Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
1,610
datasets available to search
ShareScore release 0.9.0
Dataset results
1,610 results for “elderly patients”
Exploring the Impact of Physiotherapy on Health Outcomes in Elderly Patients with Chronic Diseases: A Cross-Sectional Analysis
<p>In this cross-sectional analysis, we investigate the transformative impact of physiotherapy on health outcomes among elderly patients grappling with chronic diseases. Physiotherapy emerges as a pivotal intervention, offering multifaceted benefits that extend beyond mere symptom management. Through tailored exercises, mobility enhancements, and targeted pain management strategies, physiotherapy not only mitigates physical limitations but also fosters greater independence and quality of life. By examining a diverse cohort of elderly individuals diagnosed with chronic conditions such as osteoarthritis and cardiovascular diseases, this study underscores the profound role of physiotherapy in promoting functional mobility, reducing healthcare burdens, and enhancing overall well-being among this vulnerable population."</p>
The Brain and Propranolol Pharmacokinetics in the Elderly-Figure 1.(a)Results of the Monte-Carlo simulations to describe pharmacokinetics of young patients with validation from the Taegtmeyer 2014 publication(Taegtmeyer et al., 2014)
<p>Propranolol has been found to be therapeutically effective, to obtain a clinical response by<br> beta-adrenoceptor blockade, at plasma levels of greater than 20 ng/mL(Coltart et al., 1971;<br> Frishman, 1988; Johnsson and Regàrdh, 1976). Thus, to display the data, we used highlighted<br> plasma concentration where the pharmacokinetic curve falls below 20ng/mL threshold for<br> therapeutic efficacy in the patient’s plasma.</p>
Figure 2.(a)Results of the Monte-Carlo simulations describing a population of elderly patients after a single oral dose of propranolol.-The Brain and Propranolol Pharmacokinetics in the Elderly
<p>In effort to identify the recommended Propranolol dosage for elderly patients, we identified<br> the patient package inserts from the Food and Drug Administration (FDA) Inderal label, who<br> manufacture propranolol. Based from FDA Wyeth Propranolol label, for dosing in the geriatric<br> population,the label states that there were not sufficient numbers of clinical study participants who<br> were 65-years and older to properly determine the difference in response young and elderly<br> patients.</p>
Figure 5.(a)Linear (y=0.45x + 57.74) dose-response relationship between plasma propranolol to % β- adrenergeric blockade derived from healthy study participants and translate into patients with angina pectoris. This image has been adapted from(Pine et al., 1975).-The Brain and Propranolol Pharmacokinetics in the Elderly
<p>Apharmacodynamic model,with parameters in the table below, may be used to visualize the<br> propranolol concentration-effect (β-blockade) relationship in patients suffering from angina pectoris.<br> These results have been adapted from the Pine et al article published in Circulation in 1975 which<br> identified a linear relationship plasma Propranolol (ng/mL) to an effect of % β-Adrenergic Blockade<br> in a single-oral dose of 40mg Propranolol in exercising individuals (Pine et al., 1975).</p>
Figure 4. Simulation (Monte-Carlo, n=200) results elderly patients taking a 10mg oral dose resulting in similar Cmax, maximum plasma concentration, to the young patients taking a 40mg oral dose. The dotted lines illustrate the 10th and 90th percentiles of plasma levels of the elderly population with a 10mg oral administration of propranolol.-The Brain and Propranolol Pharmacokinetics in the Elderly
<p>Thus, the package insert (see 1) recommends clinicians start at the lower end of the dosing<br> range, without further details.<br> Similarly, Pfizer manufactures Inderal® LA (Propranolol HCI), which is the long-acting<br> form of propranolol and their package insert (see 2) states, “There is no information available for<br> elderly patients.” Though the kinetics for the long-acting formdiffers from the standard form,<br> manufactured by Wyeth, we would suspect a 10mg dose for the elderly would achieve a similar<br> maximum plasma concentration (Cmax) to that of the younger patient cohort.This 10mg, which is<br> 25% of the original 40mg, dosing schedule is based on our simulations at 10mg in the geriatric<br> population.</p>
Continuous Digital Monitoring of Walking Speed in Frail Elderly Patients: Noninterventional Validation Study and Longitudinal Clinical Trial (Data for independent validation study)
<p>Digital technologies and advanced analytics have drastically improved our ability to capture and interpret health relevant data from patients. However, to date, limited data and results have been published detailing real-world patient compliance, demonstrating accuracy in target indications or examining what novel insights and clinical value can be derived. Here we present novel, digital mobility data from two studies: an independent, non-interventional validation study with elderly, naturally slow walking subjects, and a global, multi-site phase IIb clinical trial involving patients with age-related muscle loss and slow walking speed (sarcopenia). Based on these data, we validate the accuracy of a novel algorithm for capturing in-clinic and real-world gait speed in frail, slow-walking adults. We demonstrate the feasibility of continuous monitoring with a wearable inertial sensor in elderly adults in real-world settings, and propose minimum thresholds for compliance required for robust capture of gait behaviors in this population. We also show how simple, inferred contextual information, describing the length of a given walking bout, can explain some of the variation in real-world gait speed, and use this information to demonstrate for the first time a relationship between in-clinic performance and real-world gait speed behavior. This work lays a foundation for exploration of the clinical relevance and value of such measures and is a first step in building a more complete chain of evidence between standardized physical performance assessment, real-world behavior, and subjective perceptions of mobility, independence and health.</p> <p>This dataset contains data collected during the independent validation study: derived data from raw accelerometry data, and summary performance data.</p> <p>The full dataset, including raw accelerometry data, is available here: <a href="https://mueller-et-al-2019.s3.amazonaws.com/index.html">https://mueller-et-al-2019.s3.amazonaws.com/index.html</a></p>
Expiratory Muscle Strength Training and Phonation Resistance Training Exercises For Elderly Patients With Vocal Fold Atrophy
ClinicalTrials.gov study NCT03696576. IPD Sharing: YES. Countries: 1. Publications: 33.
Dosage of Epidural Morphine in Elderly Patients
ClinicalTrials.gov study NCT04316871. IPD Sharing: YES. Countries: 1. Publications: 2.
DATASET RELATED TO ARTICLE "Brain Tumor Resection in Elderly Patients Potential Factors of Postoperative Worsening in a Predictive Outcome Model"
<p><span>clinical database including information on patients included in the study at title</span></p>
Shared Decision-Making for Elderly Depressed Primary Care Patients
ClinicalTrials.gov study NCT01031134. IPD Sharing: NO. Countries: 1. Publications: 1.
Alteplase Treatment in Elderly Acute Ischaemic Stroke (AIS) Patients
ClinicalTrials.gov study NCT05401149. IPD Sharing: NO. Countries: 1. Publications: 1.
A Study of Bevacizumab (Avastin) in Combination With Capecitabine (Xeloda) in Elderly Patients With Metastatic Colorectal Cancer
ClinicalTrials.gov study NCT00484939. IPD Sharing: Not stated. Countries: 12. Publications: 1.
Observational Clinical Study on Elderly Patients With Fracture of the Proximal Femur Treated With the Chimaera Nail
ClinicalTrials.gov study NCT05197335. IPD Sharing: UNDECIDED. Countries: 1. Publications: 7.
Using the SEDLine for the Titration of Sevoflurane in Elderly Patients Recovery Using the SEDLine TM for the Titration of Sevoflurane in Elderly Patients Undergoing Non-Cardiac Surgery After Beta-Adre
ClinicalTrials.gov study NCT00938782. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of ACE-inhibitors on Aortic Stiffness in Elderly Patients With Chronic Kidney Disease
ClinicalTrials.gov study NCT00874432. IPD Sharing: Not stated. Countries: 1. Publications: 34.
Midostaurin and Azacitidine in Treating Elderly Patients With Acute Myelogenous Leukemia
ClinicalTrials.gov study NCT01093573. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Efficacy Study of Oral Sapacitabine to Treat Acute Myeloid Leukemia in Elderly Patients
ClinicalTrials.gov study NCT00590187. IPD Sharing: NO. Countries: 1. Publications: 1.
Study of Bendamustine and Ofatumumab in Elderly Patients With Newly Diagnosed Diffuse Large B-Cell Lymphoma Who Are Poor Candidates for R-CHOP Chemotherapy
ClinicalTrials.gov study NCT01626352. IPD Sharing: Not stated. Countries: 1. Publications: 23.
Administration of GRASPA (Suspension of Erythrocytes Encapsulating L-asparaginase) in Elderly Patients With First Line Acute Lymphoblastic Leukemia
ClinicalTrials.gov study NCT01523782. IPD Sharing: NO. Countries: 0. Publications: 1.
Exercise Intolerance in Elderly Patients With HFpEF(Heart Failure With Preserved Ejection Fraction)
ClinicalTrials.gov study NCT02636439. IPD Sharing: NO. Countries: 1. Publications: 2.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.