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10,107 results for “chemotherapy”
TCGA Chemotherapy Response Dataset
<p>Dataset on chemotherapeutic drug responses in TCGA cancer patients, cross-referenced for a hit in TCIA.at database, consisting of clinical (TCGA), cancer tissue gene-expression (TCGA) and tumor-immunome (TCIA) features. The dataset consists of 5 common chemotherapy agents, 3 CRC agents (FOLFOX, 5FU, Oxaliplatin) and 2 Lung agents (Carboplatin, Cisplatin). FOLFOX as a combinational therapy or regimen, was compiled from timings of monotherapies given to patients and as such is a novel dataset derived from TCGA data. FOLFOX dataset is primarily firstline treatment, while other drugs are not to be interpreted as firstline treatments. Drug datasets are individually available in own CSV files.</p> <p><strong>Citation</strong><br> Dalibor Hrg, Balthasar Huber, Lukas A. Huber. (2020). TCGA Chemotherapy Response Dataset. Zenodo. <a href="http://doi.org/10.5281/zenodo.3719291">http://doi.org/10.5281/zenodo.3719291</a></p> <p>The results here are in whole or part based upon data generated by the TCGA Research Network: <a href="https://www.cancer.gov/about-nci/organization/ccg/research/structural-genomics/tcga">https://www.cancer.gov/tcga</a>.</p> <p><strong>License </strong><br> CC BY-SA 4.0 International <a href="https://creativecommons.org/licenses/by-sa/4.0">https://creativecommons.org/licenses/by-sa/4.0</a>. Authors take no liability for any use of this data.</p> <p><strong>Contributions</strong><br> D. Hrg and B. Huber acknowledge major and equal work effort: data understanding, data science and dataset preparation (monotherapies and FOLFOX); L. A. Huber: help with dictionary of drug names and curration/cleaning of FOLFOX entries, clinical validation.</p> <p><strong>Contact & Maintenance</strong><br> <a href="mailto:dalibor.hrg@gmail.com">dalibor.hrg@gmail.com</a><br> dalibor.hrg@i-med.ac.at</p>
Resources for Mitigating Chemotherapy Side Effects through Targeted Gamma-Ray Delivery and CNNs
<p>This repository includes datasets and code used in the study "Mitigating Chemotherapy Side Effects through Targeted Gamma-Ray Delivery and Convolutional Neural Networks." The resources comprise:<br>- Binding Affinity Data: Used for simulations.<br>- Brain Tumor MRI and Chest CT Scan Datasets: Used for model training.<br>- Lightweight Deep CNN: Code for building and testing models.</p>
Additional data: Longitudinal single-cell multiomic atlas of high-risk neuroblastoma reveals chemotherapy-induced tumor microenvironment rewiring
<p>This repository provides additional data for the manuscript titled "Longitudinal single-cell multiomic atlas of high-risk neuroblastoma reveals chemotherapy-induced tumor microenvironment rewiring", currently under revision at Nature Genetics. The primary data cohort has been deposited in the HTAN data portal. This repository includes processed 10x Xenium spatial transcriptomic data for six TH-MYCN mice (three chemotherapy-treated and three treatment-naive) as well as processed scRNA-seq data for CHLA15 and CHLA20 neuroblastoma (NBL) cells. The scRNA-seq data includes mono-cultured, co-cultured cells with THP-1 macrophages, and co-culture cells treated with Afatinib/CRM197. </p>
Alterations in Patterns of Gene Expression and Perturbed Pathways Associated With Chemotherapy-Induced Nausea
<p>This dataset contains the supplementary materials describing in detail the methods and the results of the analyses. The manuscript has been submitted for publication. Please cite both the paper as well as the DOI of this dataset if you make use of the data.</p>
A Data-Driven Epigenetic Characterization of Morning Fatigue Severity in Oncology Patients Receiving Chemotherapy: Associations with Epigenetic Age Acceleration, Blood Cell Types, and Expression-Associated Methylation
<p>This dataset contains supplementary materials including the eCpG mapping analysis results and annotation. The manuscript has been accepted for publication at Cancer Medicine. Please cite both the paper as well as the DOI of this dataset if you make use of the data.</p>
Modulation of the tumour promoting functions of cancer associated fibroblasts by phosphodiesterase type 5 inhibition increases the efficacy of chemotherapy in human preclinical models of esophageal adenocarcinoma
<p>These are whole-slide digital pathology images of esophageal adenocarcinoma (EAC) patient-derived xenograft models. EAC biopsy specimens were cultured <em>in vitro</em> before implanting into immuno-deficient mice. Mice were then divided into the following treatment groups and treated with combinations of chemotherapy and PDE5 inhibitors as follows:</p> <ol> <li>Untreated</li> <li>Epirubicin + Cisplatin + Capecitabine (ECX)</li> <li>ECX + Vardenafil</li> <li>ECX + Tadalafil</li> </ol> <p>All whole slide images are in Olympus .vsi format and can be opened using the BioFormats library in QuPath. We have also included classifiers and scripts for performing the digital pathology analysis in QuPath, and information to link each mouse with treatment groups and corresponding whole slide images.</p> <p>File metadata:</p> <p>classifiers.zip - Folder containing pixel classifiers used for segmentation of IHC stains. These classifiers are to be important into QuPath for the respective analysis of Periostin (POSTN) and alpha Smooth Muscle Actin (SMA) staining using the included Groovy scripts in the scripts folder.</p> <p>SMA.zip - Folder containing whole slide images of mouse patient-derived xenograft tumours in .vsi format (Olympus VS110). Immunohistochemistry with anti-alpha Smooth Muscle Actin antibody.<br> POSTN.zip - Folder containing whole slide images of mouse patient-derived xenograft tumours in .vsi format (Olympus VS110). Immunohistochemistry with anti-Periostin antibody.</p> <p>scripts.zip - Folder containing all groovy scripts used in QuPath for tissue detection (Whole Section Tissue Detection.groovy), and segmentation of POSTN (POSTN Quantification Mice.groovy) and SMA staining tissue areas (SMA Quantification Mice.groovy).</p> <p>POSTN.xlsx - Data on the mice for which anti-POSTN IHC is available. Column names as follows:<br> Image: file name (corresponding to .vsi file).<br> Mouse_ID: Mouse identifier.<br> Treatment: Treatment administered. ECX - Epirubicin, Cisplatin and Capecitabine.<br> POSTN_Area: Total measured area of POSTN+ tissue in the tissue section (in um^2).<br> Total_Area: Total area of the tissue section (in um^2).<br> percentage_POSTN: Percentage of total tissue area that is stained with POSTN (%).</p> <p>SMA.xlsx - Data on the mice for which anti-SMA IHC is available. Column names as follows:<br> Image: file name (corresponding to .vsi file).<br> Mouse_ID: Mouse identifier.<br> Treatment: Treatment administered. ECX - Epirubicin, Cisplatin and Capecitabine.<br> SMA_Area: Total measured area of SMA+ tissue in the tissue section (in um^2).<br> Total_Area: Total area of the tissue section (in um^2).<br> percentage_SMA: Percentage of total tissue area that is stained with SMA (%).</p>
Study to Compare the Combination of Ribociclib Plus Goserelin Acetate With Hormonal Therapy Versus Combination Chemotherapy in Premenopausal or Perimenopausal Patients With Advanced or Metastatic Brea
ClinicalTrials.gov study NCT03839823. IPD Sharing: YES. Countries: 13. Publications: 1.
Study of REGN 2810 Compared to Platinum-Based Chemotherapies in Participants With Metastatic Non-Small Cell Lung Cancer (NSCLC)
ClinicalTrials.gov study NCT03088540. IPD Sharing: YES. Countries: 24. Publications: 4.
Study to Assess the Safety and Efficacy of Midostaurin (PKC412) in Combination With Standard Chemotherapy During Induction and Consolidation Followed by 12 Months of Maintenance Monotherapy in Patient
ClinicalTrials.gov study NCT03379727. IPD Sharing: YES. Countries: 15. Publications: 1.
Platinum-Based Chemotherapy With/Without INCMGA00012, an Anti-PD-1 Antibody, in Non-Small Cell Lung Cancer
ClinicalTrials.gov study NCT04205812. IPD Sharing: YES. Countries: 17. Publications: 1.
LDK378 Versus Chemotherapy in Previously Untreated Patients With ALK Rearranged Non-small Cell Lung Cancer
ClinicalTrials.gov study NCT01828099. IPD Sharing: YES. Countries: 29. Publications: 2.
Chemotherapy and Lapatinib or Trastuzumab in Treating Women With HER2/Neu-Positive Metastatic Breast Cancer
ClinicalTrials.gov study NCT00667251. IPD Sharing: YES. Countries: 21. Publications: 3.
LDK378 Versus Chemotherapy in ALK Rearranged (ALK Positive) Patients Previously Treated With Chemotherapy (Platinum Doublet) and Crizotinib
ClinicalTrials.gov study NCT01828112. IPD Sharing: UNDECIDED. Countries: 20. Publications: 2.
Efficacy and Safety of Pazopanib Monotherapy After First Line Chemotherapy in Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
ClinicalTrials.gov study NCT00866697. IPD Sharing: UNDECIDED. Countries: 17. Publications: 7.
A Study of Tislelizumab (BGB-A317) in Combination With Chemotherapy as First Line Treatment in Participants With Advanced Esophageal Squamous Cell Carcinoma
ClinicalTrials.gov study NCT03783442. IPD Sharing: YES. Countries: 16. Publications: 2.
Using Romiplostim to Treat Low Platelet Counts Following Chemotherapy and Autologous Hematopoietic Cell Transplantation in People With Blood Cancer
ClinicalTrials.gov study NCT04478123. IPD Sharing: YES. Countries: 1. Publications: 1.
Quizartinib With Standard of Care Chemotherapy and as Continuation Therapy in Patients With Newly Diagnosed FLT3-ITD (+) Acute Myeloid Leukemia (AML)
ClinicalTrials.gov study NCT02668653. IPD Sharing: YES. Countries: 28. Publications: 4.
LOGiC - Lapatinib Optimization Study in ErbB2 (HER2) Positive Gastric Cancer: A Phase III Global, Blinded Study Designed to Evaluate Clinical Endpoints and Safety of Chemotherapy Plus Lapatinib
ClinicalTrials.gov study NCT00680901. IPD Sharing: YES. Countries: 23. Publications: 2.
OSE2101 Versus Chemotherapy in HLA-A2 Positive Patients With Advanced NSCLC After Immune Checkpoint Inhibitor Failure
ClinicalTrials.gov study NCT02654587. IPD Sharing: NO. Countries: 10. Publications: 1.
A Study of Epacadostat in Combination With Pembrolizumab and Chemotherapy in Participants With Advanced or Metastatic Solid Tumors (ECHO-207/KEYNOTE-723)
ClinicalTrials.gov study NCT03085914. IPD Sharing: YES. Countries: 1. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.