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38 results for “antifungal activity”
Antifungal activity of propolis extract against Candida albicans in patients with vulvovaginal candidiasis
<p>Abstract</p> <p><strong>Objective:</strong> To evaluate the antifungal activity of propolis extract against <em>Candida Albicans</em> (or <em>C. Albicans</em>) in patients with vulvovaginal candidiasis.</p> <p><strong>Method:</strong> The research presents a quantitative approach with an experimental design, with a population of <em>C. Albicans</em> strains isolated from patients diagnosed with vulvovaginal candidiasis who were admitted to the Gynecology Service of the Maria del Socorro Clinic, district of Ate - Lima, from which a sample of 34 strains was chosen in total, considering three repetitions per strain, obtaining 102 experimental units.</p> <p>The antifungal susceptibility test was carried out by the disc diffusion plate method using a single concentration of propolis extract, with fluconazole as a positive control.</p> <p><strong>Resultados:</strong> Propolis extract was shown to inhibit all strains of <em>C. albicans</em>, as was fluconazole, with the effect of the latter being significantly greater than that of the product under investigation.</p> <p><strong>Conclusion:</strong> The conclusion is that propolis extract does show antifungal activity against <em>C. albicans</em> in patients with vulvovaginal candidiasis.</p> <p><strong>Keywords:</strong> Propolis extract, <em>Candida Albicans</em>, Antifungal activity, Vulvovaginal candidiasis.</p> <p> </p>
Bacterial mediated green synthesis of silver nanoparticles and their antibacterial and antifungal activities against drug-resistant pathogens
<p>In the healthcare sector, the production of bioactive silver nanoparticles (AgNPs) with antimicrobial properties is of great importance. In this study, a novel bacterial strain, <em>Paenibacillus</em> sp. MAHUQ-63, was identified as a potential candidate for facile and rapid biosynthesis of AgNPs. The synthesized AgNPs were used to control the growth of human pathogens, <em>Salmonella</em> Enteritidis and <em>Candida</em> <em>albicans</em>. The bacterial culture supernatant was utilized to synthesize the nanoparticles. FE-TEM examination showed spherical-shaped nanoparticles with 15 to 55 nm in size. FTIR analysis identified various functional groups. The synthesized AgNPs demonstrated remarkable activity against <em>S</em>. Enteritidis and <em>C. albicans</em>. The zone of inhibition (ZOI) for 100 µL (0.5 mg/mL) of AgNPs against <em>S</em>. Enteritidis and <em>Candida</em> <em>albicans</em> were 18.0 ± 1.0 and 19.5 ± 1.3 mm, respectively. The minimum inhibitory concentrations (MICs) were 25.0 and 12.5 μg/mL against <em>S</em>. Enteritidis and <em>Candida albicans</em>, respectively. Additionally, the minimum bactericidal concentrations (MBC) were 25.0 μg/mL against both pathogenic microbes. The FE-SEM analysis showed that the treatment of AgNPs caused morphological and structural damage to both <em>S</em>. Enteritidis and <em>Candida albicans</em>. Therefore, these AgNPs can be used as a new and effective antimicrobial agent.</p>
Bacterial mediated green synthesis of silver nanoparticles and their antibacterial and antifungal activities against drug-resistant pathogens
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Data from: Young but not defenseless: antifungal activity during embryonic development of a social insect
Termites live in environments heavily colonized by diverse microbial communities, including pathogens. Eggs laid within the nest likely experience similar pathogenic pressures as their older nestmates. Consequently, they may have also been under selective pressures to be immune-competent. Through in vitro experiments, we tested the ontogeny, location and strength of embryos' antifungal activity against the fungus Metarhizium brunneum. Extraembryonic washes and intraembryonic components were incubated with fungal conidia, which was then scored for viability. Fungistatic activity was location- and stage-dependent. Extraembryonic washes had relatively weak antifungal activity. Conversely, intraembryonic contents were highly antifungal, exhibiting increased potency through development. Boiling both embryonic washes and intraembryonic contents rescued conidia viability, indicating the antifungal agent(s) is (are) likely proteinaceous. Embryonic protein profiles shifted from putative vitellogenins in young embryos to multiple proteins in subsequent stages, suggesting that the increase in fungistatic activity may be due to the expression of endogenous proteins during embryogenesis. This study is the first to address embryonic antifungal activity in a hemimetabolous eusocial taxon. Our results support the hypothesis that microbes have been significant agents of selection, fostering the evolution of antifungal properties even in the most immature and supposed, most vulnerable stage of development.
ZIF-8 encapsulation improves the antifungal activity of benzaldehyde and methyl anthranilate in films
<p>Relevant Data for publication wit DOI <a title="Link to landing page via DOI" href="https://doi.org/10.1039/D3DT03229A">10.1039/D3DT03229A</a></p>
Fig. 2 in Terpenoids from the Chinese liverwort Odontoschisma grosseverrucosum and their antifungal virulence activity
Fig. 2. Selected HMBC (H→C), 1H–1H COSY (H▬H) and NOESY correlations (H↔H) of 1 (A/B), 4 (D/E), 8 (F\G) and the X-ray crystallographic structure of 3 (C).
Fig. 3 in Terpenoids from the Chinese liverwort Odontoschisma grosseverrucosum and their antifungal virulence activity
Fig. 3. (A) The inhibition effect of compound 1 on the morphologic transition. (B) The inhibitory effect of compound 1 on the adhesion of C. albicans to A549 cells. (C) The number of adherent cells was determined by measuring the total size of the picture. The bars represent means ± SDs. * denotes P <0.05, **P <0.01, and ***P <0.001. (D) The inhibition effect of compound 1 on C. albicans biofilm formation. (E) The biofilm was detected with a CCK-8 reduction assay. The bars represent means ± SDs. * denotes P <0.05, and ** denotes P <0.01. (F) The downregulation of genes that are involved in virulence of C. albicans. The bars represent means ± SDs. * denotes P <0.05, **P <0.01, and ***P <0.001.
Fig. 2 in Identification, characterization, and antifungal activity of cysteine peptidases from Calotropis procera latex
Fig. 2. Three-dimensional models of cysteine peptidases from Calotropis procera (CpCP A, CpCP C and CpCP D). The models were generated with the SWISSMODEL platform and show their active sites for proteolytic activity, which are constituted by the triad Cys, Asn and His. The cysteine peptidase (PDB: 1BY8) was used as a reference.
Fig. 7 in Identification, characterization, and antifungal activity of cysteine peptidases from Calotropis procera latex
Fig. 7. Detection of ROS in spores of F. oxysporum after treatment with latex peptidases (CpCP1, CpCP2 and CpCP3) or inhibited with iodoacetamide (CpCP 1-IAA, CpCP 2-IAA and CpCP 3-IAA). Uptake of DAB was identified by the presence of a reddish-brown precipite. Samples (50 μg/mL) were incubated with spores for 30 min at 27 ̊C, pH 7.0. Control: 50 mM sodium phosphate buffer (pH 7.0). (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Fig. 1 in Identification, characterization, and antifungal activity of cysteine peptidases from Calotropis procera latex
Fig. 1. Multiple amino acid sequence alignment of C. procera cysteine peptidases. Sequence alignment was performed with C. procera cysteine peptidases (CpCP A-E), (SnuCalCp 01–20), procerain B, procerain and papain. The highly conserved cysteine residues that participate in the disulfide bond formation are highlighted in gray and the conserved residues involved in the active site are indicated by vertical black arrows.
Fig. 4 in Identification, characterization, and antifungal activity of cysteine peptidases from Calotropis procera latex
Fig. 4. Antifungal activity of three cysteine peptidases (CpCP1, CpCP2 and CpCP3) from Calotropis procera latex on Fusarium oxysporum and Colletotrichum acutatum. The fungal growth was measured by absorbance at 620 nm after 72 h at 27 ̊C. Control: 50 mM sodium phosphate buffer (pH 7.0, containing 1 mM L-Cysteine). The samples were dissolved in 50 mM sodium phosphate buffer, containing 1 mM L-cysteine, at 50 μg/mL. Different letters indicate statistical difference compared with the control (p <0.05).
Fig. 6 in Identification, characterization, and antifungal activity of cysteine peptidases from Calotropis procera latex
Fig. 6. Membrane permeabilization induced by cysteine peptidases from Calotropis procera latex in spores of Fusarium oxysporum. Peptidases (50 μg/mL) were incubated with spore suspensions (2 × 106 spores/mL) for 30 min at 27 ̊C and then the fluorescence of propidium iodide was detected using fluorescence microscopy. Bars: 5 μm. Control: 50 mM sodium phosphate buffer (pH 7.0).
Fig. 5 in Identification, characterization, and antifungal activity of cysteine peptidases from Calotropis procera latex
Fig. 5. Atomic force microscopic images of Fusarium oxysporum spores treated with the three cysteine peptidases from Calotropis procera (CpCP1, CpCP2 and CpCP3). The changes in the cell morphology (gray arrows) and the leakage of cellular (white arrows) content in the vicinity of the spores treated with peptidases can be observed. Peptidases (50 μg/ mL) were incubated with spore suspensions for 30 min at 27 ̊C. Control: 50 mM sodium phosphate buffer (pH 7.0).
Glucosamine Sulphate and Ginkgo Biloba as Antifungal Activity for Treating Tinea Pedis
ClinicalTrials.gov study NCT02882438. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Data from: Antifungal activity of water-stable copper-containing metal–organic frameworks
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Data from: Young but not defenseless: antifungal activity during embryonic development of a social insect
Open the record for dataset details and reuse information.
Young but not defenseless: Antifungal activity during embryonic development of a social insect
<p> Termites live in environments heavily colonized by diverse microbial communities, including pathogens. Eggs laid within the nest likely experience similar pathogenic pressures as their older nestmates. Consequently, they may have also been under selective pressures to be immune-competent. Through <i>in vitro</i> experiments, we tested the ontogeny, location and strength of embryos' antifungal activity against the fungus <i>Metarhizium brunneum</i>. Extraembryonic washes and intraembryonic components were incubated with fungal conidia, which was then scored for viability. Fungistatic activity was location- and stage-dependent. Extraembryonic washes had relatively weak antifungal activity. Conversely, intraembryonic contents were highly antifungal, exhibiting increased potency through development. Boiling both embryonic washes and intraembryonic contents rescued conidia viability, indicating the antifungal agent(s) is (are) heat-sensitive, and likely proteinaceous. Embryonic protein profiles shifted from putative vitellogenins in young embryos to multiple proteins in subsequent stages, suggesting that the increase in fungistatic activity may be due to the expression of endogenous proteins during embryogenesis. This study is the first to address embryonic antifungal activity in a hemimetabolous, eusocial taxon. Our results support the hypothesis that microbes have been significant agents of selection, fostering the evolution of antifungal properties in termite eggs, the most immature and supposed, most vulnerable stage of development.</p>
Figure 1 from: Hrytsyk RA, Kutsyk RV, Yurchyshyn OI, Struk ОА, Kireev IV, Grytsyk AR (2021) The investigation of antimicrobial and antifungal activity of some Artemisia L. species. Pharmacia 68(1): 93-100. https://doi.org/10.3897/pharmacia.68.e47521
Figure 1 Antimicrobial activity of Artemisia absinthium L., Artemisia vulgaris L., Artemisia abrotanum L. extracts in relation to the test cultures of microorganisms: АEsherichia coli, BStaphylococcus epidermidis, CCandida tropicalis, DAspergillus niger, EEnterococcus faecalis, FStaphylococcus aureus
Data for / Comparison of Antifungal Activity of Thymus Vulgaris Essential Oil and Triple Antibiotic Paste Against Candida Albicans Isolated from Root Canal (In Vitro Study)
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Figure 1 from: Fadhilah QG, Santoso I, Maryanto AE, Abdullah S, Yasman Y (2021) Evaluation of the antifungal activity of marine actinomycetes isolates against the phytopathogenic fungi Colletotrichum siamense KA: A preliminary study for new antifungal compound discovery. Pharmacia 68(4): 837-843. https://doi.org/10.3897/pharmacia.68.e72817
Figure 1 Results of the antibiosis assay of SM14 isolate in PDA filtrate medium. A. control, B. 6 days, C. 9 days, D. 12 days.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.