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zenodo44/100

Investigating the effect of cochlear synaptopathy on envelope following responses using a model of the auditory nerve

<p>Dataset&nbsp;containing the recorded and simulated data reported in the&nbsp;manuscript &quot;Investigating the effect of cochlear synaptopathy on envelope following responses using a model of the auditory nerve&quot; published in the&nbsp;Journal of the Association for Research in Otolaryngology, JARO (<a href="https://doi.org/10.1007/s10162-019-00721-7">https://doi.org/10.1007/s10162-019-00721-7</a>):</p> <ol> <li>RECORDED Envelope Following Responses (EFR) in normal-hearing (NH) threshold and hearing-impaired (HI) human listeners using deeply (m = 85%) and shallowly (m = 25%) modulated sinusoidally amplitude modulated (SAM) tones.</li> <li>SIMULATED EFRs using the auditory nerve (AN) model by&nbsp;Zilany et al. (2009, 2014).</li> </ol> <p>Files content and structure:</p> <p><strong>Recorded EFRs</strong></p> <p><strong>Fig. 2:</strong></p> <ul> <li><em>fig2__recorded_efr.csv</em>: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<br> EFR recordings as a function of stimulus level (EFR magnitude-level&nbsp;functions)&nbsp;for the NH and HI listeners using two modulation depths.</li> </ul> <p>The file&nbsp;containing the recorded EFR data have the following columns:</p> <ul> <li><em>lvl</em>: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; Stimulation level</li> <li><em>m85_ok: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;</em>EFR magnitude (dB re to 1&nbsp;&micro;V) using m =&nbsp;85%. Significant responses (F-test = 1)</li> <li><em>m85_ko: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;</em>EFR magnitude (dB re to 1&nbsp;&micro;V) using m =&nbsp;85%. Non-significant responses (F-test = 0)</li> <li><em>m85_bkg:&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;&nbsp;</em>Estimated background noise magnitude (dB re to 1&nbsp;&micro;V) for&nbsp;the recordings when m = 85%</li> <li><em>m25_ok: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;</em>EFR magnitude (dB re to 1&nbsp;&micro;V) using m = 25%. Significant responses (F-test = 1)</li> <li><em>m25_ko: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;</em>EFR magnitude (dB re to 1&nbsp;&micro;V) using m = 25%. Non-significant responses (F-test = 0)</li> <li><em>m25_bkg:&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;&nbsp;</em>Estimated background noise magnitude (dB re to 1&nbsp;&micro;V) for&nbsp;the recordings when m = 25%&nbsp;</li> <li><em>subj: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;</em>Listener id</li> <li>hearing: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; Hearing group (nh | hi) of the listener</li> </ul> <p><strong>Simulated EFRs:</strong></p> <p><strong><em>Files with the simulation results summing across frequency and SR fiber type</em></strong></p> <p><strong>Fig. 4:</strong></p> <ul> <li><em>fig4a__simul_efr__nh_23ohc_13ihc__no_cs.csv</em>:&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<br> Simulated EFR magnitude-level&nbsp;function for the NH threshold listeners (average) assuming 2/3 of OHC loss and 1/3 of IHC loss (Fig. 4a).</li> <li><em>fig4b__simul_efr__nh_slp_thres_all_ohc__no_cs.csv</em>: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<br> Simulated EFR magnitude-level function for the NH threshold listeners (average) assuming sloping threshold at extended high frequencies (EHF) and all of OHC loss&nbsp;(Fig. 4b).</li> <li><em>fig4c__simul_efr__nh_slp_thres_all_ihc__no_cs.csv</em>:&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<br> Simulated EFR magnitude-level function for the NH threshold listeners (average) assuming sloping threshold at extended high frequencies (EHF) and all of IHC loss&nbsp;(Fig. 4c).</li> <li><em>fig4d__simul_efr__hi_23ohc_13ihc__no_cs.csv</em>:&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<br> Simulated EFR magnitude-level&nbsp;function for the HI listeners (average) assuming 2/3 of OHC loss and 1/3 of IHC loss (Fig. 4d).</li> <li><em>fig4e__simul_efr__hi_all_ohc__no_cs.csv</em>:&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<br> Simulated EFR magnitude-level function for the HI threshold listeners (average) assuming&nbsp;all of OHC loss&nbsp;(Fig. 4e).</li> <li><em>fig4f__simul_efr__hi_all_ihc__no_cs.csv</em>:&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<br> Simulated EFR magnitude-level function for the HI threshold listeners (average) assuming all of IHC loss&nbsp;(Fig. 4f).</li> <li><em>fig4g__simul_efr__hi_slp_thres_23ohc_13ihc__no_cs.csv</em>:&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<br> Simulated EFR magnitude-level&nbsp;function for the HI listeners (average) assuming&nbsp;sloping threshold at EHF&nbsp;and 2/3 of OHC loss and 1/3 of IHC loss (Fig. 4d).</li> <li><em>fig4h__simul_efr__hi_slp_thres_all_ohc__no_cs.csv</em>:&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<br> Simulated EFR magnitude-level function for the HI threshold listeners (average) assuming sloping threshold at EHF&nbsp;and all of OHC loss&nbsp;(Fig. 4e).</li> <li><em>fig4i__simul_efr__hi_slp_thres_all_ihc__no_cs.csv</em>:&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<br> Simulated EFR magnitude-level function for the HI threshold listeners (average) assuming sloping threshold at EHF&nbsp;and and all of IHC loss&nbsp;(Fig. 4f).</li> </ul> <p>&nbsp;</p> <p><strong>Fig. 5:</strong></p> <ul> <li><em>fig5a__simul_efr__nh__cs_ms_ls_100p.csv</em>: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<br> Simulated EFR magnitude-level function for the NH threshold listeners (average) assuming&nbsp;cochlear synaptopathy (CS) of a 100% of loss of only medium- and low-spontaneous rate (SR)&nbsp;AN fibers&nbsp;(Fig. 5a).</li> <li><em>fig5b__simul_efr__nh09_cs__approx</em>.<em>csv</em>: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<br> Simulated EFR magnitude-level function to approximate the data for the NH threshold listener NH09 including CS (Fig. 5b).</li> <li><em>fig5c__simul_efr__hi04_cs__approx</em>.<em>csv</em>: &nbsp;<br> Simulated EFR magnitude-level function to approximate the data for the HI listener HI04&nbsp;including CS (Fig. 5c).</li> </ul> <p>&nbsp;</p> <p><strong>Fig. 6:</strong></p> <p>Files with the simulation results for the NH threshold listener&nbsp;in different characteristic frequency (CF) bands and SR fiber types</p> <ul> <li><em>fig6__simul_efr__nh_cf_band_analys__no_cs__m12.mat</em>: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<br> Simulated EFR magnitude-level function for the NH using a SAM tone with m = 12%.</li> <li><em>fig6__simul_efr__nh_cf_band_analys__no_cs__m25.mat</em>: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<br> Simulated EFR magnitude-level function for the NH using a SAM tone with m = 25%.</li> <li><em>fig6__simul_efr__nh_cf_band_analys__no_cs__m50.mat</em>: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<br> Simulated EFR magnitude-level function for the NH using a SAM tone with m = 50%.</li> <li><em>fig6__simul_efr__nh_cf_band_analys__no_cs__m85.mat</em>: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<br> Simulated EFR magnitude-level function for the NH using a SAM tone with m = 85%.</li> <li><em>fig6__simul_efr__nh_cf_band_analys__no_cs__m100.mat</em>: &nbsp; &nbsp; &nbsp; &nbsp;<br> Simulated EFR magnitude-level function for the NH using a SAM tone with m = 100%.</li> </ul> <p>&nbsp;</p> <p><strong>Fig. 7:</strong></p> <ul> <li><em>fig7a__simul_efr__bw_analys__32oct_[20, 40, 60, 80, 100]p.csv</em>: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<br> Simulated EFR magnitude-level function for the NH threshold listeners assuming&nbsp;CS of a bandwidth (BW) of 3/2-octave for a loss of AN fibers ranging from 20% to&nbsp;100% (Fig. 7a).</li> <li><em>fig7b__simul_efr__bw_analys__1oct_[20, 40, 60, 80, 100]p.csv</em>: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<br> Simulated EFR magnitude-level function for the NH threshold listeners assuming&nbsp;CS of a bandwidth (BW) of 1-octave for a loss of AN fibers ranging from 20% to&nbsp;100% (Fig. 7b).</li> <li><em>fig7c__simul_efr__bw_analys__13oct_[20, 40, 60, 80, 100]p.csv</em>:<br> Simulated EFR magnitude-level function for the NH threshold listeners assuming&nbsp;CS of a bandwidth (BW) of 1/3-octave for a loss of AN fibers ranging from 20% to&nbsp;100% (Fig. 7c).</li> </ul> <p>&nbsp;</p> <p>-----------------------------------------------------------------------------------------------------------------------------------------------------------------</p> <p>&nbsp;</p> <p>The structure of the .csv files that contain the EFR simulations is:</p> <ul> <li><em>lvl</em>: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;Stimulation level</li> <li><em>mgn_mxxx: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;</em>Simulated EFR magnitude (a.u. in dB) for each modulation depth (100%, 85%, 50%, 25% and 12%)</li> <li><em>bkg_mxxx: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;&nbsp;</em>Estimate of the background noise floor (a.u. in dB)&nbsp;for each modulation depth.&nbsp;</li> <li><em>ftest_mxxx: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;</em>Result of the F-test statistical test&nbsp;(0 or 1) for each modulation depth.</li> </ul> <p>&nbsp;</p> <p>The structure of the .mat&nbsp;files that contain the EFR simulations is:</p> <ul> <li><em>exper_type</em>:&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;Name of the simulated experiment</li> <li><em>species</em>:&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;Species used in the AN model (in this study is always 2: human)</li> <li><em>species_age</em>:&nbsp; &nbsp; &nbsp; &nbsp; &nbsp;(Not used in this work). Age of the animal when species is 4: mouse</li> <li>modulation<em>: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;</em>Modulation depth of the SAM tone used in the simulation <em>(100%, 85%, 50%, 25% or 12%)</em></li> <li><em>f_on: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;</em>Center frequency of the on-frequency band (<em>2000 Hz</em>)</li> <li><em>f_off_hf: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;&nbsp;</em>Center frequency of the first off-frequency band (<em>3000 Hz</em>)</li> <li><em>f_off_vhf: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; </em>Center frequency of the second off-frequency band (<em>7000 Hz</em>)&nbsp;</li> <li><em>f_off_uvhf: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; </em>Center frequency of the third&nbsp;off-frequency band (<em>12000 Hz</em>)</li> <li><em>lvl_vect: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; </em>Stimulus level vector&nbsp;<em>(from 5 to 100 dB SPL, in steps of 5 dB)</em></li> <li><em>simul_efr &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;&nbsp;</em>&nbsp;&nbsp;Structure with the simulated data <ul> <li>The data structure contains many fields which are&nbsp;matricies of size 3x20. The columns are the 20 stimulus levels defined in <em>lvl_vect</em>, and the first row is the simulated EFR, the second row is the estimates background noise floor in the simulation, and the third row is the output of the F-test statistics.</li> <li>The structure fields can be divided in&nbsp;4 groups: <ul> <li><em>ihc_</em> &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; Responses from the IHC (not shown in the paper)</li> <li><em>an_hs_</em> &nbsp; &nbsp; &nbsp;Responses from the High-SR fibers in the AN</li> <li><em>an_ms_</em> &nbsp; &nbsp; Responses from the Medium-SR fibers in the AN</li> <li><em>an_ls_</em> &nbsp; &nbsp; &nbsp; Responses from the Low-SR fibers in the AN</li> </ul> </li> <li>Each group has 5 responses corresponding to the on-frequency band (<em>_on</em>) and the three off-frequency bands (<em>_off_hf</em>, <em>_off_vhf</em>, <em>_off_uvhf</em>); and the sum across frequencies (<em>_across_f</em>)</li> </ul> </li> </ul>

opencc-by-4.0Aug 2017View details →
zenodo40/100

On the use of envelope following responses to estimate peripheral level compression in the auditory system

<p>Dataset&nbsp;containing the envelope following responses (EFR) recordings related to the manuscript &quot;Can envelope following responses be used to estimate level compression in the auditory system?&quot;.</p> <p>Files content and structure:</p> <p><strong>EFR:</strong></p> <ul> <li><em>1_data__efr_nh.csv</em>: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; EFR recordings from&nbsp;the normal-hearing (NH) listeners</li> <li><em>2_data__efr_hi.csv</em>: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;EFR recordings from&nbsp;the hearing-impaired (HI) listeners</li> <li><em>3_data__efr_nh_repeat.csv</em>: &nbsp; &nbsp; Repeated EFR recordings from&nbsp;the NH listeners</li> </ul> <p>The files regarding the EFR recordings contain:</p> <ul> <li><em>subject</em>: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; Listener id</li> <li><em>lvl_vect</em>: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;Stimulation level</li> <li><em>efr_magn_xxxx_hz: &nbsp;</em>EFR magnitude (dB re to 1&nbsp;&micro;V) for each of the simultaneously recorded frequencies (0.5, 1, 2 and 4 kHz).</li> <li><em>efr_bkg_xxxx_hz: &nbsp; &nbsp;&nbsp;</em>Magnitude (dB re to 1&nbsp;&micro;V)&nbsp;of an estimate of the background noise floor of the recording for each frequency.&nbsp;</li> <li><em>ftest_xxxx_hz: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;</em>Ftest (0 or 1) value for each frequency.</li> </ul> <p>&nbsp;</p> <p>Distortion-product otoacoustic emissions (DPOAE) were also recorded in the same listeners although the data was not included in the final manuscript. Details of the methodology used can be given on request.</p> <p><strong>DPOAE:</strong></p> <ul> <li><em>4_data__dpoae_nh.csv</em>: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;DPOAE recordings from&nbsp;the NH listeners.</li> </ul> <p>The files regarding the DPOAE recordings contain:</p> <ul> <li><em>subject</em>: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; Listener id</li> <li><em>lvl_vect</em>: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;Stimulation level</li> <li><em>dpoae_magn_xxxx_hz: &nbsp;</em>DPOAE magnitude (dB SPL) for each of the simultaneously recorded frequencies (0.5, 1, 2 and 4 kHz).</li> <li><em>dpoae_bkg_xxxx_hz: &nbsp; &nbsp;&nbsp;</em>Magnitude (dB SPL)&nbsp;of an estimate of the background noise floor of the recording for each frequency.&nbsp;</li> <li><em>signif_xxxx_hz: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;</em>Satisfaction of the significance criterion&nbsp;(0 or 1) for each frequency.</li> </ul> <p>&nbsp;</p>

opencc-by-4.0Aug 2017View details →

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