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21 results for “bone strain”
INFLUENCE OF DENTAL IMPLANT INSERTION DEPTH ON STRAIN IN PERIIMPLANT BONE TISSUE
<p>Geometry models of cortical and cancellous bone tissue for the conference paper "Influence of dental implant insertion depth on strain in periimplant bone tissue".</p>
The Effect of Bone Graft Substitute in Healing Fractures with Bone Defects Through Examination of Alkaline Phosphatase and Radiology in the Murine Model (Rattus norvegicus) Wistar strain
<p>Raw data for manuscript with the title <strong>The Effect of Bone Graft Substitute in Healing Fractures with Bone Defects Through Examination of Alkaline Phosphatase and Radiology in the Murine Model (<em>Rattus norvegicus</em>) Wistar strain </strong></p>
Data from: Subchondral bone fatigue injury in the parasagittal condylar grooves of the third metacarpal bone in Thoroughbred racehorses elevates site-specific strain concentration
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BONE STRAIN INDEX AS A PREDICTOR OF FURTHER VERTEBRAL FRACTURE IN OSTEOPOROTIC WOMEN
<p>Background: Osteoporosis is an asymptomatic disease of high prevalence and incidence, leading to bone fractures burdened by high mortality and disability, mainly when several subsequent fractures occur. A fragility fracture predictive model, Artificial Intelligence-based, to identify dual X-ray absorptiometry (DXA) variables able to characterise those patients who are prone to further fractures called Bone Strain Index, was evaluated in this study.</p> <p>Methods: In a prospective, longitudinal, multicentric study 172 female outpatients with at least one vertebral fracture at the first observation were enrolled. They performed a spine X-ray to calculate spine deformity index (SDI) and a lumbar and femoral DXA scan to assess bone mineral density (BMD) and bone strain index (BSI) at baseline and after a follow-up period of 3 years in average. At the end of the follow-up, 93 women developed a further vertebral fracture. The further vertebral fracture was considered as one unit increase of SDI. We assessed the predictive capacity of supervised Artificial Neural Networks (ANNs) to distinguish women consistently with a further fracture from those without a further fracture and to identify the variables expressing the maximal amount of relevant information to discriminate the two groups. ANNs were allowed to choose relevant input data automatically (TWIST-system). Moreover, we constructed a semantic connectivity map with Auto Contractive Map to offer some insight regarding the complex biological connections among the studied variables and the two conditions (further fracture vs no further fracture).</p> <p>Results: TWIST system selected 5 out of 13 available variables: age, menopause age, BMI, FTot BMC, FTot BSI. With training testing procedure, ANNs reached predictive accuracy of 79.36%, with a sensitivity of 75% and a specificity of 83.72%. The semantic connectivity map highlighted the role of BSI in predicting the risk of a further fracture.</p> <p>Conclusions: Artificial Intelligence is a useful method to analyse a complex system like that regarding osteoporosis, able to identify patients prone to a further fragility fracture. BSI appears to be a useful DXA index in identifying those patients who are at risk of further vertebral fractures.</p>
The Effect of the Probiotic Strains on Bone Mineral Density in Postmenopausal Women
ClinicalTrials.gov study NCT06375668. IPD Sharing: NO. Countries: 1. Publications: 1.
METHODS. Bovine ilia were used in the simulations because their histological structure (a fibrolamellar cortex overlying cancellous bone26) was found to match that of the Triceratops ilium. Bone sections 10 x 50 x 縠 3.0 cm with cortices ranging from 0.5 to 5.5 mm in depth (the range of initial cortical-thickness estimates based on gross morphology) were mounted on a servohydraulic mechanical loading frame (MTS Bionix, Minneapolis) and penetrated with an aluminium-bronze T. rex tooth replica. The replica was cast from an actual adult T. rex maxillary tooth, after casts made from some ofthe deeper bite marks revealed the size and shape of the teeth that had impacted the pelvis8 • The replica was penetrated into the ilia sections at 1 mm s-1 to a depth of 11.5 mm, equivalent to the maximum depth of the deepest ilium bite mark8 • Forces were measured with an MTS 25 N strain-gauge-based axial load cell accurate to 0.2%. The forces increased with increasing penetration depth even after the cortical layer had been perforated and the underlying cancellous bone was being crushed. The increase in force with penetration depth is attributed to a greater cortical surface area coming into contact with the semi-conical penetrator tooth as it descended through the ilia. in Bite-force estimation for Tyrannosaurus rex from tooth-marked bones
METHODS. Bovine ilia were used in the simulations because their histological structure (a fibrolamellar cortex overlying cancellous bone26) was found to match that of the Triceratops ilium. Bone sections 10 x 50 x 縠 3.0 cm with cortices ranging from 0.5 to 5.5 mm in depth (the range of initial cortical-thickness estimates based on gross morphology) were mounted on a servohydraulic mechanical loading frame (MTS Bionix, Minneapolis) and penetrated with an aluminium-bronze T. rex tooth replica. The replica was cast from an actual adult T. rex maxillary tooth, after casts made from some ofthe deeper bite marks revealed the size and shape of the teeth that had impacted the pelvis8 • The replica was penetrated into the ilia sections at 1 mm s-1 to a depth of 11.5 mm, equivalent to the maximum depth of the deepest ilium bite mark8 • Forces were measured with an MTS 25 N strain-gauge-based axial load cell accurate to 0.2%. The forces increased with increasing penetration depth even after the cortical layer had been perforated and the underlying cancellous bone was being crushed. The increase in force with penetration depth is attributed to a greater cortical surface area coming into contact with the semi-conical penetrator tooth as it descended through the ilia.
Data from: Differential changes in bone strength of two inbred mouse strains following administration of a sclerostin-neutralizing antibody during growth
Administration of sclerostin-neutralizing antibody (Scl-Ab) treatment has been shown to elicit an anabolic bone response in growing and adult mice. Prior work characterized the response of individual mouse strains but did not establish whether the impact of Scl-Ab on whole bone strength would vary across different inbred mouse strains. Herein, we tested the hypothesis that two inbred mouse strains (A/J and C57BL/6J (B6)) will show different whole bone strength outcomes following sclerostin-neutralizing antibody (Scl-Ab) treatment during growth (4.5 – 8.5 weeks of age). Treated B6 femurs showed a significantly greater stiffness (S) (68.8% vs. 46.0%) and maximum load (ML) (84.7% vs. 44.8%) compared to A/J. Although treated A/J and B6 femurs showed greater cortical area (Ct.Ar) similarly relative to their controls (37.7% in A/J and 41.1% in B6), the location of new bone deposition responsible for the greater mass differed between strains and may explain the greater whole bone strength observed in treated B6 mice. A/J femurs showed periosteal expansion and endocortical infilling, while B6 femurs showed periosteal expansion. Post-yield displacement (PYD) was smaller in treated A/J femurs (-61.2%, p < 0.001) resulting in greater brittleness compared to controls; an effect not present in B6 mice. Inter-strain differences in S, ML, and PYD led to divergent changes in work-to-fracture (Work). Work was 27.2% (p = 0.366) lower in treated A/J mice and 66.2% (p < 0.001) greater in treated B6 mice relative to controls. Our data confirmed the anabolic response to Scl-Ab shown by others, and provided evidence suggesting the mechanical benefits of Scl-Ab administration may be modulated by genetic background, with intrinsic growth patterns of these mice guiding the location of new bone deposition. Whether these differential outcomes will persist in adult and elderly mice remains to be determined.
Data from: Differential changes in bone strength of two inbred mouse strains following administration of a sclerostin-neutralizing antibody during growth
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Expression data from mouse bone marrow macrophages from a strain intercross
GEO Series GSE8512. Mus musculus. 207 samples. Type: Expression profiling by array.
Bone marrow progenitors and IL-2 signaling contribute to the strain differences of kidney innate lymphoid cells
GEO Series GSE208404. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Bone gene expression profiles after ovariectomy in multiple inbred strains
GEO Series GSE68303. Mus musculus. 23 samples. Type: Expression profiling by array.
Transcriptional response of Mycobacterium tuberculosis ΔlucA::hyg and complemented strains vs. WT in resting murine bone marrow-derived macrophages
GEO Series GSE98792. Mycobacterium tuberculosis. 16 samples. Type: Expression profiling by array.
5-strain Probiotic Formulation in HR-positive Breast Cancer Receiving Aromatase Inhibitor to Prevent Bone Loss
ClinicalTrials.gov study NCT07044310. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Does Vibration Therapy Induce Higher Than Normal Bone Strains and Strain Rates Than Those Experienced During Habitual Daily Activities
ClinicalTrials.gov study NCT01430858. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Transcriptomic analysis by Next Generation Sequencing of mouse bone marrow derived macrophages (BMDMs) infected by Wild-Type and gra18 mutant strains of T. gondii.
GEO Series GSE103113. Mus musculus; Toxoplasma gondii. 8 samples. Type: Expression profiling by high throughput sequencing.
Comparative analysis of genome-wide gene expression profiles in heart, liver, spleen, ears and bone marrow in the murine strains of MRL/MpJ, C57B/6J, and Balb/C
GEO Series GSE64624. Mus musculus. 15 samples. Type: Expression profiling by array.
Gene Expression Timecourse of WT, DUBmut, and EndoUmut Mouse Hepatitis Virus Strain A59 infected C57bl/6 Bone Marrow derived macrophages
GEO Series GSE144882. Mus musculus. 39 samples. Type: Expression profiling by high throughput sequencing.
Distinct gene expression patterns of ‘multipotent' versus ‘unipotent' single colony-derived strains (SCDSs) of human bone marrow stromal cells (BMSCs)
GEO Series GSE64789. Homo sapiens. 6 samples. Type: Expression profiling by array.
Malaria Host Pathogen Interaction Center Experiment 03: Host and parasite gene transcript abundance measures from bone marrow for Macaca mulatta infected with Plasmodium coatneyi Hackeri strain from 7
GEO Series GSE103042. Macaca mulatta; Plasmodium coatneyi. 35 samples. Type: Expression profiling by high throughput sequencing.
Mouse bone marrow-derived macrophages infected with T. gondii (Type I, RH strain) for 6 hr
GEO Series GSE27972. Mus musculus. 6 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.