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9 results for “centriole”
Homogeneous multifocal excitation for high-throughput super-resolution imaging - Expanded centriole particles
<p>Datasets containing the segmented expanded centriole particles. The prefix Hs is used to denote particles acquired in synchronized RPE-1 human cells. Otherwise particles were collected from expanded isolated centrioles from <em>Chlamydomoanas reinhardtii</em>. Resized datasets have uniform voxel size of 14x14x14 nm3 after expansion (56x56x56 nm3 before expansion). Non-resized datasets have 14x14x30 pixel size (56x56x120 nm3 before expansion). All files should be mirrored horizontally/vertically to account for the chirality inversion due to the imaging process</p> <p>The channels in different datasets are:</p> <ul> <li>Chlamy acetylated sample: <ul> <li>C1: acetylated tubulin-Alexa488</li> <li>C2: aTubulin-Alexa568</li> </ul> </li> <li>Chlamy MonoE sample <ul> <li>C1: aTubulin-Alexa488</li> <li>C2: GT335-Alexa568</li> </ul> </li> <li>Chlamy PolyE sample <ul> <li>C1: PolyE-Alexa488</li> <li>C2: aTubulin-Alexa568</li> </ul> </li> <li>Hs sample: <ul> <li>C1: PolyE-Alexa488</li> <li>C2: acetylated tubulin-Alexa586</li> </ul> </li> </ul>
Dataset for Extensive programmed centriole elimination unveiled in C. elegans embryos
<p>Spreadsheets, confocal and wide field microscopy images and related scripts. Related to the publication "Extensive programmed centriole elimination unveiled in C. elegans embryos." For the complete dataset, please refer to https://doi.org/10.5075/epfl-upgon-305930 </p>
Evolutionary conservation of centriole rotational asymmetry in the human centrosome
<p><span>Centrioles are formed by microtubule triplets in a nine-fold symmetric arrangement. In flagellated protists and in animal multiciliated cells, accessory structures tethered to specific triplets render the centrioles rotationally asymmetric, a property that is key to cytoskeletal and cellular organization in these contexts. In contrast, centrioles within the centrosome of animal cells display no conspicuous rotational asymmetry. Here, we uncover rotationally asymmetric molecular features in human centrioles. Using ultrastructure expansion microscopy, we show that LRRCC1, the ortholog of a protein originally characterized in flagellate green algae, associates preferentially to two consecutive triplets in the distal lumen of human centrioles. LRRCC1 partially co-localizes and affects the recruitment of another distal component, C2CD3, which also has an asymmetric localization pattern in the centriole lumen. Together, LRRCC1 and C2CD3 delineate a structure reminiscent of a filamentous density observed by electron microscopy in flagellates, termed the 'acorn'. Functionally, the depletion of LRRCC1 in human cells induced defects in centriole structure, ciliary assembly and ciliary signaling, supporting that LRRCC1 cooperates with C2CD3 to organizing the distal region of centrioles. Since a mutation in the <em>LRRCC1</em> gene has been identified in Joubert syndrome patients, this finding is relevant in the context of human ciliopathies. Taken together, our results demonstrate that rotational asymmetry is an ancient property of centrioles that is broadly conserved in human cells. Our work also reveals that asymmetrically localized proteins are key for primary ciliogenesis and ciliary signaling in human cells.</span></p>
Evolutionary conservation of centriole rotational asymmetry in the human centrosome
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The SON splicing factor is required for intracellular trafficking that promotes centriole assembly
GEO Series GSE164278. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Multicilin drives centriole biogenesis via E2f proteins
GEO Series GSE59309. Xenopus laevis. 22 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Differential gene expression in embryonic lung and small intestine after epithelial deletion of centrioles
GEO Series GSE188585. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
The Unkempt RNA binding protein reveals a local translation program in centriole overduplication
GEO Series GSE297133. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
Multicilin promotes centriole assembly and ciliogenesis during multiciliate cell differentiation.
GEO Series GSE32452. Xenopus laevis. 4 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.