Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
701
datasets available to search
ShareScore release 0.9.0
Dataset results
701 results for “Neoplasms”
Cell-free DNA Fragmentomics and Second Malignant Neoplasm Risk in Patients with PTEN Hamartoma Tumor Syndrome
<p><strong>Supplementary dataset for manuscript:</strong></p> <p><strong>Cell-free DNA Fragmentomics and Second Malignant Neoplasm Risk in Patients with PTEN Hamartoma Tumor Syndrome</strong></p> <p>Affiliations:</p> <p><sup>1</sup>Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA</p> <p><sup>2</sup>Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195, USA</p> <p><sup>3</sup>Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, Cleveland, OH 44195, USA</p> <p><sup>4</sup>Center for Personalized Genetic Healthcare, Medical Specialties Institute, Cleveland Clinic, Cleveland, OH 44195, USA</p> <p><sup>5</sup>Center for Immunotherapy and Precision Immuno-oncology, Cleveland Clinic, Cleveland, OH 44195, USA</p> <p><sup>6</sup>Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH 44195, USA</p> <p><sup>7</sup>Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA</p> <p><sup>8</sup>Germline High Risk Cancer Focus Group, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA</p> <p><strong><em>Correspondence</em></strong>:</p> <p>Darren Liu, MD, MS (<a href="https://orcid.org/0000-0002-6703-1843">https://orcid.org/0000-0002-3693-5145)</a></p> <p>Cleveland Clinic Genomic Medicine Institute</p> <p>9500 Euclid Avenue, Cleveland, OH 44195, USA</p> <p>E-mail: liud5@ccf.org </p>
Endoscopic Ultrasound-guided Ethanol Injection of Pancreatic Cystic Neoplasms
ClinicalTrials.gov study NCT02158039. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
A Study to Evaluate the Efficacy and Safety of Pemigatinib (INCB054828) in Subjects With Myeloid/Lymphoid Neoplasms With FGFR1 Rearrangement - (FIGHT-203)
ClinicalTrials.gov study NCT03011372. IPD Sharing: YES. Countries: 11. Publications: 3.
Characterizing and classifying neuroendocrine neoplasms through microRNA sequencing and data mining
<p>Neuroendocrine neoplasms (NENs) are clinically diverse and incompletely characterized cancers that are challenging to classify. MicroRNAs (miRNAs) are small regulatory RNAs that can be used to classify cancers. Recently, a morphology-based classification framework for evaluating NENs from different anatomic sites was proposed by experts, with the requirement of improved molecular data integration. Here, we compiled 378 miRNA expression profiles to examine NEN classification through comprehensive miRNA profiling and data mining. Following data preprocessing, our final study cohort included 221 NEN and 114 non-NEN samples, representing 15 NEN pathological types and five site-matched non-NEN control groups. Unsupervised hierarchical clustering of miRNA expression profiles clearly separated NENs from non-NENs. Comparative analyses showed that miR-375 and miR-7 expression is substantially higher in NEN cases than non-NEN controls. Correlation analyses showed that NENs from diverse anatomic sites have convergent miRNA expression programs, likely reflecting morphologic and functional similarities. Using machine learning approaches, we identified 17 miRNAs to discriminate 15 NEN pathological types and subsequently constructed a multi-layer classifier, correctly identifying 217 (98%) of 221 samples and overturning one histologic diagnosis. Through our research, we have identified common and type-specific miRNA tissue markers and constructed an accurate miRNA-based classifier, advancing our understanding of NEN diversity.</p>
Non-Canonical Hedgehog Signaling Mediates Profibrotic Hematopoiesis-Stroma Crosstalk in Myeloproliferative Neoplasms
<p>We provide results regarding the bioinformatic analysis of scRNA-seq from bone marrow fibrosis mouse models. This includes final processed scRNA-seq data containing QC information, dimensionality reduction, and annotation of cell types. Additional tables including DE genes and markers can be found in the supplementary information of the publication.</p>
Molecular deciphering of primary liver neuroendocrine neoplasms confirms its distinct existence with foregut-like profile
<p>Isolated hepatic localizations of neuroendocrine tumors (NETs) are generally considered as metastatic NETs of unknown primary but could correspond to primary hepatic NETs (PHNETs), a poorly explored entity. We aimed to describe the clinicopathological and molecular features of PHNETs and compare them with other primary NETs. We assembled a retrospective cohort of patients managed for hepatic localization of NET without extra-hepatic primary tumor after exhaustive clinical, imaging and immunohistochemical characterization. We performed whole-exome sequencing with mutational and copy number analysis. Transcriptomic profiles were compared to pancreatic (n=31), small-bowel (n=22) and lung (n=15) NETs using principal component analysis, unsupervised clustering and gene-set enrichment analysis.Among 27 screened patients, 16 had PHNET (solitary tumor in 63%, median size 11 cm, G2 NETs in 81%) following clinical and pathological review. DNA analyses showed “foregut-like” genomic profiles with frequent alterations in pathways of Fanconi DNA repair (75%), histone modifiers (58%), adherens junctions (58%) and cell cycle control (50%). The most frequently involved genes were <em>KMT2A</em> (58%), <em>ATM</em> (42%), <em>CDH1</em>, <em>CDKN2C</em>, <em>FANCF</em> and <em>MEN1</em> (33% each). Transcriptomic analyses showed that PHNETs clustered closer to foregut (pancreatic, lung) NETs than to midgut (small-bowel) NETs, while remaining a distinct entity with specific profile. Assessment of potentially predictive biomarkers suggested efficacy of treatments usually active in foregut NETs. In conclusion, PHNETs display a foregut-like molecular profile distinct from other types of NETs, with recurrent molecular alterations. Upon exhaustive work-up to exclude unrecognized primary tumor, PHNETs should not be considered metastatic NETs from an unknown primary.</p>
Detection of Neoplasms by Metagenomic Sequencing of Cerebrospinal Fluid
<p>Detection of Neoplasms by Metagenomic Sequencing of Cerebrospinal Fluid</p> <p>Wei Gu, MD, PhD<sup>1,2</sup>*, Andreas M. Rauschecker, MD, PhD<sup>3</sup>, Elaine Hsu, BS<sup>1</sup>, Kelsey C. Zorn, BS<sup>4</sup>, Yasemin Sucu, BS<sup>1</sup>, Scot Federman, BS<sup>1</sup>, Allan Gopez, BS<sup>1</sup>, Shaun Arevalo, BS<sup>1</sup>, Hannah A. Sample, BS<sup>4</sup>, Eric Talevich, PhD<sup>5</sup>, Eric D. Nguyen, MD, PhD<sup> 1</sup>, Marc Gottschall, BS<sup>1</sup>, Bardia Nourbakhsh, MD, MAS<sup>6</sup>, Carl A. Gold, MD, MS<sup>7</sup>, Bruce A.C. Cree, MD, PhD, MAS<sup>8</sup>, Vanja Douglas, MD<sup>8</sup>, Megan B. Richie, MD<sup>8</sup>, Maulik P. Shah, MD, MHS<sup>8</sup>, S. Andrew Josephson, MD<sup>8</sup>, Jeffrey M. Gelfand, MD, MAS<sup>8</sup>, Steve Miller, MD, PhD<sup> 1</sup>, Linlin Wang, MD<sup>1</sup>, Tarik Tihan, MD, PhD<sup>9</sup>, Joseph L. DeRisi, PhD<sup>4,10</sup>, Charles Y. Chiu, MD, PhD<sup>11,12</sup>, Michael R. Wilson, MD, MAS<sup>8</sup>*</p> <p> </p> <p><sup>1</sup>Department of Laboratory Medicine, University of California San Francisco, CA 94107, USA</p> <p><sup>2</sup>Department of Pathology, Stanford University, CA 94305, USA</p> <p><sup>3</sup>Department of Radiology and Biomedical Imaging, University of California San Francisco, CA 94107, USA</p> <p><sup>4</sup>Department of Biochemistry and Biophysics, University of California San Francisco, CA 94107, USA</p> <p><sup>5</sup>DNANexus, Mountain View, CA 94040, USA</p> <p><sup>6</sup>Department of Neurology, Johns Hopkins University, MD 21287, USA</p> <p><sup>7</sup>Department of Neurology, Stanford University, CA 94305, USA</p> <p><sup>8</sup>Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, CA 94107, USA</p> <p><sup>9</sup>Department of Pathology, University of California San Francisco, CA 94107, USA</p> <p><sup>10</sup>Chan Zuckerberg Biohub, San Francisco, CA 94107, USA</p> <p><sup>11</sup>UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, CA 91407, USA</p> <p><sup>12</sup>Department of Medicine, Division of Infectious Diseases, University of California San Francisco, CA 94107, USA</p> <p> </p> <p>* Corresponding authors:</p> <p>Michael Wilson, MD, MAS</p> <p>UCSF Department of Neurology</p> <p>675 Nelson Rising Lane, NS212</p> <p>San Francisco, CA 94158</p> <p><a href="mailto:Michael.Wilson@ucsf.edu">Michael.Wilson@ucsf.edu</a></p> <p> </p> <p>Wei Gu, MD, PhD</p> <p>Stanford University, Department of Pathology</p> <p>3373 Hillview Ave, 218</p> <p>Palo Alto, CA 94304</p> <p>650-723-1914</p> <p><a href="mailto:weigu@stanford.edu">weigu@stanford.edu</a></p>
Study of BGB-A317 in Participants With Relapsed or Refractory Mature T- and NK-cell Neoplasms
ClinicalTrials.gov study NCT03493451. IPD Sharing: YES. Countries: 5. Publications: 1.
Study of Pomalidomide in Persons With Myeloproliferative-Neoplasm-Associated Myelofibrosis and RBC-Transfusion-Dependence
ClinicalTrials.gov study NCT01178281. IPD Sharing: Not stated. Countries: 16. Publications: 2.
Platinum-doublet Chemotherapy and Nivolumab for the Treatment of Subjects With Neuroendocrine Neoplasms (NENs) of the Gastroenteropancreatic (GEP) Tract or of Unknown (UK) Origin.
ClinicalTrials.gov study NCT03980925. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Myeloproliferative Neoplasms: an In-depth Case-control Study
ClinicalTrials.gov study NCT01831635. IPD Sharing: YES. Countries: 1. Publications: 3.
Multiparametric Magnetic Resonance Imaging Versus Fine Needle Aspiration Cytology for Parotid Gland Neoplasms
ClinicalTrials.gov study NCT03849482. IPD Sharing: NO. Countries: 1. Publications: 4.
Durvalumab (MEDI4736) Plus Tremelimumab for Advanced Neuroendocrine Neoplasms of Gastroenteropancreatic or Lung Origin
ClinicalTrials.gov study NCT03095274. IPD Sharing: NO. Countries: 1. Publications: 1.
Pembrolizumab in Neoplasms or Lymphomas
ClinicalTrials.gov study NCT03316573. IPD Sharing: NO. Countries: 1. Publications: 1.
Tagraxofusp in Patients With Blastic Plasmacytoid Dendritic Cell Neoplasm or Acute Myeloid Leukemia
ClinicalTrials.gov study NCT02113982. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Screening for Stomach Diseases and Colorectal Neoplasms With the Fecal Testing
ClinicalTrials.gov study NCT01741363. IPD Sharing: NO. Countries: 1. Publications: 2.
Tagraxofusp in Treating Patients With Blastic Plasmacytoid Dendritic Cell Neoplasm After Stem Cell Transplant
ClinicalTrials.gov study NCT04317781. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Luspatercept With or Without Hydroxyurea for the Treatment of Myelodysplastic/Myeloproliferative Neoplasms With Ring Sideroblasts and Thrombocytosis or Unclassifiable With Ring Sideroblasts
ClinicalTrials.gov study NCT05005182. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Phase 1b/2 Safety and Efficacy of APR-246 w/Azacitidine for tx of TP53 Mutant Myeloid Neoplasms
ClinicalTrials.gov study NCT03072043. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Trial of Niraparib in BAP1 and Other DNA Damage Response (DDR) Deficient Neoplasms (UF-STO-ETI-001)
ClinicalTrials.gov study NCT03207347. IPD Sharing: NO. Countries: 1. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.