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19
datasets available to search
ShareScore release 0.9.0
Dataset results
19 results for “Xenotransplantation”
Supplementary data: The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia in a xenotransplantation model of Alzheimer's disease
<p>Supplementary data for: The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia in a xenotransplantation model of Alzheimer’s disease. </p> <p>Supplementary_Table1_QC: Excel sheet containing QC metrics for the RNA-seq data and the other containing QC metrics for the ATAC-seq data. </p> <p>Supplementary_Table2_DEGs: Excel sheet containing DeSeq2 differential expression analysis results for the following comparisons: APOE2 vs APOE3, APOE4 vs APOE3, APOE4 vs APOE2, APOE-KO vs APOE3. </p> <p>Supplementary_Table3_MAGMA_geneset_analysis_res: CSV file containing MAGMA gene set analysis results using the differentially expressed genes (FDR < 0.05) for the comparisons outlined in Supplementary_Table2_DEGs and three independent AD GWAS. </p> <p>Supplementary_Table4_DARs: Excel sheet containing DeSeq2 differential accessibility analysis results for the following comparisons: APOE2 vs APOE3, APOE4 vs APOE3, APOE4 vs APOE2, APOE-KO vs APOE3. </p> <p>Supplementary_Table5_sLDSC_res.csv: CSV file containing s-LDSC results using the consensus set of ATAC-seq peaks with three brain disorder GWAS (Alzheimer's disease, autism spectrum disorder, and amyotrophic lateral sclerosis). </p> <p>Supplementary_Table6_WGCNA_clusterProfiler_pathway_enrichment.csv: CSV file containing pathway enrichment results using two WGCNA-identified modules that were significantly upregulated in APOE2-expressing microglia. </p> <p>Supplementary_Table7_homer_motifEnrichment_res.xlsx: Excel sheet containing Homer motif enrichment analysis results using top 100 peaks with increased and decreased chromatin accessibility for APOE2 vs APOE3, APOE4 vs APOE3, and APOE4 vs APOE2.</p>
Xenotransplantation of Primary Cancer Samples in Zebrafish Embryos
ClinicalTrials.gov study NCT03668418. IPD Sharing: NO. Countries: 1. Publications: 2.
Porcine Kidney Xenotransplantation in Patients With End-Stage Kidney Disease
ClinicalTrials.gov study NCT05340426. IPD Sharing: NO. Countries: 1. Publications: 1.
Safety and Efficacy Study of Islets Xenotransplantation
ClinicalTrials.gov study NCT03162237. IPD Sharing: NO. Countries: 1. Publications: 0.
Rat BAT Xenotransplantation Recovers the Fertility and Metabolic Health of PCOS Mice
<p><strong>Supplementary dataset 1</strong></p> <p>This file contains datasets for all 230 overlapped DEGs (Fig. 6A and B) among RTM, MTM, and control group compared with the PCOS group in F0 model mice. It has two sheets: "F0 up-regulated DEGs" contained all DEGs that have significantly higher (|log2| > 1) expression levels in RTM, MTM, and control group than PCOS group; "F0 down-regulated DEGs" contained all DEGs that have significantly lower (|log2| > 1) expression level in RTM, MTM, and control group than PCOS group. For each gene, both FPKM of each repeat and the average FPKM of three repeats are shown.</p> <p><strong>Supplementary dataset 2</strong></p> <p>This file, corresponding to Fig. 7, contains 4 sheets of datasets for all DEGs that overlapped between human PCOS studies and corrent study. From left to right, in sheet 1, the datasets from column A-AB are for the DEGs in current study; the datasets from column AD-BL are for the DEGs in Lan et al (36). In sheet 2, the datasets from column A-AA are for the DEGs in our study; the datasets from column AC-AI are for the DEGs in Wissing et al (37). In sheet 3, the datasets from column A-AB are for the DEGs in our study; the datasets from column AD-AL are for the DEGs in Lu et al (38). In sheet 4, the datasets from column A-AB are for the DEGs in our study; the datasets from column AD-AG are for the DEGs in Kaur et al (39). For a clear distinguishment between our data and the reference data, column AC in sheet 1, column AB in sheet 2, column AC in sheet 3, and column AC in sheet 4 are left blank and highlighted in green; Two columns with title "symbol" and red typed in each sheet list all overlapping DEGs between our data and reference data.</p> <p><strong>Supplementary dataset </strong><strong>3</strong></p> <p>This file contains 4 sheets. Each sheet includes KEGG information for the DEGs that overlapped between human PCOS studies and current study.</p> <p><strong>Supplementary dataset </strong><strong>4</strong></p> <p>This dataset contains all 126 overlapped DEGs (Supplementary Fig. 6A and B) among RTM, MTM, and control group compared with the PCOS group in F1 model mice. It has two sheets: "F1 up-regulated DEGs" contained all DEGs that have significantly higher (|log2| > 1) expression level in RTM, MTM, and control group than in PCOS group; "F1 down-regulated DEGs" contained all DEGs that have significantly lower (|log2| > 1) expression level in RTM, MTM, and control group than in PCOS group. For each gene, both FPKM of each repeat and the average FPKM of three repeats are shown.</p>
The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia in a xenotransplantation model of Alzheimer’s disease [RNA-seq]
GEO Series GSE271385. Homo sapiens. 19 samples. Type: Expression profiling by high throughput sequencing.
The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia in a xenotransplantation model of Alzheimer’s disease [ATAC-seq]
GEO Series GSE271384. Homo sapiens. 20 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Cellular dynamics of pig-to-human kdiney xenotransplantation [RNA-seq]
GEO Series GSE257541. Sus scrofa. 5 samples. Type: Expression profiling by high throughput sequencing.
Single-cell RNA analysis reveals reduced frequency and activity of CXCR5+ atypical memory B cells in islet xenotransplantation treated with clinically applicable immunosuppressants including Belimumab
GEO Series GSE305843. Macaca mulatta. 4 samples. Type: Expression profiling by high throughput sequencing.
Investigation of the Safety and Efficacy of NTCELL® [Immunoprotected (Alginate-Encapsulated) Porcine Choroid Plexus Cells for Xenotransplantation] in Patients With Parkinson's Disease
ClinicalTrials.gov study NCT02683629. IPD Sharing: YES. Countries: 1. Publications: 0.
Xenotransplantation of Human PSC-derived Microglia Creates a Chimeric Mouse Brain Model that Recapitulates Features of Adult Human Microglia
GEO Series GSE129178. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Cellular dynamics of pig-to-human kdiney xenotransplantation [single cell RNA-seq]
GEO Series GSE257542. Homo sapiens; Sus scrofa. 12 samples. Type: Expression profiling by high throughput sequencing.
Time-course analysis of transcriptomes of human long-term (LT) and short-term (ST) hematopoietic stem cells (HSC) after xenotransplantation
GEO Series GSE58299. Homo sapiens. 36 samples. Type: Expression profiling by array.
Clinical and molecular correlation defines activity of physiological pathways in life-sustaining kidney xenotransplantation [RNA-Seq]
GEO Series GSE216029. Sus scrofa. 9 samples. Type: Expression profiling by high throughput sequencing.
Gene expression changes induced by BAY1436032 (IDH1mut inhibitor) in sorted human (CD45+) cells from bone marrow of IDH1mut patient derived xenotransplantation mice model
GEO Series GSE83485. Homo sapiens. 6 samples. Type: Expression profiling by array.
Clinical and molecular correlation defines activity of physiological pathways in life-sustaining kidney xenotransplantation [scRNA-Seq]
GEO Series GSE216033. Sus scrofa. 8 samples. Type: Expression profiling by high throughput sequencing.
Clinical and molecular correlation defines activity of physiological pathways in life-sustaining kidney xenotransplantation
GEO Series GSE216034. Sus scrofa. 17 samples. Type: Expression profiling by high throughput sequencing.
scRNA-seq of Gene-edited Porcine Kidneys Prior to Xenotransplantation into Cynomolgus Macaques
GEO Series GSE210557. Sus scrofa. 4 samples. Type: Expression profiling by high throughput sequencing.
Cetacean single-nucleus RNA-sequencing positions the cardioprotective gene FHL2 as a target for advancing pig-to-human heart xenotransplantation
GEO Series GSE310739. Sus scrofa; Homo sapiens; Steno bredanensis. 7 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.