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15 results for “Trichuris muris”
SBF-SEM of the Trichuris muris Stichosome
<p>This image stack is a Serial Blockface Scanning Electron Microscopy (SBF-SEM) acquisition of the <em>Trichuris muris</em> stichosome. Structures of interest included within the data are the stichosome, bacillary pores and cells, sensory neurons and cuticular inflations.</p> <p>The worm was taken from a mouse host (Severe Combined Immunodeficient on a BALB/c background), and sample preparation was carried out according to Deerinck et al. (2010).</p> <p>Imaging was carried out on a Quanta 250 FEG (Thermo Fisher Scientific, Massachusetts), with the blockface recorded at 3.8kV, spot size 3.5 and pressure of 0.4Torr. Pixel size of the lateral plain was 12 nm. Slice thickness was 100 nm.</p> <p> </p> <p></p> <p><span>Deerinck, T. <em>et al.</em> Enhancing Serial Block-Face Scanning Electron Microscopy to enable high resolution 3-D nanohistology of cells and tissues. <em>Microsc. Microanal.</em> <strong>16</strong>, 1138–1139 (2010).</span></p>
Data from: Strong effects of lab-to-field environmental transitions on the bacterial intestinal microbiota of Mus musculus are modulated by Trichuris muris infection
<p>Studies of controlled lab animals and natural populations represent two insightful extremes of microbiota research. We bridged these two approaches by transferring lab-bred female C57BL/6 mice from a conventional mouse facility to an acclimation room and then to an outdoor enclosure, to investigate how the gut microbiota changes with environment. Mice residing under constant conditions served as controls. Using 16S rRNA sequencing of fecal samples, we found that the shift in temperature and humidity, as well as exposure to a natural environment, increased microbiota diversity and altered community composition. Community composition in mice exposed to high temperatures and humidity diverged as much from the microbiota of mice housed outdoors as from the microbiota of control mice. Additionally, infection with the nematode <i>Trichuris muris</i> modulated how the microbiota responded to environmental transitions: The dynamics of several families were buffered by the nematodes, while invasion rates of two taxa acquired outdoors were magnified. These findings suggest that gut bacterial communities respond dynamically and simultaneously to changes within the host's body (e.g., the presence of nematodes) and to changes in the wider environment of the host.</p>
Data from: Strong effects of lab-to-field environmental transitions on the bacterial intestinal microbiota of Mus musculus are modulated by Trichuris muris infection
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RNA-sequencing data of intestinal tissue of mice adminstered proanthocyanidins (PAC) and infected with Trichuris muris (Tm)
GEO Series GSE176182. Mus musculus. 29 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic analysis of murine splenic basophils in steady-state or on day 14 of Trichuris muris infection
GEO Series GSE129056. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
miRNA data from extracellular vesicles secreted by Trichuris muris
GEO Series GSE107985. Trichuris muris. 2 samples. Type: Non-coding RNA profiling by high throughput sequencing.
mRNA data from extracellular vesicles secreted by Trichuris muris
GEO Series GSE107986. Trichuris muris. 1 samples. Type: Expression profiling by high throughput sequencing.
Data from: Chronic Trichuris muris Infection Decreases Diversity of the Intestinal Microbiota and Concomitantly Increases the Abundance of Lactobacilli
The intestinal microbiota is vital for shaping the local intestinal environment as well as host immunity and metabolism. At the same time, epidemiological and experimental evidence suggest an important role for parasitic worm infections in maintaining the inflammatory and regulatory balance of the immune system. In line with this, the prevalence of persistent worm infections is inversely correlated with the incidence of immune-associated diseases, prompting the use of controlled parasite infections for therapeutic purposes. Despite this, the impact of parasite infection on the intestinal microbiota, as well as potential downstream effects on the immune system, remain largely unknown. We have assessed the influence of chronic infection with the large-intestinal nematode Trichuris muris, a close relative of the human pathogen Trichuris trichiura, on the composition of the murine intestinal microbiota by 16S ribosomal-RNA gene-based sequencing. Our results demonstrate that persistent T. muris infection dramatically affects the large-intestinal microbiota, most notably with a drop in the diversity of bacterial communities, as well as a marked increase in the relative abundance of the Lactobacillus genus. In parallel, chronic T. muris infection resulted in a significant shift in the balance between regulatory and inflammatory T cells in the intestinal adaptive immune system, in favour of inflammatory cells. Together, these data demonstrate that chronic parasite infection strongly influences the intestinal microbiota and the adaptive immune system. Our results illustrate the complex interactions between these factors in the intestinal tract, and contribute to furthering the understanding of this interplay, which is of crucial importance considering that 500 million people globally are suffering from these infections and their potential use for therapeutic purposes.
Data from: Chronic Trichuris muris Infection Decreases Diversity of the Intestinal Microbiota and Concomitantly Increases the Abundance of Lactobacilli
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An Optimised Faecal microRNA Sequencing Pipeline Reveals Fibrosis in Trichuris muris Infection
GEO Series GSE267555. Mus musculus. 31 samples. Type: Non-coding RNA profiling by high throughput sequencing.
RNA sequencing data of mouse intestinal epithelial cells following different dietary treatments and Trichuris muris infection
GEO Series GSE284172. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
Excretory/secretory microRNAs from the gastrointestinal nematode Trichuris muris in culture
GEO Series GSE93667. Mus musculus; Trichuris muris. 1 samples. Type: Non-coding RNA profiling by high throughput sequencing.
RNA-sequencing data of mice fed either a control diet or inulin-enriched diet and infected with either Trichuris muris or Citrobacter rodentium
GEO Series GSE223377. Mus musculus. 19 samples. Type: Expression profiling by high throughput sequencing.
Extracellular vesicles from Heligmosomoides bakeri and Trichuris muris contain distinct small RNAs
GEO Series GSE152591. Heligmosomoides polygyrus bakeri; Trichuris muris. 15 samples. Type: Non-coding RNA profiling by high throughput sequencing; Third-party reanalysis.
Effect of B cell-intrinsic deletion of MLL1 on gene expression of germinal centre B cells during day 13 Trichuris muris infection
GEO Series GSE237391. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.