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18 results for “Silk fibroin”
FTIR dataset from the article "Resistance to Degradation of Silk Fibroin Hydrogels Exposed to Neuroinflammatory Environments"
<p>The attached archive encounters the FTIR data used for the calculation of the β-sheet content of the silk fibroin hydrogels in the in-vitro experiments. Such data is used in main Figures 2<strong>c</strong> and 2<strong>d</strong>, 4<strong>a </strong>and 7<strong>a</strong> as well as Supplementary Figure 2<strong>a</strong> of the associated article.</p> <p> </p> <p>The acquisition of the files has been performed as indicated below:</p> <ul> <li><strong>Equipment:</strong> Thermo Scientific™ Nicolet™ iS™ 5 Spectrometer (Thermofisher, United States)</li> <li><strong>Acquisition Software:</strong> OMNIC 9.2.86 (Thermofisher, United States)</li> <li><strong>Number of Scans:</strong> 64</li> <li><strong>Data Spacing: </strong>0.482 cm<sup> -1</sup></li> </ul> <p> </p> <p>The files have been reported as raw complete spectrum including the absorbances in the wavenumbers from 600 to 1500 cm<sup> -1</sup> in the format of “.SPA”. In the following lines, we provide examples of software to process and analyze the spectra files included in the database.</p> <ul> <li>Python version 3.8 to 3.10 upon the availability of the “SpectroChemPy” (Travert and Christian, 2023) function.</li> <li>Matlab R2016a and newer upon the availability of the “LoadSpectra” (Oldenburg, 2023) function.</li> <li>OMNIC 9 (Thermofisher, United States).</li> <li>Essential FTIR (Operant LLC, United States).</li> </ul> <p> </p> <p>Provision of the data in other formats is available upon request. Inquiries may be directed to <a href="mailto:daniel.gonzalez@ctb.upm.es?subject=FTIR%20Samples%20Format">Daniel González-Nieto</a> or <a href="mailto:mahdi.yonesi@ctb.upm.es?subject=FTIR%20Samples%20Format">Mahdi Yonesi</a>.</p> <p><strong>References:</strong></p> <p>OLDENBURG, K. 2023. LoadSpectra. MATLAB Central File Exchange.</p> <p>TRAVERT, A. & CHRISTIAN, F. 2023. SpectroChemPy, a framework for processing, analyzing and modeling spectroscopic data for chemistry with Python. Github.</p> <p> </p>
Results from: Angiogenic property of silk fibroin scaffolds with adipose-derived stem cells on chick chorioallantoic membrane
<p>Angiogenesis is a key step in tissue regeneration and repair. Biomaterials that allow or promote angiogenesis are thus beneficial. In this study, angiogenic properties of salt-leached silk fibroin (SF) scaffolds seeded with human adipose stem cells (hADSCs) were studied using chick chorioallantoic membrane (CAM) as a model. The hADSC-seeded SF scaffolds (SF-hADSC) with porosity of 77.34 ± 6.96 % and pore diameter of 513.95 ± 4.99 µm were implanted on CAM of chick embryos that were on embryonic day 8 (E8) of development. The SF-hADSC scaffolds induced a spoke-wheel pattern of capillary network indicative of angiogenesis, which was evident since E11. Moreover, ingrowth of blood vessels into the scaffolds was seen in histological sections. The unseeded scaffolds induced the same extent of angiogenesis later on E14. In contrast, the control group could not induce angiogenesis to the same extent even as late. <i>In vitro</i> cytotoxicity tests and <i>in vivo</i> angioirritative study reaffirmed the biocompatibility of the scaffolds. This work highlighted that the biocompatible SF-hADSC scaffolds accelerates angiogenesis, and hence they can be a promising biomaterial for regeneration of tissues that require angiogenesis.</p>
Spectra related to the study about the Permselectivity of Silk Fibroin Hydrogels for Advanced Drug Delivery Neurotherapies
<p>This material is associated with the study about the Permselectivity of Silk Fibroin Hydrogels for Advanced Drug Delivery Neurotherapies. Herein are enclosed the FTIR spectra of silk fibroin solutions and hydrogels, and representative spectra from mass spectrometry technique for the quantification of cholesteronitrone F2 released from silk fibroin hydrogels.</p> <ul> <li>FTIR spectra prior to sonication are named as SF_2%_pre-sonication_0X and SF_6%_pre-sonication_0X, being 2 and 6% the concentration of silk fibroin in the solution and X the number of replicate.</li> <li>FTIR spectra 24 hours after sonication are named as SF_2%_post-sonication_0X and SF_6%_post-sonication_0X, being 2 and 6% the concentration of silk fibroin in the hydrogel and X the number of replicate.</li> <li>The files with file format .mzXML and named as spectrum are representative spectra from mass spectrometry technique from the calibration curve (Spectrum_matrix; Spectrum_IS_10uM; Spectrum_F2_10uM; Spectrum_IS+F2_10uM) and the quatification of F2 released from SF hydrogels (Spectrum_2%_X; Spectrum_6%_X; being X the time point of release).</li> </ul> <p> </p>
Evaluation of Cross-linked Collagen Membrane With and Without Silk Fibroin Around Immediate Dental Implants
ClinicalTrials.gov study NCT06552065. IPD Sharing: NO. Countries: 1. Publications: 1.
A New Drug Delivery System - Silk Fibroin Film Loaded or Not With Insulin on Palatal Mucosa Wound Healing
ClinicalTrials.gov study NCT05171400. IPD Sharing: YES. Countries: 1. Publications: 5.
Manufacturing, Characterization and Evaluation of the Effect of Silk Fibroin Membranes, Loaded or Not With Neurotensins on Open Wounds in the Palate
ClinicalTrials.gov study NCT05191082. IPD Sharing: UNDECIDED. Countries: 1. Publications: 4.
Results from: Angiogenic property of silk fibroin scaffolds with adipose-derived stem cells on chick chorioallantoic membrane
Open the record for dataset details and reuse information.
Prospective Evaluation of Silk Fibroin Incision Dressings in ACL Reconstruction
ClinicalTrials.gov study NCT07217613. IPD Sharing: NO. Countries: 1. Publications: 0.
Efficacy and Safety of Silk Fibroin With Bioactive Coating Layer Dressing
ClinicalTrials.gov study NCT02091076. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Novel Silk Fibroin Nanofiber Membrane Using Minimally Invasive Surgery in Treatment of Periodontal Intrabony Defects: A Randomized Clinical Trial
ClinicalTrials.gov study NCT06371027. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Exploring the Feasibility of Silk Fibroin Surgical Mesh in Rotator Cuff Tears Repair Enhancement
ClinicalTrials.gov study NCT06766630. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
DNA methylation dynamics during esophageal epithelial regeneration following repair with acellular silk fibroin grafts in rat
GEO Series GSE203028. Rattus norvegicus. 14 samples. Type: Methylation profiling by high throughput sequencing.
Local Delivery of Silk Fibroin and Chlorhexidine
ClinicalTrials.gov study NCT06050863. IPD Sharing: Not stated. Countries: 0. Publications: 0.
MiR146a-loaded engineered exosomes released from silk fibroin patch promote diabetic wound healing
GEO Series GSE217981. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Bilayer Heterogeneous Methacrylated-Silk Fibroin Scaffold with Antibacterial and Osteoinductive Functions for Treating Infectious Bone Defects
GEO Series GSE308538. Rattus norvegicus. 6 samples. Type: Expression profiling by high throughput sequencing.
Entorhino-hippocampal slice culture on 3D-printed silk fibroin insert
<p>20230406_LM_slice_culture: A TIF-file showing an LM-image (Carl Zeiss-Stemi 305 - 3.0X) of cultured entorhino-hippocampal slice cultures (22 days) on the metal frame spider silk.</p> <p>20230426_CM_slice_culture: a TIF-file showing an LSM-image (Leica TCS SP8, 20X (NA 0.75;Leica)) of PI and DAPI staining of hippocampal-entorhinal cortical slices (22 days in vitro) on the metal frame spider silk.</p> <p>20230522_LM_slice_culture01: A TIF-file showing an LM-image (Carl Zeiss-Stemi 305 - 2.0X) of entorhino-hippocampal slice culture (7 days in vitro) on the 3D-printed insert.</p> <p>20230627_LM_slice_culture02: A TIF-file showing an LM-image (Carl Zeiss-Stemi 305 - 4.0X) of entorhino-hippocampal slice culture (5 days invitro) on the 3D-printed insert.</p>
Silk fibroin scaffold functionalization
<p>First tests of peptides immobilization over silk fibroin microfibres.</p> <p>Initial steps of silk fibroin degradation using proteinase K, dor the future creation of more complex scaffold designs. </p>
Silk fibroin scaffolds fabrication
<p>Production of different formats of silk fibroin scaffolds.</p> <p>Meshes for the organoid cultures and tubular scaffolds for the microfluidic system and the vasculature creation and guidance.</p>
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