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346 results for “PTEN”
Cell-free DNA Fragmentomics and Second Malignant Neoplasm Risk in Patients with PTEN Hamartoma Tumor Syndrome
<p><strong>Supplementary dataset for manuscript:</strong></p> <p><strong>Cell-free DNA Fragmentomics and Second Malignant Neoplasm Risk in Patients with PTEN Hamartoma Tumor Syndrome</strong></p> <p>Affiliations:</p> <p><sup>1</sup>Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA</p> <p><sup>2</sup>Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195, USA</p> <p><sup>3</sup>Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, Cleveland, OH 44195, USA</p> <p><sup>4</sup>Center for Personalized Genetic Healthcare, Medical Specialties Institute, Cleveland Clinic, Cleveland, OH 44195, USA</p> <p><sup>5</sup>Center for Immunotherapy and Precision Immuno-oncology, Cleveland Clinic, Cleveland, OH 44195, USA</p> <p><sup>6</sup>Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH 44195, USA</p> <p><sup>7</sup>Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA</p> <p><sup>8</sup>Germline High Risk Cancer Focus Group, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA</p> <p><strong><em>Correspondence</em></strong>:</p> <p>Darren Liu, MD, MS (<a href="https://orcid.org/0000-0002-6703-1843">https://orcid.org/0000-0002-3693-5145)</a></p> <p>Cleveland Clinic Genomic Medicine Institute</p> <p>9500 Euclid Avenue, Cleveland, OH 44195, USA</p> <p>E-mail: liud5@ccf.org </p>
Supplementary files for manuscript "Effects of alpelisib treatment on murine Pten-deficient lipomas"
<p>Supplementary datasets for figures of the manuscript "Effects of alpelisib treatment on murine Pten-deficient lipomas"</p>
Dataset: Patterson-UTI Energy, Inc. (PTEN) Stock Performance
This dataset provides historical stock market performance data for specific companies. It enables users to analyze and understand the past trends and fluctuations in stock prices over time. This information can be utilized for various purposes such as investment analysis, financial research, and market trend forecasting.
Reactivating PTEN to impair glioma stem cells by inhibiting cytosolic iron-sulfur assembly pathway
<p>Glioblastoma (GBM), the most lethal primary brain tumor, harbors glioma stem cells (GSCs) that not only initiate and maintain malignant phenotypes but also enhance therapeutic resistance. Although frequently mutated in GBMs, the function and regulation of PTEN in PTEN-intact GSCs are unknown. Here we found that PTEN directly interacts with MMS19 and competitively disrupts MMS19-based cytosolic iron-sulfur (Fe-S) cluster assembly (CIA) machinery in the differentiated glioma cells (DGCs). Interrogation of GSCs, when compared with their matched DGCs, revealed that PTEN is specifically succinated at cysteine (C) 211 in GSCs. Isotope tracing coupled with mass spectrometry analysis confirmed that fumarate, generated by adenylosuccinate lyase (ADSL) in <em>de novo</em> purine synthesis pathway which is highly activated in GSCs, promotes PTEN C211 succination. This modification abrogates the interaction between PTEN and MMS19, thereby reactivating CIA machinery pathway in GSCs. Functionally, inhibiting PTEN C211 succination through re-expressing PTEN C211S mutant, depleting ADSL, or consuming fumarate by N-acetylcysteine (NAC), an FDA-approved prescription drug, impairs GSC maintenance. Importantly, re-expressing PTEN C211S or treating with NAC sensitizes GSC-derived brain tumors to temozolomide and irradiation, the standard-of-care treatments for GBM patients, by retarding CIA machinery-mediated DNA damage repair. These findings reveal an immediately practicable strategy to target GSCs for treating GBMs by combined therapy with repurposing NAC.</p>
PI3Kbeta Inhibitor AZD8186 and Docetaxel in Treating Patients Advanced Solid Tumors With PTEN or PIK3CB Mutations That Are Metastatic or Cannot Be Removed by Surgery
ClinicalTrials.gov study NCT03218826. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Sirolimus to Treat Cowden Syndrome and Other PTEN Hamartomatous Tumor Syndromes
ClinicalTrials.gov study NCT00971789. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Feasibility of Parasacral Transcutaneous Electrical Nerve Stimulation PTENS for Voiding Dysfunction in Peds Population
ClinicalTrials.gov study NCT04570605. IPD Sharing: NO. Countries: 1. Publications: 2.
RAD001 and Neurocognition in PTEN Hamartoma Tumor Syndrome
ClinicalTrials.gov study NCT02991807. IPD Sharing: YES. Countries: 1. Publications: 1.
Natural History With Focus on Oncological Risk Evaluation in Pediatric Patients With PTEN Pathogenic Variants - Observational Study
ClinicalTrials.gov study NCT06805734. IPD Sharing: YES. Countries: 1. Publications: 3.
Vevorisertib (ARQ 751) as a Single Agent or in Combination With Other Anti-Cancer Agents, in Solid Tumors With PIK3CA / AKT / PTEN Mutations (MK-4440-001)
ClinicalTrials.gov study NCT02761694. IPD Sharing: YES. Countries: 1. Publications: 1.
Reactivating PTEN to impair glioma stem cells by inhibiting cytosolic iron-sulfur assembly pathway
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Myeloid PTEN loss affects the therapeutic response by promoting stress granule assembly and impairing phagocytosis by macrophages in breast cancer
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Data from: PTEN controls glandular morphogenesis through a juxtamembrane β-Arrestin1/ARHGAP21 scaffolding complex
PTEN controls three-dimensional (3D) glandular morphogenesis by coupling juxtamembrane signalling to mitotic spindle machinery. While molecular mechanisms remain unclear, PTEN interacts through its C2 membrane-binding domain with the scaffold protein β-Arrestin1. Because β-Arrestin1 binds and suppresses the Cdc42 GTPase-activating protein ARHGAP21, we hypothesize that PTEN controls Cdc42-dependent morphogenic processes through a β-Arrestin1-ARHGAP21 complex. Here we show that PTEN knockdown (KD) impairs β-Arrestin1 membrane localization, β-Arrestin1-ARHGAP21 interactions, Cdc42 activation, mitotic spindle orientation and 3D glandular morphogenesis. Effects of PTEN-deficiency were phenocopied by β-Arrestin1 KD or inhibition of β-Arrestin1-ARHGAP21 interactions. Conversely, silencing of ARHGAP21 enhanced Cdc42 activation and rescued aberrant morphogenic processes of PTEN-deficient cultures. Expression of the PTEN C2 domain mimicked effects of full-length PTEN but a membrane-binding defective mutant of the C2 domain abrogated these properties. Our results show that PTEN controls multicellular assembly through a membrane-associated regulatory protein complex composed of β-Arrestin1, ARHGAP21 and Cdc42.
The structural basis of PTEN regulation by multi-site phosphorylation
<p>PTEN is a phosphatidylinositol-3,4,5-triphosphate (PIP<sub>3</sub>) phospholipid phosphatase that is commonly mutated or silenced in cancer. PTEN's catalytic activity, cellular membrane localization, and stability are orchestrated by a cluster of C-terminal phosphorylation events on Ser380, Thr382, Thr383, and Ser385, but the molecular details of this multifaceted regulation have remained uncertain. Here we use a combination of protein semisynthesis, biochemical analysis, NMR, X-ray crystallography, and computational simulations on human PTEN and its sea squirt homolog VSP to obtain a detailed picture of how the phospho-C-tail belts around PTEN's C2 and phosphatase domains. We also visualize a previously proposed dynamic N-terminal alpha-helix and show it is key for PTEN catalysis but disordered upon phospho-C-tail interaction. This structural model provides a comprehensive framework for how C-tail phosphorylation can impact PTEN's cellular functions. </p>
Study Assessing the Efficacy and Safety of Alpelisib + Nab-paclitaxel in Subjects With Advanced TNBC Who Carry Either a PIK3CA Mutation or Have PTEN Loss
ClinicalTrials.gov study NCT04251533. IPD Sharing: YES. Countries: 30. Publications: 0.
Access to Resources for Patients With PTEN Hamartoma Tumor Syndrome
ClinicalTrials.gov study NCT03680924. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Capivasertib+Abiraterone as Treatment for Patients With Metastatic Hormone-sensitive Prostate Cancer and PTEN Deficiency
ClinicalTrials.gov study NCT04493853. IPD Sharing: YES. Countries: 32. Publications: 0.
French Digestive Polyposis Cohorte Family Adenomatous Polyposis With APC and MYH Gene Mutations , Cowden's Disease With PTEN Gene Mutation, Peutz Jeghers Disease With STK 11 Gene Mutation ,juvénil Pol
ClinicalTrials.gov study NCT01987518. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Relationship Between PTEN and Glycemic Variability and Outcome in Critically Ill Patients
ClinicalTrials.gov study NCT01796847. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Natural History Study of Individuals With Autism and Germline Heterozygous PTEN Mutations
ClinicalTrials.gov study NCT02461446. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ScienceDex guides
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Allen Brain Atlas
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.