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415 results for “diterpenoid”
Data from: A high-quality genome assembly of the tetraploid Teucrium chamaedrys unveils a recent whole genome duplication and a large biosynthetic gene cluster for diterpenoid metabolism
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Supplementary material 1 from: Kola-Mustapha AT (2023) De novo design of pimarane diterpenoid compounds as potential alternatives to sarecycline for acne vulgaris treatment. Pharmacia 70(4): 1167-1176. https://doi.org/10.3897/pharmacia.70.e113065
Grid box within which Sandaracopimar-15-ene-6.beta., 8.beta.-diol binds is 192.5686 × 260.3472 × 119.6532 along the X, Y, Z-axis
Fig. 2 in Two seco-norabietane diterpenoids with unprecedented skeletons from the roots of Salvia abrotanoides (Kar.) Sytsma
Fig. 2. (A) Key HMBC (blue arrows), 1H–1H COSY (red bonds) correlations of compounds 1 and 2, and (B) NOESY correlations of compound 1. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Fig. 5 in Bond reactivity indices approach analysis of the [2+2] cycloaddition of jatrophane skeleton diterpenoids from Euphorbia gaditana Coss to tetracyclic gaditanone
Fig. 5. Selected NOESY correlations exhibited by 4. β-face correlations in red and α-face correlations in blue. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Fig. 2 in Ent-abietane and ent-pimarane diterpenoids from Croton mubango (Euphorbiaceae)
Fig. 2. Calculated (ent- and normal series) and experimental ECD spectra for compounds 1, 2, 4 and 14.
Fig. 6 in Bond reactivity indices approach analysis of the [2+2] cycloaddition of jatrophane skeleton diterpenoids from Euphorbia gaditana Coss to tetracyclic gaditanone
Fig. 6. Selected NOESY correlations exhibited by 5. β-face correlations in red and α-face correlations in blue. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Fig. 6 in Bioactive diterpenoids and sesquiterpenoids with different skeletons from Salvia digitaloides Diels
Fig. 6. The anti-inflammatory activity of compounds 1–11, 13 and 14 toward lipopolysaccharide (LPS)-stimulated rat macrophage NR8383 cells. (a) Cells were treated with compounds 1–11, 13 and 14 (100 μM) for 24 h. Cell viability was determined using the CCK-8 assay. (b) The cells were treated with LPS (40 μg/mL) and LPS (40 μg/mL) plus compounds 1 or 13 (100 μM) for 24 h. The TNF-α level was determined using an ELISA kit from R&D Systems (p <0.05).
Fig. 7 in Bioactive diterpenoids and sesquiterpenoids with different skeletons from Salvia digitaloides Diels
Fig. 7. (a) Neuroprotective effects of compounds 2, 4, and 13 on the C. elegans model. Representative fluorescence images showing the anterior dopaminergic neurons of the transgenic strain BZ555. The efficacy was expressed in terms of the brightness of green fluorescent protein (GFP) tagged to the dopaminergic neuronal soma and indicated by the difference in fluorescence between 6-OHDA- and compound 2,4,13,n-butylidenephthalide (positive control)-coexposed worms from the intact (blank reference) and 6-OHDA-treated (negative control) groups (n = 30–60). Mean fluorescence intensity of anterior dopaminergic neurons in BZ555 C. elegans. Data are presented as the means ± standard errors of the means (SEM). (****) p <0.0001. (b) Neuroprotective effects of compounds 3 and 14 on the C. elegans model. The experimental methods and observed indicators were the same as those in (a). Data are presented as the means ± standard errors of the means (SEM). (****) p <0.0001. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
Fig. 10 in Diterpenoids from Sigesbeckia glabrescens with anti-inflammatory and AChE inhibitory activities
Fig. 10. The inhibition kinetics of 3-O-acetyldarutigenol (15) towards AChE. (A) Lineweaver-Burk plots for the inhibition of AChE by 3-O-acetyldarutigenol. (B) Determination of Ki using the slopes from Lineweaver–Burk plot towards the concentration of 3-O-acetyldarutigenol.
Fig. 8. Siegetalis H in Diterpenoids from Sigesbeckia glabrescens with anti-inflammatory and AChE inhibitory activities
Fig. 8. Siegetalis H (11) blocks LPS-induced activation of the NF-κB pathway. (A) The phosphorylated and total protein levels of IκBα, as well as the protein level of β-actin, were quantified by immunoblotting in cell lysates of RAW264.7 cells. (B) The quantitative analysis of p- IκBα and IκBα protein levels, normalized against β-actin. (C) Immunoblot analysis of the cytoplasmic and nuclear distribution of p65 NF-κB in RAW264.7 cells. (D) Quantitative analysis of p65 protein levels, normalized against Histone H3 or β-actin. Data are presented as means ± SD, n = 3; #p <0.05, ##p <0.01, ###p <0.001, ####p <0.0001 vs control; *p <0.05, **p <0.01, ***p <0.001, ****p <0.0001 vs LPS only.
Fig. 7 in Diterpenoids from Sigesbeckia glabrescens with anti-inflammatory and AChE inhibitory activities
Fig. 7. Effect of siegetalis H (11) on inflammatory factors on LPS-induced RAW264.7 cells. (A) The cell lysates were collected to detect the expression of iNOS and COX-2. (B) Quantitative analysis of iNOS and COX-2 protein levels, normalized against β-actin. Data are presented as means ± SD, n = 3; #p <0.05, ##p <0.01, ###p <0.001, ####p <0.0001 vs control; *p <0.05, **p <0.01, ***p <0.001, ****p <0.0001 vs LPS only.
Fig. 8. Compound 14 activated Nrf2 in Diterpenoids with anti-inflammatory activity from Euphorbia wallichii
Fig. 8. Compound 14 activated Nrf2/HO-1 signaling pathway. (A–C) The expressions of Nrf2 and HO-1 were determined by Western blot analysis and the quantification of protein expression was performed by Image J. (D) The inhibitory effect of 14 (16 μM) on the nuclear translocation of Nrf2 induced by LPS via confocal laser scanning microscopy. RAW264.7 cells stained for Nrf2 (red) and nuclei (DAPI, blue) (scale bar: 10 μm). The values are presented as mean ± SD of three independent experiments, n 3. ###p <0.001, vs. the control group; **p <0.01, ***p <0.001, vs. LPS-treated group. (For interpretation of the references to color in = this figure legend, the reader is referred to the Web version of this article.)
Fig. 7. Compound 14 in Diterpenoids with anti-inflammatory activity from Euphorbia wallichii
Fig. 7. Compound 14 reduced LPS-induced inflammatory factors production and inhibited NF-κB nuclear translocation. (A–C) The expressions of iNOS and COX-2 were determined by Western blot analysis. (D–F) The expressions of NF-κB, p-IκBα, and IκBα were determined by Western blot analysis. The quantification of protein expression was performed by Image J. (G) The inhibitory effect of compound 14 (16 μM) on the nuclear translocation of NF-κB p65 induced by LPS via confocal laser scanning microscopy. RAW264.7 cells stained for NF-κB (green) and nuclei (DAPI, blue) (scale bar: 10 μm). The values were presented as mean ± SD of three independent experiments, n 3. ###p <0.001, vs. the control group; **p <0.01, ***p <0.001, vs. LPS-treated group. (For interpretation of the references to color in = this figure legend, the reader is referred to the Web version of this article.)
Fig. 6. Compound 14 in Diterpenoids with anti-inflammatory activity from Euphorbia wallichii
Fig. 6. Compound 14 reduced LPS-induced pro-inflammatory cytokines release. (A) The NO inhibition curve of compound 14, with an IC50 of 3.84 ± 0.25 μM. (B) Cell viability rate of RAW264.7 cells treated with compound 14 (0, 3.125, 6.25, 12.5, 25, 50, 100 μM) for 24 h. (C–D) Effects of compound 14 on production of inflammatory cytokines (IL-6 and TNF-α) in LPS-induced RAW264.7 cells. ###, p <0.001 vs. control group. *, p <0.1, **, p <0.01 and ***, p <0.001 vs. LPStreated group.
Fig. 5 in Diterpenoids with anti-inflammatory activity from Euphorbia wallichii
Fig. 5. Effect of compounds 1–23 (20 μM) on LPS-induced NO production, using dexamethasone (Dex) as the reference drug.
Fig. 5 in Labdane diterpenoids from the heartwood of Leucosceptrum canum that impact on root growth and seed germination of Arabidopsis thaliana
Fig. 5. Biological function of leucolactones A-K (1–11) on the growth and development of Arabidopsis thaliana. (A) Seed germination rate of A. thaliana on MS-agar plates in the presence of 10, 20, 30, 40 μM compound 8. Different letters represent significant differences (one-way ANOVA followed by Tukey's test, P <0.05). (B–D) A. thaliana seedlings after 5 days on MS-agar plates containing 0.1% ethanol (B), 10 μM compound 8 (C), 20 μM compound 8 (D); (E–F) Effect of compound 8 on auxin reporter of A. thaliana DR5::GUS after 24 h incubation in solution with 0.1% ethanol (E) or 20 μM compound 8 (F). The images were representatives of at least three independent experiments with>25 seedlings examined for each experiment.
Fig. 3 in Diterpenoids and p-methoxycinnamic acid diol esters from Kaempferia saraburiensis Picheans. (Zingiberaceae): Structural assignment of saraburol and their biological activities
Fig. 3. Selected NOESY correlations for the assignment of the relative configuration and corresponding interatomic distance (Å) of compound 3.
Fig. 4 in Diterpenoids and p-methoxycinnamic acid diol esters from Kaempferia saraburiensis Picheans. (Zingiberaceae): Structural assignment of saraburol and their biological activities
Fig. 4. (A) Experimental ECD spectra of compounds 2 (black); TDDFT-calculated curves of normal (blue) and ent series (red), (B) Experimental and calculated ECD spectra of compound 3. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
Fig. 11 in Diverse diterpenoids with α-glucosidase and β-glucuronidase inhibitory activities from Euphorbia milii
Fig. 11. The Lineweaver–Burk plots of (A) 9, (B) 11, and (C) 15 against acarbose and 11 against DSL (D). All data were expressed as mean ± SD of triplicate reactions.
Fig. 3 in Diverse diterpenoids with α-glucosidase and β-glucuronidase inhibitory activities from Euphorbia milii
Fig. 3. Key NOE correlations (blue dashed arrows) in 1–7. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
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