Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
135
datasets available to search
ShareScore release 0.9.0
Dataset results
135 results for “drug delivery”
Source data for "Cyclic jetting enables microbubble-mediated drug delivery"
<p>This repository provides the source data associated with the paper <em>"</em><strong>Cyclic jetting enables microbubble-mediated drug delivery</strong><em>"</em> by Marco Cattaneo <em>et al.</em>, published in <em>Nature Physics</em>.</p> <ul> <li>The "<strong>Cattaneo_Fig_X.xlsx</strong>" files contain the data necessary for reproducing Fig. X.</li> <li>The "<strong>Cattaneo_VideoSourceData.zip</strong>" file includes the video source data not included within the article used to generate Fig. 4a-c. For further details, please refer to the "Cattaneo_Fig_4.xlsx" file.</li> </ul>
A Safety and Dose Ranging Study of Idursulfase (Intrathecal) Administration Via an Intrathecal Drug Delivery Device in Pediatric Patients With Hunter Syndrome Who Have Central Nervous System Involveme
ClinicalTrials.gov study NCT00920647. IPD Sharing: YES. Countries: 2. Publications: 1.
Nano MOFs as targeted drug delivery agents to combat antibiotic resistant bacterial infections
<p>The drug resistance of bacteria is a significant threat to human civilization while the action of antibiotics against drug-resistant bacteria is severely limited due to the hydrophobic nature of drug molecules, which unquestionably inhibit its permanency for clinical applications. The antibacterial action of nanomaterials offers major modalities to combat drug resistance of bacteria. The current work reports, the use of nano MOFs encapsulating drug molecules to enhance its antibacterial activity against model drug-resistant free living bacteria and biofilm of the bacteria. We have attached rifampicin (RF), a well-documented antituberculosis drug with tremendous pharmacological significance, into the pore surface of zeolitic imidazolate framework 8 (ZIF8) by a <span><span>simple synthetic procedure</span></span><span>.</span> The synthesized ZIF8 has been characterized using X-ray diffraction (XRD) method before and after drug encapsulation. The electron microscopic strategies such as scanning electron microscope (SEM) and transmission electron microscope (TEM) methods was performed to characterize the binding between ZIF8 and RF. We have also performed picosecond resolved fluorescence spectroscopy to validate the formation of the ZIF8-RF nanohybrids (NHs). The drug release profile experiment demonstrates that ZIF8-RF depicts pH-responsive drug delivery and ideal for targeting bacterial disease corresponding to its inherent acidic nature. Most remarkably, ZIF8-RF gives enhanced antibacterial activity against methicillin-resistant <i>S. aureus</i> (MRSA) bacteria and also prompts entire damage of structurally robust bacterial biofilms. Overall, the present study depicts a detailed physical insight for manufactured antibiotic-encapsulated NHs presenting tremendous antimicrobial activity that can be beneficial for manifold practical applications.</p>
TRATAMENTO DO MELASMA COM MICROAGULHAMENTO ASSOCIADO AO DRUG DELIVERY DE ÁCIDO TRANEXÂMICO: RELATO DE CASO
<p>Introdução: Clinicamente caracterizado por máculas amarronzadas de bordas irregulares e nítidas, o melasma é um distúrbio pigmentar cutâneo muito comum, afetando principlamente áreas fotoexpostas como face e pescoço. É comumente identificado em mulheres em idade reprodutiva e frequentemente descrita em tipos de pele Fitzpatrick IV a VI. Por ser um problema inestético, o melasma pode ter impacto na qualidade de vida como fator de estresse psicossocial e constrangimento. Objetivo: Descrever o uso do microagulhamento associado ao drug delivery de ácido tranexâmico para tratamento do melasma facial. Material e métodos: Relato de caso, paciente do sexo feminino, fototipo IV, 41 anos, portadora de melasma, a qual foi selecionada para ser tratada durante dois meses com duas sessões mensais de microagulhamento associado ao drug delivery de 1,0ml de ácido tranexâmico 8mg/2ml. A paciente foi avaliada antes e após o tratamento com os seguintes parâmetros: evolução fotográfica, autoavaliação com questionário capaz de avaliar objetivamente a qualidade de vida dos paciente acometidos pelo melasma e melhora do MASI. Resultados e discussão: Em relação ao MASI, houve uma melhora significativa, com redução de 54,4 ± 7,53 para 29,9 ± 7,60 (p = 0,007) (45%) e redução não significativa de 13,1 ± 3,79 para 10,8 ± 3,79 (p=0,022) (17%) no MELASQol. Conclusão: O percentual médio de melhora após tratamento por MASI foi de 45% e por MELASQol, de 17%. Não foi encontrada associação significativa entre os percentuais de melhora do MASI e do MELASQol (p=0,3641) refletindo que mesmo obtendo boa resposta na melhora do melasma, a persistência da mancha, ainda era fator de incômodo para a paciente. A associação proposta apresentou resultados satisfatórios, constituindo uma modalidade terapêutica inovadora, replicável e segura para o tratamento do melasma.</p>
Overcoming Membrane Transporters to Improve CNS Drug Delivery - Improving Brain Antioxidants After Traumatic Brain Injury
ClinicalTrials.gov study NCT01322009. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Study in Healthy Adults to Determine the Effect That Food Has on the Absorption and Delivery of the Drug Cystagon™
ClinicalTrials.gov study NCT01432561. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Observational Study of Rapid Sequence Intubation Drug Delivery Using Intraosseous and Intravenous Access.
ClinicalTrials.gov study NCT01486407. IPD Sharing: Not stated. Countries: 1. Publications: 10.
Negative Pressure Wound Therapy as a Drug Delivery System
ClinicalTrials.gov study NCT02463487. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Drug Delivery Via Pressurized Metered-dose Inhaler and Valved Holding Chamber in Asthmatic Children: Determination of Delivered Dose Following Coordinated and Uncoordinated Use
ClinicalTrials.gov study NCT01714063. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Measuring Signatures in the Fluid Surrounding the Spinal Cord in Patients Who Have Problems With Intrathecal Drug Delivery
ClinicalTrials.gov study NCT01117090. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Reducing Prehospital Medication Errors & Time to Drug Delivery by EMS During Simulated Pediatric CPR
ClinicalTrials.gov study NCT03921346. IPD Sharing: YES. Countries: 1. Publications: 21.
Nano MOFs as targeted drug delivery agents to combat antibiotic resistant bacterial infections
Open the record for dataset details and reuse information.
Soft robots with autonomous adaptation for effective drug delivery amidst fibrous encapsulation
Open the record for dataset details and reuse information.
DNA mechanocapsules for programmable piconewton responsive drug delivery
<p>The mechanical dysregulation of cells is associated with a number of disease states, that spans from fibrosis to tumorigenesis. Hence, it is highly desirable to develop strategies to deliver drugs based on the "mechanical phenotype" of a cell. To achieve this goal, we outline and synthesize DNA mechanocapsules (DMC) comprised of DNA tetrahedrons that are force responsive. Modeling shows the trajectory of force-induced DMC rupture and predicts how applied force spatial position and orientation tunes the force-response threshold. DMCs functionalized with adhesion ligands mechanically denature <i>in vitro</i> as a result of cell receptor forces. DMCs are designed to encapsulate macromolecular cargos such as dextran and oligonucleotide drugs with minimal cargo leakage and high nuclease resistance. Force-induced release and uptake of DMC cargo is validated using flow cytometry. Finally, we demonstrate force-induced mRNA knockdown of HIF-1α in a manner that is dependent on the magnitude of cellular traction forces. These results show that DMCs can be effectively used to target biophysical phenotypes which may find useful applications in immunology and cancer biology. </p>
Hierarchical mesoporous NanoMUV-2 for the selective delivery of macromolecular drugs
<p>Relevant data for publication with DOI: <a title="Link to landing page via DOI" href="https://doi.org/10.1039/D3TB01819A">10.1039/D3TB01819A</a></p>
Dual-Responsive Nanoparticles for Smart Drug Delivery: a NIR light Sensitive and Redox- Reactive PEG-PCL based System
<p>This folder contains raw data for the paper titled "Dual-Responsive Nanoparticles for Smart Drug Delivery: A NIR Light-Sensitive and Redox-Reactive PEG–PCL-Based System" authored by Nancy Ferrentino, Taha Behroozi Kohlan, Shokoufeh Mehrtashfar, Anna Finne-Wistrand, and Daniela Pappalardo, published in Biomacromolecules journal. <a title="DOI URL" href="https://doi.org/10.1021/acs.biomac.4c00889">https://doi.org/10.1021/acs.biomac.4c00889</a></p>
Resveratrol loaded chitosan-pectin core-shell nanoparticles as novel drug delivery vehicle for sustained release and improved antioxidant activities
<p><span>Resveratrol, chemically known as 3, 5, 4'-trihydroxy-trans-stilbene, is a natural polyphenol with promising multi-targeted health benefits. The optimal therapeutic uses of resveratrol are limited due to its poor solubility, rapid metabolism and low bioavailability. To address the issues, we have encapsulated resveratrol inside the nanosized core made of chitosan and coated this core with pectin - shell in order to fabricate a drug delivery vehicle which can entrap resveratrol for a longer period of time. The core - shell nanoparticles fabricated in this way were characterized with the help of Fourier Transform Infrared Spectrometer (FTIR), Field Emission Scanning Electron Microscope (FESEM), Field Emission Transmission electron microscopy/Selected Area Electron Diffraction (FETEM/SAED), High-Resolution Transmission Electron Microscope (HRTEM)), Dynamic Light Scattering (DLS) and Zeta Potential measurements. In vitro drug release study showed the ability of the core-shell nanoparticles to provide sustained release of resveratrol for almost 30 hours. The release efficiency of the drug was found to be pH dependent and a sequential control over drug release can be obtained varying the shell thickness. The resveratrol encapsulated in a nanocarrier was found to have a better in vitro antioxidant activity than free resveratrol as determined by DPPH radical scavenging method. This work finally offers a novel nano-based drug delivery system.</span></p>
Spectra related to the study about the Permselectivity of Silk Fibroin Hydrogels for Advanced Drug Delivery Neurotherapies
<p>This material is associated with the study about the Permselectivity of Silk Fibroin Hydrogels for Advanced Drug Delivery Neurotherapies. Herein are enclosed the FTIR spectra of silk fibroin solutions and hydrogels, and representative spectra from mass spectrometry technique for the quantification of cholesteronitrone F2 released from silk fibroin hydrogels.</p> <ul> <li>FTIR spectra prior to sonication are named as SF_2%_pre-sonication_0X and SF_6%_pre-sonication_0X, being 2 and 6% the concentration of silk fibroin in the solution and X the number of replicate.</li> <li>FTIR spectra 24 hours after sonication are named as SF_2%_post-sonication_0X and SF_6%_post-sonication_0X, being 2 and 6% the concentration of silk fibroin in the hydrogel and X the number of replicate.</li> <li>The files with file format .mzXML and named as spectrum are representative spectra from mass spectrometry technique from the calibration curve (Spectrum_matrix; Spectrum_IS_10uM; Spectrum_F2_10uM; Spectrum_IS+F2_10uM) and the quatification of F2 released from SF hydrogels (Spectrum_2%_X; Spectrum_6%_X; being X the time point of release).</li> </ul> <p> </p>
A novel microfluidic tool for the evaluation of local drug delivery systems in simulated in vivo conditions
Open the record for dataset details and reuse information.
A pH-responsive amphiphilic hydrogel based on pseudo-peptides and poly(ethylene glycol) for oral drug delivery
<p>The original data for the paper titled "A pH-responsive amphiphilic hydrogel based on pseudo-peptides and poly(ethylene glycol) for oral drug delivery"</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.