01859923. IPD Sharing: YES. Countries: 2. Publications: 1.
Data from: Impact of treatment and re-treatment with Artemether-Lumefantrine and Artesunate-Amodiaquine on selection of Plasmodium falciparum Multidrug Resistance Gene-1 polymorphisms in the Democratic Republic of Congo and Uganda
Open the record for dataset details and reuse information.
Personalized inhaled bacteriophage therapy for treatment of multidrug-resistant Pseudomonas aeruginosa in cystic fibrosis
Open the record for dataset details and reuse information.
In silico dataset of features for multidrug resistant efflux transporter protein familes
<p>This dataset constitutes in silico features as amino acids fractions, dipeptide count, and other basic features information for efflux transporter family proteins.</p>
States of genome assembly supporting data for complete genome assembly of clinical multidrug resistant Bacteroides fragilis isolates enables comprehensive identification of antimicrobial resistance genes and plasmids.
<p>Assemblies for each isolate and assembly stage is in .gfa and .fasta format.</p> <p>the best SPAdes assembly is also included in the .zip files.</p> <p>1) Unicycler with illumina data and Nanopore data from the first sequencing run, filtered with FiltLong.<br> 2) Unicycler with illumina data and Nanopore data from the first sequencing run, filtered with FiltLong and error corrected with Canu<br> 3) Unicycler with illumina data and Nanopore data from the first and second sequencing run, filtered with FiltLong.<br> 4) manual finshing of assembly 3. <br> Methods are described in the paper and at the github repository (https://github.com/thsyd/bfassembly)</p> <p> </p>
Tigecycline among clinically significant multidrug resistant pathogens
<p><span><strong>Purpose</strong>:</span> Tigecycline, a glycylcycline antibiotic is a promising option for the treatment of single or multidrug-resistant pathogens. The aim of the study was to evaluate the in-vitro Tigecycline susceptibility of various pathogens from clinical samples received at tertiary care hospitals in South India. </p> <p><span><strong>Methods</strong>:</span> The analysis of specimens from patients admitted was carried out in this retrospective cross-sectional study. The identification and antimicrobial susceptibility testing were performed by semi-automated Vitek 2 systems and Kirby Bauer method. The pattern of data analysis was done by descriptive statistics.</p> <p><span><strong>Results</strong>:</span> Among 2,574 isolates, 812 isolates were gram-positive pathogens and 1762 isolates were gram-negative pathogens. Resistance to Tigecycline was more common among gram-negative pathogens (18.62%) in comparison to the gram-positive pathogens (0.49%). Among 740 Extended Spectrum Beta Lactamases (ESBL) producers such as <em>Klebsiella</em> species & <em>E</em>. <em>coli</em>, 629 isolates were susceptible, and 93 isolates were resistant to the tigecycline. All the Methicillin Resistant <em>Staphylococcus</em> <em>aureus</em> (MRSA) isolates were susceptible to tigecycline. Tigecycline was found to be highly effective in vitro for elimination of infections caused by both gram-positive and gram-negative pathogens.</p> <p><span><strong>Conclusion</strong>:</span> Multidrug-resistant (MDR) pathogens like <em>Acinetobacter</em> species and <em>Klebsiella</em> species are highly susceptible to Tigecycline, and it remains one of the key drugs in monotherapy & combination therapy. All MRSA were sensitive to tigeclycline. The use of combination therapy becomes crucial to prevent the development of Pan Drug resistance.</p>
Fig. 4. Compounds 1, 21 in Six C21 steroidal glycosides from Cynanchum wallichii Wight roots and their multidrug resistance reversal activities
Fig. 4. Compounds 1, 21, and 25 can reverse drug resistance by decreasing P-gp, NF-κB, and c-jun gene and protein expression. (A–C) MDR1, NFκB, and JUN gene expression in MCF-ADR and HepG2-ADM cells following co-treatment with 1, 21, and 25 and Doxorubicin. (D–E) MDR1, NFκB, and Jun protein expression in MCFADR and HepG2-ADM cells treated with 1, 21, and 25 in combination with DOX.
Fig. 3. The C21 in Six C21 steroidal glycosides from Cynanchum wallichii Wight roots and their multidrug resistance reversal activities
Fig. 3. The C21 steroid compounds (1–28) exhibited DOX resistance reversing activity (A) Cell viability following treatment with compounds 1–28. (B) CI value for DOX and the isolated compounds in HepG2/ ADM and MCF7/ADR cells. (C) Intersection diagram for DOX and 50% of the steroid compounds with the highest IC50 values at the same concentration. (D) Molecular docking model findings for the computer simulation of the multidrug resistance-associated protein (P-gp) and the steroid compounds.
Fig. 2 in Six C21 steroidal glycosides from Cynanchum wallichii Wight roots and their multidrug resistance reversal activities
Fig. 2. NF-κB expression in breast cancer and hepatocellular carcinoma Adriamycin-resistant cell lines with increased P-gp expression and significant drug resistance (A) Cell viability in DOX-treated MCF-7 and HepG2 cells and drug-resistant MCF-7/ADR and HepG2/ADM cells. (B–D) Background expression of proteins (P-gp) and genes (MDR1, NFκB, JUN) in DOX-treated MCF-7 and HepG2 cells and in drug-resistant MCF-7/ADR and HepG2/ADM cells.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.