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12 results for “TRPM8”
TRPM8 thermosensation in ectotherms mediates both skin colour and locomotor performance responses to cold temperature
<p>Thermoregulation is a homeostatic process to maintain an organism's internal temperature within a physiological range compatible with life. In ectotherms, body temperature fluctuates with that of the environment, with both physiological and behavioral responses employed to modify body temperature. Changing skin colour/reflectance and locomotor activity are both well-recognized temperature regulatory mechanisms, but little is known of the participating thermosensor/s. We find that <em>Xenopus laevis</em> tadpoles put in the cold exhibit a temperature-dependent and rapid melanosome aggregation in melanophores, which lightens the skin. To identify the cold-sensor, we focused on <em>transient receptor potential</em> (trp) channel genes from group 1 (TRPA, TRPM, TRPV and TRPC families). Of particular interest were TRPM family members, known as cold sensors. mRNAs for several TRPMs are present in <em>Xenopus</em> tails, and TRPM8 protein is present in skin melanophores. Temperature-induced melanosome aggregation is mimicked by the Trpm8 agonist menthol (WS12) and blocked by the Trpm8 antagonist PF05105679. The degree of skin lightening induced by cooling or the WS12 TRPM8 agonist correlates with the extent of alterations in locomotor performance. We propose that TRPM8 serves as a cool thermosensor in ectotherms that helps coordinate skin lightening and behavioural locomotor performance as adaptive thermoregulatory responses to cold.</p>
Structure of human TRPM8 channel
<p>This repository includes the following source datasets:</p> <p><strong>1. modeling.zip</strong><br> Modeling of icilin binding to HsTRPM8 (Figure 3e, 3f, 3g, 3h)<br> - HsTRPM8-KX7_opt.pdb: original pose (Figure 3e, 3f)<br> - HsTRPM8-KX7_opt_rotated.pdb: rotates pose (Figure 3g, 3h)</p> <p><strong>2. activation_assay.zip</strong><br> HsTRPM8 activation assay results (Figure 3i and Supplementary Figure 5)<br> - HsTRPM8_activation_assay_results.pzf: GraphPad file with activation Assay results</p> <p><strong>3. Fr-TM.zip</strong><br> Structure-based multiple sequence alignment of TRPM channels (Supplementary Figure 4a)<br> - Fr-TM_info.txt: description of procedure used to create alignment<br> - TRPM_new_raw_pairwise_alignments.fas: raw pairwise alignment of new TRPM sequences to 6CO7 reference<br> - TRPM_S6_restriction_site_aligned.fas: final multiple sequence alignment used to generate Supplementary Figure 4a</p> <p><strong>4. 3Dvar.zip</strong><br> HsTRPM8 3D Variability Analysis results (Supplementary Movie 1)<br> - *.mrc files: composite maps with extreme frames for two analyzed components (aligned with focused MHR1/2 map)<br> - *.pdb files: HsTRPM8 models fitted (MDFF) to above maps and used to generate Supplementary Movie 1</p> <p><strong>5. Supplementary_Movie_1.mp4</strong><br> Morphing between different conformations of HsTRPM8 resolved by 3D Variability analysis (Supplementary Movie 1).</p>
TRPM8 in Acute Ischemic Stroke by Topical Menthol
ClinicalTrials.gov study NCT05877079. IPD Sharing: NO. Countries: 1. Publications: 1.
TRPM8 thermosensation in ectotherms mediates both skin colour and locomotor performance responses to cold temperature
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Data from: Sex-specific vascular effects of menthol: TRPM8 and TRPA1-dependent relaxation in female mouse aorta and pudendal arteries
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Mechanism of Human Cold Pain Perception - Involvement of TRPA1, TRPM8, Nav1.7 and Nav1.8
ClinicalTrials.gov study NCT05935280. IPD Sharing: YES. Countries: 1. Publications: 1.
TRPM8 inhibits substance P release from primary sensory neurons via PKA/GSK-3beta to protect colonic epithelium in colitis
GEO Series GSE242559. Rattus norvegicus. 12 samples. Type: Expression profiling by high throughput sequencing.
Constitutive activity of the cation channel TRPM8 regulates the function and differentiation of human monocytes
GEO Series GSE131415. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
Characterization of New Human Models of Non-histaminergic Itch and Their Interaction With the TRPM8 Receptor
ClinicalTrials.gov study NCT04554888. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effects of an Anti-TRPM8 in the Atopic Dermatitis Pruritus
ClinicalTrials.gov study NCT03610386. IPD Sharing: NO. Countries: 1. Publications: 0.
Effect of overexpression of TRPM8 on gene expression of tumor pericytes
GEO Series GSE216780. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
AMTB, a TRPM8 Antagonist, Suppresses Growth and Metastasis of Osteosarcoma through Repressing the TGFβ Signaling Pathway
GEO Series GSE188304. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.