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24 results for “biological substances”
Physical stabilization of water-soluble PVA nanofibrous materials functionalized with biologically active substances
<p>Tissue engineering aims to develop materials that enhance biological activity and promote tissue healing and regeneration. One promising approach is to functionalize nanofibrous materials with antimicrobial substances, such as lipophosphonoxin (LPPO), and use water-soluble polymers like polyvinyl alcohol (PVA) to incorporate bioactive molecules into fibers. However, water-soluble materials often face the issue of "burst release," releasing over 90% of the active substances within the initial 24 hours. This research focuses on preparing functionalized nanofibrous materials based on PVA containing the experimental antimicrobial compound LPPO and subsequent physical stabilization of the materials using the "Heat treatment" method. The applied stabilization successfully reduced the incorporated substance's release rate by up to 50%. The resulting materials have the potential to provide functional cross-linked PVA nanofiber scaffolds for regenerative medicine applications in large and chronic skin injuries.</p>
Supporting Information from The Next Frontier of Environmental Unknowns: Substances of Unknown or Variable Composition, Complex Reaction Products, or Biological Materials (UVCBs)
<p>Supporting Information (Open Data) from The Next Frontier of Environmental Unknowns: Substances of Unknown or Variable Composition, Complex Reaction Products, or Biological Materials (UVCBs)</p>
Figure 2 from: Hadzhieva BR, Mihaylova AA, Dimitrov MV, Kilova KP (2024) Changes in the list of over-the-counter drugs containing biologically active substances of plant origin which are intended to be applied among pediatric patients in Bulgaria. Pharmacia 71: 1-5. https://doi.org/10.3897/pharmacia.71.e121793
Figure 2 OTC drugs containing BAS of plant origin, a derivative or and in a combined composition applied among children aged 0+ - 18 years.
Figure 1 from: Hadzhieva BR, Mihaylova AA, Dimitrov MV, Kilova KP (2024) Changes in the list of over-the-counter drugs containing biologically active substances of plant origin which are intended to be applied among pediatric patients in Bulgaria. Pharmacia 71: 1-5. https://doi.org/10.3897/pharmacia.71.e121793
Figure 1 Distribution of the OTC drugs based on the active substance, which are intended to be applied among pediatric patients.
Figure 3 from: Hadzhieva BR, Mihaylova AA, Dimitrov MV, Kilova KP (2024) Changes in the list of over-the-counter drugs containing biologically active substances of plant origin which are intended to be applied among pediatric patients in Bulgaria. Pharmacia 71: 1-5. https://doi.org/10.3897/pharmacia.71.e121793
Figure 3 ОТС drugs containing BAS of plant origin, a derivative or and in a combined composition applied among children with various indications.
Figure 5 from: Dadayan AS, Stepanyan LA, Sargsyan TH, Hovhannisyan AM, Dadayan SA (2021) Quantitative analysis of biologically active substances and the investigation of antioxidant and antimicrobial activities of some extracts of Osage orange fruits. Pharmacia 68(4): 731-739. https://doi.org/10.3897/pharmacia.68.e70180
Figure 5 Results of quantification and identification of flavonoids in ethanol extract of Osage Orange.
Figure 4 from: Dadayan AS, Stepanyan LA, Sargsyan TH, Hovhannisyan AM, Dadayan SA (2021) Quantitative analysis of biologically active substances and the investigation of antioxidant and antimicrobial activities of some extracts of Osage orange fruits. Pharmacia 68(4): 731-739. https://doi.org/10.3897/pharmacia.68.e70180
Figure 4 Results of quantification and identification of flavonoids in aqueous extract of Osage Orange.
Figure 10 from: Dadayan AS, Stepanyan LA, Sargsyan TH, Hovhannisyan AM, Dadayan SA (2021) Quantitative analysis of biologically active substances and the investigation of antioxidant and antimicrobial activities of some extracts of Osage orange fruits. Pharmacia 68(4): 731-739. https://doi.org/10.3897/pharmacia.68.e70180
Figure 10 Evaluation of the antimicrobial activity of Osage Orange extracts on strains of Bacillus subtilis 1820, E. Coli 5002, Serratia marcescens 5251 and Staphylococcus aureus ATCC-6538.
Figure 6 from: Dadayan AS, Stepanyan LA, Sargsyan TH, Hovhannisyan AM, Dadayan SA (2021) Quantitative analysis of biologically active substances and the investigation of antioxidant and antimicrobial activities of some extracts of Osage orange fruits. Pharmacia 68(4): 731-739. https://doi.org/10.3897/pharmacia.68.e70180
Figure 6 Results of quantification and identification of flavonoids in ethyl acetate extract of Osage Orange.
An add-on Study to the FIGARO-DKD Study Called FIGARO-BM to Learn About the Link Between Biomarkers (Substances in the Blood Used as Indicators of Biological Processes, Disease Processes or Responses
ClinicalTrials.gov study NCT05013008. IPD Sharing: NO. Countries: 21. Publications: 0.
Figure 2 from: Esad M, Popova M, Apostolova E, Bivolarska A (2024) Signal transduction in wound healing: The effects of plant-derived biologically active substances. Pharmacia 71: 1-7. https://doi.org/10.3897/pharmacia.71.e117793
Figure 2 Content and effects of M. vulgare methanolic extract.
Figure 3 from: Esad M, Popova M, Apostolova E, Bivolarska A (2024) Signal transduction in wound healing: The effects of plant-derived biologically active substances. Pharmacia 71: 1-7. https://doi.org/10.3897/pharmacia.71.e117793
Figure 3 Effects of V. Vinifera on wound healing.
Figure 1 from: Esad M, Popova M, Apostolova E, Bivolarska A (2024) Signal transduction in wound healing: The effects of plant-derived biologically active substances. Pharmacia 71: 1-7. https://doi.org/10.3897/pharmacia.71.e117793
Figure 1 Inflammatory stage of early healing.
Figure 4 from: Hadzhieva BR, Mihaylova AA, Dimitrov MV, Kilova KP (2024) Changes in the list of over-the-counter drugs containing biologically active substances of plant origin which are intended to be applied among pediatric patients in Bulgaria. Pharmacia 71: 1-5. https://doi.org/10.3897/pharmacia.71.e121793
Figure 4 ОТС drugs with BAS of plant origin applied among children with a cold and flu.
Figure 8 from: Dadayan AS, Stepanyan LA, Sargsyan TH, Hovhannisyan AM, Dadayan SA (2021) Quantitative analysis of biologically active substances and the investigation of antioxidant and antimicrobial activities of some extracts of Osage orange fruits. Pharmacia 68(4): 731-739. https://doi.org/10.3897/pharmacia.68.e70180
Figure 8 Quantitative content of vitamin C in ethanol extract of Osage Orange.
Figure 7 from: Dadayan AS, Stepanyan LA, Sargsyan TH, Hovhannisyan AM, Dadayan SA (2021) Quantitative analysis of biologically active substances and the investigation of antioxidant and antimicrobial activities of some extracts of Osage orange fruits. Pharmacia 68(4): 731-739. https://doi.org/10.3897/pharmacia.68.e70180
Figure 7 Quantitative content of vitamin C in aqueous extract of Osage Orange.
Figure 3 from: Dadayan AS, Stepanyan LA, Sargsyan TH, Hovhannisyan AM, Dadayan SA (2021) Quantitative analysis of biologically active substances and the investigation of antioxidant and antimicrobial activities of some extracts of Osage orange fruits. Pharmacia 68(4): 731-739. https://doi.org/10.3897/pharmacia.68.e70180
Figure 3 Results of chromatography of organic acids in ethyl acetate extract of Osage Orange.
Figure 1 from: Dadayan AS, Stepanyan LA, Sargsyan TH, Hovhannisyan AM, Dadayan SA (2021) Quantitative analysis of biologically active substances and the investigation of antioxidant and antimicrobial activities of some extracts of Osage orange fruits. Pharmacia 68(4): 731-739. https://doi.org/10.3897/pharmacia.68.e70180
Figure 1 Results of chromatography of organic acids in aqueous extract of Osage Orange.
Figure 9 from: Dadayan AS, Stepanyan LA, Sargsyan TH, Hovhannisyan AM, Dadayan SA (2021) Quantitative analysis of biologically active substances and the investigation of antioxidant and antimicrobial activities of some extracts of Osage orange fruits. Pharmacia 68(4): 731-739. https://doi.org/10.3897/pharmacia.68.e70180
Figure 9 Quantitative content of vitamin C in ethyl acetate extract of Osage Orange.
Figure 2 from: Dadayan AS, Stepanyan LA, Sargsyan TH, Hovhannisyan AM, Dadayan SA (2021) Quantitative analysis of biologically active substances and the investigation of antioxidant and antimicrobial activities of some extracts of Osage orange fruits. Pharmacia 68(4): 731-739. https://doi.org/10.3897/pharmacia.68.e70180
Figure 2 Results of chromatography of organic acids in ethanol extract of Osage Orange.
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Allen Brain Atlas
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International Brain Laboratory public data
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OpenNeuro
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